Professor | Yongsen Ruan | Asia Growth Partners

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Name	Yongsen Ruan
Contact Information	ruanys3@mail.sysu.edu.cn
Language ability	Chinese, English
Province	Guangdong

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Name

Yongsen Ruan

Contact Information

ruanys3@mail.sysu.edu.cn

Language ability

Chinese, English

Province

Guangdong

University/Lab Affiliation and Title	Sun Yat-Sen University
Faculty	Life Sciences
Academic Background & Achievements	2011.09 - 2015.07 Bachelor of Science in Biotechnology: Sun Yat-sen University 2015.09 - 2020.08 Doctor of Science in Biochemistry and Molecular Biology: Sun Yat-sen University (Supervisor: Professor Zhongyi Wu) Innovative introduction of branching process theory to construct viral cross-species transmission evolution models
Work Experience	2020.11 - 2022.10 Sun Yat-sen University, School of Life Sciences, Postdoctoral Researcher (Co-supervisor: Professor Suhua Shi), Postdoctoral Innovative Talent Program 2022.11 - 2024.05 Sun Yat-sen University, School of Life Sciences, Special Associate Researcher 2024.06 - Present Sun Yat-sen University, School of Life Sciences, Pre-tenure Assistant Professor (Associate Professor position, Doctoral Supervisor)
Awards	2021: Second Prize of Beijing Science and Technology Award 2021: Selected for the Postdoctoral Innovative Talent Support Program

University/Lab Affiliation and Title

Sun Yat-Sen University

Faculty

Life Sciences

Academic Background & Achievements

2011.09 - 2015.07 Bachelor of Science in Biotechnology: Sun Yat-sen University
2015.09 - 2020.08 Doctor of Science in Biochemistry and Molecular Biology: Sun Yat-sen University (Supervisor: Professor Zhongyi Wu)
Innovative introduction of branching process theory to construct viral cross-species transmission evolution models

Work Experience

2020.11 - 2022.10 Sun Yat-sen University, School of Life Sciences, Postdoctoral Researcher (Co-supervisor: Professor Suhua Shi), Postdoctoral Innovative Talent Program
2022.11 - 2024.05 Sun Yat-sen University, School of Life Sciences, Special Associate Researcher
2024.06 - Present Sun Yat-sen University, School of Life Sciences, Pre-tenure Assistant Professor (Associate Professor position, Doctoral Supervisor)

Awards

2021: Second Prize of Beijing Science and Technology Award
2021: Selected for the Postdoctoral Innovative Talent Support Program

Areas of Focus	Adaptive evolution of viruses Theoretical research on traditional evolutionary processes Genotype-phenotype prediction using machine models
Publications	Intra- vs. Interhost Evolution of SARS-CoV-2 Driven by Uncorrelated Selection-The Evolution Thwarted., Hou M#, Shi J#, Gong Z, Wen H, Lan Y, Deng X, Fan Q, Li J, Jiang M, Tang X, Wu C I, Li F* & Ruan Y., 2023 On the epicenter of COVID-19 and the origin of the pandemic strain., Ruan Y, Wen H, Hou M, Zhai W, Xu S & Lu X., 2023 The Runaway Evolution of SARS-CoV-2 Leading to the Highly Evolved Delta Strain., Ruan Y#, Hou M#, Tang X#, He X, Lu X, Lu J, Wu C I* & Wen H., 2022 The twin-beginnings of COVID-19 in Asia and Europe-one prevails quickly., Ruan Y, Wen H, Hou M, He Z, Lu X, Xue Y, He X, Zhang Y P & Wu C I., 2022 On the founder effect in COVID-19 outbreaks: how many infected travelers may have started them all?, Ruan Y, Luo Z, Tang X, Li G, Wen H, He X, Lu X, Lu J & Wu C I., 2021 A theoretical exploration of the origin and early evolution of a pandemic., Ruan Y, Wen H, He X & Wu C I., 2021 Mutations Beget More Mutations-Rapid Evolution of Mutation Rate in Response to the Risk of Runaway Accumulation., Ruan Y, Wang H, Chen B, Wen H* & Wu C I., 2020 On the origin of SARS-CoV-2-The blind watchmaker argument., Wu C I, Wen H, Lu J, Su X D, Hughes A C, Zhai W, Chen C, Chen H, Li M, Song S, Qian Z, Wang Q, Chen B, Guo Z, Ruan Y, Lu X, Wei F, Jin L, Kang L, Xue Y, Zhao G & Zhang Y P., 2021 Very large hidden genetic diversity in one single tumor: evidence for tumors-in-tumor., Chen B#, Wu X#, Ruan Y, Zhang Y, Cai Q, Zapata L, Wu C I, Lan P & Wen H., 2022 Prevalence and spectrum of DNA mismatch repair gene variation in the general Chinese population., Zhang L#, Qin Z#, Huang T, Tam B, Ruan Y, Guo M, Wu X, Li J, Zhao B, Chian J S, Wang X, Wang L & Wang S M., 2021 Dynamic global analysis of transcription reveals the role of miRNAs in synergistic stabilization of gene expression., Ma F#, Lu G-A#, Chen Q, Ruan Y, Li X, Lu X* & Li C*., 2020

