Professor | Hou-Zao Chen | Asia Growth Partners

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Name	Hou-Zao Chen
Contact Information	chenhouzao@ibms.cams.cn
Language ability	Chinese, English
Province	Beijing

Upload Avatar (500 x 500)

Name

Hou-Zao Chen

Contact Information

chenhouzao@ibms.cams.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Peking Union Medical College
Faculty	Basic Medical Sciences
Academic Background & Achievements	PhD in Biochemistry and Molecular Biology 2013: Promoted to Doctoral Supervisor Published over 70 SCI research papers and reviews
Work Experience	2012/04-present: Editorial Board Member, Frontiers in Physiology 2018/01-present: Editorial Board Member, Cardiovascular Drugs and Therapy 2020/01-present: Editorial Board Member, Free Radical Biology and Medicine 2020/10-present: Editorial Board Member, Mechanisms of Ageing and Development
Awards	2021: Ninth National Health and Family Planning Commission Outstanding Contribution Young and Middle-aged Expert 2019: National Leading Talent in the Ten Thousand Talents Program 2018: Ministry of Science and Technology Young and Middle-aged Science and Technology Innovation Leading Talent 2016: Ministry of Education Young Changjiang Scholar 2015: Central Organization Department Young Top Talent 2014: National Natural Science Foundation of China Excellent Young Scientist Fund 2013: Beijing Science and Technology New Star 2011: Peking Union Medical College New Star

University/Lab Affiliation and Title

Peking Union Medical College

Faculty

Basic Medical Sciences

Academic Background & Achievements

PhD in Biochemistry and Molecular Biology
2013: Promoted to Doctoral Supervisor
Published over 70 SCI research papers and reviews

Work Experience

2012/04-present: Editorial Board Member, Frontiers in Physiology
2018/01-present: Editorial Board Member, Cardiovascular Drugs and Therapy
2020/01-present: Editorial Board Member, Free Radical Biology and Medicine
2020/10-present: Editorial Board Member, Mechanisms of Ageing and Development

Awards

2021: Ninth National Health and Family Planning Commission Outstanding Contribution Young and Middle-aged Expert
2019: National Leading Talent in the Ten Thousand Talents Program
2018: Ministry of Science and Technology Young and Middle-aged Science and Technology Innovation Leading Talent
2016: Ministry of Education Young Changjiang Scholar
2015: Central Organization Department Young Top Talent
2014: National Natural Science Foundation of China Excellent Young Scientist Fund
2013: Beijing Science and Technology New Star
2011: Peking Union Medical College New Star

