Professor | Li Yingqiu | Asia Growth Partners

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Name	Li Yingqiu
Contact Information	lsslyq@mail.sysu.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Li Yingqiu

Contact Information

lsslyq@mail.sysu.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Sun Yat-Sen University
Faculty	Life Sciences
Academic Background & Achievements	1987 - Bachelor's degree in Science: East China Normal University 1990 - Master's degree in Science: East China Normal University 1995 - Doctorate in Science: Sun Yat-sen University Selected for the Ministry of Education's 'New Century Excellent Talents Support Program'
Work Experience	1997-2004 - The Scripps Research Institute and La Jolla Institute for Allergy and Immunology - Postdoc Fellow, Senior Scientist 2005-present - Sun Yat-sen University - Professor
Awards	New Century Excellent Talents Support Program: Ministry of Education

University/Lab Affiliation and Title

Sun Yat-Sen University

Faculty

Life Sciences

Academic Background & Achievements

1987 - Bachelor's degree in Science: East China Normal University
1990 - Master's degree in Science: East China Normal University
1995 - Doctorate in Science: Sun Yat-sen University
Selected for the Ministry of Education's 'New Century Excellent Talents Support Program'

Work Experience

1997-2004 - The Scripps Research Institute and La Jolla Institute for Allergy and Immunology - Postdoc Fellow, Senior Scientist
2005-present - Sun Yat-sen University - Professor

Awards

New Century Excellent Talents Support Program: Ministry of Education

Areas of Focus	Immune cell signal transduction Immune response
Publications	T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1., He Y, Yang Z, Zhao CS, Xiao Z, Gong Y, Li YY, Chen Y, Du Y, Feng D, Altman A, Li Y, 2021 Identification and Characterization of the Amphioxus Lck and Its Associated Tyrosine Phosphorylation-Dependent Inhibitory LRR Receptor., Zhou J, Xiao Z, Zhan Y, Qu X, Mou S, Deng C, Zhang T, Lan X, Huang S, Li Y, 2021 The p38-interacting protein p38IP suppresses TCR and LPS signaling by targeting TAK1., Wang XD, Zhao CS, Wang QL, Zeng Q, Feng XZ, Li L, Chen ZL, Gong Y, Han J, Li Y, 2020 T Cell Receptor (TCR)-Induced PLC-γ1 Sumoylation via PIASxβ and PIAS3 SUMO E3 Ligases Regulates the Microcluster Assembly and Physiological Function of PLC-γ1., Wang QL, Liang JQ, Gong BN, Xie JJ, Yi YT, Lan X, Li Y, 2019 Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling., Xie J, Han X, Zhao C, Canonigo-Balancio AJ, Yates JR 3rd, Li Y, Lillemeier BF, Altman A, 2019 Characterisation of amphioxus protein kinase C-δ/θ reveals a unique proto-V3 domain suggesting an evolutionary mechanism for PKC-θ unique V3., Chen ZL, Gong BN, Wang QL, Xiao ZH, Deng C, Wang WQ, Li Y, 2018 Molecular mechanisms underlying the evolution of the slp76 signalosome., Qu X, Lan X, Deng C, Zhou J, Du J, Huang S, Li Y, 2017 A novel miR-200b-3p/p38IP pair regulates monocyte/macrophage differentiation., Yu X, Wang QL, Li YF, Wang XD, Xu A, Li Y, 2016 TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation., Wang XD, Gong Y, Chen ZL, Gong BN, Xie JJ, Zhong CQ, Wang QL, Diao LH, Xu A, Han J, Altman A, Li Y, 2015 The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5., Liu X, Xiao W, Wang XD, Li YF, Han J, Li Y, 2013 TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter., Xie JJ, Liang JQ, Diao LH, Altman A, Li Y, 2013 NEMO differentially regulates TCR and TNF-α induced NF-κB pathways and has an inhibitory role in TCR-induced NF-κB activation., Wang K, Diao LH, Gong Y, Liu X, Li Y, 2012 p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation., Zohn IE, Li Y, Skolnik EY, Anderson KV, Han J, Niswander L, 2006 Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation., Li Y, Sedwick CE, Hu J, Altman A, 2005 SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway., Li Y, Hu J, Vita R, Sun B, Tabata H, Altman A, 2004 Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase., Li Y, Jiang B, Ensign WY, Vogt PK, Han J, 2000

