Professor | Li Xiaolong | Asia Growth Partners

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Name	Li Xiaolong
Contact Information	xiaolongli@ustc.edu.cn
Language ability	English, Chinese
Province	Anhui

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Name

Li Xiaolong

Contact Information

xiaolongli@ustc.edu.cn

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Life Sciences
Academic Background & Achievements	2011-2016: PhD from University of Science and Technology of China Joint training at Peking University (2012-2014) and Harvard Medical School (2014-2016) Published in journals like Science, Nature Chemical Biology, Nature Communications
Work Experience	2016-2021: Postdoctoral research at Dana-Farber 2021-present: Research Scientist at Ragon Institute of MGH, MIT and Harvard 2023-present: Associate Professor at University of Science and Technology of China
Awards	Ragon Fellowship Harvard Medical School Distinguished Biomedical Research Award

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Life Sciences

Academic Background & Achievements

2011-2016: PhD from University of Science and Technology of China
Joint training at Peking University (2012-2014) and Harvard Medical School (2014-2016)
Published in journals like Science, Nature Chemical Biology, Nature Communications

Work Experience

2016-2021: Postdoctoral research at Dana-Farber
2021-present: Research Scientist at Ragon Institute of MGH, MIT and Harvard
2023-present: Associate Professor at University of Science and Technology of China

Awards

Ragon Fellowship
Harvard Medical School Distinguished Biomedical Research Award

Areas of Focus	Molecular basis of MHC in T cell thymic development Molecular mechanisms of HIV control by T cell recognition Techniques for antigen presentation and T cell immune response T cell immunity in infectious diseases and tumors
Publications	Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide, Li X#, Singh NK, Ng R, Zhang A, Lamothe-Molina PA, Shahinian P, Xu S, Tan K, Piechocka-Trocha A, Weber JK, Collins G, Mbah OCT, Huynh T, Birnbaum M, Zhou R, Walker BD#, Wang JH#, 2023 Pre-T cell receptors topologically sample self-ligands during thymocyte β-selection, Li X, Mizsei R, Tan K, Mallis RJ, Duke-Cohan JS, Akitsu A, Tetteh PW, Dubey A, Hwang W, Wagner G, Lang MJ, Arthanari H, Wang JH, Reinherz EL, 2021 HLA class I Amino Acid Residues Associated with HIV Control Modulate Both TCR and KIR Recognition of HLA-peptide Complexes, Tano-Menka R, Singh NK, Muzhingi I, Li X, Mandanas MV, Kaseke C, Zhang A, Ogunshola F, Vecchiarello L, Piechocka-Trocha A, Birnbaum M, Carrington M, Walker BD, Gaiha GD, 2023 Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility, Tan K, Chen J, Kaku Y, Wang Y, Donius L Khan A.R., Li X, Richter H, Walz T. Seaman M.S. Hwang W, Reinherz E.L. Kim M, 2023 PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2, Jiang C, Liu J, He S, Xu W, Huang R, Pan W, Li X, Dai X, Guo J, Zhang T, Inuzuka H, Wang P, Asara JM, Xiao J, Wei W, 2023 Comprehensive Oncogenic Features of Coronavirus Receptors in Glioblastoma Multiforme, Chen A, Zhao W, Li X, Sun G, Ma Z, Peng L, Shi Z, Li X, Yan J, 2022 A Leucine Zipper Dimerization Strategy to Generate Soluble T Cell Receptors Using the Escherichia Coli Expression System, Zhang A, Piechocka-Trocha A, Li X#, Walker BD#, 2022 A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes, Mizsei R, Li X, Chen WN, Szabo M, Wagner G, Wang JH, Reinherz EL, Mallis RJ, 2021 The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction, Xu S, Liu Y, Li X, Liu Y, Meijers R, Zhang Y, Wang JH, 2018 Crystal structure of HLA-B5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation, Li X, Lamothe PA, Walker BD, Wang JH, 2017 Crystal structure of HLA-B5801, a protective HLA allele for HIV-1 infection, Li X, Lamothe PA, Ng R, Xu S, Teng M, Walker BD, Wang JH, 2016 Terazosin activates Pgk1 and Hsp90 to promote stress resistance, Chen X, Zhao C, Li X, Wang T, Li Y, Cao C, Ding Y, Dong M, Finci L, Wang JH, Li X, Liu L, 2015 Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime, Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ, 2015 Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβTCR Recognition during T Lineage Subset Commitment, Li X, Teng M, Reinherz EL, Wang JH, 2013 ΔSACE_0065，ΔSACE_2559 and ΔSACE_2565 genes mutation in Saccharopolyspora erythraea and their effect on spore differentiation, Li X, Sun J, Pan B, Zhu L, Huang X, Zhang B, 2011

