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Juan Chen
Nutrition and health
China Agricultural University
Beijing
Language: Chinese, English
Immunodeficiency
Pathogenic Mechanisms
Therapeutic Targets
Intervention Strategies
Disease
Immune System
Treatment
Health
Biomedical Research
Clinical Applications
Areas of Focus
- Pathogenic mechanisms, therapeutic targets, and intervention strategies for immunodeficiency diseases
Work Experience
- 2022.10-present - China Agricultural University - Associate Professor
- 2019.01-2022.09 - Institute of Biophysics, Chinese Academy of Sciences - Associate Researcher
- 2015.05-2018.12 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher
Academic Background & Achievements
- 2009.09-2015.01 PhD in Animal Physiology: China Agricultural University
- 2005.09-2009.06 Bachelor in Biological Sciences: Hebei Normal University
Publications
- PARN maintains RNA stability to regulate insulin maturation and GSIS in pancreatic b cells., Xie XM, Chen XX, Wang CF, Sun LJ, Yu WR, Lv Z, Tian S, Yao XH, Wang FC, Ding DQ*, Chen J*, Liu JL*., 2024
- Programmable Chemical Evolution with Natural/non-natural Building Blocks., Liu P#, Jannatul Refeya#, Chen J#, Hou LH#, Gao MJ, Wang PJ, Jin DK, Chen H, Liu R, Wang R, Jia LR, Li YX, Fang B, Sun YN, Zhang YX, Ren FZ, Lin WL., 2024
- Temporal-specific single-cell atlas of human type A aortic dissection reveals immune cell dynamics and therapeutic targets., Zhao WT#, Chen J#, Xia Y#, Wei ZX, Wan ST, Guo HY, Hao YL, Jiang WJ, Zhang HJ, Ren FZ*, An P*, Luo YT*, Luo JJ*., 2024
- Emerging roles of RNA ac4C modification and NAT10 in mammalian development and human diseases., Zhang YG, Lei YM, Dong YB, Chen SW, Sun SY, Zhou FE, Zhao ZW, Chen BN, Wei L*, Chen J*, Meng ZJ*., 2024
- The Future landscape and framework of precision nutrition., Han TS, Wei W, Jiang WB, Geng YD, Liu ZJ, Yang RM, Jin CR, Lei YT, Sun XY, Xu JX, Zhou N, Chen J*, Sun CH*., 2024
- Splicing factor SRSF1 is essential for homing of precursor spermatogonial stem cells in mice., Sun LJ, Lv Z, Chen XX, Ye R, Tian S, Wang CF, Xie XM, Yan L, Yao XH, Shao YJ, Cui S, Chen J*, Liu JL*., 2024
- TSPAN4 influences glioblastoma progression through regulating EGFR stability., Dong YB, Tang XL, Zhao WH, Liu P, Yu WR, Ren JL, Chen Y, Cui YF, Chen J*, Liu YS*., 2024
- ERV: a promising new target for lung adenocarcinoma treatment., Sun SY, Fang B, Wang R, Ren FZ, Chen J*., 2023
- SRSF1 is crucial for male meiosis through alternative splicing during homologous pairing and synapsis in mice., Sun LJ#, Chen J#, Ye R, Lv Z, Chen XX, Xie XM, Li YH, Wang CF, Lv PB, Yan L, Tian S, Yao XH, Chen C, Cui S, Liu JL*., 2023
- The RNA-binding protein ROD1/PTBP3 cotranscriptionally defines AID-loading sites to mediate antibody class switch in mammalian genomes., Chen J, Cai ZK, Bai MZ, Yu XH, Zhang C, Cao CC, Hu XH, Wang L, Su RB, Wang D, Wang L, Yao YP, Ye R, Hou BD, Yu Y, Yu SY, Li JS, Xue YC*., 2018
- Emerging roles of non-coding RNAs in epigenetic regulation., Chen J, Xue YC*., 2016
- LIM-homeodomain transcription factor Isl-1 mediates kisspeptin’s effect on insulin secretion in mice., Chen J, Fu R, Cui Y, Pan JR, Li YS, Zhang XX, Evans Sylvia M, Cui S, Liu JL*., 2014
- LIM-homeodomain transcription factor Isl-1 mediates the effect of leptin on insulin secretion in mice., Chen J, Fu R, Cui Y, Li YS, Pan JR, Liu JL, Luo HS, Yin JD, Li DF*, Cui S*., 2013
- SARS-CoV-2 RNA stabilizes host mRNAs to elicit immunopathogenesis., Zhao HL, Cai ZK, Rao J, Wu D, Ji L, Ye R, Wang D, Chen J, Cao CC, Hu NJ, Shu T, Zhu P, Wang JW, Zhou X, Xue YC., 2024
- Complementary Alu sequences mediate enhancer-promoter selectivity., Liang L, Cao CC, Ji L, Cai ZK, Wang D, Ye R, Chen J, Yu XH, Zhou J, Bai ZB, Wang RY, Yang XG, Zhu P, Xue YC*., 2023
- RIC-seq for global in situ profiling of RNA - RNA spatial interactions., Cai ZK, Cao CC, Ji L, Ye R, Wang D, Xia C, Wang S, Du ZC, Hu NJ, Yu XH, Chen J, Wang L,Yang XG, He SM, Xue YC*., 2020
- The architecture of the SARS-CoV-2 RNA genome inside virion., Cao CC, Cai ZK, Xiao X, Rao J, Chen J, Hu NJ, Yang MN, Xing XR, Wang YL, Li MM, Zhou B, Wang XX, Wang JW*, Xue YC*., 2021
