Professor | Xianchi Dong | Asia Growth Partners

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Name	Xianchi Dong
Contact Information	xianchidong@nju.edu.cn
Language ability	English, Chinese
Province	Jiangsu

Upload Avatar (500 x 500)

Name

Xianchi Dong

Contact Information

xianchidong@nju.edu.cn

Language ability

English, Chinese

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing University
Faculty	Life Sciences
Academic Background & Achievements	Bachelor's: Nanjing University, School of Life Sciences Ph.D.: Shanghai Institute of Life Sciences, Chinese Academy of Sciences Postdoctoral: Harvard Medical School
Work Experience	Lecturer: Harvard Medical School Professor: Nanjing University, School of Life Sciences

University/Lab Affiliation and Title

Nanjing University

Faculty

Life Sciences

Academic Background & Achievements

Bachelor's: Nanjing University, School of Life Sciences
Ph.D.: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
Postdoctoral: Harvard Medical School

Work Experience

Lecturer: Harvard Medical School
Professor: Nanjing University, School of Life Sciences

Areas of Focus	Research on important proteins and protein complexes in the immune and coagulation systems
Publications	Discovery of a potent apo-IDO1 inhibitor for cancer immunotherapy, Wen Liu, Yi Zou, Kaiming Li, Shushan Ge, Haiqing Zhong, Yuanyuna Wang, Yue Hu, Yisheng Lai, Xianchi Dong, Qiang Xu, Wenjie Guo, 2022 N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2, Tian F, Tong B, Sun L, Shi S, Zheng B, Wang Z, Dong X, Zheng P, 2021 Disulfide Exchange in Multimerization of von Willebrand factor and Gel-forming Mucins, Dong X., Springer T.A., 2021 The von Willebrand Factor D’D3 Assembly and Structural Principles for Factor VIII binding and Concatemer Biogenesis, Dong X., Leksa N.C., Chhabra E.S., Arndt J.W., Lu Q., Knockenhauer K.E., Peter R., Springer T.A., 2019 Fusion surface structure, function, and dynamics of gamete fusogen HAP2, Feng J., Dong X., Pinello J.F., Zhang J., Lu C., Iacob R.E., Engen J.R., Snell W.J., Springer T.A., 2018 High integrin αVβ6 affinity reached by hybrid domain deletion slows ligand-binding on-rate, Dong X., Zhao B., Lin F. Lu C., Roger B.N., Springer T.A., 2018 Force Interacts with Macromolecular Structure in Activation of TGF-b, Dong X., Zhao B., Iacob R.E., Zhu J., Koksal A.C., Lu C., Engen J.R., Springer T.A., 2017 Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus, Kotecha A., Wang Q., Dong X., Ilca S., Ondiviela M., Rao Z., Seago J., Charleston B., Fry E., Abrescia N., Springer A., Huiskonen J., Stuart D., 2017 Atypical Interactions of Integrin αvβ8 with pro-TGF-β1, Wang J, Dong X., Zhao B., Li J., Lu C., Springer T.A., 2017 Structural determinants of integrin β-subunit specificity for latent TGF-β, Dong X., Hudson N., Lu C., Springer T.A., 2014 Towards the structural basis of regulation by force of von Willebrand factor binding to Glycoprotein Ib, Blenner M.A., Dong X., Springer T.A., 2014 αVβ3 Integrin crystal structures and their functional implications, Dong X., Mi L., Zhu J., Wang W., Hu P., Luo B. H., Springer T.A., 2012 GARP regulates the bioavailability and activation of TGF-β, Wang R., Zhu J., Dong X., Shi M., Lu C., Springer T.A., 2012 Docking-based virtual screening of potential human P2Y12 receptor antagonists, Chen H., Dong X., Zhou M., Shi H., Luo X., 2011 A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13, Zhou M., Dong X., Baldauf C., Chen H., Zhou Y., Springer T.A., Lu X., Zhong, C., Grater, F., Ding, J., 2011 SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation, Zhou B., Wang S., Xu L.X., Meng F.L., Xuan Y.J., Duan Y.M., Wang J.Y., Hu H., Dong X., Ding J., Zhou J.Q., 2010 Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design, Zhou M., Dong X., Shen N., Zhong C., Ding J., 2010 Crystal structure of Pyrococcus horikoshii tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetase, Dong X., Zhou M., Zhong C., Yang B., Shen N., Ding J., 2010 Molecular basis of the acceleration of the GDP-GTP exchange of human Ras homolog enriched in brain by human translationally controlled tumor protein, Dong X., Yang B., Li Y., Zhong C., Ding J., 2009

