2000-2003 PhD in Biochemistry and Molecular Biology: Sun Yat-sen University
1993-1996 Master's in Physiology: Sun Yat-sen University
Published over 30 papers in renowned journals with over 400 citations
First to report the protein crystal structure of the A2 domain in vWF in PNAS
2005-2021 - Sun Yat-sen University - Associate Professor, Doctoral Supervisor
2015-2016 - University of Toronto - Senior Scientist, Collaboration with Professor Heyu Ni
2008-2009 - Harvard Medical School - Postdoctoral Researcher, Collaboration with Professor Tim Springer
1996-2005 - Sun Yat-sen University - Lecturer
2019: Sun Yat-sen University Life Sciences College Outstanding Mentor Award
Research
Structure and function of blood molecules and their dynamic regulation of thrombosis Regulatory role of platelet-derived exosomes on hematopoietic and tumor cells Impact of thrombopoietin receptor on leukemia differentiation, proliferation, and drug resistance Cancer evolution: evolution and metastasis of cancer
Platelet-derived extracellular vesicles inhibit ferroptosis and promote distant metastasis of nasopharyngeal carcinoma by upregulating ITGB3, Fei Li, Ting Xu, Pei-Jiun Chen, Rui Sun, Chao-yang Li, Xin Zhao, Jinxin Ou, Jingyao Li, Tao Liu, Maozhen Zeng, Wei Zheng, Yunchen Lin, Le Yang, Zecang Li, Haisheng Chen, Qing Zhang, 2022
c-Mpl-del, a c-Mpl alternative splicing isoform, promotes AMKL progression and chemoresistance, Fei Li, Y. Xiong, Mo Yang, Pei-Jiun Chen, Jingkai Zhang, Qiong Wang, Miao Xu, Yiming Wang, Zuyong He, Xin Zhao, Junyu Huang, Xiaoqiong Gu, Li Zhang, Rui Sun, Xunsha Sun, Jingyao Li, Jinxin Ou, Tingjuan Xu, Xueying Huang, Yange Cao, X. Xu, Danielle Karakas, June Li, H. Ni, Qing Zhang, 2022
Long non-coding RNAs and circular RNAs in tumor angiogenesis: From mechanisms to clinical significance, Chen-Guang Liu, Juan Li, Yanhua Xu, Wan Li, Shu-Xian Fang, Qing Zhang, Hong-Wu Xin, Zhaowu Ma, 2021
Dendritic cell biology and its role in tumor immunotherapy, Wang Y, Xiang Y, Xin VW, Wang XW, Peng XC, Liu XQ, Wang D, Li N, Cheng JT, Lyv YN, Cui SZ, Ma Z, Zhang Q, Xin HW, 2020
Optimizing Human Epidermal Growth Factor for its Endurance and Specificity Via Directed Evolution: Functional Importance of Leucine at Position 8, Yujie Sun, Nanyan Yang, Fei Li, Jinxin Ou, Xin Liu, Qing Zhang, 2020
The integrin PSI domain has an endogenous thiol isomerase function and is a novel target for antiplatelet therapy, Guangheng Zhu, Qing Zhang, Emily Reddy, Naadiya Carrim, Yunfeng Chen, Xiaohong Ruby Xu, Miao Xu, Yiming Wang, Yan Hou, Li Ma, Yan Li, Min Rui, Tania Petruzziello-Pellegrini, Christopher Lavalle, Tyler Stratton, Xi Lei, Reheman Adili, Pingguo Chen, Cheng Zhu, John Wilkins, Richard Hynes, John Freedman, Heyu Ni, 2017
Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor, Zhang Q, Zhou YF, Zhang CZ, Zhang X, Lu C, Springer TA, 2009
Micro-concentration Lipopolysaccharide as a Novel Stimulator of Megakaryocytopoiesis that Synergizes with IL-6 for Platelet Production, D Wu, J Xie, X Wang, B Zou, Y Yu, T Jing, S Zhang, Q Zhang, 2015
miR-29a/b Enhances Cell Migration and Invasion in Nasopharyngeal Carcinoma Progression by Regulating SPARC and COL3A1 Gene Expression, Feifei Qiu, Rui Sun, Ning Deng, Tianyu Guo, Yange Cao, Ying Yu, Xuejun Wang, Bingcheng Zou, Tao Ling, Jun Xie, Qing Zhang, 2015
The unfolded von Willebrand factor response in bloodstream: the self-association perspective, Yuan H, Deng N, Zhang S, Cao Y, Wang Q, Liu X, Zhang Q, 2012
