Postdoctoral research at Scripps Research Institute
Published over 30 research papers in international journals
Current - Chinese Academy of Medical Sciences/Peking Union Medical College - Distinguished Professor and Doctoral Supervisor
AACR-Inglenook Vineyards Scholar-in-Training Award (2003): For research on multifunctional gene vaccines
AACR-Glaxo Smith Kline Outstanding Clinical Scholar Awards (2005): For research on gene vaccines targeting tumor-associated macrophages
AACR Susan G. Komen Scholar in Training Award (2010): For research on tumor microenvironment and cancer stem cells
Research
Tumor immune escape mechanisms Relationship between immune system and tumorigenesis Gene and immunotherapy for tumors
IKKβ enforces a LIN28B/TCF7L2 positive feedback loop that promotes cancer cell stemness and metastasis, Chen C, Cao F, Bai L, Liu Y, Xie J, Wang W, Si Q, Yang J, Chang A, Liu D, Liu D, Chuang TH, Xiang R and Luo Y, 2015
MicroRNA-19a-3p inhibits breast tumor metastasis and progression by inducing Macrophage polarization through down-regulating the expression of Fra-1 gene, Yang J, Chen C, Liu Y, Si Qin, Chuang TH, Reisfeld RA, Xiang R, Luo Y, 2013
Tumor associated macrophages regulate murine breast cancer stem cells through a novel paracrine EGFR/Stat3/Sox-2 signaling pathway, Yang J, Liao D, Chen C, Liu Y, Chuang TH, Xiang R, Markowitzb D, Reisfeld RA, Luo Y, 2013
Knockdown of transcription factor Sox2 in cancer stem cells suppresses metastasis of murine non-small cell lung cancer cells, Xiang R, Liao D, Cheng TM, Zhou H, Chung TH, Markowitz D, Reisfeld RA, Luo Y, 2011
Functional interaction of Hsp90 and Beclin 1 modulates Toll-like receptor-mediated autophagy, Xu C, Liu J, Hsu LC, Luo Y, Xiang R, Chuang TH, 2011
MTDH/AEG-1-based DNA vaccine suppresses lung metastasis and enhances chemosensitivity to doxorubicin in breast cancer, Qian BJ, Yan F, Li N, Liu QL, Lin YH, Liu CM, Luo Y, Guo F, Li HZ, 2011
Synthetic enzyme inhibitor: a novel targeting ligand for nanotherapeutic drug delivery inhibiting tumor growth without systemic toxicity, Liao D, Liu Z, Wrasidlo W, Chen T, Luo Y, Xiang R, Reisfeld RA, 2011
Cancer Associated Fibroblast Promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model, Liao D, Luo Y, Markowitz, Xiang R Reisfeld RA, 2010
Transcriptional regulation of tumor-associated macrophages (TAMs) controls invasion, angiogenesis and metastasis of breast cancer cells, Luo Y, Zhou H, Krueger J, Kaplan C, Liao D, Markowitz D, Liu C, Chen T, Reisfeld RA and Xiang R, 2010
NF-kB activation primes cells to a pro-inflammatory polarized response to a TLR7 agonist, Lee J, Hayash M, Lo JF, Fearns C, Chu WM, Luo Y, Xiang R, Chuang TH, 2009
A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition, Liu J, Xu C, Hsu LC, Luo Y, Xiang R, Chuang TH, 2010
Oral DNA vaccines target the tumor vasculature and microenvironment and suppress tumor growth and metastasis, Xiang R, Luo Y, Niethammer AG, Reisfeld RA, 2008
A Legumain-based minigene vaccine targets the tumor stroma and suppresses breast cancer growth and angiogenesis, Lewēn S, Zhou H, Hu HD, Cheng TM, Markowitz D, Reisfeld RA, Xiang R and Luo Y, 2008
FLK-1-based minigene vaccines induce T cell-mediated suppression of angiogenesis and tumor protective immunity in syngeneic BALB/c mice, Luo Y, Dorothy Markowitz, Rong Xiang, He Zhou and Ralph A. Reisfeld, 2007
Adenovirus fiber shaft contains a trimerization element that supports peptide fusion for targeted gene delivery, Jiali Li, Sonya Lad, Guang Yang, Luo Y, Milena Iacobelli-Martinez, F. James Primus, Ralph A. Reisfeld, and Erguang Ll, 2006
Induction of tumor-specific T cell memory by a DNA vaccine targeting Fos-related Antigen 1, Luo Y, Zhou, H., Kaplan CD., Kruger JA, Lee SH, Xiang R, Reisfeld RA, 2006
Novel Model fro the In Vivo Study of Stem Cell Like Cancer Cells in Immune Competent Mice, Kruger JA, Kaplan CD, Luo Y , Zhou H, Markowitz D, Xiang R, Reisfeld RA, 2006
Anovel DNA vaccine encoding PDGFRb suppresses growth and dissemination of murine colon, lung and breast carcinoma, Kaplan CD, Kruger JA, Zhou, H, Luo Y, Xiang R, Reisfeld RA, 2006
Endoglin(CD105) is a Target for an oral DNA Vaccine against breast cancer, Lee SH, Mizutani M, Mizutani N, Luo Y, Zhou, H, Kaplan CD, Xiang R, Reisfeld RA, 2006
Targeting Cell-Impermeable Prodrug Activation to Tumor Microenvironment Eradicates Multiple Drug-Resistant Neoplasm, Luo Y, Wu WY, Sun CZ, Liu Y, Kuo P, Varga J, Xiang R, Reisfeld R, Kim D, Thomas J, Edgington S, Liu C, 2006
A DNA-based cancer vaccine enhances lymphocyte crosstalk by engaging the NKG2D receptor, Zhou H, Luo Y, Kaplan CD, Kruger JA, Lee SH, Xiang R, Reisfeld RA, 2005
A DNA vaccine targeting Fos-related antigen 1 enhanced by IL-18 induces long-lived T-cell memory against tumor recurrence, Luo Y, Zhou H, Mizutani M, Mizutani N, Xiang R, Reisfeld R, 2005
DNA-based vaccines activate innate and adaptive anti-tumor immunity by engaging the NKG2D receptor, Zhou H, Luo Y, Kaplan CD, Kruger JA, Lee SH, Xiang R, Reisfeld RA, 2005
T cell-mediated suppression of angiogenesis results in tumor protective immunity, Zhou H, Luo Y , Mizutani M, Mizutani N, Reisfeld RA Xiang R, 2005
A DNA Vaccine Targeting Survivin Combines Tumor Cell Apoptosis with Suppression of Angiogenesis in the Eradication of Lung Tumor Metastases, Rong Xiang R, Mizutani N, Luo Y, Chiodini C, Zhou H, Mizutani M, Ba Y, Becker JC, Reisfeld RA, 2005
