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Xiaofeng Zhang
Life Science
University of Science and Technology of China
Anhui
Language: Chinese, English
Rna Processing
Rna Transport
Rna Function
Molecular Mechanisms
Macromolecular Machines
Intracellular
Structure
Function
Biochemistry
Structural Biology
Areas of Focus
- Molecular mechanisms of RNA processing, transport, and function
- Structure and function of other important intracellular macromolecular machines
Work Experience
- 2019-2022 - Westlake University - Postdoctoral Researcher, Assistant Researcher
- 2022-Present - University of Science and Technology of China - Special Researcher, Doctoral Supervisor
Academic Background & Achievements
- 2015 - Bachelor's Degree: Huazhong University of Science and Technology
- 2019 - Doctorate: Tsinghua University
Publications
- An Atomic Structure of the Human Spliceosome, Xiaofeng Zhang, Chuangye Yan, Jing Hang, Lorenzo Finci, Jianlin Lei and Yigong Shi, 2017
- Structure of a Human Catalytic Step I Spliceosome, Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Jianlin Lei and Yigong Shi, 2018
- Structure of the Human Activated Spliceosome in Three Conformational States, Xiaofeng Zhang, Chuangye Yan, Xiechao Zhan, Lijia Li, Jianlin Lei and Yigong Shi, 2018
- Structures of the human spliceosomes before and after release of the ligated exon, Xiaofeng Zhang, Chuangye Yan, Xiechao Zhan, Wenyu Zhang, Dongliang Liu, Jianlin Lei and Yigong Shi, 2019
- TFPI is an intestinal glandular receptor for C. difficile toxin B from the hypervirulent clade 2 lineages, Jianhua Luo, Qi Yang, Xiaofeng Zhang, Yuanyuan Zhang, Li Wan, Xiechao Zhan, Yao Zhou, Liuqing He, Dnayang Li, Dazhi Jin, Ying Zhen, Jing Huang, Min Dong, Yanyan Li, and Liang Tao, 2022
- Structural Basis of Pre-tRNA Intron Removal by Human tRNA Splicing Endonuclease, Xiaofeng Zhang, Fenghua Yang, Xiechao Zhan, Tong Bian, Zhihan Xing, Yichen Lu and Yigong Shi, 2023
- Structural Insights into Branch Site Proofreading by Human Spliceosome, Xiaofeng Zhang, Xiechao Zhan, Tong Bian, Fenghua Yang, Pan Li, Yichen Lu, Zhihan Xing, Rongyan Fan, Qiangfeng Zhang, Yigong Shi, 2023
- Structures of the human pre-catalytic spliceosome and its precursor spliceosome, Xiechao Zhan, Chuangye Yan, Xiaofeng Zhang, Wenyu Zhang, Jianlin Lei and Yigong Shi, 2018
- The Cryo-EM Structure of the SF3b Spliceosome Complex Bound to a Splicing Modulator Reveals a Pre-mRNA Substrate Competitive Mechanism of Action, Lorenzo Finci, Xiaofeng Zhang, Xiuliang Huang, Qiang Zhou, Jennifer Tsai, Teng Teng, Betty Chan, Sean Irwin, Craig Karr, Andrew Cook, Silvia Buonamici, and Nicholas A. Larsen, 2018
- Mechanism of exon ligation by human spliceosome, Xiechao Zhan, Yicheng Lu, Xiaofeng Zhang, Chuanye Yan and Yigong Shi, 2022
- Structure of the yeast Swi/Snf complex in a nucleosome-free state, Chengcheng Wang, Zhouyan Guo, Xiechao Zhan, Fenghua Yang and Xiaofeng Zhang, 2020
- Mechanisms of the RNA Helicases DDX42 and DDX46 in Human U2 snRNP Assembly, Fenghua Yang, Tong Bian, Xiechao Zhan, Zhe Chen, Zhihan Xing, Nicolas A. Larsen, Xiaofeng Zhang, and Yigong Shi, 2023