Areas of Focus

Molecular basis of MHC in T cell thymic development
Molecular mechanisms of HIV control by T cell recognition
Techniques for antigen presentation and T cell immune response
T cell immunity in infectious diseases and tumors

Publications

Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide, Li X#, Singh NK, Ng R, Zhang A, Lamothe-Molina PA, Shahinian P, Xu S, Tan K, Piechocka-Trocha A, Weber JK, Collins G, Mbah OCT, Huynh T, Birnbaum M, Zhou R, Walker BD#, Wang JH#, 2023
Pre-T cell receptors topologically sample self-ligands during thymocyte β-selection, Li X*, Mizsei R*, Tan K, Mallis RJ, Duke-Cohan JS, Akitsu A, Tetteh PW, Dubey A, Hwang W, Wagner G, Lang MJ, Arthanari H, Wang JH, Reinherz EL, 2021
HLA class I Amino Acid Residues Associated with HIV Control Modulate Both TCR and KIR Recognition of HLA-peptide Complexes, Tano-Menka R*, Singh NK*, Muzhingi I*, Li X*, Mandanas MV, Kaseke C, Zhang A, Ogunshola F, Vecchiarello L, Piechocka-Trocha A, Birnbaum M, Carrington M, Walker BD, Gaiha GD, 2023
Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility, Tan K, Chen J, Kaku Y, Wang Y, Donius L Khan A.R., Li X, Richter H, Walz T. Seaman M.S. Hwang W, Reinherz E.L. Kim M, 2023
PRMT1 orchestrates with SAMTOR to govern mTORC1 methionine sensing via Arg-methylation of NPRL2, Jiang C, Liu J, He S, Xu W, Huang R, Pan W, Li X, Dai X, Guo J, Zhang T, Inuzuka H, Wang P, Asara JM, Xiao J, Wei W, 2023
Comprehensive Oncogenic Features of Coronavirus Receptors in Glioblastoma Multiforme, Chen A, Zhao W, Li X, Sun G, Ma Z, Peng L, Shi Z, Li X, Yan J, 2022
A Leucine Zipper Dimerization Strategy to Generate Soluble T Cell Receptors Using the Escherichia Coli Expression System, Zhang A, Piechocka-Trocha A, Li X#, Walker BD#, 2022
A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes, Mizsei R, Li X, Chen WN, Szabo M, Wagner G, Wang JH, Reinherz EL, Mallis RJ, 2021
The binding of DCC-P3 motif and FAK-FAT domain mediates the initial step of netrin-1/DCC signaling for axon attraction, Xu S, Liu Y, Li X, Liu Y, Meijers R, Zhang Y, Wang JH, 2018
Crystal structure of HLA-B*5801 with a TW10 HIV Gag epitope reveals a novel mode of peptide presentation, Li X, Lamothe PA, Walker BD, Wang JH, 2017
Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection, Li X, Lamothe PA, Ng R, Xu S, Teng M, Walker BD, Wang JH, 2016
Terazosin activates Pgk1 and Hsp90 to promote stress resistance, Chen X*, Zhao C*, Li X*, Wang T*, Li Y, Cao C, Ding Y, Dong M, Finci L, Wang JH, Li X, Liu L, 2015
Force-dependent transition in the T-cell receptor β-subunit allosterically regulates peptide discrimination and pMHC bond lifetime, Das DK, Feng Y, Mallis RJ, Li X, Keskin DB, Hussey RE, Brady SK, Wang JH, Wagner G, Reinherz EL, Lang MJ, 2015
Strict Major Histocompatibility Complex Molecule Class-Specific Binding by Co-Receptors Enforces MHC-Restricted αβTCR Recognition during T Lineage Subset Commitment, Li X, Teng M, Reinherz EL, Wang JH, 2013
ΔSACE_0065，ΔSACE_2559 and ΔSACE_2565 genes mutation in Saccharopolyspora erythraea and their effect on spore differentiation, Li X, Sun J, Pan B, Zhu L, Huang X, Zhang B, 2011

Mhc T Cell Thymic Development Hiv Antigen Presentation Immune Response Infectious Diseases Tumors Molecular Mechanisms Vaccine Development

Wei Liang - University of Chinese Academy of Sciences

Wei Liang - University of Chinese Academy of Sciences

Zu Liang Jie - Xiamen University

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