Professor | Fengjin Guo | Asia Growth Partners

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Name	Fengjin Guo
Contact Information	guo.fengjin@cqmu.edu.cn
Language ability	Chinese, English
Province	Chongqing

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Name

Fengjin Guo

Contact Information

guo.fengjin@cqmu.edu.cn

Language ability

Chinese, English

Province

Chongqing

University/Lab Affiliation and Title	Chongqing Medical University
Faculty	Basic Medical Sciences
Academic Background & Achievements	1990.9–1994.7 Bachelor: Lanzhou University, Cell Biology 2001.9–2006.7 Doctorate: Chongqing Medical University, Clinical Laboratory Diagnostics Hosted 6 National Natural Science Foundation projects Published over 50 research papers in journals like ACS NANO, Experimental & Molecular Medicine
Work Experience	1994.7–Present - Chongqing Medical University, Faculty of Basic Medicine, Cell Biology and Genetics Department - Assistant/ Lecturer/ Associate Professor/ Professor/ Distinguished Professor 2017–Present - Director, Cell Biology and Genetics Department, Faculty of Basic Medicine, Chongqing Medical University 2023.12–2026.11 - Chongqing Medical University Second Affiliated Hospital, Orthopedics - Joint Professor
Awards	2014: Chongqing Natural Science Award, Third Prize 2022: ICMRS Webster Jee Young Investigator Award 2023: National Matrix Biology Conference, Young Scientist Excellent Paper Third Prize

University/Lab Affiliation and Title

Chongqing Medical University

Faculty

Basic Medical Sciences

Academic Background & Achievements

1990.9–1994.7 Bachelor: Lanzhou University, Cell Biology
2001.9–2006.7 Doctorate: Chongqing Medical University, Clinical Laboratory Diagnostics
Hosted 6 National Natural Science Foundation projects
Published over 50 research papers in journals like ACS NANO, Experimental & Molecular Medicine

Work Experience

1994.7–Present - Chongqing Medical University, Faculty of Basic Medicine, Cell Biology and Genetics Department - Assistant/ Lecturer/ Associate Professor/ Professor/ Distinguished Professor
2017–Present - Director, Cell Biology and Genetics Department, Faculty of Basic Medicine, Chongqing Medical University
2023.12–2026.11 - Chongqing Medical University Second Affiliated Hospital, Orthopedics - Joint Professor

Awards

2014: Chongqing Natural Science Award, Third Prize
2022: ICMRS Webster Jee Young Investigator Award
2023: National Matrix Biology Conference, Young Scientist Excellent Paper Third Prize

Areas of Focus	Bone/Cartilage Development and Genetic Diseases Mechanisms of Bone and Joint Function Injury and Remodeling
Publications	IRE1α protects against osteoarthritis by regulating progranulindependent XBP1 splicing and collagen homeostasis., Li Liang, Fengmei Zhang, Naibo Feng, Biao Kuang, Mengtian Fan, Cheng Chen, Yiming Pan, Pengfei Zhou, Nana Geng, Xingyue Li, Menglin Xian, Lin Deng, Xiaoli Li, Liang Kuang, Fengtao Luo, Qiaoyan Tan, Yangli Xie, Fengjin Guo, 2023 The circUbqln1, regulated by XBP1s, interplays with 14-3-3ζ to inhibit collagen synthesis and promote osteoarthritis by controlling PRODH activity and proline metabolism., Naibo Feng, Yuanlan Ye, Yiming Pan, Biao Kuang, Yu Du, Nana Geng, Cheng Chen, Kaiwen Liu, Li Liang, Menglin Xian, Yuyou Yang, Xingyue Li, Lin Deng, Fengmei Zhang, Liang Kuang, Mengtian Fan, Yangli Xie, Fengjin Guo, 2024 Treating Autoimmune Inflammatory Diseases with an siERN1-Nanoprodrug That Mediates Macrophage Polarization and Blocks Toll-like Receptor Signaling., Naibo Feng, Li Liang, Mengtian Fan, Yu Du, Cheng Chen, Rong Jiang, Dongsheng Yu, Yuyou Yang, Mengying Zhang, Lin Deng, Xingyue Li, Nana Geng, Menglin Xian, Qizhong Qin, Xiaoli Li, Qiaoyan Tan, Fengtao Luo, Fangzhou Song, Huabing Qi, Yangli Xie, Fengjin Guo, 2021 IRE1a regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization., Mengtian Fan, Nana Geng, Xingyue Li, Danyang Yin, Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng, Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi, Qiaoyan Tan, Yangli Xie, Fengjin Guo, 2022 Effect Of XBP1 Deficiency In Cartilage On The Regulatory Network Of LncRNA/circRNA-miRNA mRNA., Xiaoli Li, Yuyou Yang, Li Liang, Mengtian Fan, Xingyue Li, Naibo Feng, Yiming Pan, Qiaoyan Tan, Qingbo Xu, Yangli Xie, Fengjin Guo, 2022 Progranulin regulation of autophagy contributes to its chondroprotective effect in osteoarthritis., Yiming Pan, Yuyou Yang, Mengtian Fan, Cheng Chen, Rong Jiang, Li Liang, Menglin Xian, Biao Kuang, Nana Geng, Naibo Feng, Lin Deng, Wei Zheng, Fengmei Zhang, Xiaoli Li, Fengjin Guo, 2022 Progranulin, a moderator of estrogen/estrogen receptor α binding, regulates bone homeostasis through PERK/p-eIF2 signaling pathway., Yuyou Yang, Naibo Feng, Li Liang, Rong Jiang, Yiming Pan, Nana Geng, Mengtian Fan, Xiaoli Li, Fengjin Guo, 2022 Nanoparticle-siRNA: A potential strategy for rheumatoid arthritis therapy?, Naibo Feng, Fengjin Guo, 2020 The active nuclear form of SREBP1 amplifies ER stress and autophagy via regulation of PERK., Qin Hu, Yu Mao, Min Liu, Rui Luo, Rong Jiang, Fengjin Guo, 2020 ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling., W Zheng, W Xie, D Yin, R Luo, M Liu, Fengjin Guo, 2019

