Professor | Li Shan | Asia Growth Partners

Name	Li Shan
Contact Information	lishan@mail.hzau.edu.cn
Language ability	Chinese, English
Province	Hubei

Name

Li Shan

Contact Information

lishan@mail.hzau.edu.cn

Language ability

Chinese, English

Province

Hubei

University/Lab Affiliation and Title	Huazhong Agricultural University
Faculty	College of Biomedical and Health
Academic Background & Achievements	09/2007-06/2013 PhD in Biochemistry and Molecular Biology: Beijing Institute of Life Sciences 09/2003-07/2007 Bachelor's in Business Administration (Biotechnology Enterprise Management): China Agricultural University 09/2003-07/2007 Bachelor's in Biological Sciences: China Agricultural University Discovered and named two novel protein post-translational modifications: Arginine-GlcNAcylation and ADPR-Deacylization
Work Experience	03/2017-present - Huazhong Agricultural University - Professor, Doctoral Supervisor 01/2014-02/2017 - Taihe Hospital, Shiyan, Hubei - Director of Institute of Infectious and Immunological Diseases, Director of Central Laboratory 07/2013-03/2015 - Beijing Institute of Life Sciences - Postdoctoral Researcher 05/2022-present - Huazhong Agricultural University - Deputy Director of Major Project Management Office 09/2019-present - Huazhong Agricultural University - Secretary General of the Scientific Ethics Committee 05/2018-present - Huazhong Agricultural University - Vice Chairman of the Youth Federation
Awards	2020: Hubei Province First Hundred Outstanding Female Scientific and Technological Innovation Talents 2016: Third Prize in Hubei Province Natural Science Excellent Academic Papers 2013: Wu Rui Life Science Award 2015: Hubei Provincial Health Commission Outstanding Young Talent Project Recipient 2015: Hubei Province Outstanding Youth Project Recipient

University/Lab Affiliation and Title

Huazhong Agricultural University

Faculty

College of Biomedical and Health

Academic Background & Achievements

09/2007-06/2013 PhD in Biochemistry and Molecular Biology: Beijing Institute of Life Sciences
09/2003-07/2007 Bachelor's in Business Administration (Biotechnology Enterprise Management): China Agricultural University
09/2003-07/2007 Bachelor's in Biological Sciences: China Agricultural University
Discovered and named two novel protein post-translational modifications: Arginine-GlcNAcylation and ADPR-Deacylization

Work Experience

03/2017-present - Huazhong Agricultural University - Professor, Doctoral Supervisor
01/2014-02/2017 - Taihe Hospital, Shiyan, Hubei - Director of Institute of Infectious and Immunological Diseases, Director of Central Laboratory
07/2013-03/2015 - Beijing Institute of Life Sciences - Postdoctoral Researcher
05/2022-present - Huazhong Agricultural University - Deputy Director of Major Project Management Office
09/2019-present - Huazhong Agricultural University - Secretary General of the Scientific Ethics Committee
05/2018-present - Huazhong Agricultural University - Vice Chairman of the Youth Federation

Awards

2020: Hubei Province First Hundred Outstanding Female Scientific and Technological Innovation Talents
2016: Third Prize in Hubei Province Natural Science Excellent Academic Papers
2013: Wu Rui Life Science Award
2015: Hubei Provincial Health Commission Outstanding Young Talent Project Recipient
2015: Hubei Province Outstanding Youth Project Recipient

