Professor | Wenjing Du | Asia Growth Partners

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Name	Wenjing Du
Contact Information	wenjingdu@ibms.pumc.edu.cn
Language ability	English, Chinese
Province	Beijing

Upload Avatar (500 x 500)

Name

Wenjing Du

Contact Information

wenjingdu@ibms.pumc.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Peking Union Medical College
Faculty	Basic Medical Sciences
Academic Background & Achievements	2003-2008: PhD in Life Sciences, University of Science and Technology of China 2016: Selected for National Youth Talent Program
Work Experience	2008-2013: Postdoctoral Researcher, University of Pennsylvania School of Medicine 2013-2015: Research Assistant, University of Pennsylvania School of Medicine 2016-present: Group Leader and Doctoral Supervisor, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences 2019-present: Associate Professor, Peking Union Medical College
Awards	2016: Selected for National Youth Talent Program

University/Lab Affiliation and Title

Peking Union Medical College

Faculty

Basic Medical Sciences

Academic Background & Achievements

2003-2008: PhD in Life Sciences, University of Science and Technology of China
2016: Selected for National Youth Talent Program

Work Experience

2008-2013: Postdoctoral Researcher, University of Pennsylvania School of Medicine
2013-2015: Research Assistant, University of Pennsylvania School of Medicine
2016-present: Group Leader and Doctoral Supervisor, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences
2019-present: Associate Professor, Peking Union Medical College

Awards

2016: Selected for National Youth Talent Program

Areas of Focus	Regulation of cellular metabolic pathways under different physiological and pathological conditions Mechanisms of metabolite sensing and exploration of new functions
Publications	Functional skewing of TRIM21-SIRT5 interplay dictates IL-1β production in DSS-induced colitis., Yao Pengbo, Chen Taiqi, Jiang Peng, Li Li, Du Wenjing, 2022 Malic enzyme 2 as a therapeutic target for cancer: comments on 'Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate'., Zhang Zhenxi, Du Wenjing, 2022 Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate., Zhao Mengjia, Yao Pengbo, Mao Youxiang, Wu Jinjun, Wang Weihua, Geng Chenhui, Cheng Jie, Du Wenjing, Jiang Peng, 2022 p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth., Sun Huishan, Li Li, Li Wei, Yang Fan, Zhang Zhenxi, Liu Zizhao, Du Wenjing, 2021 NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex., Li Wei, Kou Junjie, Qin Junyin, Li Li, Zhang Zhenxi, Pan Ying, Xue Yi, Du Wenjing, 2021 MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE., Yang Fan, Kou Junjie, Li Wei, Du Wenjing, 2021 Identification of precise therapeutic targets and