Professor | Qian Hongwu | Asia Growth Partners

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Name	Qian Hongwu
Contact Information	hongwuqian@ustc.edu.cn
Language ability	Chinese, English
Province	Anhui

Upload Avatar (500 x 500)

Name

Qian Hongwu

Contact Information

hongwuqian@ustc.edu.cn

Language ability

Chinese, English

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Life Sciences
Academic Background & Achievements	2009.09-2013.06 Bachelor: Huazhong University of Science and Technology 2013.09-2018.01 PhD in Science: Tsinghua University Published several important research papers in top journals like Nature, Science, and Cell
Work Experience	2018.04-2021.04 Postdoctoral Researcher: Princeton University, Department of Molecular Biology 2021.05-present Specially Appointed Professor, Doctoral Supervisor: University of Science and Technology of China, School of Life Sciences and Medicine
Awards	2021: Anhui Province Overseas Innovation Talent Program 2022: National Overseas High-Level Talent Youth Program

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Life Sciences

Academic Background & Achievements

2009.09-2013.06 Bachelor: Huazhong University of Science and Technology
2013.09-2018.01 PhD in Science: Tsinghua University
Published several important research papers in top journals like Nature, Science, and Cell

Work Experience

2018.04-2021.04 Postdoctoral Researcher: Princeton University, Department of Molecular Biology
2021.05-present Specially Appointed Professor, Doctoral Supervisor: University of Science and Technology of China, School of Life Sciences and Medicine

Awards

2021: Anhui Province Overseas Innovation Talent Program
2022: National Overseas High-Level Talent Youth Program

Areas of Focus	Research on the structure and function of important membrane proteins in biological processes such as lipid metabolism, regulation, and transport using structural biology, biochemistry, and biophysics Study of endoplasmic reticulum protein folding and homeostasis maintenance mechanisms using structural biology, biochemistry, cell biology, and bioinformatics
Publications	Structural basis for the transport and substrate selection of human urate transporter 1, He J, Liu G, Kong F, Tan Q, Wang Z, Yang M, He Y, Jia X, Yan C, Wang C, Qian H., 2024 Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection, Gong M, Peng C, Yang C, Wang Z, Qian H, Hu X, Zhou P, Shan C, Ding Q., 2024 Structural basis for catalysis of human choline/ethanolamine phosphotransferase 1, Wang Z, Yang M, Yang Y, He Y, Qian H., 2023 Structural advances in sterol-sensing domain-containing proteins, Wu X, Yan R, Cao P, Qian H#, Yan N#., 2022 Structural basis for sterol sensing by Scap and Insig, Yan R, Cao P, Song W, Li Y, Wang T, Qian H, Yan C, Yan N., 2021 A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols, Yan R, Cao P, Song W, Qian H, Du X, Coates HW, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown AJ, Zhou Q, Yan C, Yan N., 2021 Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2, Qian H, Wu X, Du X, Yao X, Zhao X, Lee J, Yang H, Yan N., 2020 Structural basis for catalysis and substrate specificity of human ACAT1, Qian H#, Zhao X, Yan R, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N#., 2020 Structure and mechanism of human diacylglycerol O-acyltransferase 1, Wang L, Qian H, Nian Y, Han Y, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, Zhou M., 2020 Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm, Qian H, Cao P, Hu M, Gao S, Yan N, Gong X., 2019 Purification and Characterization of Human Niemann-Pick C1 Protein, Gong X, Qian H., 2019 Human SEIPIN Binds Anionic Phospholipids, Yan R, Qian H#, Lukmantara I, Gao M, Du X, Yan N#, Yang H#., 2018 Structural basis for the recognition of Sonic Hedgehog by human Patched1, Gong X, Qian H, Cao P, Zhao X, Zhou Q, Lei J, Yan N., 2018 Structure of the Human Lipid Exporter ABCA1, Qian H, Zhao X, Cao P, Lei J, Yan N, Gong X., 2017 Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization, Gong X, Qian H, Shao W, Li J, Wu J, Liu JJ, Li W, Wang HW, Espenshade P, Yan N., 2016 Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection, Gong X, Qian H, Zhou X, Wu J, Wan T, Cao P, Huang W, Zhao X, Wang X, Wang P, Shi Y, Gao GF, Zhou Q, Yan N., 2016 Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition, Gong X, Li J, Shao W, Wu J, Qian H, Ren R, Espenshade P, Yan N., 2015

