Professor | Xiaofeng Zhang | Asia Growth Partners

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Name	Xiaofeng Zhang
Contact Information	xiaofengzhang@ustc.edu.cn
Language ability	Chinese, English
Province	Anhui

Upload Avatar (500 x 500)

Name

Xiaofeng Zhang

Contact Information

xiaofengzhang@ustc.edu.cn

Language ability

Chinese, English

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Life Sciences
Academic Background & Achievements	2015 - Bachelor's Degree: Huazhong University of Science and Technology 2019 - Doctorate: Tsinghua University
Work Experience	2019-2022 - Westlake University - Postdoctoral Researcher, Assistant Researcher 2022-Present - University of Science and Technology of China - Special Researcher, Doctoral Supervisor

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Life Sciences

Academic Background & Achievements

2015 - Bachelor's Degree: Huazhong University of Science and Technology
2019 - Doctorate: Tsinghua University

Work Experience

2019-2022 - Westlake University - Postdoctoral Researcher, Assistant Researcher
2022-Present - University of Science and Technology of China - Special Researcher, Doctoral Supervisor

Areas of Focus	Molecular mechanisms of RNA processing, transport, and function Structure and function of other important intracellular macromolecular machines
Publications	An Atomic Structure of the Human Spliceosome, Xiaofeng Zhang, Chuangye Yan, Jing Hang, Lorenzo Finci, Jianlin Lei and Yigong Shi, 2017 Structure of a Human Catalytic Step I Spliceosome, Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Jianlin Lei and Yigong Shi, 2018 Structure of the Human Activated Spliceosome in Three Conformational States, Xiaofeng Zhang, Chuangye Yan, Xiechao Zhan, Lijia Li, Jianlin Lei and Yigong Shi, 2018 Structures of the human spliceosomes before and after release of the ligated exon, Xiaofeng Zhang, Chuangye Yan, Xiechao Zhan, Wenyu Zhang, Dongliang Liu, Jianlin Lei and Yigong Shi, 2019 TFPI is an intestinal glandular receptor for C. difficile toxin B from the hypervirulent clade 2 lineages, Jianhua Luo, Qi Yang, Xiaofeng Zhang, Yuanyuan Zhang, Li Wan, Xiechao Zhan, Yao Zhou, Liuqing He, Dnayang Li, Dazhi Jin, Ying Zhen, Jing Huang, Min Dong, Yanyan Li, and Liang Tao, 2022 Structural Basis of Pre-tRNA Intron Removal by Human tRNA Splicing Endonuclease, Xiaofeng Zhang, Fenghua Yang, Xiechao Zhan, Tong Bian, Zhihan Xing, Yichen Lu and Yigong Shi, 2023 Structural Insights into Branch Site Proofreading by Human Spliceosome, Xiaofeng Zhang, Xiechao Zhan, Tong Bian, Fenghua Yang, Pan Li, Yichen Lu, Zhihan Xing, Rongyan Fan, Qiangfeng Zhang, Yigong Shi, 2023 Structures of the human pre-catalytic spliceosome and its precursor spliceosome, Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Wenyu Zhang, Jianlin Lei and Yigong Shi, 2018 The Cryo-EM Structure of the SF3b Spliceosome Complex Bound to a Splicing Modulator Reveals a Pre-mRNA Substrate Competitive Mechanism of Action, Lorenzo Finci, Xiaofeng Zhang, Xiuliang Huang, Qiang Zhou, Jennifer Tsai, Teng Teng, Betty Chan, Sean Irwin, Craig Karr, Andrew Cook, Silvia Buonamici, and Nicholas A. Larsen, 2018 Mechanism of exon ligation by human spliceosome, Xiechao Zhan, Yicheng Lu, Xiaofeng Zhang, Chuanye Yan and Yigong Shi, 2022 Structure of the yeast Swi/Snf complex in a nucleosome-free state, Chengcheng Wang, Zhouyan Guo, Xiechao Zhan, Fenghua Yang and Xiaofeng Zhang, 2020 Mechanisms of the RNA Helicases DDX42 and DDX46 in Human U2 snRNP Assembly, Fenghua Yang, Tong Bian, Xiechao Zhan, Zhe Chen, Zhihan Xing, Nicolas A. Larsen, Xiaofeng Zhang, and Yigong Shi, 2023

