Professor | Han Jiahui | Asia Growth Partners

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Name	Han Jiahui
Contact Information	jhan@xmu.edu.cn
Language ability	English, Chinese
Province	Chongqing

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Name

Han Jiahui

Contact Information

jhan@xmu.edu.cn

Language ability

English, Chinese

Province

Chongqing

University/Lab Affiliation and Title	Chongqing Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1978-1982 Bachelor in Biochemistry: Peking University 1982-1985 Master in Biochemistry: Peking University 1990 PhD in Molecular Biology: Université Libre de Bruxelles Published over 320 papers, with over 66,000 citations and an H-index of 128 Elected as Academician of the Chinese Academy of Sciences in 2013
Work Experience	1990-1992 Postdoctoral Researcher: University of Texas Southwestern Medical Center 1993-2007 Assistant/Associate/Professor: The Scripps Research Institute 2001-2007 Distinguished Professor: Xiamen University 2007-present Professor: The Scripps Research Institute 2007-present Full-time Distinguished Professor: Xiamen University 2014-2020 Vice President: Xiamen University 2023-present Academician Workstation: Chongqing Medical University
Awards	1991 Jean Stas Award: Belgium 1995 Established Investigator Award: American Heart Association 2009 Changjiang Scholar Achievement Award 2009 WuXi AppTec Life Chemistry Research Award First Prize 2009 Lu Jiaxi Outstanding Mentor Award 2011 First Prize in Natural Science Research: Ministry of Education 2011 Outstanding Returned Overseas Personnel: Xiamen City 2012 First Prize for Excellent Doctoral Dissertation: Fujian Province 2012 National Excellent Doctoral Dissertation 2012 May 1st Labor Medal: Xiamen City 2012 Nanqiang Special Award: Xiamen University 2012 Contribution Award: Chinese Overseas Community 2013 Sixth Tan Jiazhen Life Science Achievement Award 2013 Second Prize in National Natural Science 2014 Outstanding Scientific and Technological Worker: Fujian Province 2014 Sanofi-Cell Research Excellent Paper Award 2014 National Outstanding Scientific and Technological Worker 2015 Major Contribution Award in Science and Technology: Fujian Province 2017 First National Innovation Award

University/Lab Affiliation and Title

Chongqing Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1978-1982 Bachelor in Biochemistry: Peking University
1982-1985 Master in Biochemistry: Peking University
1990 PhD in Molecular Biology: Université Libre de Bruxelles
Published over 320 papers, with over 66,000 citations and an H-index of 128
Elected as Academician of the Chinese Academy of Sciences in 2013

Work Experience

1990-1992 Postdoctoral Researcher: University of Texas Southwestern Medical Center
1993-2007 Assistant/Associate/Professor: The Scripps Research Institute
2001-2007 Distinguished Professor: Xiamen University
2007-present Professor: The Scripps Research Institute
2007-present Full-time Distinguished Professor: Xiamen University
2014-2020 Vice President: Xiamen University
2023-present Academician Workstation: Chongqing Medical University

Awards

1991 Jean Stas Award: Belgium
1995 Established Investigator Award: American Heart Association
2009 Changjiang Scholar Achievement Award
2009 WuXi AppTec Life Chemistry Research Award First Prize
2009 Lu Jiaxi Outstanding Mentor Award
2011 First Prize in Natural Science Research: Ministry of Education
2011 Outstanding Returned Overseas Personnel: Xiamen City
2012 First Prize for Excellent Doctoral Dissertation: Fujian Province
2012 National Excellent Doctoral Dissertation
2012 May 1st Labor Medal: Xiamen City
2012 Nanqiang Special Award: Xiamen University
2012 Contribution Award: Chinese Overseas Community
2013 Sixth Tan Jiazhen Life Science Achievement Award
2013 Second Prize in National Natural Science
2014 Outstanding Scientific and Technological Worker: Fujian Province
2014 Sanofi-Cell Research Excellent Paper Award
2014 National Outstanding Scientific and Technological Worker
2015 Major Contribution Award in Science and Technology: Fujian Province
2017 First National Innovation Award

