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Carlos Ibanez
Brain Science and Anthropology
Chinese Institute for Brain Research, Beijing
Beijing
Language: English, Chinese, German
Neurodegeneration
Death Receptors
P75Ntr
Signaling
Physiology
Neurotrophic
Bdnf
Transmembrane
Modulators
Tgf-Β
Areas of Focus
- Death receptor signaling and physiology in neurodegenerative diseases
- Metabolic regulation by activin receptors ALK4 and ALK7
- Regulation of brain microvascular system integrity and function by neurotrophic factor signaling
- Novel chemical biology approaches to identify small molecule modulators of transmembrane receptor activity and signaling
Work Experience
- Postdoctoral research at Karolinska Institute, Sweden under Håkan Persson
- 1996 - Professor of Neuroscience at Karolinska Institute, Stockholm, Sweden
- 2004 - Member of the Nobel Assembly at Karolinska Institute
- 2012 - Joint appointment as Professor at Yong Loo Lin School of Medicine, National University of Singapore (NUS), Department of Physiology
- 2020 - Joined Beijing Brain Science and Brain-Inspired Intelligence Research Institute and McGovern Institute at Peking University
Academic Background & Achievements
- Studied Biology at the University of Buenos Aires, Argentina
- Ph.D. work under Carlos Frasch at Leloir Institute (formerly Fundacion Campomar)
Publications
- Inactive variants of death receptor p75NTR reduce Alzheimer’s neuropathology by interfering with APP internalization., Chenju Yi, C., Goh, K.Y., Wong, L.-W., Ramanujan, A., Tanaka, K., Sajikumar, S. and Ibáñez, C.F., 2020
- ALK4 coordinates extracellular and intrinsic signals to regulate development of cortical somatostatin interneurons., Göngrich, C., Krapacher, F., Munguba, H., Fernandez-Suarez, D., Andersson, A., Hjerling-Leffler, J. and Ibáñez C.F., 2019
- Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity and cognitive behavior through altered Sortilin splicing., Tann, J.Y., Wong, L.-W., Sajikumar, S. and Ibáñez, C.F., 2019
- A small molecule targeting the transmembrane domain of death receptor p75NTR induces melanoma cell death and reduces tumor growth., Goh, ETH., Lin, Z., Young Ahn, B., Lopes-Rodrigues, V., Ha Dang, N., Salim, S., Berger, B., Dymock, B., Senger, D.L. and Ibáñez, C.F., 2018
- RIP2 gates TRAF6 interaction with death receptor p75NTR to regulate cerebellar granule neuron survival., Kisiswa, L., Fernandez-Suarez, D., Sergaki, M. C. and Ibáñez, C.F., 2018
