Postdoctoral Research: Royal Melbourne Hospital, Bone Marrow Research Institute
Selected for the Ministry of Education's 'New Century Excellent Talents Support Program'
Selected for Jiangsu Province's '333 High-Level Talent Training Project' second tier
2006 - Present: Professor at Nanjing University, School of Life Sciences
2013: Jiangsu Province '333 High-Level Talent Training Project' second tier
2012: Nanjing Leading Science and Technology Entrepreneurial Talent
2008: Nanjing University 'Outstanding Young and Middle-aged Academic Leader'
2007: Ministry of Education 'New Century Excellent Talents Support Program'
2006-2008: Cooley's Anemia Foundation Research Fellowship, USA
1999: Jiangsu Province Science and Technology Progress Second Prize
Research
Gene transcription and epigenetic regulation mechanisms Cancer pathogenesis and prevention research
NatD epigenetically activates FOXA2 expression to promote breast cancer progression by facilitating MMP14 expression., Xing M, Yao B; Xu J, Lu P, Li Q, Wu D, Chen B, Wei J, Su L, Zhao Q*., 2024
FOXA2 activates HIF2α expression to promote tumor progression and is regulated by the E3 ubiquitin ligase VHL in renal cell carcinoma., Yang D, Li Q, Lu P, Wu D, Li W, Meng X, Xing M, Shangguan W, Chen B, Yang J, Zhang Z, Wang Z, Huang DCS, Zhao Q*., 2024
The SMARCA4-R1157W mutation facilitates chromatin remodeling and confers PRMT1/SMARCA4 inhibitors sensitivity in colorectal cancer., Zeng X, Yao B, Liu J, Gong GW, Liu M, Li J, Pan HF, Li Q, Yang D, Lu P, Wu D, Xu P, Chen B, Chen P, Zhang M, Zen K, Jing J, Huang DCS, Chen D, Jiang ZW, Zhao Q*., 2023
Transcriptional silencing of fetal hemoglobin expression by NonO., Li X, Chen M, Liu B, Lu P, Lv X, Zhao X, Cui S, Xu P, Nakamura Y, Kurita R, Chen B, Huang DCS, Liu DP, Liu M, Zhao Q*., 2021
TCF3 is epigenetically silenced by EZH2 and DNMT3B and functions as a tumor suppressor in endometrial cancer., Gui T, Liu M, Yao B, Jiang H, Yang D, Li Q, Zeng X, Wang Y, Cao J, Deng Y, Li X, Xu P, Zhou L, Li D, Wang Z, Zen K, Huang DCS, Chen B, Wan G, Zhao Q*., 2021
PRMT1-mediated H4R3me2a recruits SMARCA4 to promote colorectal cancer progression by enhancing EGFR signaling., Yao B, Gui T, Zeng X, Deng Y, Wang Z, Wang Y, Yang D, Li Q, Xu P, Hu R, Li X, Chen B, Wang J, Zen K, Li H, Davis MJ, Herold MJ, Pan HF, Jiang ZW, Huang DCS, Liu M, Ju J, Zhao Q*., 2021
The methyltransferase PRMT1 regulates γ-globin translation., Wang Y, Li X, Ge J, Liu M, Pang X, Liu J, Luo C, Xu Y, Zhao Q*., 2021
PRMT5-dependent transcriptional repression of c-Myc target genes promotes gastric cancer progression., Liu M, Yao B, Gui T, Guo C, Wu X, Li J, Ma L, Deng Y, Xu P, Wang Y, Yang D, Li Q, Zeng X, Li X, Hu R, Ge J, Yu Z, Chen Y, Chen B, Ju J, Zhao Q*., 2020
CARM1-mediated methylation of protein arginine methyltransferase 5 represses human γ-globin gene expression in erythroleukemia cells., Nie M, Wang Y, Guo C, Li X, Wang Y, Deng Y, Yao B, Gui T, Ma C, Liu M, Wang P, Wang R, Tan R, Fang M, Chen B, He Y, Huang DCS, Ju J, Zhao Q*., 2018
Regulation of γ-globin gene expression and its clinical applications., Ju J, Zhao Q*., 2018