Areas of Focus

Research on important proteins and protein complexes in the immune and coagulation systems

Publications

Discovery of a potent apo-IDO1 inhibitor for cancer immunotherapy, Wen Liu, Yi Zou, Kaiming Li, Shushan Ge, Haiqing Zhong, Yuanyuna Wang, Yue Hu, Yisheng Lai, Xianchi Dong, Qiang Xu, Wenjie Guo, 2022
N501Y mutation of spike protein in SARS-CoV-2 strengthens its binding to receptor ACE2, Tian F, Tong B, Sun L, Shi S, Zheng B, Wang Z, Dong X, Zheng P, 2021
Disulfide Exchange in Multimerization of von Willebrand factor and Gel-forming Mucins, Dong X., Springer T.A., 2021
The von Willebrand Factor D’D3 Assembly and Structural Principles for Factor VIII binding and Concatemer Biogenesis, Dong X., Leksa N.C., Chhabra E.S., Arndt J.W., Lu Q., Knockenhauer K.E., Peter R., Springer T.A., 2019
Fusion surface structure, function, and dynamics of gamete fusogen HAP2, Feng J., Dong X., Pinello J.F., Zhang J., Lu C., Iacob R.E., Engen J.R., Snell W.J., Springer T.A., 2018
High integrin αVβ6 affinity reached by hybrid domain deletion slows ligand-binding on-rate, Dong X., Zhao B., Lin F. Lu C., Roger B.N., Springer T.A., 2018
Force Interacts with Macromolecular Structure in Activation of TGF-b, Dong X., Zhao B., Iacob R.E., Zhu J., Koksal A.C., Lu C., Engen J.R., Springer T.A., 2017
Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus, Kotecha A., Wang Q., Dong X., Ilca S., Ondiviela M., Rao Z., Seago J., Charleston B., Fry E., Abrescia N., Springer A., Huiskonen J., Stuart D., 2017
Atypical Interactions of Integrin αvβ8 with pro-TGF-β1, Wang J, Dong X., Zhao B., Li J., Lu C., Springer T.A., 2017
Structural determinants of integrin β-subunit specificity for latent TGF-β, Dong X., Hudson N., Lu C., Springer T.A., 2014
Towards the structural basis of regulation by force of von Willebrand factor binding to Glycoprotein Ib, Blenner M.A., Dong X., Springer T.A., 2014
αVβ3 Integrin crystal structures and their functional implications, Dong X., Mi L., Zhu J., Wang W., Hu P., Luo B. H., Springer T.A., 2012
GARP regulates the bioavailability and activation of TGF-β, Wang R., Zhu J., Dong X., Shi M., Lu C., Springer T.A., 2012
Docking-based virtual screening of potential human P2Y12 receptor antagonists, Chen H., Dong X., Zhou M., Shi H., Luo X., 2011
A novel calcium-binding site of von Willebrand factor A2 domain regulates its cleavage by ADAMTS13, Zhou M., Dong X., Baldauf C., Chen H., Zhou Y., Springer T.A., Lu X., Zhong, C., Grater, F., Ding, J., 2011
SWR1 complex poises heterochromatin boundaries for antisilencing activity propagation, Zhou B., Wang S., Xu L.X., Meng F.L., Xuan Y.J., Duan Y.M., Wang J.Y., Hu H., Dong X., Ding J., Zhou J.Q., 2010
Crystal structures of Saccharomyces cerevisiae tryptophanyl-tRNA synthetase: new insights into the mechanism of tryptophan activation and implications for anti-fungal drug design, Zhou M., Dong X., Shen N., Zhong C., Ding J., 2010
Crystal structure of Pyrococcus horikoshii tryptophanyl-tRNA synthetase and structure-based phylogenetic analysis suggest an archaeal origin of tryptophanyl-tRNA synthetase, Dong X., Zhou M., Zhong C., Yang B., Shen N., Ding J., 2010
Molecular basis of the acceleration of the GDP-GTP exchange of human Ras homolog enriched in brain by human translationally controlled tumor protein, Dong X., Yang B., Li Y., Zhong C., Ding J., 2009

Immune System Coagulation Proteins Protein Complexes Research Biochemistry Molecular Biology Immunotherapy Cancer Inhibitors

Lu Dongdong - Tongji University

Zhengwu Qi - Tongji University

Haiyun Wang - Tongji University

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