Professor | Jun Cui | Asia Growth Partners

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Name	Jun Cui
Contact Information	cuij5@mail.sysu.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Jun Cui

Contact Information

cuij5@mail.sysu.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Sun Yat-Sen University
Faculty	Life Sciences
Academic Background & Achievements	PhD: Not mentioned Developed a new theory on ubiquitination-autophagy-innate immunity regulation Published over 60 papers as corresponding author in high-impact journals
Awards	2011: Nomination for National Excellent Doctoral Dissertation Award 2013: Guangdong Natural Science Outstanding Youth Fund 2014: Selected for Guangdong Special Support Plan 2015: National Natural Science Foundation Excellent Youth Fund 2015: Jiangsu Science and Technology First Prize 2020: Guangdong Teaching Achievement First Prize 2021: Guangdong Youth May Fourth Medal Nomination 2022: Guangdong Science and Technology Progress First Prize 2021: Chinese Medical Science and Technology Award Second Prize 2022: Chinese Stomatological Association Science and Technology Award Second Prize

University/Lab Affiliation and Title

Sun Yat-Sen University

Faculty

Life Sciences

Academic Background & Achievements

PhD: Not mentioned
Developed a new theory on ubiquitination-autophagy-innate immunity regulation
Published over 60 papers as corresponding author in high-impact journals

Awards

2011: Nomination for National Excellent Doctoral Dissertation Award
2013: Guangdong Natural Science Outstanding Youth Fund
2014: Selected for Guangdong Special Support Plan
2015: National Natural Science Foundation Excellent Youth Fund
2015: Jiangsu Science and Technology First Prize
2020: Guangdong Teaching Achievement First Prize
2021: Guangdong Youth May Fourth Medal Nomination
2022: Guangdong Science and Technology Progress First Prize
2021: Chinese Medical Science and Technology Award Second Prize
2022: Chinese Stomatological Association Science and Technology Award Second Prize

Areas of Focus	Innate immune system recognition and regulation Signal transduction mechanisms Disease correlation (tumor and autoimmune diseases) System biology research
Publications	Modulation of virus-induced neuroinflammation by the autophagy receptor SHISA9 in mice., Zheng Y, Wang L, Liu Q, Xian H, Zhang C, Cai S, Yang S, Jin S, Cui J, 2023 Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy., Wang L, Cai J, Zhao X, Ma L, Zeng P, Zhou L, Liu Y, Yang S, Cai Z, Zhang S, Zhou L, Yang J, Liu T, Jin S, Cui J, 2022 Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response., Yang S, Jin S, Xian H, Zhao Z, Wang L, Wu Y, Zhou L, Li M, Cui J, 2023 Tetherin suppresses type I interferon signaling by targeting MAVS for NDP52-mediated selective autophagic degradation in human cells., Jin S, Tian S, Luo M, Xie W, Liu T, Duan T, Wu Y, Cui J, 2017 USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome., Lin M, Zhao Z, Yang Z, Meng Q, Tan P, Xie W, Qin Y, Wang RF, Cui J, 2016 TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses., Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J, Wang RF, Cui J, 2016 TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation., Liu D, Zhao Z, She Y, Zhang L, Chen X, Ma L, Cui J, 2022 Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy., Jin S, He X, Ma L, Zhuang Z, Wang Y, Lin M, Cai S, Wei L, Wang Z, Zhao Z, Wu Y, Sun L, Li C, Xie W, Zhao Y, Songyang Z, Peng K, Zhao J, Cui J, 2022 Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome., Wang LQ, Liu T, Yang S, Sun L, Zhao ZY, Li LY, She YC, Zheng YY, Ye XY, Bao Q, Dong GH, Li CW, Cui J, 2021 Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses., Liu Q, Wu Y, Qin Y, Hu J, Xie W, Qin FX, Cui J, 2018 Stratified ubiquitination of RIG-I creates robust immune response and induces selective gene expression., Xian H, Xie W, Yang S, Liu Q, Xia X, Jin S, Sun T, Cui J, 2017 Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis., Zheng Y, Liu Q, Wu Y, Ma L, Zhang Z, Liu T, Jin S, She Y, Li YP, Cui J, 2018 RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation., Wu Y, Ma L, Cai S, Zhuang Z, Zhao Z, Jin S, Xie W, Zhou L, Zhang L, Zhao J, Cui J, 2021 m6A RNA modification controls autophagy through upregulating ULK1 protein abundance., Jin S, Zhang X, Miao Y, Liang P, Zhu K, She Y, Wu Y, Liu DA, Huang J, Ren J, Cui J, 2018 Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch., Meng Q, Cai C, Sun T, Wang Q, Xie W, Wang R, Cui J, 2015

