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Li-Min Zheng
Life Science
Sun Yat-Sen University
Guangdong
Language: Chinese, English
Cancer
Immunology
Tumor
Immune Cells
Biochemistry
Molecular Biology
Cell Interaction
Clinical Significance
Liver Cancer
Immune Regulation
Areas of Focus
- Tumor Immunology
- Immunocellular Biology
Work Experience
- 1984-1990: Doctor at Huashan Hospital, Shanghai Medical University
- 1994-1996: Postdoctoral Researcher, Department of Cell Biology, Linkoping University, Sweden
- 1996-1998: Postdoctoral Researcher, Malmo General Hospital, Lund University, Sweden
- 1999-2002: Assistant Professor, Department of Medical Microbiology, Linkoping University, Sweden
- 2002-2016: Professor and Doctoral Supervisor, School of Life Sciences, Sun Yat-sen University
- 2016-present: Dean, School of Life Sciences, Sun Yat-sen University
Academic Background & Achievements
- 1979-1984: Bachelor in Medicine, Shanghai Medical University
- 1990-1994: PhD in Immunology, Leiden University, Netherlands
- Published over 90 papers in international journals with a total impact factor of approximately 800
- Recipient of National Science Foundation key projects and Ministry of Health major projects
Publications
- Peritumoral monocytes induce cancer cell autophagy to facilitate the progression of human hepatocellular carcinoma, DP Chen, WR Ning, XF Li, Y Wei, XM Lao, JC Wang, Y Wu and L Zheng, 2018
- Monocytes /Macrophages promote vascular CXCR4 expression via the ERK pathway in hepatocellular carcinoma, YM Meng, J Liang, C Wu, J Xu, DN Zeng, XJ Yu, H Ning, L Xu, and L Zheng, 2018
- Vascular CXCR4 expression promotes vessel sprouting and sensitivity to Sorafenib treatment in hepatocellular carcinoma, J Xu, J Liang, YM Meng, J Yan, XJ Yu, CQ Liu, L Xu, SM Zhuang and L Zheng, 2017
- CD169 identifies an activated CD8 T cell subset in regional lymph nodes that predicts favorable prognosis in colorectal cancer patients, J Zhang, J Xu, RX Zhang, Y Zhang, QJ Ou, JQ Li, ZZ Jiang, XJ Wu, YJ Fang, and L Zheng, 2016
- CD169 identifies an anti-tumour macrophage subpopulation in human hepatocellular carcinoma, Y Zhang, JQ Li, ZZ Jiang, L Li, Y Wu, and L Zheng, 2016
- c-Met identifies a population of matrix metalloproteinase 9-producing monocytes in peritumoral stroma of Hepatocellular carcinoma, L Zhao, Y Wu, XD Xie, YF Chu, JQ Li, and L Zheng, 2015
- Increased autophagy sustains the survival and protumorigenic effects of neutrophils in human cancers, XF Li, DP Chen, FZ Ouyang, MM Chen, Y Wu, DM Kuang, and L Zheng, 2015
- B7-H1-expressing antigen-presenting cells mediate polarization of pro-tumorigenic Th22 subset, DM Kuang, X Xiao, Q Zhao, MM Chen, XF Li, RX Liu, Y Wei, FZ Ouyang, DP Chen, Y Wu, XM Lao, H Deng, and L Zheng, 2014
- Circulating hematopoietic stem and progenitor cells are myeloid-biased in cancer patients, WC Wu, HW Sun, HT Chen, J Liang, XJ Yu, C Wu, Z Wang, and L Zheng, 2014
- Monocyte /Macrophage-elicited NK cell dysfunction in Hepatocellular carcinoma is mediated by CD48/2B4 interactions, Y Wu, DM Kuang, WD Pan, YL Wan, XM Lao, D Wang, XF Li, L Zheng, 2013
- In Situ molecular signature predict early recurrence in Hepatitis B virus-related hepatocellular carcinoma, J Xu, T Ding, Q He, X Yu, W Wu, W Jia, J Yun, Y Zhang, M Shi, C Shao, WD Pan, X Yin, J Min, SM Zhuang, L Zheng, 2012
- Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages, Q Zhao, DM Kuang, Y Wu, X Xiao, X Li, T Li, L Zheng, 2012
- Peritumoral neutrophils link inflammatory response to disease progression by fostering angiogenesis in hepatocellular carcinoma, DM Kuang, Q Zhao, Y Wu, C Peng, J Wang, Z Xu, X Yin, L Zheng, 2011
- Tumor activated monocytes promote expansion of IL-17-producing CD8+ T cells in hepatocellular carcinoma patients, DM Kuang, C Peng, Q Zhao, Y Wu, MS Chen, L Zheng, 2010
- Activated monocytes in peritumoral stroma of hepatocellular carcinoma promote expansion of memory Th17 cells, DM Kuang, C Peng, Q Zhao, Y Wu, MS Chen, L Zheng, 2010
- Increased intratumoral IL-17-producing cells correlate with poor survival in hepatocellular carcinoma patients, JP Zhang, J Yan, J Xu, XH Pang, MS Chen, L Li, C Wu, SP Li, L Zheng, 2009
- Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients, J Zhou, T Ding, LY Zhu, W Pan, L Li, L Zheng, 2009
- Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1, DM Kuang, QY Zhao, C Peng, J Xu, JP Zhang, L Zheng, 2009
Awards
- 2004: National Outstanding Youth
- 2014: Selected as one of Guangdong's 'Top 100 Talents'
- 2016: 13th Guangdong Ding Ying Science and Technology Award