Areas of Focus	Molecular mechanisms of pathogen-host interactions Development of human immune disease treatment methods based on bacterial proteins Nutritional health regulation mechanism of 'dietary improvement-gut microecology-immunity'
Publications	Pathogen Hijacks Programmed Cell Death Signaling by Arginine ADPR-Deacylization of Caspases, Peng T, Tao X, Xia Z, Hu S, Xue J, Zhu Q, Pan X, Zhang Q, Li S, 2022 Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector, Ding J, Yao Q, Li L, Dong N, Li S, Shao F, 2019 Structural insights into caspase ADPR-deacylization catalyzed by a bacterial effector and host calmodulin, Zhang K, Peng T, Tao X, Tian M, Li Y, Wang Z, Ma S, Hu S, Pan X, Xue J, Fu Y, Li S, 2022 Arginine Glcnacylation and Activity Regulation of Phop by a Type Iii Secretion System Effector in Salmonella, Xue J, Huang Y, Zhang H, Hu J, Pan X, Peng T, Lv J, Meng K, Li S, 2022 Arginine GlcNAcylation of Rab small GTPases by the pathogen Salmonella Typhimurium, Meng K, Zhang X, Peng T, Yang J, Liu X, Shao F, Li S, 2020 Detection of SARS-CoV-2 RNA residue on object surfaces in nucleic acid testing laboratory using droplet digital PCR, Lv J, Yang J, Xue J, Li S, 2020 Investigation of potential safety hazards during medical waste disposal in SARS-CoV-2 testing laboratory, Lv J, Yang J, Xue J, Zhu P, Liu L, Li S, 2021 Auto arginine-GlcNAcylation is crucial for bacterial pathogens in regulating host cell death, Xue J, Pan X, Peng T, Duan M, Du L, Zhuang X, Cai X, Yi X, Fu Y, Li S, 2020 Bacteria-catalyzed arginine glycosylation in pathogens and host, Pan X, Luo J, Li S, 2020 Arg-GlcNAcylation of TRADD by NleB and SseK1 is crucial for bacterial pathogenesis, Xue J, Hu S, Huang Y, Yi X, Zhang Q, Li S, 2020 Hijacking of death receptor signaling by bacterial pathogen effectors, Luo J, Hu J, Zhang Y, Hu Q, Li S, 2015 Sweet talk: protein glycosylation in bacterial interaction with the host, Lu Q, Li S, and Shao F, 2015 Pathogen blocks host death receptor signaling by arginine GlcNAcylation of death domains, Li S, Zhang L, Yao Q, Li L, Dong N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S, Shao F, 2013 Synthesis and Specific Antibody generation of Glycopeptides with ArginineN-GlcNAcylation, Pan M, Li S, Li X, Shao F, Liu L, and Hu H, 2014 An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis, Lu Q, Yao Q, Xu Y, Li L, Li S, Liu Y, Gao W, Niu M, Sharon M, Ben-Nissan G, Zamyatina A, Liu X, Chen S, Shao F, 2014 Total Synthesis of the G2/M DNA Damage Checkpoint Inhibitor Psilostachyin C, Li C, Tu S, Wen S, Li S, Chang J, Shao F, Lei X, 2011 Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family, Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, Liu L, Zheng N, Chen S, Shao F, 2010 Chemical probing reveals insights into the signaling mechanism of inflammasome activation, Gong YN, Wang X, Wang J, Yang Z, Li S, Yang J, Liu L, Lei X, Shao F, 2010 A Legionella type IV effector activates the NF-κB pathway by phosphorylating the IκB family of inhibitors, Ge J, Xu H, Li T, Zhou Y, Zhang Z, Li S, Liu L, Shao F, 2009 Novel microRNAs uncovered by deep sequencing of small RNA transcriptomes in bread wheat (Triticum aestivum L.) and Brachypodium distachyon (L.) Beauv, Wei B, Cai T, Zhang R, Li A, Huo N, Li S, Gu YQ, Vogel J, Jia J, Qi Y, Mao L, 2009 Sorting of small RNAs into Arabidopsis Argonaute complexes is directed by the 5’ terminal nucleotide, Mi S, Cai T, Hu Y, Chen Y, Hodges E, Ni F, Wu L, Li S, Zhou H, Long C, Chen S, Hannon G, Qi Y, 2008 A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii, Zhao T, Li G, Mi S, Li S, Hannon G, Wang XJ, Qi Y, 2007

Areas of Focus

Molecular mechanisms of pathogen-host interactions
Development of human immune disease treatment methods based on bacterial proteins
Nutritional health regulation mechanism of 'dietary improvement-gut microecology-immunity'

