Pathogenic bacteria/human microbiome and host interaction Probiotic resource exploration and its molecular mechanism for disease improvement
Gut Microbiota-Derived 3-Hydroxybutyrate Blocks GPR43-Mediated IL6 Signaling to Ameliorate Radiation Proctopathy, Zhenhuang Ge, Chun Chen, Junyi Chen, Zhou Jiang, Lingming Chen, Yingqi Wei, Haiyang Chen, Lei He, Yi Zou, Xiaoxuan Long, Hongyu Zhan, Huaiming Wang, Hui Wang, and Yongjun Lu, 2024
High-fat diet promotes cancer progression by inducing gut microbiota-mediated leucine production and MDSC differentiation, Jiewen Chen, Xiyuan Liu, Junli Gong, Xiaorong Lin, Hongyan Huang, Jianli Zhao, Phei Er Saw, Yongjun Lu, Hai Hu, Erwei Song, 2024
Design, synthesis and biological evaluation of 3-substituted-2-thioxothiazolidin-4- one (rhodanine) derivatives as antitubercular agents against Mycobacterium tuberculosis protein tyrosine phosphatase B, Shihao Cheng, Yi Zou, Xi Chen, Jiahao Chen, Bin Wang, Jinying Tian, Fei Ye, Yu Lu, Haihong Huang, Yongjun Lu, Dongfeng Zhang, 2023
Identification of fecal microbiome signatures associated with familial longevity and candidate metabolites for healthy aging, Gong, J., Liu, S., Wang, S., Ruan, H., Mou, Q., Fan, P., Chen, T., Cai, W., Lu, Y., & Lu, Z., 2023
Discovery of biphenyls bearing thiobarbiturate fragment by structure-based strategy as Mycobacterium tuberculosis protein tyrosine phosphatase B inhibitors, Shihao Cheng, Qinglin Wang, Xi Chen, Jiahao Chen, Bin Wang, Dongni Chen, Dong Shen, Jinying Tian, Fei Ye, Yu Lu, Haihong Huang, Yongjun Lu, Dongfeng Zhang, 2022
Comparative genomics analysis of Bacillus velezensis LOH112 isolated from a nonagenarian provides insights into its biocontrol and probiotic traits, Zhenhuang Ge, Zhiqi Kuang, Jiahao Chen, Junyi Chen, Tianhao Liu, Zhigang She and Yongjun Lu, 2022
New global insights on the regulation of the biphasic life cycle and virulence via ClpP-dependent proteolysis in Legionella pneumophila, Zhenhuang Ge, Peibo Yuan, Lingming Chen, Junyi Chen, Dong Shen, Zhigang She and Yongjun Lu, 2022
DNA aptamers specific for Legionella pneumophila: systematic evolution of ligands by exponential enrichment in whole bacterial cells, Lina Xiong, Mingchen Xia, Qinglin Wang, Zhen Meng, Jie Zhang, Guohui Yu, Zhangyong Dong, Yongjun Lu, Yunhao Sun, 2022
Gut Akkermansia muciniphila ameliorates metabolic-dysfunction associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis, Yong Rao, Zhiqi Kuang, Chan Li, Shiyao Guo, Yaohao Xu, Dandan Zhao, Yutao Hu, Bingbing Song, Zhi Jiang, Zhenhuang Ge, Xiyuan Liu, Chengdao Li, Shuobin Chen, Jiming Ye, Zhishu Huang, Yongjun Lu, 2021
The oxidation cascade of a rare multifunctional P450 enzyme involved in Asperterpenoid A biosynthesis, Hui-Yun Huang, Jia-Hua Huang, Yong-Heng Wang, Dan Hu, Yong-jun Lu, Zhi-Gang She, Guo-Dong Chen, Xin-Sheng Yao, Hao Gao, 2021
A new anthraquinone from mangrove endophytic fungus Aspergillus sp. 16-5C, Ze'en Xiao, Shao'e Lin, Zhigang She, Yongjun Lu, Zhen Tan, Yonghong Liu, 2021
Identification of fusarielin M as a novel inhibitor of Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB), Dongni Chen, Lan Liu, Yongjun Lu, Senhua Chen, 2021
