Professor | Huang De | Asia Growth Partners

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Name	Huang De
Contact Information	huangde@ustc.edu.cn
Language ability	Chinese, English
Province	Anhui

Upload Avatar (500 x 500)

Name

Huang De

Contact Information

huangde@ustc.edu.cn

Language ability

Chinese, English

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Basic Medical Sciences
Academic Background & Achievements	2016 - PhD: University of Science and Technology of China Recipient of the National High-level Overseas Young Talent Program Selected for the Chinese Academy of Sciences Pioneer Talent Program
Work Experience	2017-2022 - Duke University Medical Center - Postdoctoral Research 2022-Present - University of Science and Technology of China - Life Sciences and Medicine Department
Awards	Chinese Academy of Sciences President's Excellence Award Duke University Robert J. Fitzgerald Scholar Award

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Basic Medical Sciences

Academic Background & Achievements

2016 - PhD: University of Science and Technology of China
Recipient of the National High-level Overseas Young Talent Program
Selected for the Chinese Academy of Sciences Pioneer Talent Program

Work Experience

2017-2022 - Duke University Medical Center - Postdoctoral Research
2022-Present - University of Science and Technology of China - Life Sciences and Medicine Department

Awards

Chinese Academy of Sciences President's Excellence Award
Duke University Robert J. Fitzgerald Scholar Award

Areas of Focus	Exploring the role and mechanism of specific metabolites in regulating tumor immunity Research on the regulatory mechanism of tumor neuroinvasion on tumor development Screening and exploration of new anti-tumor drugs
Publications	Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response., L Tan, T Yin, H Xiang, L Wang, P Mudgal, J Chen, Y Ding, G Wang, BW Lim, Y Huang, D Huang, Y Liang, PB. Alexander, KX, E Wang, C Yan, Z Ma, M Tan, QJ Li & XF Wang, 2024 Breaking NGF-TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection., T Yin, G Wang, L Wang, P Mudgal, E Wang, C Pan, P Alexander, H Wu, C Cao, Y Liang, L Tan, D Huang, M Chong, R Chen, W Lim, K Xiang, W Xue, L Wan, H Hu, YH Loh, XF Wang and, QJ Li, 2024 Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype., Y Liang, C Pan, T Yin, L Wang, X Gao, E Wang, H Quang, D Huang, L Tan, K Xiang, Y Wang, PB Alexander, QJ Li, TP Yao, Z Zhang, and, XF Wang, 2024 Therapy-induced senescent tumor cells in cancer relapse., KX Song, JX Wang, De Huang, 2023 Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing., C Pan, R Maeso-Díaz, TR Lewis, K Xiang, L Tan, Y Liang, L Wang, F Yang, T Yin, C Wang, K Du, D Huang, SH Oh, E Wang, BJW Lim, M Chong, PB Alexander, X Yao, VY Arshavsky, QJ Li, AM Diehl, and XF Wang, 2023 Parkin coordinates mitochondrial lipid remodeling to execute mitophagy., CC Lin, J Yan, MD Kapur, KL Norris, CW Hsieh, D Huang, N Vitale, KL Lim, Z Guan, XF Wang, JT Chi, WY Yang, TP Yao, 2022 GABAergic signaling beyond synapses: an emerging target for cancer therapy., D Huang, PB Alexander, QJ Li, and XF Wang, 2022 Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression., D Huang, Y Wang, JW Thompson, T Yin, PB Alexander, D Qin, P Mudgal, H Wu, Y Liang, L Tan, C Pan, L Yuan, Y Wan, QJ Li, and XF Wang, 2022 Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis., S Li, D Huang, S Shen, Y Cai, S Xing, G Wu, Z Jiang, Y Hao, M Yuan, N Wang, L Zhu, R Yan, D Yang, L Wang, Z Liu, X Hu, R Zhou, K Qu, A Li, X Duan, H Zhang, and P Gao, 2020 Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1., Y Zhang, C Li, C Hu, Q Wu, Y Cai, S Xing, H Lu, L Wang, D Huang, L Sun, T Li, X He, X Zhong, J Wang, P Gao, Z J Smith, W Jia, and H Zhang, 2019 Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death., L Yuan, L Zhai, L Qian, D Huang, Y Ding, H Xiang, X Liu, J. W Thompson, J Liu, YH He, XQ Chen, J Hu, QP Kong, M Tan, and XF Wang, 2018 Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers., Y Ding, C Gong, D Huang, R Chen, P Sui, KH. Lin, G Liang, L Yuan, H Xiang, J Chen, T Yin, PB. Alexander, QF Wang, EW Song, QJ Li, KC. Wood, and XF Wang, 2018 Menin enhances c-Myc-mediated transcription to promote cancer progression., G Wu, M Yuan, S Shen, X Ma, J Fang, L Zhu, L Sun, Z Liu, X He, D Huang, T Li, C Li, J Wu, X Hu, Z Li, L Song, K Qu, H Zhang, and P Gao, 2017 Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway., X Ma, L Wang, D Huang, Y Li, D Yang, T Li, F Li, L Sun, H Wei, K He, F Yu, D Zhao, L Hu, S Xing, Z Liu, K Li, J Guo, Z Yang, X Pan, A Li, Y Shi, J Wang, P Gao, and H Zhang, 2017 Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress., D Huang, T Li, L Wang, L Zhang, R Yan, K Li, S Xing, G Wu, L Hu, W Jia, S Lin, C. V. Dang, L Song, P Gao, and H Zhang, 2016 miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency., Y Cao, W Guo, S Tian, X He, X Wang, X Liu, K Gu, X Ma, D Huang, L Hu, Y Cai, H Zhang, Y Wang, and P Gao, 2015 Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1., X Ma, C Li, L Sun, D Huang, T Li, X He, G Wu, Z Yang, X Zhong, L Song, P Gao, and H Zhang, 2014 HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression., D Huang, T Li, X Li, L Zhang, L Sun, X He, X Zhong, D Jia, L Song, G. L. Semenza, P Gao, and H Zhang, 2014 Hypoxia and cancer cell metabolism., D Huang, C Li, and H Zhang, 2014

