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Chao Li
national institute of biological sciences，Beijing
National Institute of Biological Sciences，Beijing
Beijing
Language: English, Chinese
Catalysis
Synthesis
Chemical Bonds
Natural Products
Bioactivity
Mechanism
Molecular Probes
Biological Macromolecules
Drug Discovery
Chemical Tools
Areas of Focus
- Development of new catalytic reactions
- Total synthesis of bioactive natural products
- Mechanism of action of bioactive small molecules
- Development of novel molecular probes
Work Experience
- 2023-Present - National Institute of Biological Sciences, Beijing - Associate Investigator
- 2017-2023 - National Institute of Biological Sciences, Beijing - Assistant Investigator
- 2014-2017 - The Scripps Research Institute, CA, USA - Postdoctoral Research Fellow
Academic Background & Achievements
- 2013 - Ph.D. in Organic Synthesis: National Institute of Biological Science (NIBS), Beijing & Tianjin University, Tianjin, China
- 2008 - B.S. in Pharmaceutical Engineering: Qingdao University of Science and Technology, Qingdao, China
Publications
- Electrochemically Enabled, Nickel-Catalyzed Dehydroxylative Cross-Coupling of Alcohols with Aryl Halides, Li, Z.; Sun, W.; Wang, X.; Li, L; Zhang, Y.; Li, C., 2021
- Total Synthesis of (-)-Daphnezomines A and B, Xu, G.; Wu, J.; Li, L.; Lu, Y.; Li, C., 2020
- Nickel-Catalyzed Direct Acylation of Aryl and Alkyl Bromides with Acylimidazoles, Zhuo, J.; Zhang, Y.; Li, Z.; Li, C., 2020
- Tandem Decarboxylative Cyclization/Alkenylation Strategy for Total Syntheses of (+)-Longirabdiol, (-)-Longirabdolactone, and (-)-Effusin, Zhang, J.; Li, Z.; Zhuo, J.; Cui, Y.; Han, T.; Li, C., 2019
- Electrochemically Enabled, Ni-Catalyzed Amination, Li, C.; Kawamata, Y.; Nakamura, H.; Vantourout, J. C.; Liu, Z.; Hou, Q.; Bao, D.; Star, J. T.; Chen, J.; Yan, M.; Baran, P. S., 2017
- Decarboxylative Borylation, Li, C.; Wang, J.; Barton, L. M.; Yu, S.; Tian, M.; Peters, D. S.; Kumar, M.; Yu, A. W.; Johnson, K. A.; Chatterjee, A. K.; Yan, M.; Baran, P. S., 2017
- A General Alkyl-Alkyl Cross-Coupling Enabled by Redox-Active Esters and Alkylzinc Reagents, Qin, T.; Cornella, J.; Li, C.; Malins, L. R.; Edwards, J. T.; Kawamura, S.; Maxwell, B. D.; Eastgate, M. D.; Baran, P. S., 2016
- Synthesis and Mode of Action of Oligomeric Sesquiterpene Lactones, Li, C.; Jones, A. X.; Lei, X., 2016
- Natural Product Kongensin A is a Non-Canonical HSP90 Inhibitor that Blocks RIP3-dependent Necroptosis, Li, D.; Li, C.; Li, L.; Chen, S.; Wang, L.; Li, Q.; Wang, X.; Lei, X.; Shen, Z., 2016
- Enantioselective Total Synthesis of (−)-Incarviatone A, Hong, B.; Li, C.; Wang, Z.; Chen, J.; Li, H.; Lei, X., 2015
- Hydromethylation of Unactivated Olefins, Dao, H. T.; Li, C.; Michaudel, Q.; Maxwell, B. D.; Baran, P. S., 2015
- Ainsliadimer A Selectively Inhibits IKKα/β by Covalently Binding a Conserved Cysteine, Dong, T.; Li, C.; Wang, X.; Dian, L.; Zhang, X.; Li, L.; Chen, S.; Cao, R.; Li, L.; Huang, N.; He, S.; Lei, X., 2015
- Probing the Anticancer Mechanism of (−)-Ainsliatrimer A through Diverted Total Synthesis and Bioorthogonal Ligation, Li, C.; Dong, T.; Li, Q.; Lei, X., 2014
- Strategies toward the Biomimetic Syntheses of Oligomeric Sesquiterpenoids, Li, C.; Lei, X., 2014
- Biomimetic Syntheses and Structural Elucidation of the Apoptosis-Inducing Sesquiterpenoid Trimers: (-)-Ainsliatrimers A and B, Li, C.; Dong, T.; Dian, L.; Zhang, W.; and Lei, X., 2013
- Diversity-oriented Synthesis of Bicyclic Ring Systems via a Conjugate Addition/aldol/RCM Process, Li, C.; Li, X.; Wang, X.; Lei, X., 2013
- Biomimetic Syntheses of (-)-Gochnatiolides A-C and (-)-Ainsliadimer B, Li, C.; Dian, L.; Zhang, W.; Lei, X., 2012
- Total Synthesis of the G2/M DNA Damage Checkpoint Inhibitor Psilostachyin C, Li, C.; Tu, S.; Wen, S.; Li, S.; Chang, J.; Shao, F, Lei, X., 2011
- A Biomimetic Total Synthesis of (+)-Ainsliadimer A, Li, C.; Yu, X.; Lei, X., 2010