Areas of Focus	Molecular and cellular mechanisms of innate immunity and their functions in inflammatory diseases
Publications	Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death, Chen X, Zhu R, Zhong J, Ying Y, Wang W, Cao Y, Cai H, Li X, Shuai J, Han J, 2022 NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice, Zhang P, Liu Y, Hu L, Huang K, Hong M, Wang Y, Fan X, Richard J. Ulevitch, Han J, 2021 A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade, Yang Z, Wu X, He P, Wang X, Wu J, Ai T, Zhong C, Wu X, Cong Y, Zhu R, Li H, Cai ZY, Mo W, Han J, 2020 Gut Stem Cell Necroptosis by Genome Instability Triggers Bowel Inflammation, Wang R, Li H, Wu J, Cai ZY, Li B, Ni H, Qiu X, Chen H, Liu W, Yang ZH, Liu M, Hu J, Liang Y, Lan P, X, Han J, Mo W, 2020 RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis, Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J, 2018 RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Zhang Y, Su SS, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J, 2017 Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion, He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J, 2015 Ppm1b negatively regulates necroptosis through dephosphorylating Rip3, Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, Chen F, Yang C, Zhou Z, Sean Su S, Zheng X, Zhang Z, Zhong CQ, Wan H, Xiao M, Lin X, Feng XH, Han J, 2015 RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis, Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J, 2009 PRAK is essential for ras-induced senescence and tumor suppression, Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, 3rd, Wright PE, Han J, 2007 Involvement of microRNA in AU-rich element-mediated mRNA instability, Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, Di Padova F, Lin SC, Gram H, Han J, 2005 MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha, Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J, 2002 Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation, Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ, 1997 A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells, Han J, Lee JD, Bibbs L, Ulevitch RJ, 1994

Areas of Focus

Molecular and cellular mechanisms of innate immunity and their functions in inflammatory diseases

Publications

Mosaic composition of RIP1-RIP3 signalling hub and its role in regulating cell death, Chen X, Zhu R, Zhong J, Ying Y, Wang W, Cao Y, Cai H, Li X, Shuai J, Han J, 2022
NLRC4 inflammasome-dependent cell death occurs by a complementary series of three death pathways and determines lethality in mice, Zhang P, Liu Y, Hu L, Huang K, Hong M, Wang Y, Fan X, Richard J. Ulevitch, Han J, 2021
A Non-canonical PDK1-RSK Signal Diminishes Pro-caspase-8-Mediated Necroptosis Blockade, Yang Z, Wu X, He P, Wang X, Wu J, Ai T, Zhong C, Wu X, Cong Y, Zhu R, Li H, Cai ZY, Mo W, Han J, 2020
Gut Stem Cell Necroptosis by Genome Instability Triggers Bowel Inflammation, Wang R, Li H, Wu J, Cai ZY, Li B, Ni H, Qiu X, Chen H, Liu W, Yang ZH, Liu M, Hu J, Liang Y, Lan P, X, Han J, Mo W, 2020
RIP3 targets pyruvate dehydrogenase complex to increase aerobic respiration in TNF-induced necroptosis, Yang Z, Wang Y, Zhang Y, He X, Zhong CQ, Ni H, Chen X, Liang Y, Wu J, Zhao S, Zhou D, Han J, 2018
RIP1 autophosphorylation is promoted by mitochondrial ROS and is essential for RIP3 recruitment into necrosome, Zhang Y, Su SS, Zhao S, Yang Z, Zhong CQ, Chen X, Cai Q, Yang ZH, Huang D, Wu R, Han J, 2017
Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion, He WT, Wan H, Hu L, Chen P, Wang X, Huang Z, Yang ZH, Zhong CQ, Han J, 2015
Ppm1b negatively regulates necroptosis through dephosphorylating Rip3, Chen W, Wu J, Li L, Zhang Z, Ren J, Liang Y, Chen F, Yang C, Zhou Z, Sean Su S, Zheng X, Zhang Z, Zhong CQ, Wan H, Xiao M, Lin X, Feng XH, Han J, 2015
RIP3, an energy metabolism regulator that switches TNF-induced cell death from apoptosis to necrosis, Zhang DW, Shao J, Lin J, Zhang N, Lu BJ, Lin SC, Dong MQ, Han J, 2009
PRAK is essential for ras-induced senescence and tumor suppression, Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR, 3rd, Wright PE, Han J, 2007
Involvement of microRNA in AU-rich element-mediated mRNA instability, Jing Q, Huang S, Guth S, Zarubin T, Motoyama A, Chen J, Di Padova F, Lin SC, Gram H, Han J, 2005
MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha, Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J, 2002
Activation of the transcription factor MEF2C by the MAP kinase p38 in inflammation, Han J, Jiang Y, Li Z, Kravchenko VV, Ulevitch RJ, 1997
A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells, Han J, Lee JD, Bibbs L, Ulevitch RJ, 1994

Innate Immunity Molecular Mechanisms Cellular Mechanisms Inflammation Diseases Immune Response Cell Signaling Pathogenesis Immune Regulation Biomedical Research

Bai Yun - Peking University

Jun-Zhu Wu - Wuhan University

Hanyang Hu - Wuhan University

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