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Xionglei He
Life Science
Sun Yat-Sen University
Guangdong
Language: Chinese, English
Gene Expression
Mutation
Phenotype
Yeast
Cell Lineage
Development
Somatic Mutation
Tumor Evolution
Genomics
Bioinformatics
Areas of Focus
- Gene complex systems operation and evolution
- Cell lineage during development
- Tumor evolution
Work Experience
- 2007.7 - Present - Sun Yat-sen University, School of Life Sciences - Professor
- 2012.1 - 2016.12 - Ministry of Education Changjiang Scholar Distinguished Professor
Academic Background & Achievements
- 1994.9 - 1998.7 Bachelor's: Sun Yat-sen University, Major in Microbiology, Minor in Computer Science
- 1998.9 - 2001.7 Master's: Sun Yat-sen University, Major in Biochemistry and Molecular Biology
- 2004.1 - 2007.4 Ph.D.: University of Michigan - Ann Arbor, Major in Evolutionary Genomics
- 2012 Received National Outstanding Youth Fund
- Contributions to functional differentiation of duplicate genes and dosage compensation of sex chromosomes
Publications
- Mutation signatures inform the natural host of SARSCoV-2, Shanjun Deng, Ke Xing, Xionglei He, 2022
- Mapping single-cell-resolution cell phylogeny reveals cell population dynamics during organ development, Kehui Liu, Shanjun Deng, Chang Ye, Zeqi Yao, Jianguo Wang, Han Gong, Li Liu, and Xionglei He, 2021
- Decoupling gene functions from knockout effects by evolutionary analyses, Li Liu, Mengdi Liu, Di Zhang, Shanjun Deng, Piaopiao Chen, Jing Yang, Yunhan Xie and Xionglei He, 2020
- The Origin of Additive Genetic Variance Driven by Positive Selection, Li Liu, Yayu Wang, Di Zhang, Zhuoxin Chen, Xiaoshu Chen, Zhijian Su, and Xionglei He, 2020
- The Genotype–Phenotype Relationships in the Light of Natural Selection, Han Chen, Chung-I Wu and Xionglei He, 2018
- The nonessentiality of essential genes in yeast provides therapeutic insights into a human disease, Piaopiao Chen, Dandan Wang, Han Chen, Zhenzhen Zhou, and Xionglei He, 2016
- The Biology Complicated by Genetic Analysis, Xionglei He, 2016
- Toward a prospective molecular evolution, Xionglei He, Li Liu, 2016
- The Convergent Cancer Evolution toward a Single Cellular Destination, Han Chen, Xionglei He, 2016
- The reverse evolution from multicellularity to unicellularity during carcinogenesis, Han Chen, Fangqin Lin, Ke Xing, and Xionglei He, 2015
- The dJ/dS ratio test reveals hundreds of novel putative cancer drivers, Han Chen, Ke Xing, Xionglei He, 2015
- Reassessing the “duon” hypothesis of protein evolution, Ke Xing and Xionglei He, 2015
- Expression reduction in mammalian X chromosome evolution refutes Ohno's hypothesis of dosage compensation, Fangqin Lin, Ke Xing, Jiangzhi Zhang, and Xionglei He, 2012
- Nucleosomes suppress spontaneous mutations base-specifically in eukaryotes, Xiaoshu Chen, Zhidong Chen, Han Chen, Zhijian Su, Jianfeng Yang, Fangqin Lin, Suhua Shi, and Xionglei He, 2012
- RNA sequencing shows no dosage compensation of the active X-chromosome, Yuanyan Xiong, Xiaoshu Chen, Zhidong Chen, Xunzhang Wang, Suhua Shi, Xueqin Wang, Jianzhi Zhang, and Xionglei He, 2010
Awards
- 2012: National Outstanding Youth Fund