High salt diet may promote progression of breast tumor through eliciting immune response, Chen Jie-wen, Liu Xi-yuan, Huang Hong-yan, Zhang Fang-fang, Lu Yong-jun, Hu Hai, 2020
Proteomic characterization of Mycobacterium tuberculosis reveals potential targets of bostrycin, Yuan PB, He L, Chen DN, Sun YH, Ge ZH, Shen D, Lu YJ, 2020
Polypropionate Derivatives with Mycobacterium tuberculosis Protein Tyrosine Phosphatase B Inhibitory Activities from the Deep-Sea- Derived Fungus Aspergillus fischeri FS452, Zhaoming Liu, Qinglin Wang, Saini Li, Hui Cui, Zhanghua Sun, Dongni Chen, Yongjun Lu, Hongxin Liu, and Weimin Zhang, 2019
The Temporal Expression of Global Regulator Protein CsrA Is Dually Regulated by ClpP During the Biphasic Life Cycle of Legionella pneumophila, Zhen-huang Ge, Qin-sha Long, Pei-bo Yuan, Xin Pan, Dong Shen and Yong-jun Lu, 2019
Gut dysbiosis and lack of short chain fatty acids in a Chinese cohort of patients with multiple sclerosis, Qin Zeng, Junli Gong, Xiyuan Liu, Chen Chen, Xiaobo Sun, Huijuan Li, Yifan Zhou, ChunPing Cui, Yuge Wang, Yu Yang, Aimin Wu, Yaqing Shu, Xueqiang Hu, Zhengqi Lu, Song Guo Zheng, Wei Qiu, Yongjun Lu, 2019
The Legionella pneumophila effector WipA disrupts host F-actin polymerisation by hijacking phosphotyrosine signaling, He L, Lin Y, Ge ZH, He SY, Zhao BB, Shen D, He JG, Lu YJ, 2019
Docking- and pharmacophore-based virtual screening for the identification of novel Mycobacterium tuberculosis protein tyrosine phosphatase B (MptpB) inhibitor with a thiobarbiturate scaffold, Dongfeng Zhang, Yun Lin, Xi Chen, Wenting Zhao, Dongni Chen, Meng Gao, Qinglin Wang, Bin Wang, Haihong Huang, Yongjun Lu, Yu Lu, 2019
Biosynthesis of an anti-tuberculosis sesterterpenoid asperterpenoid A, Jia-Hua Huang, Jian-Ming Lv, Qiao-Zhen Wang, Jian Zou, Yong-Jun Lu, Qing-Lin Wang, Dong-Ni Chen, Xin-Sheng Yao, Hao Gao and Dan Hu, 2019
Peptides and polyketides isolated from the marine sponge-derived fungus Aspergillus terreus SCSIO 41008, LUO X-W, LIN Y, LU Y-J, Zhou XF, Liu YH, 2019
The Ralstonia solanacearum effector RipN suppresses plant PAMP-triggered immunity, localizes to the endoplasmic reticulum and nucleus, and alters the NADH/NAD+ ratio in Arabidopsis, Sun yunhao, Li Pai, Shen Dong, Wei Qiaoling, He Jianguo, Lu Yongjun, 2019
Lack of short-chain fatty acids and overgrowth of opportunistic pathogens define dysbiosis of neuromyelitis optica spectrum disorders: A Chinese pilot study, Gong JL, Qiu W, Zeng Q, Liu XY, Sun XB, Li HJ, Yang Y, Wu AM, Bao J, Wang YG, Shu YQ, Hu XQ, Bellanti JA, Zheng SG, Lu YJ, Lu ZQ, 2018
Peptides from the Soft Coral-associated Fungus Simplicillium sp. SCSIO41209, Yu Dai, Yun Lin, Xiaoyan Pang, Xiaowei Luo, Limbadri salendra, Junfeng Wang, Xuefeng Zhou, Yongjun Lu, Bin Yang, Yonghong Liu, 2018
Legionella pneumophila effector WipA, a bacterial PPP protein phosphatase with PTP activity, Qian Jia, Yun Lin, Xue-jing Gou, Lei He, Dong Shen, Dong-ni Chen, Wei Xie, Yong-jun Lu, 2018
Geochemical and microbial characters of sediment from the gas hydrate area in the Taixinan Basin, South China Sea, GONG Junli, SUN Xiaoming, LIN Zhiyong, LU Hongfeng, LU Yongjun, 2017