Areas of Focus

Bone/Cartilage Development and Genetic Diseases
Mechanisms of Bone and Joint Function Injury and Remodeling

Publications

IRE1α protects against osteoarthritis by regulating progranulindependent XBP1 splicing and collagen homeostasis., Li Liang, Fengmei Zhang, Naibo Feng, Biao Kuang, Mengtian Fan, Cheng Chen, Yiming Pan, Pengfei Zhou, Nana Geng, Xingyue Li, Menglin Xian, Lin Deng, Xiaoli Li, Liang Kuang, Fengtao Luo, Qiaoyan Tan, Yangli Xie, Fengjin Guo, 2023
The circUbqln1, regulated by XBP1s, interplays with 14-3-3ζ to inhibit collagen synthesis and promote osteoarthritis by controlling PRODH activity and proline metabolism., Naibo Feng, Yuanlan Ye, Yiming Pan, Biao Kuang, Yu Du, Nana Geng, Cheng Chen, Kaiwen Liu, Li Liang, Menglin Xian, Yuyou Yang, Xingyue Li, Lin Deng, Fengmei Zhang, Liang Kuang, Mengtian Fan, Yangli Xie, Fengjin Guo, 2024
Treating Autoimmune Inflammatory Diseases with an siERN1-Nanoprodrug That Mediates Macrophage Polarization and Blocks Toll-like Receptor Signaling., Naibo Feng, Li Liang, Mengtian Fan, Yu Du, Cheng Chen, Rong Jiang, Dongsheng Yu, Yuyou Yang, Mengying Zhang, Lin Deng, Xingyue Li, Nana Geng, Menglin Xian, Qizhong Qin, Xiaoli Li, Qiaoyan Tan, Fengtao Luo, Fangzhou Song, Huabing Qi, Yangli Xie, Fengjin Guo, 2021
IRE1a regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization., Mengtian Fan, Nana Geng, Xingyue Li, Danyang Yin, Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng, Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi, Qiaoyan Tan, Yangli Xie, Fengjin Guo, 2022
Effect Of XBP1 Deficiency In Cartilage On The Regulatory Network Of LncRNA/circRNA-miRNA mRNA., Xiaoli Li, Yuyou Yang, Li Liang, Mengtian Fan, Xingyue Li, Naibo Feng, Yiming Pan, Qiaoyan Tan, Qingbo Xu, Yangli Xie, Fengjin Guo, 2022
Progranulin regulation of autophagy contributes to its chondroprotective effect in osteoarthritis., Yiming Pan, Yuyou Yang, Mengtian Fan, Cheng Chen, Rong Jiang, Li Liang, Menglin Xian, Biao Kuang, Nana Geng, Naibo Feng, Lin Deng, Wei Zheng, Fengmei Zhang, Xiaoli Li, Fengjin Guo, 2022
Progranulin, a moderator of estrogen/estrogen receptor α binding, regulates bone homeostasis through PERK/p-eIF2 signaling pathway., Yuyou Yang, Naibo Feng, Li Liang, Rong Jiang, Yiming Pan, Nana Geng, Mengtian Fan, Xiaoli Li, Fengjin Guo, 2022
Nanoparticle-siRNA: A potential strategy for rheumatoid arthritis therapy?, Naibo Feng, Fengjin Guo, 2020
The active nuclear form of SREBP1 amplifies ER stress and autophagy via regulation of PERK., Qin Hu, Yu Mao, Min Liu, Rui Luo, Rong Jiang, Fengjin Guo, 2020
ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling., W Zheng, W Xie, D Yin, R Luo, M Liu, Fengjin Guo, 2019

Bone Development Cartilage Genetic Diseases Joint Function Injury Remodeling Mechanisms Research Drug Development Clinical Studies

Fengjin Guo - Chongqing Medical University

Jie Wang - Central South University

Duan Ma - Fudan University

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