Professor | Peng Chen | Asia Growth Partners

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Name	Peng Chen
Contact Information	perchen@smu.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Peng Chen

Contact Information

perchen@smu.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Southern Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	2003—2007: Bachelor's degree at Nanjing University of Science and Technology 2007—2012: Doctorate at Nanjing University of Science and Technology 2012—2015: Postdoctoral research at University of California, San Diego
Work Experience	2015-present: Professor and Doctoral Supervisor at Southern Medical University
Awards	2016: Guangdong High-level Talent 2020: Ministry of Education Young High-level Talent

University/Lab Affiliation and Title

Southern Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

2003—2007: Bachelor's degree at Nanjing University of Science and Technology
2007—2012: Doctorate at Nanjing University of Science and Technology
2012—2015: Postdoctoral research at University of California, San Diego

Work Experience

2015-present: Professor and Doctoral Supervisor at Southern Medical University

Awards

2016: Guangdong High-level Talent
2020: Ministry of Education Young High-level Talent

Areas of Focus	Gut microbiota Liver failure Sepsis
Publications	Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism., Li D, Chen Y, Wan M, Mei F, Wang F, Gu P, Zhang X, Wei R, Zeng Y, Zheng H, Chen B, Xiong Q, Xue T, Guan T, Guo J, Tian Y, Zeng LY, Liu Z, Yuan H, Yang L, Liu H, Dai L, Yu Y, Qiu Y, Wu P, Win S, Than TA, Wei R, Schnabl B, Kaplowitz N, Jiang Y, Ma Q, Chen P., 2024 Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis., Xie S, Li J, Lyu F, Xiong Q, Gu P, Chen Y, Chen M, Bao J, Zhang X, Wei R, Deng Y, Wang H, Zeng Z, Chen Z, Deng Y, Lian Z, Zhao J, Gong W, Chen Y, Liu KX, Duan Y, Jiang Y, Zhou HW, Chen P., 2024 An engineered Escherichia coli Nissle strain prevents lethal liver injury in a mouse model of tyrosinemia type 1., Gu P, Xie L, Chen T, Yang Q, Zhang X, Liu R, Guo J, Wei R, Li D, Jiang Y, Chen Y, Gong W, Chen P., 2024 A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis., Gu P, Liu R, Yang Q, Xie L, Wei R, Li J, Mei F, Chen T, Zeng Z, He Y, Zhou H, Peng H, Nandakumar KS, Chu H, Jiang Y, Gong W, Chen Y, Schnabl B, Chen P., 2023 Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2 complex to attenuate inflammation and protect against sepsis., Li J, Chen Y, Li R, Zhang X, Chen T, Mei F, Liu R, Chen M, Ge Y, Hu H, Wei R, Chen Z, Fan H, Zeng Z, Deng Y, Luo H, Hu S, Cai S, Wu F, Shi N, Wang Z, Zeng Y, Xie M, Jiang Y, Chen Z, Jia W, Chen P., 2023 Microbial liberation of daidzein by β-galactosidase suppresses acetaminophen induced hepatocyte ferroptosis in mice., Zeng Y, Wu R, Wang F, Li S, Li L, Li Y, Qin P, Wei M, Yang J, Wu J, Chen A, Ke G, Yan Z, Yang H, Chen Z, Wang Z, Xiao W, Jiang Y, Chen X, Zeng Z, Zhao X, Chen P, Gong S., 2023 Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice., Gong S, Lan T, Zeng L, Luo H, Yang X, Li N, Chen X, Liu Z, Li R, Win S, Liu S, Zhou H, Schnabl B, Jiang Y, Kaplowitz N, Chen P., 2018 Intestinal microbiota mediates the susceptibility to polymicrobial sepsis-induced liver injury by granisetron generation in mice., Gong S, Yan Z, Liu Z, Niu M, Fang H, Li N, Huang C, Li L, Chen G, Luo H, Chen X, Zhou H, Hu J, Yang W, Huang Q, Schnabl B, Chang P, Billiar TR, Jiang Y, Chen P., 2019 Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice., Wang F, Gong S, Wang T, Li L, Luo H, Wang J, Huang C, Zhou H, Chen G, Liu Z, Zhang Q, Jiang Y, Chen P., 2020 The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice., Li R, Xie L, Li L, Chen X, Yao T, Tian Y, Li Q, Wang K, Huang C, Li C, Li Y, Zhou H, Kaplowitz N, Jiang Y, Chen P., 2022 Gut commensal metabolite rhamnose promotes bacterial clearance by activating SLC12A4 in macrophages and protects against sepsis in mice., Li D, Wei R, Zhang X, Gong S, Wan M, Wang F, Li J, Chen M, Liu R, Wan Y, Hong Y, Zeng Z, Gu P, Wang Z, Nandakumar KS, Jiang Y, Zhou H, Chen P., 2024 Targeting gut microbiota to counteract acetaminophen-induced acute liver injury., Chen P., 2024

