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Yajun Jiang
Life Science
Nanjing University
Jiangsu
Language: Chinese, English
Neurodegenerative Diseases
Molecular Mechanisms
Protein Machines
Dynamic Principles
Nmr Technology
Biological Research
Molecular Biology
Protein Dynamics
Disease Regulation
Small Molecule Compounds
Areas of Focus
- Molecular mechanisms of neurodegenerative diseases
- Dynamic working principles of protein machines
- Application of ultra-large molecular biological NMR technology
Work Experience
- 2012.9-2015.7 Rutgers University, Department of Chemistry and Chemical Biology - Postdoctoral Researcher
- 2015.8-2017.7 University of Minnesota, Department of Biochemistry, Molecular Biology, and Biophysics - Postdoctoral Researcher
- 2017.8-2021.1 St. Jude Children's Research Hospital, Department of Structural Biology - Postdoctoral Researcher
- 2021.2- Nanjing University, School of Life Sciences - Distinguished Researcher
- 2021.2- Nanjing University, Institute of Chemistry and Biomedical Innovation - Distinguished Researcher
Academic Background & Achievements
- 2001.9-2005.6 Bachelor: Nanjing University, School of Life Sciences
- 2005.9-2012.1 Doctorate: Shanghai Institute of Life Sciences, Chinese Academy of Sciences
Publications
- Structural basis for client recognition and activity of Hsp40 chaperones, Jiang Y, Rossi P, Kalodimos CG, 2019
- Confirmation for conformational selection, Jiang Y, Kalodimos CG, 2018
- Automatic methyl assignment in large proteins by the MAGIC algorithm, Monneau YR, Rossi P, Bhaumik A, Huang C, Jiang Y, Saleh T, Xie T, Xing Q, Kalodimos CG, 2017
- NMR Studies of Large Proteins, Jiang Y, Kalodimos CG, 2017
- TDP-35 sequesters TDP-43 into cytoplasmic inclusions through binding with RNA, Che MX, Jiang LL, Li HY, Jiang YJ, Hu HY, 2015
- Aggregation of polyglutamine-expanded ataxin-3 sequesters its specific interacting partners into inclusions: Implication in a loss-of-function pathology, Yang H, Li JJ, Liu S, Zhao J, Jiang YJ, Song AX, Hu HY, 2014
- Autoinhibitory structure of the WW domain of HYPB/SETD2 regulates its interaction with the proline-rich region of huntingtin, Gao YG, Yang H, Zhao J, Jiang YJ, Hu HY, 2014
- Structural basis for recognition of the third SH3 domain of Full-length R85(R85FL)/Ponsin by Ataxin-7, Jiang YJ, Zhou CJ, Zhou ZR, Wu M, and Hu HY, 2013
- Interaction with Polyglutamine-expanded Huntingtin Alters Cellular Distribution and RNA Processing of Huntingtin Yeast Two-hybrid Protein A (HYPA), Jiang YJ, Che MX, Yuan JQ, Xie YY, Yan XZ, Hu HY, 2011
- Aggregation of the 35-kDa fragment of TDP-43 causes formation of cytoplasmic inclusions and alteration of RNA processing, Che MX, Jiang YJ, Xie YY, Jiang LL, Hu HY, 2011
- Structural basis for ubiquitin recognition by a novel domain from human phospholipase A2-activating protein, Fu QS, Zhou CJ, Gao HC, Jiang YJ, Zhou ZR, Hong J, Yao WM, Song AX, Lin DH, Hu HY, 2009
Awards
- National Youth Talent Program
