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Zhi Li Rong
Basic Medical Sciences
Southern Medical University
Guangdong
Language: Chinese, English
Stem Cells
Regenerative Medicine
Gene Editing
Lung Organoid
Skin Disease
Crispr
Cell Therapy
Tissue Engineering
Biomedical Research
Genetic Modification
Areas of Focus
- Stem cell and regenerative medicine
- Gene editing
Work Experience
- Director: Institute of Oncology, Southern Medical University
- Director: Institute of Dermatology, Southern Medical University
- Deputy Editor: Journal of Gene Medicine
Academic Background & Achievements
- Bachelor's and Doctorate in Biology: Tsinghua University
- Postdoctoral Research: University of California, San Diego
- Published 26 papers in journals like Cell Stem Cell, Nucleic Acids Research
- Total citations over 2900
- Co-authored a book on gene editing
- Applied for 3 international PCT patents and 10 Chinese invention patents (5 authorized)
Publications
- Single-cell transcriptome analysis reveals the dynamics of human immune cells during early fetal skin development., Xu, Y., Zhang, J., Hu, Y., Li, X., Sun, L., Peng, Y., Sun, Y., Liu, B., Bian, Z., Rong, Z., 2021
- Tag-seq: a convenient and scalable method for genome-wide specificity assessment of CRISPR/Cas nucleases., Huang, H., Hu, Y., Huang, G., Ma, S., Feng, J., Wang, D., Lin, Y., Zhou, J., Rong, Z., 2021
- Single-cell RNA-seq reveals fibroblast heterogeneity and increased mesenchymal fibroblasts in human fibrotic skin diseases., Deng, C.C., Hu, Y.F., Zhu, D.H., Cheng, Q., Gu, J.J., Feng, Q.L., Zhang, L.X., Xu, Y.P., Wang, D., Rong, Z., Yang, B., 2021
- MiniCAFE, a CRISPR/Cas9-based compact and potent transcriptional activator, elicits gene expression in vivo., Zhang, X., Lv, S., Luo, Z., Hu, Y., Peng, X., Lv, J., Zhao, S., Feng, J., Huang, G., Wan, Q.L., Liu, J., Huang, H., Luan, B., Wang, D., Zhao, X., Lin, Y., Zhou, Q., Zhang, Z.N., Rong, Z., 2021
- Host metabolism dysregulation and cell tropism identification in human airway and alveolar organoids upon SARS-CoV-2 infection., Pei, R., Feng, J., Zhang, Y., Sun, H., Li, L., Yang, X., He, J., Xiao, S., Xiong, J., Lin, Y., Wen, K., Zhou, H., Chen, J., Rong, Z., Chen, X., 2021
- OSMRβ mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients., Liu, J., Chen, J., Zhong, Y., Yu, X., Lu, P., Feng, J., Zhang, X., Ma, S., Yang, C., Yang, B., Rong, Z., 2021
- Inhibition of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Cascade Limits Chlamydia trachomatis infection., Xue, Y., Chen, W., Mai, Z., Yu, X., Wu, Q., Wan, C., Su, X., Wu, Y., Rong, Z., Zheng, H., 2021
- Enhancing site-specific DNA integration by a Cas9 nuclease fused with a DNA donor-binding domain., Ma, S., Wang, X., Hu, Y., Lv, J., Liu, C., Liao, K., Guo, X., Wang, D., Lin, Y., Rong, Z., 2020
- Cell-cell contact-induced gene editing/activation in mammalian cells using a synNotch-CRISPR/Cas9 system., Huang, H., Zhang, X., Lv, J., Yang, H., Wang, X., Ma, S., Shao, R., Peng, X., Lin, Y., Rong, Z., 2020
- Facile in situ synthesis of ultrasmall near-infrared-emitting gold glyconanoparticles with enhanced cellular uptake and tumor targeting., Wang, Y.P., Ma, S.F., Dai, Z.Y., Rong, Z., Liu, J., 2019
- TRAF4 promotes fibroblast proliferation in keloids by destabilizing p53 via interacting with the deubiquitinase USP10., Deng, C.C., Zhu, D.H., Chen, Y.J., Huang, T.Y., Peng, Y., Liu, S.Y., Lu, P., Xue, Y.H., Xu, Y.P., Yang, B., Rong, Z., 2019
- Gene activation in human cells using CRISPR/Cpf1-p300 and CRISPR/Cpf1-SunTag systems., Zhang, X., Wang, W., Shan, L., Han, L., Ma, S., Zhang, Y., Hao, B., Lin, Y., Rong, Z., 2018
- Long-Term Engraftment Promotes Differentiation of Alveolar Epithelial Cells from Human Embryonic Stem Cell Derived Lung Organoids., Chen, Y., Feng, J., Zhao, S., Han, L., Yang, H., Lin, Y., Rong, Z., 2018
- An effective approach to prevent immune rejection of human ESC-derived allografts., Rong, Z., Wang, M., Hu, Z., Stradner, M., Zhu, S., Kong, H., Yi, H., Goldrath, A., Yang, Y.G., Xu, Y., Fu, X., 2014
- A scalable approach to prevent teratoma formation of human embryonic stem cells., Rong, Z., Fu, X., Wang, M., Xu, Y., 2012
Awards
- 2015: Selected for the 11th batch of Overseas High-Level Talent Program