characteristic prognostic genes based on immune gene characteristics in uveal melanoma., Zhang Zhenxi, Su Jingyu, Li Li, Du Wenjing, 2021 MYC retards cancer cell migration through suppressing fibronectin expression., Zhao Mengjia, Jiang Peng, Du Wenjing, 2019 TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation., Li Le, Li Lijia, Li Wei, Chen Taiqi, Bin Zou, Zhao Lina, Wang Huili, Wang Xueying, Xu Lina, Liu Xiaohui, Wang Dong, Li Bo, Mak Tak W, Du Wenjing, Yang Xiaolu, Jiang Peng, 2018 Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions., Yao Pengbo, Sun Huishan, Xu Chang, Chen Taiqi, Zou Bing, Jiang Peng, Du Wenjing, 2017 TAp73 enhances the pentose phosphate pathway and supports cell proliferation., Du Wenjing, Jiang Peng, Mancuso Anthony, Stonestrom Aaron, Brewer Michael D, Minn Andy J, Mak Tak W, Wu Mian, Yang Xiaolu, 2013 Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence., Jiang Peng, Du Wenjing, Mancuso Anthony, Wellen Kathryn E, Yang Xiaolu, 2013 p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase., Jiang Peng, Du Wenjing, Wang Xingwu, Mancuso Anthony, Gao Xiang, Wu Mian, Yang Xiaolu, 2011 Suppression of p53 activity by Siva1., Du Wenjing, Jiang Peng, Li Nan, Mei Yide, Wang Xingwu, Wen Longping, Yang Xiaolu, Wu Mian, 2009 The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis., Jiang Peng, Du Wenjing, Heese Klaus, Wu Mian, 2006 p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis., Li Le, Mao Youxiang, Zhao Lina, Li Lijia, Wu Jinjun, Zhao Mengjia, Du Wenjing, Yu Li, Jiang Peng, 2019 Regulation of the pentose phosphate pathway in cancer., Jiang Peng, Du Wenjing, Wu Mian, 2014 A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation., Jiang Peng, Du Wenjing, Yang Xiaolu, 2013 p53 and regulation of tumor metabolism., Jiang Peng, Du Wenjing, Yang Xiaolu, 2013 Siva1 inhibits p53 function by acting as an ARF E3 ubiquitin ligase., Wang Xingwu, Zha Meng, Zhao Xiaocheng, Jiang Peng, Du Wenjing, Tam Andrew Y H, Mei Yide, Wu Mian, 2013 Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules., Li Nan, Jiang Peng, Du Wenjing, Wu Zhengsheng, Li Cong, Qiao Mengran, Yang Xiaolu, Wu Mian, 2011 Domain-swapped dimerization of the second PDZ domain of ZO2 may provide a structural basis for the polymerization of claudins., Wu Jiawen, Yang Yinshan, Zhang Jiahai, Ji Peng, Du Wenjing, Jiang Peng, Xie Dinghai, Huang Hongda, Wu Mian, Zhang Guangzhao, Wu Jihui, Shi Yunyu, 2007 p53 and Bad: remote strangers become close friends., Jiang Peng, Du Wenjing, Wu Mian, 2007 Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway., Ma L, Huang Y, Song Z, Feng S, Tian X, Du W, Qiu X, Heese K, Wu M, 2006 Puma(*)Mcl-1 interaction is not sufficient to prevent rapid degradation of Mcl-1., Mei Yide, Du Wenjing, Yang Yonghui, Wu Mian, 2005

