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Jianwu Dai
Institute of Biomedical Engineering
Peking Union Medical College
Beijing
Language: Chinese, English
Physical Signals
Tissue Development
Organ Regeneration
Magnetic Signals
Acoustic Signals
Optical Signals
Electrical Signals
Microenvironment
Regenerative Technology
Product Development
Areas of Focus
- Effects of physical signals on tissue and organ development and regeneration
Work Experience
- 2022-present - Chinese Academy of Medical Sciences, Institute of Biomedical Engineering - Distinguished Researcher, Executive Director, Head of Integrated Regenerative Medicine Laboratory
- 2003-present - Institute of Genetics and Developmental Biology, Chinese Academy of Sciences - Researcher, Director of Regenerative Medicine Research Center
Academic Background & Achievements
- 1984-1988 Bachelor: Wuhan University, Cell Biology
- 1988-1991 Master: Peking University Health Science Center, Biophysics
- 1996-1998 PhD: Duke University, Cell Biology
- 1998-2000 Postdoctoral Research: Harvard Medical School
Publications
- Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids., Sun Z, Chen Z, Yin M, Wu X, Guo B, Cheng X, Quan R, Sun Y, Zhang Q, Fan Y, Jin C, Yin Y, Hou X, Liu W, Shu M, Xue X, Shi Y, Chen B, Xiao Z, Dai J., Zhao Y., 2024
- Advances in electroactive bioscaffolds for repairing spinal cord injury., Liu Z, Lai J, Kong D, Zhao Y., Zhao J, Dai J., Zhang M., 2024
- Advances in Material-Assisted Electromagnetic Neural Stimulation., Sun Y, Xiao Z, Chen B, Zhao Y, Dai J., 2024
- Construction of functional neural network tissue combining CBD-NT3-modified linear-ordered collagen scaffold and TrkC-modified iPSC-derived neural stem cells for spinal cord injury repair., Wu Z, Zhou Y, Hou X, Liu W, Yin W, Wang L, Cao Y, Jiang Z, Guo Y, Chen Q, Xie W, Wang Z, Shi N, Liu Y, Gao X., Luo L., Dai J., Ren C., Jiang X., 2024
- Constructing Linear-Oriented Pre-Vascularized Human Spinal Cord Tissues for Spinal Cord Injury Repair., Fan C, Cai H, Zhang L, Wu X, Yan J, Jin L, Hu B, He J, Chen Y., Zhao Y., Dai J., 2024
- Single-cell analysis reveals region-heterogeneous responses in rhesus monkey spinal cord with complete injury., Fan Y, Wu X, Han S, Zhang Q, Sun Z, Chen B, Xue X, Zhang H, Chen Z, Yin M, Xiao Z., Zhao Y., Dai J., 2023
- Microvascular endothelial cells derived from spinal cord promote spinal cord injury repair., You Z, Gao X, Kang X, Yang W, Xiong T, Li Y, Wei F, Zhuang Y, Zhang T, Sun Y, Shen H., Dai J., 2023
- Engineered human spinal cord-like tissues with dorsal and ventral neuronal progenitors for spinal cord injury repair in rats and monkeys., Xu B, Liu D, Liu W, Long G, Liu W, Wu Y, He X, Shen Y, Jiang P, Yin M, Fan Y, Shen H, Shi L, Zhang Q, Xue W, Jin C, Chen Z, Chen B, Li J, Hu Y, Li X., Xiao Z., Zhao Y., Dai J., 2023
- Mimicked Spinal Cord Fibers Trigger Axonal Regeneration and Remyelination after Injury., Chen Z, Sun Z, Fan Y, Yin M, Jin C, Guo B, Yin Y, Quan R, Zhao S, Han S, Cheng X, Liu W, Chen B, Xiao Z, Dai J., Zhao Y., 2023
