Professor | Xiaoyan Zhang | Asia Growth Partners

Name	Xiaoyan Zhang
Contact Information	xiaoyanz@mail.hzau.edu.cn
Language ability	Chinese, English
Province	Hubei

Name

Xiaoyan Zhang

Contact Information

xiaoyanz@mail.hzau.edu.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Huazhong Agricultural University
Faculty	Life Sciences
Academic Background & Achievements	2001.9-2005.7 Bachelor in Biotechnology: Hebei University 2005.9-2010.7 PhD in Cell Biology: Peking University
Work Experience	2010.8-2015.7 - University of Michigan - Research Fellow 2015.8-2019.7 - University of Michigan - Research Laboratory Specialist Intermediate 2019.8-present - Huazhong Agricultural University - Professor

University/Lab Affiliation and Title

Huazhong Agricultural University

Faculty

Life Sciences

Academic Background & Achievements

2001.9-2005.7 Bachelor in Biotechnology: Hebei University
2005.9-2010.7 PhD in Cell Biology: Peking University

Work Experience

2010.8-2015.7 - University of Michigan - Research Fellow
2015.8-2019.7 - University of Michigan - Research Laboratory Specialist Intermediate
2019.8-present - Huazhong Agricultural University - Professor

Areas of Focus	Structure and function of the Golgi apparatus Cell autophagy
Publications	Nonredundant roles of GRASP55 and GRASP65 in the Golgi apparatus and Beyond, Zhang X, Wang Y, 2020 GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion, Zhang X#, Wang L#, Ireland SC, Ahat E, Li J, Bekier II ME, Zhang Z, Wang Y, 2019 GRASP55 senses glucose deprivation through O-GlcNAcylation to promote autophagosome-lysosome fusion, Zhang X, Wang L, Lak B, Li J, Jokitalo E, Wang Y, 2018 The Golgi stacking protein GORASP2/GRASP55 serves as an energy sensor to promote autophagosome maturation under glucose starvation, Zhang X, Wang Y, 2018 GRASP55 facilitates autophagosome maturation under glucose deprivation, Zhang X, Wang Y, 2018 Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65, Xiang Y#, Zhang X#, Nix DB, Katoh T, Aoki K, Tiemeyer M, Wang Y, 2013 Glycosylation Quality Control by the Golgi Structure, Zhang X, Wang Y, 2016 GRASPs in Golgi Structure and Function, Zhang X, Wang Y, 2016 SIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly, Zhang X, Brachner A, Kukolj E, Slade D, Wang Y, 2019 Cell cycle regulation of VCIP135 deubiquitinase activity and function in p97/p47-mediated Golgi reassembly, Zhang X, Wang Y, 2015 Phosphorylation regulates VCIP135 function in Golgi membrane fusion during the cell cycle, Zhang X, Zhang H, Wang Y, 2014 Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the γTuRC to the centrosome, Zhang X, Chen Q, Feng J, Hou J, Yang F, Liu J, Jiang Q, Zhang C, 2009 DNA damage promotes microtubule dynamics through a DNA-PK-AKT axis for enhanced repair, Ma S, Rong Z, Liu C, Qin X, Zhang X, Chen Q, 2021 Cytosolic Ca2+ Modulates Golgi Structure Through PKCα-Mediated GRASP55 Phosphorylation, Ireland S, Ramnarayanan S, Fu M, Zhang X, Zhang J, Li J, Emebo D, Wang Y, 2020 GRASP depletion-mediated Golgi destruction decreases cell adhesion and migration via the reduction of α5β1 integrin, Ahat E, Xiang Y, Zhang X, Bekier ME II, Wang Y, 2019 Knockout of the Golgi stacking proteins GRASP55 and GRASP65 impairs Golgi structure and function, Bekier, M, Wang L, Li J, Huang H, Tang D, Zhang X, Wang Y, 2017 Mena-GRASP65 interaction couples actin polymerization to Golgi ribbon linking, Tang D, Zhang X, Huang S, Yuan H, Li J, Wang Y, 2016 Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis, Zhuo X, Guo X, Zhang X, Jing G, Wang Y, Chen Q, Jiang Q, Liu J, Zhang C, 2015 Altered cofactor regulation with disease-associated p97/VCP mutations, Zhang X, Gui L, Zhang X, Bulfer SL, Sanghez V, Wong DE, Lee Y, Lehmann L, Lee JS, Shih PY, Lin HJ, Iacovino M, Weihl CC, Arkin MR, Wang Y, Chou TF, 2015 PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry, Wang G, Chen Q, Zhang X, Zhang B, Zhuo X, Liu J, Jiang Q, Zhang C, 2013 Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis, Chen Q, Zhang X, Jiang Q, Clarke PR, Zhang C, 2008

