Areas of Focus
- Biochemical and molecular mechanisms of metabolic changes associated with metabolic diseases
- Prevention of metabolic diseases through food and nutrition
- Precision/personalized intervention methods for malnutrition and overnutrition
Work Experience
- 2023/01-present - Huazhong Agricultural University, College of Food Science and Technology, College of Biomedical and Health Sciences - Professor
- 2006/08-2022/12 - University of Tennessee, Knoxville, Department of Nutrition - Tenure-track Assistant Professor, Tenured Associate Professor
- 1995/03-1997/07 - University of Texas Southwestern Medical Center - Visiting Scholar/Research Assistant
- 1987/07-1995/02 - Hubei Provincial Institute of Medical Sciences, Institute of Virology - Assistant Researcher
Academic Background & Achievements
- 1982/09-1986/07 Bachelor: Wuhan University, Department of Virology and Molecular Biology
- 1986/09-1989/07 Master: Wuhan University, Department of Virology and Molecular Biology
- 1997/08-2001/06 PhD: University of Texas Southwestern Medical Center, Department of Biochemistry and Molecular Biology
- 2001/07-2006/07 Postdoctoral: University of Texas Southwestern Medical Center, Department of Molecular Genetics
Publications
- Assaying of TGFs Produced by MA782/5s-8101 Mouse Mammary Tumor Cell Line., Chen G., 1988
- Studies of Cell Growth Stimulating Factors in Malignant Lung Adenocarcinoma Pleural Effusions., Chen, G. and Li, W.X., 1989
- Disappearance of Body Fat in Normal Rats Induced by Adenovirus-Mediated Leptin Gene Therapy., Chen, G., Koyama, K., Yuan, X., Lee, Y., Zhou, Y.-T., O’Doherty, R., Newgard, C.B., and Unger, R.H., 1996
- Selection of Insulinoma Cell Lines With Resistance to IL-1ß and IFN-γ-Induced Cytotoxicity., Chen, G., Hohmeier, H., Gasa, R., Tran, V., and Newgard, C.B., 2000
- Expression of the Transcription Factor STAT-1α in Insulinoma Cells Protects Against Cytotoxic Effects of Multiple Cytokines., Chen, G., Hohmeier, H., and Newgard, C.B., 2001
- Control of Hepatic Gluconeogenesis Through the Transcriptional Coactivator PGC-1., Yoon, J.C., Puigserver, P., Chen, G., Donovan, J., Wu, Z., Rhee, J., Adelmant, G., Kahn, C.R., Granner, D.K., Newgard, C.B., and Spiegelman, B.M., 2001
- Central Role for Liver X Receptor in Insulin-Mediated Activation of Srebp-1c Transcription and Stimulation of Fatty Acid Synthesis in Liver., Chen, G., Liang G., Ou J., Goldstein, J.L., and Brown, M.S., 2004
- Enzymatic Reduction of Oxysterols Impairs LXR Signaling in Cultured Cells and the Livers of Mice., Chen, W., Chen, G., Head, D.L., Mangelsdorf, D.L., and Russell, D.W., 2007
- Liver Lipid Molecules Induce PEPCK-C Gene Transcription and Attenuate Insulin Action., Chen, G., 2007
- Retinoids Synergize with Insulin to Induce Hepatic Gck Expression., Chen, G., Zhang, Y., Lu, D., Li, N., and Ross, A.C., 2009
- Retinoids Synergized with Insulin to Induce Srebp-1c Expression and Activated Its Promoter via the Two Liver X Receptor Binding Sites That Mediate Insulin Action., Li, R., Chen, W., Li, Y., Zhang, Y., and Chen, G., 2011
- Retinoids Induced Pck1 Expression and Attenuated Insulin-mediated Suppression of Its Expression via Activation of Retinoic Acid Receptor in Primary Rat Hepatocytes., Zhang, Y., Li, R., Chen, W., Li, Y., and Chen, G., 2011
- Insulin-Regulated Srebp-1c and Pck1 mRNA Expression in Primary Hepatocytes from Zucker Fatty But Not Lean Rats is Affected by Feeding Conditions., Zhang, Y., Li, R., Chen, W., Li, Y., Ge, Y., and Chen, G., 2011
- Roles of Vitamin A Status and Retinoids in Glucose and Fatty Acid Metabolism., Zhao, S., Li, R., Li, Y., Chen, W., Zhang, Y., and Chen, G., 2012
- Vitamin A status affects obesity development and hepatic expression of key genes for fuel metabolism in Zucker fatty rats., Zhang, Y., Li, R., Li, Y., Chen, W., Zhao, S., and Chen, G., 2012
- Is There A Role of Vitamin A in Hepatic Glucose and Fatty Acid Metabolism?, Howell, M. and Chen, G., 2012
