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Yongsen Ruan
Life Science
Sun Yat-Sen University
Guangdong
Language: Chinese, English
Virus Evolution
Sars-Cov-2
Cross-Species Transmission
Adaptive Dynamics
Epidemiology
Mathematical Modeling
Machine Learning
Genotype Prediction
Phenotype Prediction
Public Health
Areas of Focus
- Adaptive evolution of viruses
- Theoretical research on traditional evolutionary processes
- Genotype-phenotype prediction using machine models
Work Experience
- 2020.11 - 2022.10 Sun Yat-sen University, School of Life Sciences, Postdoctoral Researcher (Co-supervisor: Professor Suhua Shi), Postdoctoral Innovative Talent Program
- 2022.11 - 2024.05 Sun Yat-sen University, School of Life Sciences, Special Associate Researcher
- 2024.06 - Present Sun Yat-sen University, School of Life Sciences, Pre-tenure Assistant Professor (Associate Professor position, Doctoral Supervisor)
Academic Background & Achievements
- 2011.09 - 2015.07 Bachelor of Science in Biotechnology: Sun Yat-sen University
- 2015.09 - 2020.08 Doctor of Science in Biochemistry and Molecular Biology: Sun Yat-sen University (Supervisor: Professor Zhongyi Wu)
- Innovative introduction of branching process theory to construct viral cross-species transmission evolution models
Publications
- Intra- vs. Interhost Evolution of SARS-CoV-2 Driven by Uncorrelated Selection-The Evolution Thwarted., Hou M#, Shi J#, Gong Z, Wen H, Lan Y, Deng X, Fan Q, Li J, Jiang M, Tang X*, Wu C I*, Li F* & Ruan Y*., 2023
- On the epicenter of COVID-19 and the origin of the pandemic strain., Ruan Y, Wen H, Hou M, Zhai W, Xu S & Lu X., 2023
- The Runaway Evolution of SARS-CoV-2 Leading to the Highly Evolved Delta Strain., Ruan Y#, Hou M#, Tang X#, He X, Lu X, Lu J*, Wu C I* & Wen H*., 2022
- The twin-beginnings of COVID-19 in Asia and Europe-one prevails quickly., Ruan Y, Wen H, Hou M, He Z, Lu X, Xue Y, He X, Zhang Y P* & Wu C I*., 2022
- On the founder effect in COVID-19 outbreaks: how many infected travelers may have started them all?, Ruan Y, Luo Z, Tang X, Li G, Wen H, He X, Lu X, Lu J* & Wu C I*., 2021
- A theoretical exploration of the origin and early evolution of a pandemic., Ruan Y, Wen H, He X & Wu C I*., 2021
- Mutations Beget More Mutations-Rapid Evolution of Mutation Rate in Response to the Risk of Runaway Accumulation., Ruan Y, Wang H, Chen B, Wen H* & Wu C I*., 2020
- On the origin of SARS-CoV-2-The blind watchmaker argument., Wu C I*, Wen H, Lu J, Su X D, Hughes A C, Zhai W, Chen C, Chen H, Li M, Song S, Qian Z, Wang Q, Chen B, Guo Z, Ruan Y, Lu X, Wei F, Jin L, Kang L, Xue Y, Zhao G & Zhang Y P., 2021
- Very large hidden genetic diversity in one single tumor: evidence for tumors-in-tumor., Chen B#, Wu X#, Ruan Y, Zhang Y, Cai Q, Zapata L, Wu C I*, Lan P* & Wen H*., 2022
- Prevalence and spectrum of DNA mismatch repair gene variation in the general Chinese population., Zhang L#, Qin Z#, Huang T, Tam B, Ruan Y, Guo M, Wu X, Li J, Zhao B, Chian J S, Wang X, Wang L & Wang S M*., 2021
- Dynamic global analysis of transcription reveals the role of miRNAs in synergistic stabilization of gene expression., Ma F#, Lu G-A#, Chen Q, Ruan Y, Li X, Lu X* & Li C*., 2020
Awards
- 2021: Second Prize of Beijing Science and Technology Award
- 2021: Selected for the Postdoctoral Innovative Talent Support Program