Areas of Focus

Molecular mechanisms of RNA processing, transport, and function
Structure and function of other important intracellular macromolecular machines

Publications

An Atomic Structure of the Human Spliceosome, Xiaofeng Zhang, Chuangye Yan, Jing Hang, Lorenzo Finci, Jianlin Lei and Yigong Shi, 2017
Structure of a Human Catalytic Step I Spliceosome, Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Jianlin Lei and Yigong Shi, 2018
Structure of the Human Activated Spliceosome in Three Conformational States, Xiaofeng Zhang, Chuangye Yan, Xiechao Zhan, Lijia Li, Jianlin Lei and Yigong Shi, 2018
Structures of the human spliceosomes before and after release of the ligated exon, Xiaofeng Zhang, Chuangye Yan, Xiechao Zhan, Wenyu Zhang, Dongliang Liu, Jianlin Lei and Yigong Shi, 2019
TFPI is an intestinal glandular receptor for C. difficile toxin B from the hypervirulent clade 2 lineages, Jianhua Luo, Qi Yang, Xiaofeng Zhang, Yuanyuan Zhang, Li Wan, Xiechao Zhan, Yao Zhou, Liuqing He, Dnayang Li, Dazhi Jin, Ying Zhen, Jing Huang, Min Dong, Yanyan Li, and Liang Tao, 2022
Structural Basis of Pre-tRNA Intron Removal by Human tRNA Splicing Endonuclease, Xiaofeng Zhang, Fenghua Yang, Xiechao Zhan, Tong Bian, Zhihan Xing, Yichen Lu and Yigong Shi, 2023
Structural Insights into Branch Site Proofreading by Human Spliceosome, Xiaofeng Zhang, Xiechao Zhan, Tong Bian, Fenghua Yang, Pan Li, Yichen Lu, Zhihan Xing, Rongyan Fan, Qiangfeng Zhang, Yigong Shi, 2023
Structures of the human pre-catalytic spliceosome and its precursor spliceosome, Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Wenyu Zhang, Jianlin Lei and Yigong Shi, 2018
The Cryo-EM Structure of the SF3b Spliceosome Complex Bound to a Splicing Modulator Reveals a Pre-mRNA Substrate Competitive Mechanism of Action, Lorenzo Finci, Xiaofeng Zhang, Xiuliang Huang, Qiang Zhou, Jennifer Tsai, Teng Teng, Betty Chan, Sean Irwin, Craig Karr, Andrew Cook, Silvia Buonamici, and Nicholas A. Larsen, 2018
Mechanism of exon ligation by human spliceosome, Xiechao Zhan, Yicheng Lu, Xiaofeng Zhang, Chuanye Yan and Yigong Shi, 2022
Structure of the yeast Swi/Snf complex in a nucleosome-free state, Chengcheng Wang, Zhouyan Guo, Xiechao Zhan, Fenghua Yang and Xiaofeng Zhang, 2020
Mechanisms of the RNA Helicases DDX42 and DDX46 in Human U2 snRNP Assembly, Fenghua Yang, Tong Bian, Xiechao Zhan, Zhe Chen, Zhihan Xing, Nicolas A. Larsen, Xiaofeng Zhang, and Yigong Shi, 2023

Rna Processing Rna Transport Rna Function Molecular Mechanisms Macromolecular Machines Intracellular Structure Function Biochemistry Structural Biology

Shui Wang - Shanghai Normal University

Fang Yu - Shanghai Normal University

Jiaohong Zhao - Shanghai Normal University

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