Areas of Focus
- Development of precise regulation strategies for protein lipidation to combat aging and age-related diseases
- Identification of therapeutic lipidation targets related to aging and age-related diseases
- Creation of small molecule-based strategies for precise regulation of protein lipidation
- Establishment of new functional proteomics methods to characterize active small molecules and elucidate their mechanisms
Work Experience
- 2022/06-present - Huazhong Agricultural University, College of Biomedical and Health Sciences - Researcher and Doctoral Supervisor
- 2017/02-2022/04 - Cornell University, Department of Chemistry and Chemical Biology/Howard Hughes Medical Institute - Postdoctoral Researcher
Academic Background & Achievements
- 2011/9-2016/11 Doctorate: Peking University, College of Chemistry and Molecular Engineering, Chemical Biology
- 2007/09-2011/06 Bachelor's: Wuhan University, College of Chemistry and Molecular Sciences, Applied Chemistry
Publications
- Long-Chain Fatty Acyl Coenzyme A inhibits NME1/2 and regulates cancer metastasis, S Zhang, O. D. Nelson, I. R. Price, C. Zhu, I. R. Fernandez, X. Lu, R. S. Weiss, H. Lin, 2022
- Comparative proteomics reveal distinct chaperone-client interactions in supporting bacterial acid resistance, S. Zhang, D. He, Y. Yang, S. Lin, M. Zhang, S. Dai, P. R. Chen, 2016
- Conditional chaperone–client interactions revealed by genetically encoded photo-cross-linkers, S. Zhang, D. He, Z. Lin, Y. Yang, H. Song, P. R. Chen, 2017
- Global Profiling of Sirtuin Deacylase Substrates Using a Chemical Proteomic Strategy and Validation by Fluorescent Labeling, S. Zhang, N. A. Spiegelman, H. N. Lin, 2019
- NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle, Kosciuk, T., I. R. Price, X. Zhang, C. Zhu, K. N. Johnson, S. Zhang, S. L. Halaby, G. P. Komaniecki, M. Yang, C. J. DeHart, P. M. Thomas, N. L. Kelleher, J. C. Fromme, H. Lin, 2020
- Genetically encoded cleavable and mass spectrometry-identifiable Protein photocrosslinker, Y. Yang, H. Song, D. He, S. Zhang, S. Lin, S. Dai, R. Meng, C. Wang, P. R. Chen, 2016
- Genetically encoded releasable photo-cross-linking strategies for studying protein–protein interactions in living cells, Y. Yang, H. Song, D. He, S. Zhang, S. Dai, X. Xie, P. R. Chen, 2017
- Genetically encoded cleavable protein photocrosslinker, S. Lin, D. He, T. Long, S. Zhang, R. Meng, P. R. Chen, 2014
- First implementation of alkaline polymer electrolyte water electrolysis working only with pure water, L. Xiao, S. Zhang, J. Pan, C. Yang, M. He, L Zhuang, J. Lu, 2012
