2006.09-2010.06 Bachelor of Science: Sun Yat-sen University
2010.09-2015.06 Doctor of Science: Sun Yat-sen University
Published over 30 papers in SCI journals
Research featured in Nature magazine's '365 days: Nature’s 10' in 2015
Research cited in Nature magazine's '2017 in news: The science events that shaped the year'
Total citations exceed 2000 times (Google Scholar)
2015.07-2018.06 - Sun Yat-sen University - Special Associate Researcher
2018.07-present - Sun Yat-sen University - Associate Professor
Research
Gene Editing Technology Development Gene Editing Therapy Molecular Directed Evolution
CRISPR-assisted transcription activation by phase-separation proteins., Liu JQ, Chen YX, Nong BT, Luo X, Cui KX, Li Z, Zhang PF, Tan WQ, Yang Y, Ma WB, Liang PP, Songyang Z., 2023
Systematic identification of CRISPR off-target effects by CROss-seq., Li Y, Zhi SY, Wu T, Chen HX, Kang R, Ma DZ, Songyang Z, He C, Liang PP, Luo GZ., 2023
Homology-based repair induced by CRISPR-Cas nucleases in mammalian embryo genome editing., Zhang XY, Li T, Ou JP, Huang JJ, Liang PP., 2022
Dual-AAV delivering split prime editor system for in vivo genome editing., Zhi SY, Chen YX, Wu GL, Wen JK, Wu JN, Liu QY, Li Y, Kang R, Hu SH, Wang JH, Liang PP, Huang JJ., 2021
Single AAV-mediated CRISPR/Nme2Cas9 efficiently reduces mutant hTTR expression in a transgenic mouse model of transthyretin amyloidosis., Wen JK, Cao TQ, Wu JN, Chen YX, Zhi SY, Huang YM, Zheng PL, Wu GL, Aagaard L, Zhong JX, Liang PP, Huang JJ., 2021
USP19 suppresses inflammation and promotes M2-like macrophage polarization by manipulating NLRP3 function via autophagy., Liu T, Wang LQ, Liang PP, Wang XJ, Liu YK, Cai J, She YC, Wang D, Wang Z, Guo ZY, Bates S, Xia XJ, Huang JJ, Cui J., 2020
Repurposing type I-F CRISPR-Cas system as a transcriptional activation tool in human cells., Chen YX, Liu JQ, Zhi SY, Zheng Q, Ma WB, Huang JJ, Liu YZ, Liu D, Liang PP, Songyang Z., 2020
Development of highly efficient dual-AAV split adenosine base editor for in vivo gene therapy., Chen YX, Zhi SY, Liu WL, Wen JK, Hu SH, Cao TQ, Sun HW, Li Y, Huang L, Liu YZ, Liang PP, Huang JJ., 2020
Cost-effective generation of A-to-G mutant mice by zygote electroporation of adenine base editor ribonucleoproteins., Sun HW, Zhi SY, Wu GF, Wu GL, Cao TQ, Hao H, Songyang Z, Liang PP, Huang JJ., 2020
TRIM14 promotes noncanonical NF-kB activation by modulating p100/p52 stability via selective autophagy., Chen MX, Zhao ZY, Meng QC, Liang PP, Su ZX, Wu YX, Huang JJ, Cui J., 2019
Off-target effects of cytidine base editors and adenine base editor: What can we do?, Liang PP, Wen JK, Huang JJ., 2019
Off-target challenge for base editor-mediated genome editing., Liang PP, Huang JJ., 2019
A novel undifferentiated spermatogonia-specific surface protein (USSP1) in neonatal mice., Lin ZH, Liang PP, Yao ZK, Chen YX, Zhang XY, Huang R, Zhang Z, Li MY, Ma WB, Zheng HY, Cao SB, Shi G, Zhao XY, Songyang Z, Huang JJ., 2019
HBB-deficient Macaca fascicularis monkey presents with human β-thalassemia., Huang Y, Ding CH, Liang PP, Li DD, Tang Y, Meng W, Sun HW, Lu HY, Chen Y, Chen XY, Huang QS, Fang JP, Zhou CQ, Yang SH, Huang JJ., 2019
Genome-wide profiling of adenine base editor specificity by EndoV-seq., Liang PP, Xie XW, Zhi SY, Sun HW, Zhang XY, Chen Y, Chen YX, Xiong YY, Ma WB, Liu D, Huang JJ, Songyang Z., 2019
Effective and precise adenine base editing in mouse zygotes., Liang PP, Sun HW, Zhang XY, Xie XW, Zhang JR, Bai YF, Ouyang XL, Zhi SY, Xiong YY, Ma WB, Liu D, Huang JJ, Songyang Z., 2018
Correction of beta-thalassemia mutant by base editor in human embryos., Liang PP, Ding CH, Sun HW, Xie XW, Xu YW, Zhang XY, Sun Y, Xiong YY, Ma WB, Liu YX, Wang YL, Fang JP, Liu D, Songyang Z, Zhou CQ, Huang JJ., 2017
Effective gene editing by high-fidelity base editor 2 in mouse zygotes., Liang PP, Sun HW, Sun Y, Zhang XY, Xie XW, Zhang JR, Zhang Z, Chen YX, Ding CH, Xiong YY, Ma WB, Liu D, Huang JJ, Songyang Z., 2017
Developmental history and application of CRISPR in human disease., Liang PP, Zhang XY, Chen YX, Huang JJ., 2017
Glycerol kinase-like proteins cooperate with Pld6 in regulating sperm mitochondrial sheath formation and male fertility., Chen YX, Liang PP, Huang Y, Li MY, Zhang XY, Ding CH, Feng JY, Zhang Z, Zhang XQ, Gao YZ, Zhang QF, Cao SB, Zheng HY, Liu D, Songyang Z, Huang JJ., 2017
Testis-specific Lypd9 is dispensable for spermatogenesis in mouse., Feng JY, Liang PP, Chen YX, Zhang XY, Songyang Z, Zheng HY, Cao SB, Huang JJ., 2017
Efficient Production of Gene-Modified Mice using Staphylococcus aureus Cas9., Zhang XY, Liang PP, Ding CH, Zhang Z, Zhou JW, Xie XW, Huang R, Sun Y, Sun HW, Zhang JR, Xu YW, Songyang Z, Huang JJ., 2016
CRISPR/Cas9-mediated gene editing in human tripronuclear zygotes., Liang PP, Xu YW, Zhang XY, Ding CH, Huang R, Zhang Z, Lv J, Xie XW, Chen YX, Li YJ, Sun Y, Bai YF, Songyang Z, Ma WB, Zhou CQ, Huang JJ., 2015
Area of Focus
Peptides | Biochemistry | Pharmaceuticals | Drug Development | Pdt | Cancer Research | Molecular Biology | Chemical Synthesis | Protein Engineering | Therapeutics