Areas of Focus

Gut microbiota
Liver failure
Sepsis

Publications

Oral magnesium prevents acetaminophen-induced acute liver injury by modulating microbial metabolism., Li D, Chen Y, Wan M, Mei F, Wang F, Gu P, Zhang X, Wei R, Zeng Y, Zheng H, Chen B, Xiong Q, Xue T, Guan T, Guo J, Tian Y, Zeng LY, Liu Z, Yuan H, Yang L, Liu H, Dai L, Yu Y, Qiu Y, Wu P, Win S, Than TA, Wei R, Schnabl B, Kaplowitz N, Jiang Y*, Ma Q*, Chen P*., 2024
Novel tripeptide RKH derived from Akkermansia muciniphila protects against lethal sepsis., Xie S, Li J, Lyu F, Xiong Q, Gu P, Chen Y, Chen M, Bao J, Zhang X, Wei R, Deng Y, Wang H, Zeng Z, Chen Z, Deng Y, Lian Z, Zhao J, Gong W, Chen Y, Liu KX, Duan Y*, Jiang Y*, Zhou HW*, Chen P*., 2024
An engineered Escherichia coli Nissle strain prevents lethal liver injury in a mouse model of tyrosinemia type 1., Gu P, Xie L, Chen T, Yang Q, Zhang X, Liu R, Guo J, Wei R, Li D, Jiang Y, Chen Y*, Gong W*, Chen P*., 2024
A metabolite from commensal Candida albicans enhances the bactericidal activity of macrophages and protects against sepsis., Gu P, Liu R, Yang Q, Xie L, Wei R, Li J, Mei F, Chen T, Zeng Z, He Y, Zhou H, Peng H, Nandakumar KS, Chu H, Jiang Y, Gong W*, Chen Y*, Schnabl B, Chen P*., 2023
Gut microbial metabolite hyodeoxycholic acid targets the TLR4/MD2 complex to attenuate inflammation and protect against sepsis., Li J, Chen Y, Li R, Zhang X, Chen T, Mei F, Liu R, Chen M, Ge Y, Hu H, Wei R, Chen Z, Fan H, Zeng Z, Deng Y, Luo H, Hu S, Cai S, Wu F, Shi N, Wang Z, Zeng Y, Xie M, Jiang Y, Chen Z*, Jia W*, Chen P*., 2023
Microbial liberation of daidzein by β-galactosidase suppresses acetaminophen induced hepatocyte ferroptosis in mice., Zeng Y, Wu R, Wang F, Li S, Li L, Li Y, Qin P, Wei M, Yang J, Wu J, Chen A, Ke G, Yan Z, Yang H, Chen Z, Wang Z, Xiao W, Jiang Y, Chen X, Zeng Z*, Zhao X*, Chen P*, Gong S*., 2023
Gut microbiota mediates diurnal variation of acetaminophen induced acute liver injury in mice., Gong S, Lan T, Zeng L, Luo H, Yang X, Li N, Chen X, Liu Z, Li R, Win S, Liu S, Zhou H, Schnabl B, Jiang Y*, Kaplowitz N, Chen P*., 2018
Intestinal microbiota mediates the susceptibility to polymicrobial sepsis-induced liver injury by granisetron generation in mice., Gong S, Yan Z, Liu Z, Niu M, Fang H, Li N, Huang C, Li L, Chen G, Luo H, Chen X, Zhou H, Hu J, Yang W, Huang Q, Schnabl B, Chang P*, Billiar TR, Jiang Y*, Chen P*., 2019
Soyasaponin II protects against acute liver failure through diminishing YB-1 phosphorylation and Nlrp3-inflammasome priming in mice., Wang F, Gong S, Wang T, Li L, Luo H, Wang J, Huang C, Zhou H, Chen G, Liu Z, Zhang Q, Jiang Y*, Chen P*., 2020
The gut microbial metabolite, 3,4-dihydroxyphenylpropionic acid, alleviates hepatic ischemia/reperfusion injury via mitigation of macrophage pro-inflammatory activity in mice., Li R, Xie L, Li L, Chen X, Yao T, Tian Y, Li Q, Wang K, Huang C, Li C, Li Y, Zhou H, Kaplowitz N, Jiang Y*, Chen P*., 2022
Gut commensal metabolite rhamnose promotes bacterial clearance by activating SLC12A4 in macrophages and protects against sepsis in mice., Li D, Wei R, Zhang X, Gong S, Wan M, Wang F, Li J, Chen M, Liu R, Wan Y, Hong Y, Zeng Z, Gu P, Wang Z, Nandakumar KS, Jiang Y, Zhou H*, Chen P*., 2024
Targeting gut microbiota to counteract acetaminophen-induced acute liver injury., Chen P*., 2024

Microbiome Intestinal Bacteria Health Disease Metabolism Immune Therapy Probiotics Inflammation Liver Hepatic Failure Injury Cirrhosis Transplant Regeneration Function Detoxification Sepsis Infection Response Shock Organ Treatment

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