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Zhang Sheng
Basic Medical Sciences
Southern Medical University
Guangdong
Language: Chinese, English
Glia
Demyelination
Remyelination
Neurodevelopment
Neurodegenerative Disease
Glial Cells
Myelin
Immune System
Cns
Neuroscience
Areas of Focus
- Mechanisms of glial cells and myelin in neurodevelopment and immune degenerative diseases
Work Experience
- 2015-2022: Postdoctoral and Researcher at University of California, Davis and Mayo Clinic
- Led postdoctoral project at UC Davis Children's Hospital
Academic Background & Achievements
- 2009-2014: PhD at Guangzhou University of Chinese Medicine
- Published 3 SCI papers as first author in the field of Parkinson's disease
Publications
- Glial cell specific regulation of CNS angiogenesis by Hifα-activated different signaling pathways, Zhang S*, Kim BK*, et al., and Guo FZ., 2020
- The Wnt effector TCF7l2 promotes oligodendroglial differentiation by repressing autocrine BMP4-mediated signaling, Zhang S*, Wang Y*, et al., and Guo FZ., 2021
- HIFα regulates developmental myelination independent of autocrine Wnt signaling, Zhang S, Wang Y, et al., and Guo FZ., 2021
- Sox2 is essential for oligodendroglial proliferation and differentiation during postnatal brain myelination and CNS remyelination, Zhang S*, Zhu XQ*, et al., and Guo FZ., 2018
- The Stem Cell Factor Sox2 Is a Positive Timer of Oligodendrocyte Development in the Postnatal Murine Spinal Cord, Zhang S, et al., and Guo FZ., 2018
- Sox2 is essential for astrocyte maturation and its deletion leads to hyperactive behavior in mice, Wang Y*, Zhang S*, Zhaohui Lan* et al., and Guo FZ., 2022
- PARP1-mediated PARylation activity is essential for oligodendroglial differentiation and CNS myelination, Wang Y, Zhang YH, Zhang S, et al., and Guo FZ., 2021
Awards
- 2016: Guangdong Science and Technology Progress Award, Second Prize
- 2017: Chinese Association of Traditional Chinese Medicine Science and Technology Award, Third Prize
- 2016: Patent for a drug composition for Parkinson's disease