Areas of Focus	Cardiovascular Disease Mechanisms Epigenetic Modifications in Aging and Metabolism
Publications	Short-chain Enoyl-CoA Hydratase Mediates Histone Crotonylation and Contributes to Cardiac Homeostasis., Xiaoqiang Tang, Xiao-Feng Chen, Xin Sun, Peng Xu, Xiang Zhao, Ying Tong, Xiao-Man Wang, Ke Yang, Yu-Tong Zhu, De-Long Hao, Zhu-Qin Zhang, De-Pei Liu, Hou-Zao Chen, 2021 Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases., Wang F, Chen HZ, 2020 Global Lysine Crotonylation Profiling of Mouse Liver., Liu JF, Wu SF, Liu S, Sun X, Wang XM, Xu P, Chen HZ, Yang JT, 2020 Metabolic regulation of immune cells in proinflammatory microenvironments and diseases during ageing., Li PH, Zhang R, Cheng LQ, Liu JJ, Chen HZ, 2020 Cardiomyocyte Senescence and Cellular Communications Within Myocardial Microenvironments., Tang X, Li PH, Chen HZ, 2020 Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks., Pei JF, Li XK, Li WQ, Gao Q, Zhang Y, Wang XM, Fu JQ, Cui SS, Qu JH, Zhao X, Hao DL, Ju D, Liu N, Carroll KS, Yang J, Zhang EE, Cao JM, Chen HZ, Liu DP, 2019 Caloric Restriction Induces MicroRNAs to Improve Mitochondrial Proteostasis., Zhang R, Wang X, Qu JH, Liu B, Zhang P, Zhang T, Fan PC, Wang XM, Xiao GY, Su Y, Xie Y, Liu Y, Pei JF, Zhang ZQ, Hao DL, Xu P, Chen HZ, Liu DP, 2019 Sirtuins and Insulin Resistance., Zhou S, Tang X, Chen HZ, 2018 SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy., Tang X, Chen XF, Wang NY, Wang XM, Liang ST, Zheng W, Lu YB, Zhao X, Hao DL, Zhang ZQ, Zou MH, Liu DP, Chen HZ, 2017 Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity., Luo YX, Tang X, An XZ, Xie XM, Chen XF, Zhao X, Hao DL, Chen HZ, Liu DP, 2017 Calorie restriction protects against experimental abdominal aortic aneurysms in mice., Liu Y, Wang TT, Zhang R, Fu WY, Wang X, Wang F, Gao P, Ding YN, Xie Y, Hao DL, Chen HZ, Liu DP, 2016 Epigenetic regulation in cell senescence., Cheng LQ, Zhang ZQ, Chen HZ, Liu DP, 2017 Mitochondrial Sirtuins in cardiometabolic diseases., Tang X, Chen XF, Chen HZ, Liu DP, 2017 The Paraoxonase Gene Cluster Protects Against Abdominal Aortic Aneurysm Formation., Yan YF, Pei JF, Zhang R, Wang F, Gao P, Zhang ZQ, Wang TT, Zhang Y, She ZG, Chen HZ, Liu DP, 2016 Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice., Pei JF, Yan YF, Tang X, Zhang Y, Cui SS, Zhang ZQ, Chen HZ, Liu DP, 2016 The Four Layers of Aging., R Zhang, HZ Chen, DP Liu, 2015 SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence., Wan YZ, Gao P, Zhou S, Zhang ZQ, Hao DL, Lian LS, Li YJ, Chen HZ, Liu DP, 2014 Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure., Mu W, Zhang Q, Tang X, Fu W, Zheng W, Lu Y, Li H, Wei Y, Li L, She Z, Chen H, Liu D, 2014 Mechanistic perspectives of calorie restriction on vascular homeostasis., Liu Y, Chen H, Liu D, 2014 Mitochondria, Endothelial Cell Function and Vascular Diseases., Xiaoqiang Tang, Yu-Xuan Luo, Hou-Zao Chen, De-Pei Liu, 2014 Overexpression of Mitofilin in the Mouse Heart Promotes Cardiac Hypertrophy in Response to Hypertrophic Stimuli., Zhang Y, Xu J, Luo YX, An XZ, Zhang R, Liu G, Li H, Chen HZ, Liu DP, 2014 Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice., Gao P, Xu TT, Lu J, Li L, Xu J, Hao DL, Chen HZ, Liu DP, 2014 SIRT1 mediates the protective function of Nkx2.5 during stress in cardiomyocytes., Zheng W, Lu YB, Liang ST, Zhang QJ, Xu J, She ZG, Zhang ZQ, Yang RF, Mao BB, Xu Z, Li L, Hao DL, Lu J, Wei YS, Chen HZ, Liu DP, 2013 SIRT1 as a Novel Potential Treatment Target for Vascular Aging and Age-related Vascular Diseases., Wang F, Chen HZ, Lv X, Liu DP, 2013 SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells., Jia Y, Gao P, Chen H, Wan Y, Zhang R, Zhang Z, Yang R, Wang X, Xu J, Liu D, 2013

Areas of Focus

Cardiovascular Disease Mechanisms
Epigenetic Modifications in Aging and Metabolism

