Upload Avatar (500 x 500)
Jun Cui
Life Science
Sun Yat-Sen University
Guangdong
Language: Chinese, English
Innate Immunity
Regulation
Signal Transduction
Autophagy
Inflammation
Antiviral Immunity
Tumor
Autoimmune Diseases
System Biology
Mathematical Modeling
Areas of Focus
- Innate immune system recognition and regulation
- Signal transduction mechanisms
- Disease correlation (tumor and autoimmune diseases)
- System biology research
Academic Background & Achievements
- PhD: Not mentioned
- Developed a new theory on ubiquitination-autophagy-innate immunity regulation
- Published over 60 papers as corresponding author in high-impact journals
Publications
- Modulation of virus-induced neuroinflammation by the autophagy receptor SHISA9 in mice., Zheng Y, Wang L, Liu Q, Xian H, Zhang C, Cai S, Yang S, Jin S, Cui J, 2023
- Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy., Wang L, Cai J, Zhao X, Ma L, Zeng P, Zhou L, Liu Y, Yang S, Cai Z, Zhang S, Zhou L, Yang J, Liu T, Jin S, Cui J, 2022
- Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response., Yang S, Jin S, Xian H, Zhao Z, Wang L, Wu Y, Zhou L, Li M, Cui J, 2023
- Tetherin suppresses type I interferon signaling by targeting MAVS for NDP52-mediated selective autophagic degradation in human cells., Jin S, Tian S, Luo M, Xie W, Liu T, Duan T, Wu Y, Cui J, 2017
- USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome., Lin M, Zhao Z, Yang Z, Meng Q, Tan P, Xie W, Qin Y, Wang RF, Cui J, 2016
- TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses., Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J, Wang RF, Cui J, 2016
- TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation., Liu D, Zhao Z, She Y, Zhang L, Chen X, Ma L, Cui J, 2022
- Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy., Jin S, He X, Ma L, Zhuang Z, Wang Y, Lin M, Cai S, Wei L, Wang Z, Zhao Z, Wu Y, Sun L, Li C, Xie W, Zhao Y, Songyang Z, Peng K, Zhao J, Cui J, 2022
- Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome., Wang LQ, Liu T, Yang S, Sun L, Zhao ZY, Li LY, She YC, Zheng YY, Ye XY, Bao Q, Dong GH, Li CW, Cui J, 2021
- Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses., Liu Q, Wu Y, Qin Y, Hu J, Xie W, Qin FX, Cui J, 2018
- Stratified ubiquitination of RIG-I creates robust immune response and induces selective gene expression., Xian H, Xie W, Yang S, Liu Q, Xia X, Jin S, Sun T, Cui J, 2017
- Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis., Zheng Y, Liu Q, Wu Y, Ma L, Zhang Z, Liu T, Jin S, She Y, Li YP, Cui J, 2018
- RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation., Wu Y, Ma L, Cai S, Zhuang Z, Zhao Z, Jin S, Xie W, Zhou L, Zhang L, Zhao J, Cui J, 2021
- m6A RNA modification controls autophagy through upregulating ULK1 protein abundance., Jin S, Zhang X, Miao Y, Liang P, Zhu K, She Y, Wu Y, Liu DA, Huang J, Ren J, Cui J, 2018
- Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch., Meng Q, Cai C, Sun T, Wang Q, Xie W, Wang R, Cui J, 2015
Awards
- 2011: Nomination for National Excellent Doctoral Dissertation Award
- 2013: Guangdong Natural Science Outstanding Youth Fund
- 2014: Selected for Guangdong Special Support Plan
- 2015: National Natural Science Foundation Excellent Youth Fund
- 2015: Jiangsu Science and Technology First Prize
- 2020: Guangdong Teaching Achievement First Prize
- 2021: Guangdong Youth May Fourth Medal Nomination
- 2022: Guangdong Science and Technology Progress First Prize
- 2021: Chinese Medical Science and Technology Award Second Prize
- 2022: Chinese Stomatological Association Science and Technology Award Second Prize