Areas of Focus

Adaptive evolution of viruses
Theoretical research on traditional evolutionary processes
Genotype-phenotype prediction using machine models

Publications

Intra- vs. Interhost Evolution of SARS-CoV-2 Driven by Uncorrelated Selection-The Evolution Thwarted., Hou M#, Shi J#, Gong Z, Wen H, Lan Y, Deng X, Fan Q, Li J, Jiang M, Tang X*, Wu C I*, Li F* & Ruan Y*., 2023
On the epicenter of COVID-19 and the origin of the pandemic strain., Ruan Y, Wen H, Hou M, Zhai W, Xu S & Lu X., 2023
The Runaway Evolution of SARS-CoV-2 Leading to the Highly Evolved Delta Strain., Ruan Y#, Hou M#, Tang X#, He X, Lu X, Lu J*, Wu C I* & Wen H*., 2022
The twin-beginnings of COVID-19 in Asia and Europe-one prevails quickly., Ruan Y, Wen H, Hou M, He Z, Lu X, Xue Y, He X, Zhang Y P* & Wu C I*., 2022
On the founder effect in COVID-19 outbreaks: how many infected travelers may have started them all?, Ruan Y, Luo Z, Tang X, Li G, Wen H, He X, Lu X, Lu J* & Wu C I*., 2021
A theoretical exploration of the origin and early evolution of a pandemic., Ruan Y, Wen H, He X & Wu C I*., 2021
Mutations Beget More Mutations-Rapid Evolution of Mutation Rate in Response to the Risk of Runaway Accumulation., Ruan Y, Wang H, Chen B, Wen H* & Wu C I*., 2020
On the origin of SARS-CoV-2-The blind watchmaker argument., Wu C I*, Wen H, Lu J, Su X D, Hughes A C, Zhai W, Chen C, Chen H, Li M, Song S, Qian Z, Wang Q, Chen B, Guo Z, Ruan Y, Lu X, Wei F, Jin L, Kang L, Xue Y, Zhao G & Zhang Y P., 2021
Very large hidden genetic diversity in one single tumor: evidence for tumors-in-tumor., Chen B#, Wu X#, Ruan Y, Zhang Y, Cai Q, Zapata L, Wu C I*, Lan P* & Wen H*., 2022
Prevalence and spectrum of DNA mismatch repair gene variation in the general Chinese population., Zhang L#, Qin Z#, Huang T, Tam B, Ruan Y, Guo M, Wu X, Li J, Zhao B, Chian J S, Wang X, Wang L & Wang S M*., 2021
Dynamic global analysis of transcription reveals the role of miRNAs in synergistic stabilization of gene expression., Ma F#, Lu G-A#, Chen Q, Ruan Y, Li X, Lu X* & Li C*., 2020

Virus Evolution Sars-Cov-2 Cross-Species Transmission Adaptive Dynamics Epidemiology Mathematical Modeling Machine Learning Genotype Prediction Phenotype Prediction Public Health

Jie Cui - Fudan University

Yudong Cai - Shanghai University

Weihua Cao - Peking University

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