Publications

Pathogen Hijacks Programmed Cell Death Signaling by Arginine ADPR-Deacylization of Caspases, Peng T, Tao X, Xia Z, Hu S, Xue J, Zhu Q, Pan X, Zhang Q, Li S, 2022
Structural and Functional Insights into Host Death Domains Inactivation by the Bacterial Arginine GlcNAcyltransferase Effector, Ding J, Yao Q, Li L, Dong N, Li S, Shao F, 2019
Structural insights into caspase ADPR-deacylization catalyzed by a bacterial effector and host calmodulin, Zhang K, Peng T, Tao X, Tian M, Li Y, Wang Z, Ma S, Hu S, Pan X, Xue J, Fu Y, Li S, 2022
Arginine Glcnacylation and Activity Regulation of Phop by a Type Iii Secretion System Effector in Salmonella, Xue J, Huang Y, Zhang H, Hu J, Pan X, Peng T, Lv J, Meng K, Li S, 2022
Arginine GlcNAcylation of Rab small GTPases by the pathogen Salmonella Typhimurium, Meng K, Zhang X, Peng T, Yang J, Liu X, Shao F, Li S, 2020
Detection of SARS-CoV-2 RNA residue on object surfaces in nucleic acid testing laboratory using droplet digital PCR, Lv J, Yang J, Xue J, Li S, 2020
Investigation of potential safety hazards during medical waste disposal in SARS-CoV-2 testing laboratory, Lv J, Yang J, Xue J, Zhu P, Liu L, Li S, 2021
Auto arginine-GlcNAcylation is crucial for bacterial pathogens in regulating host cell death, Xue J, Pan X, Peng T, Duan M, Du L, Zhuang X, Cai X, Yi X, Fu Y, Li S, 2020
Bacteria-catalyzed arginine glycosylation in pathogens and host, Pan X, Luo J, Li S, 2020
Arg-GlcNAcylation of TRADD by NleB and SseK1 is crucial for bacterial pathogenesis, Xue J, Hu S, Huang Y, Yi X, Zhang Q, Li S, 2020
Hijacking of death receptor signaling by bacterial pathogen effectors, Luo J, Hu J, Zhang Y, Hu Q, Li S, 2015
Sweet talk: protein glycosylation in bacterial interaction with the host, Lu Q, Li S, and Shao F, 2015
Pathogen blocks host death receptor signaling by arginine GlcNAcylation of death domains, Li S, Zhang L, Yao Q, Li L, Dong N, Rong J, Gao W, Ding X, Sun L, Chen X, Chen S, Shao F, 2013
Synthesis and Specific Antibody generation of Glycopeptides with ArginineN-GlcNAcylation, Pan M, Li S, Li X, Shao F, Liu L, and Hu H, 2014
An iron-containing dodecameric heptosyltransferase family modifies bacterial autotransporters in pathogenesis, Lu Q, Yao Q, Xu Y, Li L, Li S, Liu Y, Gao W, Niu M, Sharon M, Ben-Nissan G, Zamyatina A, Liu X, Chen S, Shao F, 2014
Total Synthesis of the G2/M DNA Damage Checkpoint Inhibitor Psilostachyin C, Li C, Tu S, Wen S, Li S, Chang J, Shao F, Lei X, 2011
Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family, Cui J, Yao Q, Li S, Ding X, Lu Q, Mao H, Liu L, Zheng N, Chen S, Shao F, 2010
Chemical probing reveals insights into the signaling mechanism of inflammasome activation, Gong YN, Wang X, Wang J, Yang Z, Li S, Yang J, Liu L, Lei X, Shao F, 2010
A Legionella type IV effector activates the NF-κB pathway by phosphorylating the IκB family of inhibitors, Ge J, Xu H, Li T, Zhou Y, Zhang Z, Li S, Liu L, Shao F, 2009
Novel microRNAs uncovered by deep sequencing of small RNA transcriptomes in bread wheat (Triticum aestivum L.) and Brachypodium distachyon (L.) Beauv, Wei B, Cai T, Zhang R, Li A, Huo N, Li S, Gu YQ, Vogel J, Jia J, Qi Y, Mao L, 2009
Sorting of small RNAs into Arabidopsis Argonaute complexes is directed by the 5’ terminal nucleotide, Mi S, Cai T, Hu Y, Chen Y, Hodges E, Ni F, Wu L, Li S, Zhou H, Long C, Chen S, Hannon G, Qi Y, 2008
A complex system of small RNAs in the unicellular green alga Chlamydomonas reinhardtii, Zhao T, Li G, Mi S, Li S, Hannon G, Wang XJ, Qi Y, 2007

Pathogen Host Interaction Molecular Mechanism Bacterial Protein Immune Disease Treatment

Xin-Jun Liang - Huazhong Agricultural University

Ke Shui - Huazhong Agricultural University

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