Areas of Focus

Regulation of cellular metabolic pathways under different physiological and pathological conditions
Mechanisms of metabolite sensing and exploration of new functions

Publications

Functional skewing of TRIM21-SIRT5 interplay dictates IL-1β production in DSS-induced colitis., Yao Pengbo, Chen Taiqi, Jiang Peng, Li Li, Du Wenjing, 2022
Malic enzyme 2 as a therapeutic target for cancer: comments on 'Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate'., Zhang Zhenxi, Du Wenjing, 2022
Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate., Zhao Mengjia, Yao Pengbo, Mao Youxiang, Wu Jinjun, Wang Weihua, Geng Chenhui, Cheng Jie, Du Wenjing, Jiang Peng, 2022
p53 transcriptionally regulates SQLE to repress cholesterol synthesis and tumor growth., Sun Huishan, Li Li, Li Wei, Yang Fan, Zhang Zhenxi, Liu Zizhao, Du Wenjing, 2021
NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex., Li Wei, Kou Junjie, Qin Junyin, Li Li, Zhang Zhenxi, Pan Ying, Xue Yi, Du Wenjing, 2021
MYC Enhances Cholesterol Biosynthesis and Supports Cell Proliferation Through SQLE., Yang Fan, Kou Junjie, Li Wei, Du Wenjing, 2021
Identification of precise therapeutic targets and characteristic prognostic genes based on immune gene characteristics in uveal melanoma., Zhang Zhenxi, Su Jingyu, Li Li, Du Wenjing, 2021
MYC retards cancer cell migration through suppressing fibronectin expression., Zhao Mengjia, Jiang Peng, Du Wenjing, 2019
TAp73-induced phosphofructokinase-1 transcription promotes the Warburg effect and enhances cell proliferation., Li Le, Li Lijia, Li Wei, Chen Taiqi, Bin Zou, Zhao Lina, Wang Huili, Wang Xueying, Xu Lina, Liu Xiaohui, Wang Dong, Li Bo, Mak Tak W, Du Wenjing, Yang Xiaolu, Jiang Peng, 2018
Evidence for a direct cross-talk between malic enzyme and the pentose phosphate pathway via structural interactions., Yao Pengbo, Sun Huishan, Xu Chang, Chen Taiqi, Zou Bing, Jiang Peng, Du Wenjing, 2017
TAp73 enhances the pentose phosphate pathway and supports cell proliferation., Du Wenjing, Jiang Peng, Mancuso Anthony, Stonestrom Aaron, Brewer Michael D, Minn Andy J, Mak Tak W, Wu Mian, Yang Xiaolu, 2013
Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence., Jiang Peng, Du Wenjing, Mancuso Anthony, Wellen Kathryn E, Yang Xiaolu, 2013
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase., Jiang Peng, Du Wenjing, Wang Xingwu, Mancuso Anthony, Gao Xiang, Wu Mian, Yang Xiaolu, 2011
Suppression of p53 activity by Siva1., Du Wenjing, Jiang Peng, Li Nan, Mei Yide, Wang Xingwu, Wen Longping, Yang Xiaolu, Wu Mian, 2009
The Bad guy cooperates with good cop p53: Bad is transcriptionally up-regulated by p53 and forms a Bad/p53 complex at the mitochondria to induce apoptosis., Jiang Peng, Du Wenjing, Heese Klaus, Wu Mian, 2006
p53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis., Li Le, Mao Youxiang, Zhao Lina, Li Lijia, Wu Jinjun, Zhao Mengjia, Du Wenjing, Yu Li, Jiang Peng, 2019
Regulation of the pentose phosphate pathway in cancer., Jiang Peng, Du Wenjing, Wu Mian, 2014
A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation., Jiang Peng, Du Wenjing, Yang Xiaolu, 2013
p53 and regulation of tumor metabolism., Jiang Peng, Du Wenjing, Yang Xiaolu, 2013
Siva1 inhibits p53 function by acting as an ARF E3 ubiquitin ligase., Wang Xingwu, Zha Meng, Zhao Xiaocheng, Jiang Peng, Du Wenjing, Tam Andrew Y H, Mei Yide, Wu Mian, 2013
Siva1 suppresses epithelial-mesenchymal transition and metastasis of tumor cells by inhibiting stathmin and stabilizing microtubules., Li Nan, Jiang Peng, Du Wenjing, Wu Zhengsheng, Li Cong, Qiao Mengran, Yang Xiaolu, Wu Mian, 2011
Domain-swapped dimerization of the second PDZ domain of ZO2 may provide a structural basis for the polymerization of claudins., Wu Jiawen, Yang Yinshan, Zhang Jiahai, Ji Peng, Du Wenjing, Jiang Peng, Xie Dinghai, Huang Hongda, Wu Mian, Zhang Guangzhao, Wu Jihui, Shi Yunyu, 2007
p53 and Bad: remote strangers become close friends., Jiang Peng, Du Wenjing, Wu Mian, 2007
Livin promotes Smac/DIABLO degradation by ubiquitin-proteasome pathway., Ma L, Huang Y, Song Z, Feng S, Tian X, Du W, Qiu X, Heese K, Wu M, 2006
Puma(*)Mcl-1 interaction is not sufficient to prevent rapid degradation of Mcl-1., Mei Yide, Du Wenjing, Yang Yonghui, Wu Mian, 2005

Cellular Metabolism Metabolic Pathways Physiological Conditions Pathological Conditions Metabolite Sensing Biochemical Methods Molecular Biology Mouse Models Metabolic Diseases Therapeutic Strategies

Wei Xu - Chongqing Medical University

Ruilin Zhang - Wuhan University

Li Dongmin - Xi'an Jiaotong University

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