Areas of Focus

Innate immune system recognition and regulation
Signal transduction mechanisms
Disease correlation (tumor and autoimmune diseases)
System biology research

Publications

Modulation of virus-induced neuroinflammation by the autophagy receptor SHISA9 in mice., Zheng Y, Wang L, Liu Q, Xian H, Zhang C, Cai S, Yang S, Jin S, Cui J, 2023
Palmitoylation prevents sustained inflammation by limiting NLRP3 inflammasome activation through chaperone-mediated autophagy., Wang L, Cai J, Zhao X, Ma L, Zeng P, Zhou L, Liu Y, Yang S, Cai Z, Zhang S, Zhou L, Yang J, Liu T, Jin S, Cui J, 2022
Metabolic enzyme UAP1 mediates IRF3 pyrophosphorylation to facilitate innate immune response., Yang S, Jin S, Xian H, Zhao Z, Wang L, Wu Y, Zhou L, Li M, Cui J, 2023
Tetherin suppresses type I interferon signaling by targeting MAVS for NDP52-mediated selective autophagic degradation in human cells., Jin S, Tian S, Luo M, Xie W, Liu T, Duan T, Wu Y, Cui J, 2017
USP38 inhibits type I interferon signaling by editing TBK1 ubiquitination through NLRP4 signalosome., Lin M, Zhao Z, Yang Z, Meng Q, Tan P, Xie W, Qin Y, Wang RF, Cui J, 2016
TRIM14 inhibits cGAS degradation mediated by selective autophagy receptor p62 to promote innate immune responses., Chen M, Meng Q, Qin Y, Liang P, Tan P, He L, Zhou Y, Chen Y, Huang J, Wang RF, Cui J, 2016
TRIM14 inhibits OPTN-mediated autophagic degradation of KDM4D to epigenetically regulate inflammation., Liu D, Zhao Z, She Y, Zhang L, Chen X, Ma L, Cui J, 2022
Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy., Jin S, He X, Ma L, Zhuang Z, Wang Y, Lin M, Cai S, Wei L, Wang Z, Zhao Z, Wu Y, Sun L, Li C, Xie W, Zhao Y, Songyang Z, Peng K, Zhao J, Cui J, 2022
Perfluoroalkyl substance pollutants activate the innate immune system through the AIM2 inflammasome., Wang LQ, Liu T, Yang S, Sun L, Zhao ZY, Li LY, She YC, Zheng YY, Ye XY, Bao Q, Dong GH, Li CW, Cui J, 2021
Broad and diverse mechanisms used by deubiquitinase family members in regulating the type I interferon signaling pathway during antiviral responses., Liu Q, Wu Y, Qin Y, Hu J, Xie W, Qin FX, Cui J, 2018
Stratified ubiquitination of RIG-I creates robust immune response and induces selective gene expression., Xian H, Xie W, Yang S, Liu Q, Xia X, Jin S, Sun T, Cui J, 2017
Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis., Zheng Y, Liu Q, Wu Y, Ma L, Zhang Z, Liu T, Jin S, She Y, Li YP, Cui J, 2018
RNA-induced liquid phase separation of SARS-CoV-2 nucleocapsid protein facilitates NF-κB hyper-activation and inflammation., Wu Y, Ma L, Cai S, Zhuang Z, Zhao Z, Jin S, Xie W, Zhou L, Zhang L, Zhao J, Cui J, 2021
m6A RNA modification controls autophagy through upregulating ULK1 protein abundance., Jin S, Zhang X, Miao Y, Liang P, Zhu K, She Y, Wu Y, Liu DA, Huang J, Ren J, Cui J, 2018
Reversible ubiquitination shapes NLRC5 function and modulates NF-κB activation switch., Meng Q, Cai C, Sun T, Wang Q, Xie W, Wang R, Cui J, 2015

Innate Immunity Regulation Signal Transduction Autophagy Inflammation Antiviral Immunity Tumor Autoimmune Diseases System Biology Mathematical Modeling

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