Professor | Xionglei He | Asia Growth Partners

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Name	Xionglei He
Contact Information	hexiongl@mail.sysu.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Xionglei He

Contact Information

hexiongl@mail.sysu.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Sun Yat-Sen University
Faculty	Life Sciences
Academic Background & Achievements	1994.9 - 1998.7 Bachelor's: Sun Yat-sen University, Major in Microbiology, Minor in Computer Science 1998.9 - 2001.7 Master's: Sun Yat-sen University, Major in Biochemistry and Molecular Biology 2004.1 - 2007.4 Ph.D.: University of Michigan - Ann Arbor, Major in Evolutionary Genomics 2012 Received National Outstanding Youth Fund Contributions to functional differentiation of duplicate genes and dosage compensation of sex chromosomes
Work Experience	2007.7 - Present - Sun Yat-sen University, School of Life Sciences - Professor 2012.1 - 2016.12 - Ministry of Education Changjiang Scholar Distinguished Professor
Awards	2012: National Outstanding Youth Fund

University/Lab Affiliation and Title

Sun Yat-Sen University

Faculty

Life Sciences

Academic Background & Achievements

1994.9 - 1998.7 Bachelor's: Sun Yat-sen University, Major in Microbiology, Minor in Computer Science
1998.9 - 2001.7 Master's: Sun Yat-sen University, Major in Biochemistry and Molecular Biology
2004.1 - 2007.4 Ph.D.: University of Michigan - Ann Arbor, Major in Evolutionary Genomics
2012 Received National Outstanding Youth Fund
Contributions to functional differentiation of duplicate genes and dosage compensation of sex chromosomes

Work Experience

2007.7 - Present - Sun Yat-sen University, School of Life Sciences - Professor
2012.1 - 2016.12 - Ministry of Education Changjiang Scholar Distinguished Professor

Awards

2012: National Outstanding Youth Fund

Areas of Focus	Gene complex systems operation and evolution Cell lineage during development Tumor evolution
Publications	Mutation signatures inform the natural host of SARSCoV-2, Shanjun Deng, Ke Xing, Xionglei He, 2022 Mapping single-cell-resolution cell phylogeny reveals cell population dynamics during organ development, Kehui Liu, Shanjun Deng, Chang Ye, Zeqi Yao, Jianguo Wang, Han Gong, Li Liu, and Xionglei He, 2021 Decoupling gene functions from knockout effects by evolutionary analyses, Li Liu, Mengdi Liu, Di Zhang, Shanjun Deng, Piaopiao Chen, Jing Yang, Yunhan Xie and Xionglei He, 2020 The Origin of Additive Genetic Variance Driven by Positive Selection, Li Liu, Yayu Wang, Di Zhang, Zhuoxin Chen, Xiaoshu Chen, Zhijian Su, and Xionglei He, 2020 The Genotype–Phenotype Relationships in the Light of Natural Selection, Han Chen, Chung-I Wu and Xionglei He, 2018 The nonessentiality of essential genes in yeast provides therapeutic insights into a human disease, Piaopiao Chen, Dandan Wang, Han Chen, Zhenzhen Zhou, and Xionglei He, 2016 The Biology Complicated by Genetic Analysis, Xionglei He, 2016 Toward a prospective molecular evolution, Xionglei He, Li Liu, 2016 The Convergent Cancer Evolution toward a Single Cellular Destination, Han Chen, Xionglei He, 2016 The reverse evolution from multicellularity to unicellularity during carcinogenesis, Han Chen, Fangqin Lin, Ke Xing, and Xionglei He, 2015 The dJ/dS ratio test reveals hundreds of novel putative cancer drivers, Han Chen, Ke Xing, Xionglei He, 2015 Reassessing the “duon” hypothesis of protein evolution, Ke Xing and Xionglei He, 2015 Expression reduction in mammalian X chromosome evolution refutes Ohno's hypothesis of dosage compensation, Fangqin Lin, Ke Xing, Jiangzhi Zhang, and Xionglei He, 2012 Nucleosomes suppress spontaneous mutations base-specifically in eukaryotes, Xiaoshu Chen, Zhidong Chen, Han Chen, Zhijian Su, Jianfeng Yang, Fangqin Lin, Suhua Shi, and Xionglei He, 2012 RNA sequencing shows no dosage compensation of the active X-chromosome, Yuanyan Xiong, Xiaoshu Chen, Zhidong Chen, Xunzhang Wang, Suhua Shi, Xueqin Wang, Jianzhi Zhang, and Xionglei He, 2010

Areas of Focus

Gene complex systems operation and evolution
Cell lineage during development
Tumor evolution

Publications

Mutation signatures inform the natural host of SARSCoV-2, Shanjun Deng, Ke Xing, Xionglei He, 2022
Mapping single-cell-resolution cell phylogeny reveals cell population dynamics during organ development, Kehui Liu, Shanjun Deng, Chang Ye, Zeqi Yao, Jianguo Wang, Han Gong, Li Liu, and Xionglei He, 2021
Decoupling gene functions from knockout effects by evolutionary analyses, Li Liu, Mengdi Liu, Di Zhang, Shanjun Deng, Piaopiao Chen, Jing Yang, Yunhan Xie and Xionglei He, 2020
The Origin of Additive Genetic Variance Driven by Positive Selection, Li Liu, Yayu Wang, Di Zhang, Zhuoxin Chen, Xiaoshu Chen, Zhijian Su, and Xionglei He, 2020
The Genotype–Phenotype Relationships in the Light of Natural Selection, Han Chen, Chung-I Wu and Xionglei He, 2018
The nonessentiality of essential genes in yeast provides therapeutic insights into a human disease, Piaopiao Chen, Dandan Wang, Han Chen, Zhenzhen Zhou, and Xionglei He, 2016
The Biology Complicated by Genetic Analysis, Xionglei He, 2016
Toward a prospective molecular evolution, Xionglei He, Li Liu, 2016
The Convergent Cancer Evolution toward a Single Cellular Destination, Han Chen, Xionglei He, 2016
The reverse evolution from multicellularity to unicellularity during carcinogenesis, Han Chen, Fangqin Lin, Ke Xing, and Xionglei He, 2015
The dJ/dS ratio test reveals hundreds of novel putative cancer drivers, Han Chen, Ke Xing, Xionglei He, 2015
Reassessing the “duon” hypothesis of protein evolution, Ke Xing and Xionglei He, 2015
Expression reduction in mammalian X chromosome evolution refutes Ohno's hypothesis of dosage compensation, Fangqin Lin, Ke Xing, Jiangzhi Zhang, and Xionglei He, 2012
Nucleosomes suppress spontaneous mutations base-specifically in eukaryotes, Xiaoshu Chen, Zhidong Chen, Han Chen, Zhijian Su, Jianfeng Yang, Fangqin Lin, Suhua Shi, and Xionglei He, 2012
RNA sequencing shows no dosage compensation of the active X-chromosome, Yuanyan Xiong, Xiaoshu Chen, Zhidong Chen, Xunzhang Wang, Suhua Shi, Xueqin Wang, Jianzhi Zhang, and Xionglei He, 2010

Gene Expression Mutation Phenotype Yeast Cell Lineage Development Somatic Mutation Tumor Evolution Genomics Bioinformatics

Qi Liu - Tongji University

Lu Dongdong - Tongji University

Guifen Liu - Tongji University

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