Professor | Yu-Hua Chen | Asia Growth Partners

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Name	Yu-Hua Chen
Contact Information	yhchen@cmu.edu.cn
Language ability	Chinese, English
Province	Liaoning

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Name

Yu-Hua Chen

Contact Information

yhchen@cmu.edu.cn

Language ability

Chinese, English

Province

Liaoning

University/Lab Affiliation and Title	China Medical University
Faculty	Life Sciences
Academic Background & Achievements	Achievement: Director of the National Health Commission Key Laboratory of Cell Biology Achievement: Director of the Ministry of Education Key Laboratory of Medical Cell Biology Achievement: Member of the Ministry of Education Basic Medical Teaching Steering Committee Achievement: Senior Director of the Chinese Society for Cell Biology Achievement: Published over 70 SCI papers
Work Experience	Former Dean - China Medical University School of Basic Medical Sciences and School of Life Sciences Former Chairman - Chinese Medical Association Medical Cell Biology Branch Former Vice President - Chinese Society for Cell Biology Medical Cell Biology Branch
Awards	Ministry of Education Science and Technology Progress Award First Prize Selected as Cross-Century Talent by the Ministry of Education State Council Special Government Allowance Liaoning Province Distinguished Professor and Teaching Master

University/Lab Affiliation and Title

China Medical University

Faculty

Life Sciences

Academic Background & Achievements

Achievement: Director of the National Health Commission Key Laboratory of Cell Biology
Achievement: Director of the Ministry of Education Key Laboratory of Medical Cell Biology
Achievement: Member of the Ministry of Education Basic Medical Teaching Steering Committee
Achievement: Senior Director of the Chinese Society for Cell Biology
Achievement: Published over 70 SCI papers

Work Experience

Former Dean - China Medical University School of Basic Medical Sciences and School of Life Sciences
Former Chairman - Chinese Medical Association Medical Cell Biology Branch
Former Vice President - Chinese Society for Cell Biology Medical Cell Biology Branch

Awards

Ministry of Education Science and Technology Progress Award First Prize
Selected as Cross-Century Talent by the Ministry of Education
State Council Special Government Allowance
Liaoning Province Distinguished Professor and Teaching Master

Areas of Focus	Mechanisms of Brain Microvascular Homeostasis and Neurodegenerative Diseases
Publications	Endothelial lincRNA-p21 alleviates cerebral ischemia/reperfusion injury by maintaining blood-brain barrier integrity., Zhao YH, Liang Y, Wang KJ, Jin SN, Yu XM, Zhang Q, Wei JY, Liu H, Fang WG, Zhao WD, Li Y, Chen YH, 2024 Monocytes release cystatin F dimer to associate with Aβ and aggravate amyloid pathology and cognitive deficits in Alzheimer's disease., Li Q, Li B, Liu L, Wang KJ, Liu MY, Deng Y, Li Z, Zhao WD, Wu LY, Chen YH, Zhang K, 2024 Endothelial depletion of Atg7 triggers astrocyte-microvascular disassociation at blood-brain barrier., Liu H, Wei JY, Li Y, Ban M, Sun Q, Wang HJ, Zhao D, Tong PG, Wang L, Wang KJ, Yue JL, Zhang HY, Fang WG, Liu DX, Shang DS, Li B, Jin YP, Cao L, Zhao WD, Chen YH, 2023 An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity., Li Y, Wei JY, Liu H, Wang KJ, Jin SN, Su ZK, Wang HJ, Shi JX, Li B, Shang DS, Fang WG, Qin XX, Zhao WD, Chen YH, 2022 A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells., Zhang SH, Liu DX, Wang L, Li YH, Wang YH, Zhang H, Su ZK, Fang WG, Qin XX, Shang DS, Li B, Han XN, Zhao WD, Chen YH, 2019 Caspr1 is a host receptor for meningitis-causing Escherichia coli., Zhao WD, Liu DX, Wei JY, Miao ZW, Zhang K, Su ZK, Zhang XW, Li Q, Fang WG, Qin XX, Shang DS, Li B, Li QC, Cao L, Kim KS, Chen YH, 2018 ZO-1 expression is suppressed by GM-CSF via miR-96/ERG in brain microvascular endothelial cells., Zhang H, Zhang S, Zhang J, Liu D, Wei J, Fang W, Zhao W, Chen Y, Shang D, 2018 Intracerebral GM-CSF contributes to transendothelial monocyte migration in APP/PS1 Alzheimer's disease mice., Shang DS, Yang YM, Zhang H, Tian L, Jiang JS, Dong YB, Zhang K, Li B, Zhao WD, Fang WG, Chen YH, 2016 Decreased expression of cathepsin D in monocytes is related to the defective degradation of amyloid-β in Alzheimer's disease., Tian L, Zhang K, Tian ZY, Wang T, Shang DS, Li B, Liu DX, Fang WG, Wang ZY, Chen YH, 2014 Elevated PLGF contributes to small cell lung cancer brain metastasis., Li B, Wang C, Zhang Y, Zhao XY, Huang B, Wu PF, Li Q, Li H, Liu YS, Cao LY, Dai WM, Fang WG, Shang DS, Cao L, Zhao WD, Chen YH, 2013 Vascular endothelial growth factor receptor 1 contributes to Escherichia coli K1 invasion of human brain microvascular endothelial cells through PI3K/Akt signaling pathway., Zhao WD, Liu W, Fang WG, Kim KS, Chen YH, 2010 Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-alpha-dependent., Liu YJ, Guo DW, Tian L, Shang DS, Zhao WD, Li B, Fang WG, Zhu L, Chen YH, 2010 Amyloid β interaction with receptor for advanced glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood-brain barrier., Li M, Shang DS, Zhao WD, Tian L, Li B, Fang WG, Zhu L, Man SM, Chen YH, 2009 Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease., Man SM, Ma YR, Shang DS, Zhao WD, Li B, Guo DW, Fang WG, Zhu L, Chen YH, 2007 Involvement of Rho/ROCK signalling in small cell lung cancer migration through human brain microvascular endothelial cells., Li B, Zhao WD, Tan ZM, Fang WG, Zhu L, Chen YH*, 2006