Megakaryopoiesis and platelet production: insight into hematopoietic stem cell proliferation and differentiation, Tianyu Guo, Xuejun Wang, Yigong Qu, Yu Yin, Tao Jing, Qing Zhang, 2015
Soluble Production and Function of Vascular Endothelial Growth Factor/Basic Fibroblast Growth Factor Complex Peptide, Qing Zhang, Xuejun Lao, Jianhua Huang, Zhongsong Zhu, Lei Pang, Yong Tang, Qifang Song, Jiangfang Huang, Jie Deng, and Ning Deng, 2014
Identification and characterization of an alternative splice variant of Mpl with a high affinity for TPO and its activation of ERK1/2 signaling, Wang Q, Sun R, Wu L, Huang J, Wang P, Yuan H, Qiu F, Xu X, Wu D, Yu Y, Liu X, Zhang Q, 2013
Live-cell visualization of intracellular interaction between a nuclear migration protein (hNUDC) and the thrombopoietin receptor (Mpl), Zheng YB, Xiao YY, Tan P, Zhang Q, Xu P, 2012
Overexpression of nuclear distribution protein (hNUDC) causes pro-apoptosis and differentiation in Dami megakaryocytes, Xiao Y, Zheng Y, Tan P, Xu P, Zhang Q, 2013
HGF stimulates proliferation through the HGF/c-Met pathway in nasopharyngeal carcinoma cells, Rui Sun, Qing Zhang, Ling Guo, Ming-Yuan Chen, Ying Sun, Brian Cao, Jian Sun, 2012
Identification of the residues in the extracellular domain of thrombopoietin receptor involved in the binding of thrombopoietin and a nuclear distribution protein (human NUDC), Chen WM, Yu B, Zhang Q, Xu P, 2010
The additive effects of combined murine nuclear migration protein with murine thrombopoietin in vitro and in vivo on normal and myelosuppressed mice, Duan XY, Yang Y, Zhang Q, Ge YC, Xu P, 2011
Prognostic Value and Differences of the Sixth and Seventh Edition UICC/AJCC Staging Systems in Nasopharyngeal Carcinoma, Rui Sun, Huizhi Qiu, Haiqiang Mai, Qing Zhang, Minghuang Hong, Yanxian Li, Jing Yang, Jian Sun, Haoyuan Mo, 2013
Prognostic value of pretreatment and recovery duration of cranial nerve palsy in nasopharyngeal carcinoma, Haoyuan Mo, Rui Sun, Jian Sun, Qing Zhang, Wenjin Huang, Yanxian Li, Jing Yang, Haiqiang Mai, 2012
Secretion Expression and Activity Assay of Fusion Protein of Thrombopoietin and Interleukin-6 in Pichia pastoris, Hu Zhiyi, Lai Wenshan, Zhang Wenze, Deng Ning, Zhang Chi, Ye Kenan, Wang Ping, Wang Qianqian, Zhang Qing, 2007
The expression of soluble extracellular domain of human thrombopoietin receptor(c-Mpl) using maltose binding protein affinity fusion system, Zhang Qing, Pan Rui-Min, Ge Yi-Chen, Xu Pei-Lin, 2004
Purification and characterization of a novel carbaryl hydrolase from Aspergillus niger PY168, Zhang Qing, Liu Yang, Liu Yu-Huan, 2003
Production of recombinant humanized antiHBsAg Fab antibody in Pichia pastoris by fermentation, Ning D, Junjian X, Qing Z, Sheng X, Wenyin C, Guirong R, Xunzhang W, 2005
Expression, Purification, and Characterization of Humanized Anti-HBs Fab Fragment, Deng Ning, Xiang Junjian, Wang Xunzhang, Chen Wenyin, Zhang Qing, Su Kuanyuan, Rao Guirong, Ren xiangrong, Long qingxin, Yu Zhouyao, 2003
Platelets are versatile cells: New discoveries in hemostasis, thrombosis, immune responses, tumor metastasis and beyond, Xiaohong Ruby Xu, Dan Zhang, Brigitta Elaine Oswald, Naadiya Carrim, Xiaozhong Wang, Yan Hou, Qing Zhang, Christopher Lavalle, Thomas McKeown, Alexandra H. Marshall & Heyu Ni, 2016
Berberine Influences Blood Glucose via Modulating the Gut Microbiome in Grass Carp, Pan H, Li Z, Xie J, Liu D, Wang H, Yu D, Zhang Q, Hu Z, Shi C, 2019
Area of Focus
Anti-Apoptosis | Drug Resistance | Tumor Cells | Metastasis | Natural Drugs | Traditional Chinese Medicine | Drug Development | Adjuvant Therapy | Pharmacodynamics | Clinical Studies