- Multifunctional Integrated Nanozymes Facilitate Spinal Cord Regeneration by Remodeling the Extrinsic Neural Environment., Xiong T, Yang K, Zhao T, Zhao H, Gao X, You Z, Fan C, Kang X, Yang W, Zhuang Y, Chen Y, Dai, J., 2023
- Spinal cord tissue engineering via covalent interaction between biomaterials and cells., Liu W, Xu B, Zhao S, Han S, Quan R, Liu W, Ji C, Chen B, Xiao Z, Yin M, Yin Y, Dai, J. Zhao Y., 2023
- The early and late intervention effects of collagen-binding FGF2 on elastase-induced lung injury., Wang X, Hou X, Zhao Y, Zhao R, Dai, J. Dai H, Wang C., 2023
- Baicalein-functionalized collagen scaffolds direct neuronal differentiation toward enhancing spinal cord injury repair., Qian L, Yang K, Liu X, Zhang L, Zhao H, Qiu LZ, Chu Y, Hao W, Zhuang Y, Chen Y, Dai, J., 2023
- Biomimetic Natural Biopolymer-Based Wet-Tissue Adhesive for Tough Adhesion, Seamless Sealed, Emergency/Nonpressing Hemostasis, and Promoted Wound Healing., Yang W, Kang X, Gao X, Zhuang Y, Fan C, Shen H, Chen Y, Dai, J., 2023
- Multifunctional hydrogel modulates the immune microenvironment to improve allogeneic spinal cord tissue survival for complete spinal cord injury repair., Gao X, You Z, Li Y, Kang X, Yang W, Wang H, Zhang T, Zhao X, Sun Y, Shen H, Dai, J., 2023
- Locally controlled release of immunosuppressive promotes survival of transplanted adult spinal cord tissue., Wang Z, Li Y, Sun C, Cui P, Han Y, Wu T, Xu B, Zhang C, Shi L, Dai, J., 2022
- Single-cell chromatin accessibility identifies enhancer networks driving gene expression during spinal cord development in mouse., Shu M, Hong D, Lin H, Zhang J, Luo Z, Du Y, Sun Z, Yin M, Yin Y, Liu L, Bao S, Liu Z, Lu F, Huang J, Dai, J., 2022
- Complexity of enhancer networks predicts cell identity and disease genes revealed by single-cell multi-omics analysis., Hong D, Lin H, Liu L, Dai J, Lu F, Tong M, Huang J., 2023
- Transplantation of neural stem progenitor cells from different sources for severe spinal cord injury repair in rat., Xu B, Yin M, Yang Y, Zou Y, Liu W, Qiao L, Zhang J, Wang Z, Wu Y, Shen H, Sun M, Liu W, Xue W, Fan Y, Zhang Q, Chen B, Wu X, Shi Y, Lu F, Zhao Y, Xiao Z, Dai, J., 2022
- A novel leptin receptor binding peptide tethered-collagen scaffold promotes lung injury repair., Zhuang Y, Yang W, Zhang L, Fan C, Qiu L, Zhao Y, Chen B, Chen Y, Shen H, Dai, J., 2022
- A functionalized collagen-I scaffold delivers microRNA 21-loaded exosomes for spinal cord injury repair., Liu X, Zhang L, Xu Z, Xiong X, Yu Y, Wu H, Qiao H, Zhong J, Zhao Z, Dai, J., Suo G., 2022
- Inflammatory Microenvironment-Responsive Nanomaterials Promote Spinal Cord Injury Repair by Targeting IRF5., Ma D, Shen H, Chen F, Liu W, Zhao Y, Xiao Z, Wu X, Chen B, Lu J, Shao D, Dai, J., 2022
- Spinal cord tissue engineering using human primary neural progenitor cells and astrocytes., Jin C, Wu Y, Zhang H, Xu B, Liu W, Ji C, Li P, Chen Z, Chen B, Li J, Wu X, Jiang p, Hu Y, Xiao Z, Zhao Y, Dai, J., 2022
- Potential mechanisms underlying the promoting effects of 3D collagen scaffold culture on stemness and drug resistance of glioma cells., Jia W, Zhu H, Zhao M, Zhou Q, Yin W, Liu W, Wang L, Xiao Z, Jiang X, Dai, J. Ren C., 2022