Areas of Focus

Research on the structure and function of important membrane proteins in biological processes such as lipid metabolism, regulation, and transport using structural biology, biochemistry, and biophysics
Study of endoplasmic reticulum protein folding and homeostasis maintenance mechanisms using structural biology, biochemistry, cell biology, and bioinformatics

Publications

Structural basis for the transport and substrate selection of human urate transporter 1, He J*, Liu G*, Kong F*, Tan Q, Wang Z, Yang M, He Y, Jia X, Yan C, Wang C, Qian H., 2024
Genome-wide CRISPR/Cas9 screen identifies SLC39A9 and PIK3C3 as crucial entry factors for Ebola virus infection, Gong M, Peng C, Yang C, Wang Z, Qian H, Hu X, Zhou P, Shan C, Ding Q., 2024
Structural basis for catalysis of human choline/ethanolamine phosphotransferase 1, Wang Z, Yang M, Yang Y, He Y, Qian H., 2023
Structural advances in sterol-sensing domain-containing proteins, Wu X, Yan R, Cao P, Qian H#, Yan N#., 2022
Structural basis for sterol sensing by Scap and Insig, Yan R, Cao P, Song W, Li Y, Wang T, Qian H, Yan C, Yan N., 2021
A structure of human Scap bound to Insig-2 suggests how their interaction is regulated by sterols, Yan R, Cao P, Song W, Qian H, Du X, Coates HW, Zhao X, Li Y, Gao S, Gong X, Liu X, Sui J, Lei J, Yang H, Brown AJ, Zhou Q, Yan C, Yan N., 2021
Structural Basis of Low-pH-Dependent Lysosomal Cholesterol Egress by NPC1 and NPC2, Qian H*, Wu X*, Du X*, Yao X, Zhao X, Lee J, Yang H, Yan N., 2020
Structural basis for catalysis and substrate specificity of human ACAT1, Qian H*#, Zhao X*, Yan R*, Yao X, Gao S, Sun X, Du X, Yang H, Wong CCL, Yan N#., 2020
Structure and mechanism of human diacylglycerol O-acyltransferase 1, Wang L*, Qian H*, Nian Y*, Han Y*, Ren Z, Zhang H, Hu L, Prasad BVV, Laganowsky A, Yan N, Zhou M., 2020
Inhibition of tetrameric Patched1 by Sonic Hedgehog through an asymmetric paradigm, Qian H*, Cao P*, Hu M, Gao S, Yan N, Gong X., 2019
Purification and Characterization of Human Niemann-Pick C1 Protein, Gong X, Qian H., 2019
Human SEIPIN Binds Anionic Phospholipids, Yan R*, Qian H*#, Lukmantara I, Gao M, Du X, Yan N#, Yang H#., 2018
Structural basis for the recognition of Sonic Hedgehog by human Patched1, Gong X*, Qian H*, Cao P*, Zhao X, Zhou Q, Lei J, Yan N., 2018
Structure of the Human Lipid Exporter ABCA1, Qian H*, Zhao X, Cao P, Lei J, Yan N, Gong X*., 2017
Complex structure of the fission yeast SREBP-SCAP binding domains reveals an oligomeric organization, Gong X*, Qian H*, Shao W*, Li J, Wu J, Liu JJ, Li W, Wang HW, Espenshade P, Yan N., 2016
Structural Insights into the Niemann-Pick C1 (NPC1)-Mediated Cholesterol Transfer and Ebola Infection, Gong X*, Qian H*, Zhou X*, Wu J*, Wan T*, Cao P, Huang W, Zhao X, Wang X, Wang P, Shi Y, Gao GF, Zhou Q, Yan N., 2016
Structure of the WD40 domain of SCAP from fission yeast reveals the molecular basis for SREBP recognition, Gong X, Li J, Shao W, Wu J, Qian H, Ren R, Espenshade P, Yan N., 2015

Membrane Proteins Lipid Metabolism Structural Biology Biochemistry Biophysics Protein Folding Endoplasmic Reticulum Homeostasis Bioinformatics Cell Biology

Shaojun Dai - Shanghai Normal University

Fang Yu - Shanghai Normal University

Yonglan Cui - Shanghai Normal University

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