Talaramide A, an Unusual Alkaloid from the Mangrove Endophytic Fungus Talaromyces sp. (HZ-YX1) as Inhibitor of Mycobacterial PknG, Senhua Chen, Liqing He, Dongni Chen, Runlin Cai, Yuhua, Long, Yongjun Lu and Zhigang She, 2017
(+)- and (-)-Ascomlactone A: a pair of novel dimeric polyketides from a mangrove endophytic fungus Ascomycota sp. SK2YWS-L, Liu Z, Chen S, Qiu P, Tan C, Long Y, Lu Y, She Z, 2017
The Ralstonia solanacearumeffector RipAK suppresses plant hypersensitive response by inhibiting the activity of host catalases, Sun Yunhao, Li Pai, Deng Mengying, Shen Dong, Dai Guangyi, Yao Nan, Lu Yongjun, 2017
Sclerotiorin inhibits protein kinase G from Mycobacterium tuberculosis and impairs mycobacterial growth in macrophages, Dongni Chen, Shuangshuang Ma, Lei He, Peibo Yuan, Zhigang She and Yongjun Lu, 2017
Antioxidative Polyketones from the Mangrove-Derived Fungus Ascomycota sp. SK2YWS-L, Chunbin Tan, Zhaoming Liu, Senhua Chen, Xishan Huang, Hui Cui, Yuhua Long, Yongjun Lu and Zhigang She, 2016
The phytopathogenic virulent effector protein RipI induces apoptosis in budding yeast Saccharomyces cerevisiae, Meng-ying Deng, Yun-hao Sun, Pai Li, Bei Fu, Dong Shen, Yong-jun Lu, 2016
ClpP-deletion impairs the virulence of Legionella pneumophila and the optimal translocation of effector proteins, Bei-bei Zhao, Xiang-hui Li, Yong-lun Zeng and Yong-jun Lu, 2016
Polyketides from the Mangrove-Derived Endophytic Fungus Nectria sp. HN001 and Their α-Glucosidase Inhibitory Activity, Hui Cui, Yayue Liu, Yang Nie, Zhaoming Liu, Zhengrui Zhang, Yongjun Lu, Lei He, Xishan Huang, Zhigang She, 2016
Aspterpenacids A and B, Two Sesterterpenoids from a Mangrove Endophytic Fungus Aspergillus terreus H010, Liu, Zhaoming; Chen, Yan; Chen, Senhua; Liu, Yayue; Lu, Yongjun; Chen, Dongni; Lin, Yongcheng; Huang, Xishan; She, Zhigang, 2016
Identification of Bostrycin Derivatives on Inhibition of MptpB Phosphatase from Mycobacterium tuberculosis, Dong-ni Chen, Hong Chen, Zhi-gang She, Yong-jun Lu, 2016
Lasiodiplodins from Mangrove Endophytic Fungus Lasiodiplodia sp. 318#, Li J, Xue YY, Yuan J, Lu YJ, Zhu X, Lin YC, Liu L, 2016
β-Resorcylic acid derivatives with a-glucosidase inhibitory activity from Lasiodiplodia sp. ZJ-HQ1, an endophytic fungus in the medicinal plant Acanthus ilicifolius, Senhua Chen, Zhaoming Liu, Hanxiang Li, Guoping Xia, Yongjun Lu, Lei He, Shaodong Huang, Zhigang She, 2015
New Depsidones and Isoindolones from the Mangrove Endophytic Fungus Meyerozyma guilliermondii (HZ-Y2) Isolated from the South China Sea, Senhua Chen, Zhaoming Liu, Yayue Liu, Yongjun Lu, Lei He, Zhigang She, 2015
Polyketides with α-Glucosidase Inhibitory Activity from a Mangrove Endophytic Fungus, Penicillium sp. HN29-3B1, Liu Y, Yang Q, Xia G, Huang H, Li H, Ma L, Lu Y, He L, Xia X, She Z, 2015
Proteomics analysis of Listeria monocytogenesATCC 19115 in response to simultaneous triple stresses, He Lei, Deng Qing-li, Chen Mou-tong, Wu Qing-ping, Lu Yong-jun, 2015
Bioactive Metabolites from Mangrove Endophytic Fungus Aspergillus sp. 16-5B, Yayue Liu, Senhua Chen, Zhaoming Liu, Yongjun Lu, Guoping Xia, Hongju Liu, Lei He and Zhigang She, 2015