- The hepatic Raldh1 expression is elevated in Zucker fatty rats and its over-expression introduced the retinal-induced Srebp-1c expression in INS-1 cells., Li, Y., Zhang, Y., Li, R., Chen, W., Howell, M., Zhang, R., and Chen, G., 2012
- Endocannabinoids and Obesity., Chen, G. and Pang, Z., 2013
- Roles of Vitamin A Metabolism in the Development of Hepatic Insulin Resistance., Chen, G., 2013
- Factors Affecting Insulin-Regulated Hepatic Gene Expression., Guan, H. and Chen, G., 2014
- The expression of Apoc3 mRNA is regulated by HNF4α and COUP-TFII, but not acute retinoid treatments, in primary rat hepatocytes and hepatoma cells., Howell, M., Li, R., Zhang, R., Li, Y., Chen, W., and Chen, G., 2014
- The roles of vitamin A in the regulation of carbohydrate, lipid and protein metabolism., Chen, W., and Chen, G., 2014
- A retinoic acid responsive element in the hepatic Gck promoter interacts with RARα, HNF4α, COUP-TFII, which affect the retinoic acid- and insulin-mediated Gck expression., Li, R., Zhang, R., Li, Y., Zhu B., Chen, W., Zhang, Y., and Chen, G., 2014
- Vitamin A and feeding statuses modulate the insulin-regulated gene expression in primary rat hepatocytes., Chen, W., Howell, M., Li, Y., Li, R., and Chen, G., 2014
- Higher Protein Kinase C ζ in Fatty Rat Liver and Its Effect on Insulin Actions in Primary Hepatocytes., Chen, W, Goff, MR, Kuang, H, Chen, G., 2015
- The link between Hepatic Vitamin A Metabolism and Nonalcoholic Fatty Liver Disease., Chen, G., 2015
- Vitamin A status and its metabolism contribute to the regulation of hepatic genes during the cycle of fasting and refeeding in rats., Li, Y., Li, R., Chen, W., and Chen, G., 2016
- Gentiopicroside and sweroside from Veratrilla baillonii Franch induced phosphorylation of Akt and suppressed Pck1 expression in hepatoma cells., Huang, XJ., Li, J., Mei, ZY., Chen, G., 2016
- Vitamin A status affects the plasma parameters and regulation of hepatic genes in streptozotocin-induced diabetic rats., Li, Y., Liu, Y. and Chen, G., 2017
- Production of extracellular lysophosphatidic acid in the regulation of adipocyte functions and liver fibrosis., Yang, F., and Chen, G., 2018
- The Impact of Egg Nutrient Composition and Its Consumption on Cholesterol Homeostasis., Kuang, H., Yang, F., Zhang, Y., Wang, T., and Chen, G., 2018
- Vitamin A Status Affects Weight Gain and Hepatic Glucose Metabolism in Rats Fed a High-Fat Diet., Kuang, H., Wei, CH., Wang, T., Eastep, J., Li, Y., Chen, G., 2019
- Long-Term Treatment with Insulin and Retinoic Acid Increased Glucose Utilization in L6 Muscle Cells via Glycogenesis., Goff, M. and Chen G., 2020
- Vitamin A and Diabetes., Zhang, Y., Wang, T., Hu, X., and Chen, G., 2020
- The Interactions of Insulin and Vitamin A Signaling Systems for the Regulation of Hepatic Glucose and Lipid Metabolism., Chen, G., 2021
- Reduction in the Dietary VA Status Prevents Type 2 Diabetes and Obesity in Zucker Diabetic Fatty Rats., Wang, T, Tang, X., Hu, X., Wang, J., and Chen, G., 2022
- Can Nutrition Interventions Tackle the Global Insulin Affordability via Improving Diabetes Management and Reducing Insulin Demand?, Lu, V., Zhang, J., and Chen, G., 2022
- Personalized nutrition for people with diabetes and at risk of diabetes has begun., Chen, R. and Chen, G., 2022
Awards
- 2020: Jacquelyn Orlando DeJonge Faculty Award, College of Education Health and Human Science, the University of Tennessee, Knoxville
- 2016: Service Excellence and Leadership Award, the University of Tennessee, Knoxville
- 2009: NPAM Young Investigator Award at American Heart Association’s Scientific Sessions 2009, Orlando, Florida
- 1999-2001: Research Trainee, NIH training grant award, UT Southwestern Medical Center at Dallas
- 1999: Sigma-Xi, University of Texas Southwestern Medical Center at Dallas
- 1998: Outstanding Scientific Poster, Graduate Student Organization Poster Session, University of Texas Southwestern Medical Center at Dallas
- 1987, 1988: Excellent Graduate Student of Wuhan University, Wuhan, China