Areas of Focus

Immune cell signal transduction
Immune response

Publications

T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1., He Y, Yang Z, Zhao CS, Xiao Z, Gong Y, Li YY, Chen Y, Du Y, Feng D, Altman A, Li Y, 2021
Identification and Characterization of the Amphioxus Lck and Its Associated Tyrosine Phosphorylation-Dependent Inhibitory LRR Receptor., Zhou J, Xiao Z, Zhan Y, Qu X, Mou S, Deng C, Zhang T, Lan X, Huang S, Li Y, 2021
The p38-interacting protein p38IP suppresses TCR and LPS signaling by targeting TAK1., Wang XD, Zhao CS, Wang QL, Zeng Q, Feng XZ, Li L, Chen ZL, Gong Y, Han J, Li Y, 2020
T Cell Receptor (TCR)-Induced PLC-γ1 Sumoylation via PIASxβ and PIAS3 SUMO E3 Ligases Regulates the Microcluster Assembly and Physiological Function of PLC-γ1., Wang QL, Liang JQ, Gong BN, Xie JJ, Yi YT, Lan X, Li Y, 2019
Phosphotyrosine-dependent interaction between the kinases PKCθ and Zap70 promotes proximal TCR signaling., Xie J, Han X, Zhao C, Canonigo-Balancio AJ, Yates JR 3rd, Li Y, Lillemeier BF, Altman A, 2019
Characterisation of amphioxus protein kinase C-δ/θ reveals a unique proto-V3 domain suggesting an evolutionary mechanism for PKC-θ unique V3., Chen ZL, Gong BN, Wang QL, Xiao ZH, Deng C, Wang WQ, Li Y, 2018
Molecular mechanisms underlying the evolution of the slp76 signalosome., Qu X, Lan X, Deng C, Zhou J, Du J, Huang S, Li Y, 2017
A novel miR-200b-3p/p38IP pair regulates monocyte/macrophage differentiation., Yu X, Wang QL, Li YF, Wang XD, Xu A, Li Y, 2016
TCR-induced sumoylation of the kinase PKC-θ controls T cell synapse organization and T cell activation., Wang XD, Gong Y, Chen ZL, Gong BN, Xie JJ, Zhong CQ, Wang QL, Diao LH, Xu A, Han J, Altman A, Li Y, 2015
The p38-interacting protein (p38IP) regulates G2/M progression by promoting α-tubulin acetylation via inhibiting ubiquitination-induced degradation of the acetyltransferase GCN5., Liu X, Xiao W, Wang XD, Li YF, Han J, Li Y, 2013
TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter., Xie JJ, Liang JQ, Diao LH, Altman A, Li Y, 2013
NEMO differentially regulates TCR and TNF-α induced NF-κB pathways and has an inhibitory role in TCR-induced NF-κB activation., Wang K, Diao LH, Gong Y, Liu X, Li Y, 2012
p38 and a p38-interacting protein are critical for downregulation of E-cadherin during mouse gastrulation., Zohn IE, Li Y, Skolnik EY, Anderson KV, Han J, Niswander L, 2006
Role for protein kinase Ctheta (PKCtheta) in TCR/CD28-mediated signaling through the canonical but not the non-canonical pathway for NF-kappaB activation., Li Y, Sedwick CE, Hu J, Altman A, 2005
SPAK kinase is a substrate and target of PKCtheta in T-cell receptor-induced AP-1 activation pathway., Li Y, Hu J, Vita R, Sun B, Tabata H, Altman A, 2004
Myogenic differentiation requires signalling through both phosphatidylinositol 3-kinase and p38 MAP kinase., Li Y, Jiang B, Ensign WY, Vogt PK, Han J, 2000

T-Cell Receptor Signal Transduction Immune Response Sumo Modification P38Ip Protein T-Cell Activation T-Cell Development T-Cell Differentiation Pkc-Θ Rangap1

Xiumei Wei - East China Normal University

Jin Jin - Zhejiang University

Xiangzong Meng - Shanghai Normal University

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