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Huang De
Basic Medical Sciences
University of Science and Technology of China
Anhui
Language: Chinese, English
Metabolites
Tumor Immunity
Regulation
Mechanism
Neuroinvasion
Tumor Development
Anti-Tumor Drugs
Screening
Exploration
Therapy
Areas of Focus
- Exploring the role and mechanism of specific metabolites in regulating tumor immunity
- Research on the regulatory mechanism of tumor neuroinvasion on tumor development
- Screening and exploration of new anti-tumor drugs
Work Experience
- 2017-2022 - Duke University Medical Center - Postdoctoral Research
- 2022-Present - University of Science and Technology of China - Life Sciences and Medicine Department
Academic Background & Achievements
- 2016 - PhD: University of Science and Technology of China
- Recipient of the National High-level Overseas Young Talent Program
- Selected for the Chinese Academy of Sciences Pioneer Talent Program
Publications
- Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response., L Tan, T Yin, H Xiang, L Wang, P Mudgal, J Chen, Y Ding, G Wang, BW Lim, Y Huang, D Huang, Y Liang, PB. Alexander, KX, E Wang, C Yan, Z Ma, M Tan, QJ Li & XF Wang, 2024
- Breaking NGF-TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection., T Yin, G Wang, L Wang, P Mudgal, E Wang, C Pan, P Alexander, H Wu, C Cao, Y Liang, L Tan, D Huang, M Chong, R Chen, W Lim, K Xiang, W Xue, L Wan, H Hu, YH Loh, XF Wang and, QJ Li, 2024
- Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype., Y Liang, C Pan, T Yin, L Wang, X Gao, E Wang, H Quang, D Huang, L Tan, K Xiang, Y Wang, PB Alexander, QJ Li, TP Yao, Z Zhang, and, XF Wang, 2024
- Therapy-induced senescent tumor cells in cancer relapse., KX Song, JX Wang, De Huang, 2023
- Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing., C Pan, R Maeso-Díaz, TR Lewis, K Xiang, L Tan, Y Liang, L Wang, F Yang, T Yin, C Wang, K Du, D Huang, SH Oh, E Wang, BJW Lim, M Chong, PB Alexander, X Yao, VY Arshavsky, QJ Li, AM Diehl, and XF Wang, 2023
- Parkin coordinates mitochondrial lipid remodeling to execute mitophagy., CC Lin, J Yan, MD Kapur, KL Norris, CW Hsieh, D Huang, N Vitale, KL Lim, Z Guan, XF Wang, JT Chi, WY Yang, TP Yao, 2022
- GABAergic signaling beyond synapses: an emerging target for cancer therapy., D Huang, PB Alexander, QJ Li, and XF Wang, 2022
- Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression., D Huang, Y Wang, JW Thompson, T Yin, PB Alexander, D Qin, P Mudgal, H Wu, Y Liang, L Tan, C Pan, L Yuan, Y Wan, QJ Li, and XF Wang, 2022
- Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis., S Li, D Huang, S Shen, Y Cai, S Xing, G Wu, Z Jiang, Y Hao, M Yuan, N Wang, L Zhu, R Yan, D Yang, L Wang, Z Liu, X Hu, R Zhou, K Qu, A Li, X Duan, H Zhang, and P Gao, 2020
- Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1., Y Zhang, C Li, C Hu, Q Wu, Y Cai, S Xing, H Lu, L Wang, D Huang, L Sun, T Li, X He, X Zhong, J Wang, P Gao, Z J Smith, W Jia, and H Zhang, 2019
- Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death., L Yuan, L Zhai, L Qian, D Huang, Y Ding, H Xiang, X Liu, J. W Thompson, J Liu, YH He, XQ Chen, J Hu, QP Kong, M Tan, and XF Wang, 2018
- Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers., Y Ding, C Gong, D Huang, R Chen, P Sui, KH. Lin, G Liang, L Yuan, H Xiang, J Chen, T Yin, PB. Alexander, QF Wang, EW Song, QJ Li, KC. Wood, and XF Wang, 2018
- Menin enhances c-Myc-mediated transcription to promote cancer progression., G Wu, M Yuan, S Shen, X Ma, J Fang, L Zhu, L Sun, Z Liu, X He, D Huang, T Li, C Li, J Wu, X Hu, Z Li, L Song, K Qu, H Zhang, and P Gao, 2017
- Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway., X Ma, L Wang, D Huang, Y Li, D Yang, T Li, F Li, L Sun, H Wei, K He, F Yu, D Zhao, L Hu, S Xing, Z Liu, K Li, J Guo, Z Yang, X Pan, A Li, Y Shi, J Wang, P Gao, and H Zhang, 2017
- Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress., D Huang, T Li, L Wang, L Zhang, R Yan, K Li, S Xing, G Wu, L Hu, W Jia, S Lin, C. V. Dang, L Song, P Gao, and H Zhang, 2016
- miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency., Y Cao, W Guo, S Tian, X He, X Wang, X Liu, K Gu, X Ma, D Huang, L Hu, Y Cai, H Zhang, Y Wang, and P Gao, 2015
- Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1., X Ma, C Li, L Sun, D Huang, T Li, X He, G Wu, Z Yang, X Zhong, L Song, P Gao, and H Zhang, 2014
- HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression., D Huang, T Li, X Li, L Zhang, L Sun, X He, X Zhong, D Jia, L Song, G. L. Semenza, P Gao, and H Zhang, 2014
- Hypoxia and cancer cell metabolism., D Huang, C Li, and H Zhang, 2014
Awards
- Chinese Academy of Sciences President's Excellence Award
- Duke University Robert J. Fitzgerald Scholar Award