Areas of Focus

Mechanisms of Brain Microvascular Homeostasis and Neurodegenerative Diseases

Publications

Endothelial lincRNA-p21 alleviates cerebral ischemia/reperfusion injury by maintaining blood-brain barrier integrity., Zhao YH, Liang Y, Wang KJ, Jin SN, Yu XM, Zhang Q, Wei JY, Liu H, Fang WG, Zhao WD, Li Y, Chen YH*, 2024
Monocytes release cystatin F dimer to associate with Aβ and aggravate amyloid pathology and cognitive deficits in Alzheimer's disease., Li Q, Li B, Liu L, Wang KJ, Liu MY, Deng Y, Li Z, Zhao WD, Wu LY, Chen YH*, Zhang K, 2024
Endothelial depletion of Atg7 triggers astrocyte-microvascular disassociation at blood-brain barrier., Liu H, Wei JY, Li Y, Ban M, Sun Q, Wang HJ, Zhao D, Tong PG, Wang L, Wang KJ, Yue JL, Zhang HY, Fang WG, Liu DX, Shang DS, Li B, Jin YP, Cao L, Zhao WD, Chen YH*, 2023
An oxygen-adaptive interaction between SNHG12 and occludin maintains blood-brain barrier integrity., Li Y, Wei JY, Liu H, Wang KJ, Jin SN, Su ZK, Wang HJ, Shi JX, Li B, Shang DS, Fang WG, Qin XX, Zhao WD, Chen YH*, 2022
A CASPR1-ATP1B3 protein interaction modulates plasma membrane localization of Na+/K+-ATPase in brain microvascular endothelial cells., Zhang SH, Liu DX, Wang L, Li YH, Wang YH, Zhang H, Su ZK, Fang WG, Qin XX, Shang DS, Li B, Han XN, Zhao WD, Chen YH*, 2019
Caspr1 is a host receptor for meningitis-causing Escherichia coli., Zhao WD, Liu DX, Wei JY, Miao ZW, Zhang K, Su ZK, Zhang XW, Li Q, Fang WG, Qin XX, Shang DS, Li B, Li QC, Cao L, Kim KS, Chen YH*, 2018
ZO-1 expression is suppressed by GM-CSF via miR-96/ERG in brain microvascular endothelial cells., Zhang H, Zhang S, Zhang J, Liu D, Wei J, Fang W, Zhao W, Chen Y*, Shang D, 2018
Intracerebral GM-CSF contributes to transendothelial monocyte migration in APP/PS1 Alzheimer's disease mice., Shang DS, Yang YM, Zhang H, Tian L, Jiang JS, Dong YB, Zhang K, Li B, Zhao WD, Fang WG, Chen YH*, 2016
Decreased expression of cathepsin D in monocytes is related to the defective degradation of amyloid-β in Alzheimer's disease., Tian L, Zhang K, Tian ZY, Wang T, Shang DS, Li B, Liu DX, Fang WG, Wang ZY, Chen YH*, 2014
Elevated PLGF contributes to small cell lung cancer brain metastasis., Li B, Wang C, Zhang Y, Zhao XY, Huang B, Wu PF, Li Q, Li H, Liu YS, Cao LY, Dai WM, Fang WG, Shang DS, Cao L, Zhao WD, Chen YH*, 2013
Vascular endothelial growth factor receptor 1 contributes to Escherichia coli K1 invasion of human brain microvascular endothelial cells through PI3K/Akt signaling pathway., Zhao WD, Liu W, Fang WG, Kim KS, Chen YH*, 2010
Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-alpha-dependent., Liu YJ, Guo DW, Tian L, Shang DS, Zhao WD, Li B, Fang WG, Zhu L, Chen YH*, 2010
Amyloid β interaction with receptor for advanced glycation end products up-regulates brain endothelial CCR5 expression and promotes T cells crossing the blood-brain barrier., Li M, Shang DS, Zhao WD, Tian L, Li B, Fang WG, Zhu L, Man SM, Chen YH*, 2009
Peripheral T cells overexpress MIP-1alpha to enhance its transendothelial migration in Alzheimer's disease., Man SM, Ma YR, Shang DS, Zhao WD, Li B, Guo DW, Fang WG, Zhu L, Chen YH*, 2007
Involvement of Rho/ROCK signalling in small cell lung cancer migration through human brain microvascular endothelial cells., Li B, Zhao WD, Tan ZM, Fang WG, Zhu L, Chen YH*, 2006

Brain Microvascular Homeostasis Neurodegenerative Diseases Mechanisms Regulation Blood-Brain Barrier Endothelial Pathology

Zhao Weidong - China Medical University

An Mingxin - China Medical University

Hui Liu - China Medical University

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