- Restoration of spinal cord biophysical microenvironment for enhancing tissue repair by injury-responsive smart hydrogel., Fan C, Yang W, Zhang L, Cai H, Zhuang Y, Chen Y, Zhao Y, Dai, J., 2022
- Metal-organic framework-based hydrogel with structurally dynamic properties as a stimuli-responsive localized drug delivery system for cancer therapy., Zeng Y, Zhang C, Du D, Li Y, Sun L, Han Y, He X, Dai, J. Shi L., 2022
- Long-term clinical observation of patients with acute and chronic complete spinal cord injury after transplantation of NeuroRegen scaffold., Tang F, Tang J, Zhao Y, Zhang J, Xiao Z, Chen B, Han G, Yin N, Jiang X, Zhao C, Cheng S, Wang Z, Chen Y, Chen Q, Song K, Zhang Z, Niu J, Wang L, Shi Q, Chen L, Yang H, Hou S, Zhang S, Dai, J., 2022
- Lineage tracing reveals the origin of Nestin-positive cells are heterogeneous and rarely from ependymal cells after spinal cord injury., Xue X, Shu M, Xiao Z, Zhao Y, Li X, Zhang H, Fan Y, Wu X, Chen B, Xu B, Yang Y, Liu W, Liu S, Dai, J., 2022
- Defective autophagy contributes to endometrial epithelial-mesenchymal transition in intrauterine adhesions., Zhou Z, Wang H, Zhang X, Song M, Yao S, Jiang P, Liu D, Wang Z, Lv H, Li R, Hong Y, Dai, J. Hu Y, Zhao G., 2022
- Flexible conductive silk-PPy hydrogel toward wearable electronic strain sensors., Han Y, Sun L, Wen C, Wang Z, Dai, J., Shi L., 2022
- Deciphering the endometrial niche of human thin endometrium at single-cell resolution., Lv H, Zhao G, Jiang P, Wang H, Wang Z, Yao S, Zhou Z, Wang L, Liu D, Deng W, Dai, J., Hu Y., 2022
- Transplantation of collagen sponge-based three-dimensional neural stem cells cultured in a RCCS facilitates locomotor functional recovery in spinal cord injury animals., Zou Y, Yin Y, Xiao Z, Zhao Y, Han J, Chen B, Xu B, Cui Y, Ma X, Dai, J., 2022
- Bioinspired bimodal micro-nanofibrous scaffolds promote the tenogenic differentiation of tendon stem/progenitor cells for achilles tendon regeneration., Yin Z, Sun L, Shi L, Nie H, Dai, J., Zhang C., 2022
- Optimized, visible light-induced crosslinkable hybrid gelatin/hyaluronic acid scaffold promotes complete spinal cord injury repair., Zhao X, Wang H, Zou Y, Xue W, Zhuang Y, Gu R, Shen H, Dai, J., 2022
- Adhesive, Stretchable, and Spatiotemporal Delivery Fibrous Hydrogels Harness Endogenous Neural Stem/Progenitor Cells for Spinal Cord Injury Repair., Chen Z, Zhang H, Fan C, Zhuang Y, Yang W, Chen Y, Shen H, Xiao Z, Zhao Y, Li X, Dai, J., 2022
- A DAMP-scavenging, IL-10-releasing hydrogel promotes neural regeneration and motor function recovery after spinal cord injury., Shen H, Xu B, Yang C, Xue W, You Z, Wu X, Ma D, Shao D, Leong K, Dai, J., 2022
Awards
- 2006: National Outstanding Youth Fund Recipient
- 2012: National Science and Technology Progress Award Second Prize for research on myocardial tissue repair and functional reconstruction after myocardial infarction
- 2014: CCTV Annual Science and Technology Innovation Figure
- 2016: Sixth China Overseas Chinese Regenerative Medicine Innovation Achievement Award
- 2017: Stem Cell Achievement Transformation Award by the Chinese Society for Cell Biology
- 2018: Jiangsu Province Science and Technology First Prize for endometrial regeneration research
