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Ruan Ke
Life Science
University of Science and Technology of China
Anhui
Language: English, Chinese
Drug Discovery
Protein Modification
Nmr Spectroscopy
Ligand Recognition
Molecular Mechanism
Covid-19
Clinical Research
Protein Dynamics
Fragment-Based Screening
Lead Compound
Areas of Focus
- Drug discovery and development
- Protein-ligand interactions
- NMR spectroscopy applications
Academic Background & Achievements
- Bachelor's and Master's Degree: Peking University, College of Chemistry and Molecular Engineering
- Ph.D.: Johns Hopkins University
Publications
- Fluorine Pseudocontact Shifts Used for Characterizing the Protein-Ligand Interaction Mode in the limit of NMR Intermediate Exchange, Gao J, Liang E, Ma R, Li F, Liu Y, Liu J, Jiang L, Li C, Dai H, Wu J, Su X, He W, Ruan K, 2017
- Repurposing low–molecular-weight drugs against the main protease of severe acute respiratory syndrome coronavirus 2, Gao J, Zhang L, Liu X, Li F, Ma R, Zhu Z, Zhang J, Wu J, Shi Y, Pan Y, Ge Y, Ruan K, 2020
- Conformational Selection in Ligand Recognition by the First Tudor Domain of PHF20L1, Lv M, Gao J, Li M, Ma R, Li F, Liu Y, Liu M, Zhang J, Yao X, Wu J, Shi Y, Tang Y, Pan Y, Zhang Z, Ruan K, 2020
- Ligand Proton Pseudocontact Shifts Determined from Paramagnetic Relaxation Dispersion in the Limit of NMR Intermediate Exchange, Xu D, Li B, Gao J, Liu Z, Niu X, Nshogoza G, Zhang J, Wu J, Su XC, He W, Ma R, Yang D, Ruan K, 2018
- Dynamic Nature of CTCF Tandem 11 Zinc Fingers in Multivalent Recognition of DNA As Revealed by NMR Spectroscopy, Xu D, Ma R, Zhang J, Liu Z, Wu B, Peng J, Zhai Y, Gong Q, Shi Y, Wu J, Wu Q, Zhang Z, Ruan K, 2018