NatD promotes lung cancer progression by preventing histone H4 serine phosphorylation to activate Slug expression., Ju J, Chen A, Deng Y, Liu M, Wang Y, Wang Y, Nie M, Wang C, Ding H, Yao B, Gui T, Li X, Xu Z, Ma C, Song Y, Kvansakul M, Zen K, Zhang CY, Luo C, Fang M, Huang DCS, Allis CD, Tan R, Zeng CK, Wei J, Zhao Q*., 2017
Heterochromatin Protein 1γ Is a Novel Epigenetic Repressor of Human Embryonic ϵ-Globin Gene Expression., Wang Y, Wang Y, Ma L, Nie M, Ju J, Liu M, Deng Y, Yao B, Gui T, Li X, Guo C, Ma C, Tan R, Zhao Q*., 2017
ϵ-globin expression is regulated by SUV4-20h1., Wang Y, Rank G, Li Z, Wang Y, Ju J, Nuber A, Wu Y, Liu M, Nie M, Huang F, Cerruti L, Ma C, Tan R, Schotta G, Jane SM, Zeng CK, Zhao Q*., 2016
Heterochromatin Protein HP1γ Promotes Colorectal Cancer Progression and Is Regulated by miR-30a., Liu M, Huang F, Zhang D, Ju J, Wu XB, Wang Y, Wang Y, Wu Y, Nie M, Li Z, Ma C, Chen X, Zhou JY, Tan R, Yang BL, Zen K, Zhang CY, Chen YG, Zhao Q*., 2015
Human fetal globin gene expression is regulated by LYAR., Ju J, Wang Y, Liu R, Zhang Y, Xu Z, Wang Y, Wu Y, Liu M, Cerruti L, Zou F, Ma C, Fang M, Tan R, Jane SM, Zhao Q*., 2014
The role of WDR5 in silencing human fetal globin gene expression., Xu Z, He Y, Ju J, Rank G, Cerruti L, Ma C, Simpson R, Moritz R, Jane S, Zhao Q*., 2012
Identification of a PRMT5-dependent repressor complex linked to silencing of human fetal globin gene expression., Rank G, Cerruti L, Moritz RL, Simpson RJ, Jane SM, Zhao Q*., 2010
PRMT5-mediated methylation of histone H4R3 recruits DNMT3A, coupling histone and DNA methylation in gene silencing., Zhao Q*, Rank G, Tan YT, Li H, Moritz RL, Simpson RJ, Cerruti L, Curtis DJ, Patel DJ, Allis CD, Cunningham JM, Jane SM., 2009
Targeting of the Tumor Suppressor GRHL3 by a miR-21-Dependent Proto-Oncogenic Network Results in PTEN Loss and Tumorigenesis., Darido C, Georgy SR, Wilanowski T, Dworkin S, Auden A, Zhao Q, Rank G, Srivastava S, Finlay MJ, Papenfuss AT, Pandolfi PP, Pearson RB, Jane SM*., 2011
Epidermal wound repair is regulated by the planar cell polarity signaling pathway., Caddy J, Wilanowski T, Darido C, Dworkin S, Ting SB, Zhao Q, Rank G, Auden A, Srivastava S, Papenfuss TA, Murdoch JN, Humbert PO, Boulos N, Weber T, Zuo J, Cunningham JM, Jane SM*., 2010
Repression of human {gamma}-globin gene expression by a short isoform of the NF-E4 protein is associated with loss of NF-E2 and RNA polymerase II recruitment to the promoter., Zhao Q, Zhou WL, Rank G, Sutton R, Wang X, Cumming H, Cerruti L, Cunningham JM, and Jane SM*., 2006
Site-specific Acetylation of the Fetal Globin Activator NF-E4 Prevents Its Ubiquitination and Regulates Its Interaction with the Histone Deacetylase, HDAC1., Zhao Q, Cumming H, Cerruti L, Cunningham JM, Jane SM*., 2004
A mitochondrial specific stress response in mammalian cells., Zhao Q, Wang J, Levichkin IV, Stasinopoulos S, Ryan MT, Hoogenraad NJ*., 2002
Area of Focus
Epigenetics | Embryonic Development | Cell Fate | Cancer | Metastasis | Drug Resistance | Gene Expression | Dna Methylation | Histone Modification | Chromatin Structure