Areas of Focus

Structure and function of the Golgi apparatus
Cell autophagy

Publications

Nonredundant roles of GRASP55 and GRASP65 in the Golgi apparatus and Beyond, Zhang X*, Wang Y*, 2020
GORASP2/GRASP55 collaborates with the PtdIns3K UVRAG complex to facilitate autophagosome-lysosome fusion, Zhang X#, Wang L#, Ireland SC, Ahat E, Li J, Bekier II ME, Zhang Z, Wang Y*, 2019
GRASP55 senses glucose deprivation through O-GlcNAcylation to promote autophagosome-lysosome fusion, Zhang X*, Wang L, Lak B, Li J, Jokitalo E, Wang Y*, 2018
The Golgi stacking protein GORASP2/GRASP55 serves as an energy sensor to promote autophagosome maturation under glucose starvation, Zhang X*, Wang Y*, 2018
GRASP55 facilitates autophagosome maturation under glucose deprivation, Zhang X*, Wang Y*, 2018
Regulation of protein glycosylation and sorting by the Golgi matrix proteins GRASP55/65, Xiang Y#, Zhang X#, Nix DB, Katoh T, Aoki K, Tiemeyer M, Wang Y*, 2013
Glycosylation Quality Control by the Golgi Structure, Zhang X, Wang Y*, 2016
GRASPs in Golgi Structure and Function, Zhang X, Wang Y*, 2016
SIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly, Zhang X, Brachner A, Kukolj E, Slade D*, Wang Y*, 2019
Cell cycle regulation of VCIP135 deubiquitinase activity and function in p97/p47-mediated Golgi reassembly, Zhang X, Wang Y*, 2015
Phosphorylation regulates VCIP135 function in Golgi membrane fusion during the cell cycle, Zhang X, Zhang H, Wang Y*, 2014
Sequential phosphorylation of Nedd1 by Cdk1 and Plk1 is required for targeting of the γTuRC to the centrosome, Zhang X, Chen Q, Feng J, Hou J, Yang F, Liu J, Jiang Q, Zhang C*, 2009
DNA damage promotes microtubule dynamics through a DNA-PK-AKT axis for enhanced repair, Ma S, Rong Z, Liu C, Qin X, Zhang X, Chen Q*, 2021
Cytosolic Ca2+ Modulates Golgi Structure Through PKCα-Mediated GRASP55 Phosphorylation, Ireland S, Ramnarayanan S, Fu M, Zhang X, Zhang J, Li J, Emebo D, Wang Y*, 2020
GRASP depletion-mediated Golgi destruction decreases cell adhesion and migration via the reduction of α5β1 integrin, Ahat E, Xiang Y, Zhang X, Bekier ME II, Wang Y*, 2019
Knockout of the Golgi stacking proteins GRASP55 and GRASP65 impairs Golgi structure and function, Bekier, M, Wang L, Li J, Huang H, Tang D, Zhang X, Wang Y*, 2017
Mena-GRASP65 interaction couples actin polymerization to Golgi ribbon linking, Tang D, Zhang X, Huang S, Yuan H, Li J, Wang Y*, 2016
Usp16 regulates kinetochore localization of Plk1 to promote proper chromosome alignment in mitosis, Zhuo X, Guo X, Zhang X, Jing G, Wang Y, Chen Q, Jiang Q, Liu J, Zhang C*, 2015
Altered cofactor regulation with disease-associated p97/VCP mutations, Zhang X, Gui L, Zhang X, Bulfer SL, Sanghez V, Wong DE, Lee Y, Lehmann L, Lee JS, Shih PY, Lin HJ, Iacovino M, Weihl CC, Arkin MR, Wang Y, Chou TF*, 2015
PCM1 recruits Plk1 to the pericentriolar matrix to promote primary cilia disassembly before mitotic entry, Wang G, Chen Q, Zhang X, Zhang B, Zhuo X, Liu J, Jiang Q, Zhang C*, 2013
Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis, Chen Q, Zhang X, Jiang Q, Clarke PR, Zhang C*, 2008

Golgi Apparatus Structure Function Cell Biology Protein Autophagy Cellular Processes Biochemistry Molecular Biology Research

Zhengwu Qi - Tongji University

Fanglin Sun - Tongji University

Jing Xie - Tongji University

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