Ling Yuan
Life Science
Central South University
Hunan
Language: Chinese, English
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Autism Neurodevelopment Genetics Pathogenesis Gene Editing Mouse Models Neuronal Activity Behavioral Studies Multidisciplinary Therapeutic Approaches
Areas of Focus
  • Autism Spectrum Disorders
Academic Background & Achievements
  • 2012-2018 PhD: Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Supervisor: Xu Zhicheng
  • Published as first and corresponding author in top journals including Science, PNAS, PLoS Biology, EBioMedicine
Publications
  • KCTD10 regulates brain development by destabilizing brain disorder-associated protein KCTD13, Ling Yuan, 2024
  • A Single Mutation in the prM Protein of Zika Virus Contributes to Fetal Microcephaly, Ling Yuan, 2017
  • MEKK3 Coordinates with FBW7 to Regulate WDR62 Stability and Neurogenesis, Ling Yuan, 2018
  • American Strain of Zika Virus Causes More Severe Microcephaly Than an Old Asian Strain in Neonatal Mice, Ling Yuan, 2017
  • Comparative Profiling of Gene Expression in Camellia Sinensis L. Cultivar AnJiBaiCha Leaves during Periodic Albinism, Ling Yuan, 2015
  • Epigenetic Regulation of Atrophin1 by Lysine-specific Demethylase 1 is Required for Cortical Progenitor Maintenance, Ling Yuan, 2014
  • Zika Virus Protease Cleavage of Host Protein Septin-2 Mediates Mitotic Defects in Neural Progenitors, Ling Yuan, 2019
  • Chloroquine, a FDA-approved Drug, Prevents Zika Virus Infection and its Associated Congenital Microcephaly in Mice, Ling Yuan, 2017
  • Zika-Virus-Encoded NS2A Disrupts Mammalian Cortical Neurogenesis by Degrading Adherens Junction Proteins, Ling Yuan, 2017
  • Fast Super-resolution Imaging Technique and Immediate Early Nanostructure Capturing by a Photo-convertible Fluorescent Protein, Ling Yuan, 2019
  • Pathophysiological Significance of WDR62 and JNK Signaling in Human Diseases, Ling Yuan, 2021
  • Zika Virus and Its Association with Neurological Disorders, Ling Yuan, 2022
  • Stress‑Activated Protein Kinase JNK Modulates Depression‑like Behaviors in Mice, Ling Yuan, 2023
  • GIGYF1 disruption associates with autism and impaired IGF-1R signaling, Ling Yuan, 2022
  • De novo variants in genes regulating stress granule assembly associate with neurodevelopmental disorders, Ling Yuan, 2022
Awards
  • 2017 Selected as 'Major Scientific and Technological Engineering Progress of China'
  • 2017 Nominated for 'Top 30 Scientific Advances in China'
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