Professor | Qiang Xu | Asia Growth Partners

Name	Qiang Xu
Contact Information	qiangxu@nju.edu.cn
Language ability	Chinese, English
Province	Jiangsu

Name

Qiang Xu

Contact Information

qiangxu@nju.edu.cn

Language ability

Chinese, English

Province

Jiangsu

University/Lab Affiliation and Title	Nanjing University
Faculty	Life Sciences
Academic Background & Achievements	Recipient of the National Science Fund for Distinguished Young Scholars Appointed as a Distinguished Professor by the Ministry of Education
Awards	China Youth Science and Technology Award (1994): Fourth session Wu Jieping-Paul Janssen Medical & Pharmaceutical Research Award (1994): Second Prize Selected for the Ministry of Education's Cross-Century Excellent Talent Training Program (1995) Title of National Young and Middle-aged Expert with Outstanding Contributions (1996) Nomination for the First Jiangsu Young Scientist Award (1996) Recipient of the National Science Fund for Distinguished Young Scholars (1999) Appointed as a Distinguished Professor by the Ministry of Education (2001) First Prize in Natural Science by the Ministry of Education (2011)

University/Lab Affiliation and Title

Nanjing University

Faculty

Life Sciences

Academic Background & Achievements

Recipient of the National Science Fund for Distinguished Young Scholars
Appointed as a Distinguished Professor by the Ministry of Education

Awards

China Youth Science and Technology Award (1994): Fourth session
Wu Jieping-Paul Janssen Medical & Pharmaceutical Research Award (1994): Second Prize
Selected for the Ministry of Education's Cross-Century Excellent Talent Training Program (1995)
Title of National Young and Middle-aged Expert with Outstanding Contributions (1996)
Nomination for the First Jiangsu Young Scientist Award (1996)
Recipient of the National Science Fund for Distinguished Young Scholars (1999)
Appointed as a Distinguished Professor by the Ministry of Education (2001)
First Prize in Natural Science by the Ministry of Education (2011)

Areas of Focus	Molecular basis and selective regulation of immune response and inflammation Molecular mechanisms of inflammation-cancer transformation Chemical biology research based on the characteristics of small molecule compounds
Publications	Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer., Wenjie Guo, Yang Sun, Wen Liu, Xingxin Wu, Lele Guo, Peifen Cai, Xuefeng Wu, Xudong Wu, Yan Shen, Yongqian Shu, Yanhong Gu, Qiang Xu, 2014 Disruption of chaperone-mediated autophagy dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization., Li Zhang, Yang Sun, Mingjian Fei, Cheng Tan, Jing Wu, Jie Zheng, Jiqing Tang, Wei Sun, Zhaoliang Lv, Jiandong Bao, Qiang Xu and Huixin Yu, 2014 SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2., Li W, Ouyang Z, Zhang Q, Wang L, Shen Y, Wu X, Gu Y, Shu Y, Yu B, Wu X, Sun Y, Xu Q, 2014 Trichomide A, a natural cyclodepsipeptide, exerts immunosuppressive activity against activated T lymphocytes by upregulating SHP2 activation to overcome contact dermatitis., Wang X, Zhang A, Gao J, Chen W, Wang S, Wu X, Shen Y, Ke Y, Hua Z, Tan R, Sun Y, Xu Q, 2014 Blocking initial infiltration of pioneer CD8+ T cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice., Luo Q, Sun Y, Gong FY, Liu W, Zheng W, Shen Y, Hua ZC, Feng GS, Xu Q, 2014 Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells distinct from cisplatin., WJ Guo, YM Zhang, L Zhang, B Huang, FF Tao, W Chen, ZJ Guo, Q Xu, Y Sun, 2013 A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide., Q Luo, Y Sun, W Liu, C Qian, B Jin, F Tao, Y Gu, X Wu, Y Shen, Q Xu, 2013 Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis., T Zhang, W Guo, Y Yang, W Liu, L Guo, Y Gu, Y Shu, L Wang, X Wu, Z Hua, Y Ke, Y Sun, Y Shen, Q Xu, 2013 Selective sequestration of STAT1 in the cytoplasm via phosphorylated SHP-2 ameliorates murine experimental colitis., X Wu, W Guo, L Wu, Y Gu, L Gu, S Xu, X Wu, Y Shen, Y Ke, R Tan, Y Sun, Q Xu, 2012 Integrin a6high cell population functions as an initiator in tumorigenesis and relapse of human liposarcoma., L Wang, L Wang, Y Gu, Y Shu, Y Shen,Q Xu, 2011 Targeting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 by curcumin induces ER stress-associated apoptosis for treating human liposarcoma., L Wang, L Wang, R Song, Y Shen, Y Sun, Y Gu, Y Shu, Q Xu, 2011 Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation., W Zhao, Y Gu, R Song, B Qu, Q Xu, 2008 Identification of a new metabolite of astilbin, 3'-O-methylastilbin, and its immunosuppressive activity against contact dermatitis., J Guo, Q Xu,T Chen, 2007 Astilbin inhibits contact hypersensitivity via negative cytokine regulation distinct from cyclosporin A., M Fei, X Wu, Q Xu, 2005 Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells., X Wu, H Zeng, X Zhang, Y Zhao, H Sha, X Ge, M Zhang, X Gao, Q Xu, 2004

