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Xiaoyang Zhao
Laboratory Medicine and Biotechnology
Southern Medical University
Guangdong
Language: Chinese, English
Stem Cells
Development
Reproduction
Infertility
Spermatogenesis
Organoids
Cell Biology
Genomics
Biotechnology
Medicine
Areas of Focus
- Stem Cells
- Developmental and Reproductive Medicine
Work Experience
- 2015 - Present: Southern Medical University
- 2011 - 2015: Institute of Zoology, Chinese Academy of Sciences
Academic Background & Achievements
- 2004 - PhD: Institute of Zoology, Chinese Academy of Sciences
- Achievement: Published 26 papers in journals like Nature, Cell Stem Cell, Nature Cell Biology
Publications
- Single-cell multi-omics sequencing of human spermatogenesis reveals a DNA demethylation event associated with male meiotic recombination., Huang YP, Li L, An G, Yang XY, Cui MM, Song XL, Lin J, Zhang XL, Yao ZK, Wan C, Zhou C, Zhao JX, Song K, Ren SF, Xia XY, Fu X, Lan Y, Hu XS, Wang W, Wang M, Zheng Y, Miao K, Bai XC, Hutchins AP, Chang G, Gao S, Zhao XY, 2023
- Lovastatin Promotes the Self-renewal of Murine and Primate Spermatogonial Stem Cells., Li CH, Yao ZK, Ma LZ, Song XL, Wang W, Wan C, Ren SF, Chen DY, Zheng Y, Zhu YT, Chang G, Wu SH, Miao K, Luo F, Zhao XY, 2023
- Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models., Song K, Yang XY, An G, Xia XY, Zhao JX, Xu XH, Wan C, Liu TY, Zheng Y, Ren SF, Wang M, Chang G, Shane Cronin, Josef Penninger, Jing T, Ou XH, Rao S, Liu ZT, Zhao XY, 2022
- The Chemical Reprogramming of Unipotent Adult Germ Cells towards Authentic Pluripotency and de novo Establishment of Imprinting., Chen YH, Lu JS, Xu YW, Huang YP, Wang DZ, Liang PL, Ren SF, Hu XS, Qin YW, Ke W, Jauch R, Hutchins AP, Wang M, Tang FC, Zhao XY, 2023
- Single-cell multi-omics sequencing reveals the reprogramming defects in embryos generated by round spermatid injection., Wang J, Zhou C, Gao S, Song XL, Yang XY, Fan JQ, Ren SF, Ma LZ, Zhao JX, Cui MM, Song K, Wang M, Li CH, Zheng Y, Luo F, Miao K, Bai XC, Hutchins AP, Li L, Chang G, Zhao XY, 2022
- Cell-fate transition and determination analysis of mouse male germ cells throughout development., Zhao JX, Lu P, Wan C, Huang YP, Cui MM, Yang XY, Hu YQ, Zheng Y, Dong J, Wang M, Zhang S, Liu ZT, Bian SH, Wang XM, Wang R, Ren SF, Wang DZ, Yao ZK, Chang G, Tang FC, Zhao XY, 2021
- CellCall: Integrating paired ligand-receptor and transcription factor activities for cell-cell communication., Zhang Y, Liu TY, Hu XS, Wang M, Wang J, Zou BH, Tan PW, Cui TY, Dou YY, Ning L, Huang Y, Rao S, Wang D, Zhao XY, 2021
- The Chromatin Accessibility Landscape Reveals Distinct Transcriptional Regulation in the Generation of Human Primordial Germ Cell-Like Cells from Pluripotent Stem Cells., Wang XM, Veerapandian V, Yang XY, Song K, Xu XH, Cui MM, Yuan WY, Huang YP, Xia XY, Yao ZK, Wan C, Luo F, Song XL, Wang XR, Zheng Y, Hutchins AP, Jauch R, Liang MY, Wang CH, Liu ZT, Chang G, Zhao XY, 2021
- Single-Cell RNA Sequencing Analysis Reveals Sequential Cell Fate Transition during Human Spermatogenesis., Wang M, Liu X, Chang G, Chen Y, An G, Yan L, Gao S, Xu Y, Cui Y, Dong J, Chen Y, Fan X, Hu Y, Song K, Zhu X, Gao Y, Yao Z, Bian S, Hou Y, Lu J, Wang R, Fan Y, Lian Y, Tang W, Wang Y, Liu J, Zhao L, Wang L, Liu Z, Yuan R, Shi Y, Hu B, Ren X, Tang F, Zhao XY, Qiao J, 2018
- Complete meiosis from ES-cell derived germ cells in vitro., Zhou Q, Wang M, Yuan Y, Wang W, Fu R, Wan H, Xie M, Liu M, Guo X, Zheng Y, Feng G, Shi Q, Zhao XY, Sha J, Zhou Q, 2016
- Androgenetic haploid embryonic stem cells produce live transgenic mice., Li W, Shuai L, Wan HF, Dong MZ, Wang M, Sang LS, Feng CJ, Luo GZ, Li TD, Li X, Wang L, Zheng QY, Sheng C, Wu HJ, Liu Z, Liu L, Wang XJ, Zhao XY, Zhou Q, 2012
- iPS cells produce viable mice through tetraploid complementation., Zhao XY, Li W, Lv Z, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng FY, Zhou Q, 2009
Awards
- 2021: National Natural Science Second Prize
- 2018: Zhongyuan Concord Life Medicine Innovation Breakthrough Award
- 2017: Stem Cell Young Researcher Award
