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Fengjin Guo
Basic Medical Sciences
Chongqing Medical University
Chongqing
Language: Chinese, English
Bone Development
Cartilage
Genetic Diseases
Joint Function
Injury
Remodeling
Mechanisms
Research
Drug Development
Clinical Studies
Areas of Focus
- Bone/Cartilage Development and Genetic Diseases
- Mechanisms of Bone and Joint Function Injury and Remodeling
Work Experience
- 1994.7–Present - Chongqing Medical University, Faculty of Basic Medicine, Cell Biology and Genetics Department - Assistant/ Lecturer/ Associate Professor/ Professor/ Distinguished Professor
- 2017–Present - Director, Cell Biology and Genetics Department, Faculty of Basic Medicine, Chongqing Medical University
- 2023.12–2026.11 - Chongqing Medical University Second Affiliated Hospital, Orthopedics - Joint Professor
Academic Background & Achievements
- 1990.9–1994.7 Bachelor: Lanzhou University, Cell Biology
- 2001.9–2006.7 Doctorate: Chongqing Medical University, Clinical Laboratory Diagnostics
- Hosted 6 National Natural Science Foundation projects
- Published over 50 research papers in journals like ACS NANO, Experimental & Molecular Medicine
Publications
- IRE1α protects against osteoarthritis by regulating progranulindependent XBP1 splicing and collagen homeostasis., Li Liang, Fengmei Zhang, Naibo Feng, Biao Kuang, Mengtian Fan, Cheng Chen, Yiming Pan, Pengfei Zhou, Nana Geng, Xingyue Li, Menglin Xian, Lin Deng, Xiaoli Li, Liang Kuang, Fengtao Luo, Qiaoyan Tan, Yangli Xie, Fengjin Guo, 2023
- The circUbqln1, regulated by XBP1s, interplays with 14-3-3ζ to inhibit collagen synthesis and promote osteoarthritis by controlling PRODH activity and proline metabolism., Naibo Feng, Yuanlan Ye, Yiming Pan, Biao Kuang, Yu Du, Nana Geng, Cheng Chen, Kaiwen Liu, Li Liang, Menglin Xian, Yuyou Yang, Xingyue Li, Lin Deng, Fengmei Zhang, Liang Kuang, Mengtian Fan, Yangli Xie, Fengjin Guo, 2024
- Treating Autoimmune Inflammatory Diseases with an siERN1-Nanoprodrug That Mediates Macrophage Polarization and Blocks Toll-like Receptor Signaling., Naibo Feng, Li Liang, Mengtian Fan, Yu Du, Cheng Chen, Rong Jiang, Dongsheng Yu, Yuyou Yang, Mengying Zhang, Lin Deng, Xingyue Li, Nana Geng, Menglin Xian, Qizhong Qin, Xiaoli Li, Qiaoyan Tan, Fengtao Luo, Fangzhou Song, Huabing Qi, Yangli Xie, Fengjin Guo, 2021
- IRE1a regulates the PTHrP-IHH feedback loop to orchestrate chondrocyte hypertrophy and cartilage mineralization., Mengtian Fan, Nana Geng, Xingyue Li, Danyang Yin, Yuyou Yang, Rong Jiang, Cheng Chen, Naibo Feng, Li Liang, Xiaoli Li, Fengtao Luo, Huabing Qi, Qiaoyan Tan, Yangli Xie, Fengjin Guo, 2022
- Effect Of XBP1 Deficiency In Cartilage On The Regulatory Network Of LncRNA/circRNA-miRNA mRNA., Xiaoli Li, Yuyou Yang, Li Liang, Mengtian Fan, Xingyue Li, Naibo Feng, Yiming Pan, Qiaoyan Tan, Qingbo Xu, Yangli Xie, Fengjin Guo, 2022
- Progranulin regulation of autophagy contributes to its chondroprotective effect in osteoarthritis., Yiming Pan, Yuyou Yang, Mengtian Fan, Cheng Chen, Rong Jiang, Li Liang, Menglin Xian, Biao Kuang, Nana Geng, Naibo Feng, Lin Deng, Wei Zheng, Fengmei Zhang, Xiaoli Li, Fengjin Guo, 2022
- Progranulin, a moderator of estrogen/estrogen receptor α binding, regulates bone homeostasis through PERK/p-eIF2 signaling pathway., Yuyou Yang, Naibo Feng, Li Liang, Rong Jiang, Yiming Pan, Nana Geng, Mengtian Fan, Xiaoli Li, Fengjin Guo, 2022
- Nanoparticle-siRNA: A potential strategy for rheumatoid arthritis therapy?, Naibo Feng, Fengjin Guo, 2020
- The active nuclear form of SREBP1 amplifies ER stress and autophagy via regulation of PERK., Qin Hu, Yu Mao, Min Liu, Rui Luo, Rong Jiang, Fengjin Guo, 2020
- ATG5 and ATG7 induced autophagy interplays with UPR via PERK signaling., W Zheng, W Xie, D Yin, R Luo, M Liu, Fengjin Guo, 2019
Awards
- 2014: Chongqing Natural Science Award, Third Prize
- 2022: ICMRS Webster Jee Young Investigator Award
- 2023: National Matrix Biology Conference, Young Scientist Excellent Paper Third Prize