Asperlones A and B, Dinaphthalenone Derivatives from a Mangrove Endophytic Fungus Aspergillus sp. 16-5C, Ze'en Xiao, Shao'e Lin, Chunbin Tan, Yongjun Lu, Lei He, Xishan Huang, Zhigang She, 2015
A simple method for constructing magnetic Escherichia coli, Sun Meng-yi, Lu Yong-jun, 2014
Vermistatin Derivatives with α-Glucosidase Inhibitory Activity from the Mangrove Endophytic Fungus Penicillium sp. HN29-3B1, Yayue Liu, Guoping Xia, Hanxiang Li, Lin Ma, Bo Ding, Yongjun Lu, Lei He, Xuekui Xia, Zhigang She, 2014
Meroterpenes and azaphilones from marine mangrove endophytic fungus Penicillium 303#, Li Jing, Yang Xin, Lin Yingying, Yuan Jie, Lu Yongjun, Zhu Xun, Li Jun, Li Mengfeng, Lin Yongcheng, He Jianguo, Liu Lan, 2014
Alterporriol-Type Dimers from the Mangrove Endophytic Fungus, Alternaria sp. (SK11), and Their MptpB Inhibitions, Guoping Xia, Jia Li, Hanxiang Li, Yuhua Long, Shao’e Lin, Yongjun Lu, Lei He, Yongcheng Lin, Lan Liu and Zhigang She, 2014
Peniphenones A-D from the Mangrove Fungus Penicillium dipodomyicola HN4-3A as Inhibitors of Mycobacterium tuberculosis Phosphatase MptpB, Li HX, Jiang J, Liu Z, Lin S, Xia G, Xia X, Ding B, He L, Lu Y, She Z, 2014
New dimeric members of the phomoxanthone family: phomolacton-exanthones A, B and deacetylphomoxanthone C isolated from the fungus Phomopsis sp., Ding B, Yuan J, Huang X, Wen W, Zhu X, Liu Y, Li H, Lu Y, He L, Tan H, She Z, 2013
Temporal and spatial diversity of bacterial communities in coastal waters of the South china sea, Du J, Xiao K, Li L, Ding X, Liu H, Lu Y, Zhou S, 2013
Asperterpenols A and B, new sesterterpenoids isolated from a mangrove endophytic fungus Aspergillus sp. 085242, Xiao Z, Huang H, Shao C, Xia X, Ma L, Huang X, Lu Y, Lin Y, Long Y, She Z, 2013
Isolation and characterization of a novel cyanophycin synthetase from a deep-sea sediment metagenomic library, Du J, Li L, Ding X, Hu H, Lu Y, Zhou S, 2013
Asperterpenoid A, a New Sesterterpenoid as an Inhibitor of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B from the Culture of Aspergillus sp. 16-5c, Huang, Xishan; Huang, Hongbo; Li, Hanxiang; Sun, Xuefeng; Huang, Huarong; Lu, Yongjun; Lin, Yongcheng; Long, Yuhua; She, Zhigang, 2013
The cytotoxicity and anticancer mechanisms of alterporriol L, a marine bianthraquinone, against MCF-7 human breast cancer cells, Huang C, Jin H, Song B, Zhu X, Zhao H, Cai J, Lu Y, Chen B, Lin Y, 2012
Screening for novel quorum-sensing inhibitors to interfere with the formation of Pseudomonas aeruginosa biofilm, Ding X, Yin B, Qian L, Zeng Z, Yang Z, Li H, Lu Y, Zhou S, 2011
Cytotoxic Norsesquiterpene Peroxides from the Endophytic Fungus Talaromyces flavus Isolated from the Mangrove Plant Sonneratia apetala, Hanxiang Li, Hongbo Huang, Changlun Shao, Huarong Huang, Jieyi Jiang, Xun Zhu, Yayue Liu Lan Liu, Yongjun Lu, Mengfeng Li, Yongcheng Lin, and Zhigang She, 2011
Three Bianthraquinone Derivatives from the Mangrove Endophytic Fungus Alternaria sp. ZJ9-6B from the South China Sea, Cai-Huan Huang, Jia-Hui Pan, Bin Chen, Miao Yu, Hong-Bo Huang, Xun Zhu, Yong-Jun Lu, Zhi-Gang She and Yong-Cheng Lin, 2011
Azaphilones and p-Terphenyls from the Mangrove Endophytic Fungus Penicillium chermesinum (ZH4-E2) Isolated from the South China Sea, Hongbo Huang, Xiaojun Feng, Ze’en Xiao, Lan Liu, Hanxiang Li, Lin Ma, Yongjun Lu, Jianhua Ju, Zhigang She, and Yongcheng Lin, 2011