Areas of Focus

Molecular basis and selective regulation of immune response and inflammation
Molecular mechanisms of inflammation-cancer transformation
Chemical biology research based on the characteristics of small molecule compounds

Publications

Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer., Wenjie Guo, Yang Sun, Wen Liu, Xingxin Wu, Lele Guo, Peifen Cai, Xuefeng Wu, Xudong Wu, Yan Shen, Yongqian Shu, Yanhong Gu, Qiang Xu*, 2014
Disruption of chaperone-mediated autophagy dependent degradation of MEF2A by oxidative stress-induced lysosome destabilization., Li Zhang, Yang Sun, Mingjian Fei, Cheng Tan, Jing Wu, Jie Zheng, Jiqing Tang, Wei Sun, Zhaoliang Lv, Jiandong Bao, Qiang Xu* and Huixin Yu, 2014
SBF-1 exerts strong anticervical cancer effect through inducing endoplasmic reticulum stress-associated cell death via targeting sarco/endoplasmic reticulum Ca(2+)-ATPase 2., Li W, Ouyang Z, Zhang Q, Wang L, Shen Y, Wu X, Gu Y, Shu Y, Yu B, Wu X, Sun Y, Xu Q*, 2014
Trichomide A, a natural cyclodepsipeptide, exerts immunosuppressive activity against activated T lymphocytes by upregulating SHP2 activation to overcome contact dermatitis., Wang X, Zhang A, Gao J, Chen W, Wang S, Wu X, Shen Y, Ke Y, Hua Z, Tan R, Sun Y, Xu Q*, 2014
Blocking initial infiltration of pioneer CD8+ T cells into the CNS via inhibition of SHP-2 ameliorates experimental autoimmune encephalomyelitis in mice., Luo Q, Sun Y, Gong FY, Liu W, Zheng W, Shen Y, Hua ZC, Feng GS, Xu Q*, 2014
Novel monofunctional platinum (II) complex Mono-Pt induces apoptosis-independent autophagic cell death in human ovarian carcinoma cells distinct from cisplatin., WJ Guo, YM Zhang, L Zhang, B Huang, FF Tao, W Chen, ZJ Guo*, Q Xu*, Y Sun*, 2013
A novel disease-modifying antirheumatic drug, iguratimod, ameliorates murine arthritis by blocking IL-17 signaling, distinct from methotrexate and leflunomide., Q Luo, Y Sun*, W Liu, C Qian, B Jin, F Tao, Y Gu, X Wu, Y Shen, Q Xu*, 2013
Loss of SHP-2 activity in CD4+ T cells promotes melanoma progression and metastasis., T Zhang, W Guo, Y Yang, W Liu, L Guo, Y Gu, Y Shu, L Wang, X Wu, Z Hua, Y Ke, Y Sun, Y Shen, Q Xu*, 2013
Selective sequestration of STAT1 in the cytoplasm via phosphorylated SHP-2 ameliorates murine experimental colitis., X Wu, W Guo, L Wu, Y Gu, L Gu, S Xu, X Wu, Y Shen, Y Ke, R Tan, Y Sun, Q Xu*, 2012
Integrin a6high cell population functions as an initiator in tumorigenesis and relapse of human liposarcoma., L Wang, L Wang, Y Gu, Y Shu, Y Shen,Q Xu*, 2011
Targeting sarcoplasmic/endoplasmic reticulum Ca2+-ATPase 2 by curcumin induces ER stress-associated apoptosis for treating human liposarcoma., L Wang, L Wang, R Song, Y Shen, Y Sun, Y Gu, Y Shu, Q Xu*, 2011
Sorafenib inhibits activation of human peripheral blood T cells by targeting LCK phosphorylation., W Zhao, Y Gu, R Song, B Qu, Q Xu*, 2008
Identification of a new metabolite of astilbin, 3'-O-methylastilbin, and its immunosuppressive activity against contact dermatitis., J Guo, Q Xu*,T Chen, 2007
Astilbin inhibits contact hypersensitivity via negative cytokine regulation distinct from cyclosporin A., M Fei, X Wu, Q Xu*, 2005
Phosphatase of Regenerating Liver-3 Promotes Motility and Metastasis of Mouse Melanoma Cells., X Wu, H Zeng, X Zhang, Y Zhao, H Sha, X Ge, M Zhang, X Gao, Q Xu*, 2004

Immune Response Inflammation Molecular Basis Selective Regulation Cancer Transformation Molecular Mechanisms Chemical Biology Small Molecules Drug Targets Biomolecular Events

Wei Bin - Shanghai University

Haiying Liu - Sun Yat-Sen University

Yihua Chen - East China Normal University

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