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Peng Chen
Basic Medical Sciences
Southern Medical University
Guangdong
Language: Chinese, English
Microbiome
Intestinal
Bacteria
Health
Disease
Metabolism
Immune
Therapy
Probiotics
Inflammation
Liver
Hepatic
Failure
Injury
Cirrhosis
Transplant
Regeneration
Function
Detoxification
Sepsis
Infection
Response
Shock
Organ
Treatment
Areas of Focus
- Gut microbiota
- Liver failure
- Sepsis
Work Experience
- 2015-present: Professor and Doctoral Supervisor at Southern Medical University
Academic Background & Achievements
- 2003—2007: Bachelor's degree at Nanjing University of Science and Technology
- 2007—2012: Doctorate at Nanjing University of Science and Technology
- 2012—2015: Postdoctoral research at University of California, San Diego
Publications
- Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism., Li D, Chen Y, Wan M, Mei F, Wang F, Gu P, Zhang X, Wei R, Zeng Y, Zheng H, Chen B, Xiong Q, Xue T, Guan T, Guo J, Tian Y, Zeng LY, Liu Z, Yuan H, Yang L, Liu H, Dai L, Yu Y, Qiu Y, Wu P, Win S, Than TA, Wei R, Schnabl B, Kaplowitz N, Jiang Y*, Ma Q*, Chen P*., 2024
- Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis., Xie S, Li J, Lyu F, Xiong Q, Gu P, Chen Y, Chen M, Bao J, Zhang X, Wei R, Deng Y, Wang H, Zeng Z, Chen Z, Deng Y, Lian Z, Zhao J, Gong W, Chen Y, Liu KX, Duan Y*, Jiang Y*, Zhou HW*, Chen P*., 2024
- An engineered Escherichia coli Nissle strain prevents lethal liver injury in a mouse model of tyrosinemia type 1., Gu P, Xie L, Chen T, Yang Q, Zhang X, Liu R, Guo J, Wei R, Li D, Jiang Y, Chen Y*, Gong W*, Chen P*., 2024
- A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis., Gu P, Liu R, Yang Q, Xie L, Wei R, Li J, Mei F, Chen T, Zeng Z, He Y, Zhou H, Peng H, Nandakumar KS, Chu H, Jiang Y, Gong W*, Chen Y*, Schnabl B, Chen P*., 2023
- Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2 complex to attenuate inflammation and protect against sepsis., Li J, Chen Y, Li R, Zhang X, Chen T, Mei F, Liu R, Chen M, Ge Y, Hu H, Wei R, Chen Z, Fan H, Zeng Z, Deng Y, Luo H, Hu S, Cai S, Wu F, Shi N, Wang Z, Zeng Y, Xie M, Jiang Y, Chen Z*, Jia W*, Chen P*., 2023
- Microbial liberation of daidzein by β-galactosidase suppresses acetaminophen induced hepatocyte ferroptosis in mice., Zeng Y, Wu R, Wang F, Li S, Li L, Li Y, Qin P, Wei M, Yang J, Wu J, Chen A, Ke G, Yan Z, Yang H, Chen Z, Wang Z, Xiao W, Jiang Y, Chen X, Zeng Z*, Zhao X*, Chen P*, Gong S*., 2023
- Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice., Gong S, Lan T, Zeng L, Luo H, Yang X, Li N, Chen X, Liu Z, Li R, Win S, Liu S, Zhou H, Schnabl B, Jiang Y*, Kaplowitz N, Chen P*., 2018
- Intestinal microbiota mediates the susceptibility to polymicrobial sepsis-induced liver injury by granisetron generation in mice., Gong S, Yan Z, Liu Z, Niu M, Fang H, Li N, Huang C, Li L, Chen G, Luo H, Chen X, Zhou H, Hu J, Yang W, Huang Q, Schnabl B, Chang P*, Billiar TR, Jiang Y*, Chen P*., 2019
- Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice., Wang F, Gong S, Wang T, Li L, Luo H, Wang J, Huang C, Zhou H, Chen G, Liu Z, Zhang Q, Jiang Y*, Chen P*., 2020
- The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice., Li R, Xie L, Li L, Chen X, Yao T, Tian Y, Li Q, Wang K, Huang C, Li C, Li Y, Zhou H, Kaplowitz N, Jiang Y*, Chen P*., 2022
- Gut commensal metabolite rhamnose promotes bacterial clearance by activating SLC12A4 in macrophages and protects against sepsis in mice., Li D, Wei R, Zhang X, Gong S, Wan M, Wang F, Li J, Chen M, Liu R, Wan Y, Hong Y, Zeng Z, Gu P, Wang Z, Nandakumar KS, Jiang Y, Zhou H*, Chen P*., 2024
- Targeting gut microbiota to counteract acetaminophen-induced acute liver injury., Chen P*., 2024
Awards
- 2016: Guangdong High-level Talent
- 2020: Ministry of Education Young High-level Talent