Identification and characterization of a novel methionine c-lyase gene from deep-sea sediment metagenomic library, Huixian Li, Yali Huang, Jiong Zhang, Jikun Du, Hongming Tan, Yongjun Lu, Shining Zhou, 2011
Seasonal and spatial diversity of microbial communities in marine sediments of the South China Sea, Jikun Du, Kai Xiao, Yali Huang, Huixian Li, Hongming Tan, Lixiang Cao, Yongjun Lu, Shining Zhou, 2011
Far3p domains involved in the interactions of Far proteins and pheromone-induced cell cycle arrest in budding yeast, Fenju Lai, Rentian Wu, Jiafeng Wang, Chunming Li, Lan Zou, Yongjun Lu and Chun Liang, 2011
Identification of Novel Factors Involved in or Regulating Initiation of DNA Replication by a Phenotypic Screen in Saccharomyces cerevisiae, Lijuan Ma, Yuanliang Zhai, Daorong Feng, Tsz-choi Chan, Yongjun Lu, Xinrong Fu, Jiafeng Wang, Yanhong Chen, Jianna Li, Ke Xu, and Chun Liang, 2010
Three Dimeric Naphtho-γ-Pyrones from the Mangrove Endophytic Fungus Aspergillus tubingensis Isolated from Pongamia pinnata, Hong-Bo Huang, Xiao-Jun Feng, Lan Liu, Bin Chen, Yong-Jun Lu, Lin Ma, Zhi-Gang She, Yong-Cheng Lin, 2010
The metabolites of mangrove endophytic fungus Zh6-B1 from the South China Sea, Kai-Kai Li, Yong-Jun Lu, Xiao-Hong Song, Zhi-Gang She, Xi-Wei Wu, Lin-Kun An, Chuang-Xing Ye, Yong-Cheng Lin, 2010
The ClpP protease homologue is required for the transmission traits and cell division of the pathogen Legionella pneumophila, Xiang-hui Li, Yong-lun Zeng, Ye Gao, Xiao-cong Zheng, Qin-fen Zhang, Shi-ning Zhou, Yong-jun Lu, 2010
ATP-Dependent Pre-Replicative Complex Assembly Is Facilitated by Adk1p in Budding Yeast, Zhen Xu, Xue Cheng, Jiafeng Wang, Yuanliang Zhai, Yongjun Lu and Chun Liang, 2010
Ctf4p Facilitates Mcm10p to Promote Initiation of DNA Replication in Budding Yeast, Jiafeng Wang, Rentian Wu, Yongjun Lu and Chun Liang, 2010
The anthracenedione compound bostrycin induces mitochondria-mediated apoptosis in the yeast Saccharomyces cerevisiae, Chun-ling Xu, Jia-feng Wang, Ye Gao, Huang-yu Lin, Lin Du, Shan-shan Yang, Si-mei Long, Zhi-gang She, Xiao-ling Cai, Shi-ning Zhou, Yong-jun Lu, 2010
A new indene derivative from the marine fungus Phomopsis sp. (No. GX7-4A), Yiguang Chen, Jiahui Pan, Fan Liu, JianXiang Yang, Caihuan Huang, Xiaolin Cai, Yongjun Lu, Zhigang She and Yongcheng Lin, 2010
Complete nucleotide sequence of pCTX-M360, an intermediate plasmid between pEL60 and pCTX-M3, from a multidrug resistant Klebsiella pneumoniae isolated in China, Wen-han Zhu, Lan Luo, Jia-yi Wang, Xiao-hong Zhuang, Ling Zhong, Kang Liao, Yan Zeng, Yong-jun Lu, 2009
The Legionella pneumophila Dps homolog is regulated by iron and involved in multiple stress tolerance, Ming-jia Yu, Jun Ren, Yong-lun Zeng, Shi-ning Zhou and Yong-jun Lu, 2009
Area of Focus
Gut Tumor | Microbiome | Epidemiology | Factors | Interaction | Mechanisms | Gut Microbiota | Metabolites | Tumor Microenvironment | Research
Area of Focus
Gut Microbiota | Obesity | Metabolic Diseases | Regulation | Mechanisms | Engineered Bacteria | Development | Utilization | Microbiome | Health