Publications

Short-chain Enoyl-CoA Hydratase Mediates Histone Crotonylation and Contributes to Cardiac Homeostasis., Xiaoqiang Tang, Xiao-Feng Chen, Xin Sun, Peng Xu, Xiang Zhao, Ying Tong, Xiao-Man Wang, Ke Yang, Yu-Tong Zhu, De-Long Hao, Zhu-Qin Zhang, De-Pei Liu, Hou-Zao Chen, 2021
Histone Deacetylase SIRT1, Smooth Muscle Cell Function, and Vascular Diseases., Wang F, Chen HZ, 2020
Global Lysine Crotonylation Profiling of Mouse Liver., Liu JF, Wu SF, Liu S, Sun X, Wang XM, Xu P, Chen HZ, Yang JT, 2020
Metabolic regulation of immune cells in proinflammatory microenvironments and diseases during ageing., Li PH, Zhang R, Cheng LQ, Liu JJ, Chen HZ, 2020
Cardiomyocyte Senescence and Cellular Communications Within Myocardial Microenvironments., Tang X, Li PH, Chen HZ, 2020
Diurnal oscillations of endogenous H2O2 sustained by p66Shc regulate circadian clocks., Pei JF, Li XK, Li WQ, Gao Q, Zhang Y, Wang XM, Fu JQ, Cui SS, Qu JH, Zhao X, Hao DL, Ju D, Liu N, Carroll KS, Yang J, Zhang EE, Cao JM, Chen HZ, Liu DP, 2019
Caloric Restriction Induces MicroRNAs to Improve Mitochondrial Proteostasis., Zhang R, Wang X, Qu JH, Liu B, Zhang P, Zhang T, Fan PC, Wang XM, Xiao GY, Su Y, Xie Y, Liu Y, Pei JF, Zhang ZQ, Hao DL, Xu P, Chen HZ, Liu DP, 2019
Sirtuins and Insulin Resistance., Zhou S, Tang X, Chen HZ, 2018
SIRT2 Acts as a Cardioprotective Deacetylase in Pathological Cardiac Hypertrophy., Tang X, Chen XF, Wang NY, Wang XM, Liang ST, Zheng W, Lu YB, Zhao X, Hao DL, Zhang ZQ, Zou MH, Liu DP, Chen HZ, 2017
Sirt4 accelerates Ang II-induced pathological cardiac hypertrophy by inhibiting manganese superoxide dismutase activity., Luo YX, Tang X, An XZ, Xie XM, Chen XF, Zhao X, Hao DL, Chen HZ, Liu DP, 2017
Calorie restriction protects against experimental abdominal aortic aneurysms in mice., Liu Y, Wang TT, Zhang R, Fu WY, Wang X, Wang F, Gao P, Ding YN, Xie Y, Hao DL, Chen HZ, Liu DP, 2016
Epigenetic regulation in cell senescence., Cheng LQ, Zhang ZQ, Chen HZ, Liu DP, 2017
Mitochondrial Sirtuins in cardiometabolic diseases., Tang X, Chen XF, Chen HZ, Liu DP, 2017
The Paraoxonase Gene Cluster Protects Against Abdominal Aortic Aneurysm Formation., Yan YF, Pei JF, Zhang R, Wang F, Gao P, Zhang ZQ, Wang TT, Zhang Y, She ZG, Chen HZ, Liu DP, 2016
Human paraoxonase gene cluster overexpression alleviates angiotensin II-induced cardiac hypertrophy in mice., Pei JF, Yan YF, Tang X, Zhang Y, Cui SS, Zhang ZQ, Chen HZ, Liu DP, 2016
The Four Layers of Aging., R Zhang, HZ Chen, DP Liu, 2015
SIRT1-mediated epigenetic downregulation of plasminogen activator inhibitor-1 prevents vascular endothelial replicative senescence., Wan YZ, Gao P, Zhou S, Zhang ZQ, Hao DL, Lian LS, Li YJ, Chen HZ, Liu DP, 2014
Overexpression of a dominant-negative mutant of SIRT1 in mouse heart causes cardiomyocyte apoptosis and early-onset heart failure., Mu W, Zhang Q, Tang X, Fu W, Zheng W, Lu Y, Li H, Wei Y, Li L, She Z, Chen H, Liu D, 2014
Mechanistic perspectives of calorie restriction on vascular homeostasis., Liu Y, Chen H, Liu D, 2014
Mitochondria, Endothelial Cell Function and Vascular Diseases., Xiaoqiang Tang, Yu-Xuan Luo, Hou-Zao Chen, De-Pei Liu, 2014
Overexpression of Mitofilin in the Mouse Heart Promotes Cardiac Hypertrophy in Response to Hypertrophic Stimuli., Zhang Y, Xu J, Luo YX, An XZ, Zhang R, Liu G, Li H, Chen HZ, Liu DP, 2014
Overexpression of SIRT1 in vascular smooth muscle cells attenuates angiotensin II-induced vascular remodeling and hypertension in mice., Gao P, Xu TT, Lu J, Li L, Xu J, Hao DL, Chen HZ, Liu DP, 2014
SIRT1 mediates the protective function of Nkx2.5 during stress in cardiomyocytes., Zheng W, Lu YB, Liang ST, Zhang QJ, Xu J, She ZG, Zhang ZQ, Yang RF, Mao BB, Xu Z, Li L, Hao DL, Lu J, Wei YS, Chen HZ, Liu DP, 2013
SIRT1 as a Novel Potential Treatment Target for Vascular Aging and Age-related Vascular Diseases., Wang F, Chen HZ, Lv X, Liu DP, 2013
SIRT1 suppresses PMA and ionomycin-induced ICAM-1 expression in endothelial cells., Jia Y, Gao P, Chen H, Wan Y, Zhang R, Zhang Z, Yang R, Wang X, Xu J, Liu D, 2013

Cardiovascular Disease Mechanisms Epigenetic Modifications Aging Metabolism Sirtuin Enzymes Research

Jingyan Han - Peking University

Pei Cheng - Wuhan University

Chengjun Hu - Wuhan University

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