Areas of Focus

Exploring the role and mechanism of specific metabolites in regulating tumor immunity
Research on the regulatory mechanism of tumor neuroinvasion on tumor development
Screening and exploration of new anti-tumor drugs

Publications

Aberrant cytoplasmic expression of UHRF1 restrains the MHC-I-mediated anti-tumor immune response., L Tan, T Yin, H Xiang, L Wang, P Mudgal, J Chen, Y Ding, G Wang, BW Lim, Y Huang, D Huang, Y Liang, PB. Alexander, KX, E Wang, C Yan, Z Ma, M Tan, QJ Li & XF Wang, 2024
Breaking NGF-TrkA immunosuppression in melanoma sensitizes immunotherapy for durable memory T cell protection., T Yin, G Wang, L Wang, P Mudgal, E Wang, C Pan, P Alexander, H Wu, C Cao, Y Liang, L Tan, D Huang, M Chong, R Chen, W Lim, K Xiang, W Xue, L Wan, H Hu, YH Loh, XF Wang and, QJ Li, 2024
Branched-Chain Amino Acid Accumulation Fuels the Senescence-Associated Secretory Phenotype., Y Liang, C Pan, T Yin, L Wang, X Gao, E Wang, H Quang, D Huang, L Tan, K Xiang, Y Wang, PB Alexander, QJ Li, TP Yao, Z Zhang, and, XF Wang, 2024
Therapy-induced senescent tumor cells in cancer relapse., KX Song, JX Wang, De Huang, 2023
Antagonizing the irreversible thrombomodulin-initiated proteolytic signaling alleviates age-related liver fibrosis via senescent cell killing., C Pan, R Maeso-Díaz, TR Lewis, K Xiang, L Tan, Y Liang, L Wang, F Yang, T Yin, C Wang, K Du, D Huang, SH Oh, E Wang, BJW Lim, M Chong, PB Alexander, X Yao, VY Arshavsky, QJ Li, AM Diehl, and XF Wang, 2023
Parkin coordinates mitochondrial lipid remodeling to execute mitophagy., CC Lin, J Yan, MD Kapur, KL Norris, CW Hsieh, D Huang, N Vitale, KL Lim, Z Guan, XF Wang, JT Chi, WY Yang, TP Yao, 2022
GABAergic signaling beyond synapses: an emerging target for cancer therapy., D Huang, PB Alexander, QJ Li, and XF Wang, 2022
Cancer-cell-derived GABA promotes β-catenin-mediated tumour growth and immunosuppression., D Huang, Y Wang, JW Thompson, T Yin, PB Alexander, D Qin, P Mudgal, H Wu, Y Liang, L Tan, C Pan, L Yuan, Y Wan, QJ Li, and XF Wang, 2022
Myc-mediated SDHA acetylation triggers epigenetic regulation of gene expression and tumorigenesis., S Li, D Huang, S Shen, Y Cai, S Xing, G Wu, Z Jiang, Y Hao, M Yuan, N Wang, L Zhu, R Yan, D Yang, L Wang, Z Liu, X Hu, R Zhou, K Qu, A Li, X Duan, H Zhang, and P Gao, 2020
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1., Y Zhang, C Li, C Hu, Q Wu, Y Cai, S Xing, H Lu, L Wang, D Huang, L Sun, T Li, X He, X Zhong, J Wang, P Gao, Z J Smith, W Jia, and H Zhang, 2019
Switching off IMMP2L signaling drives senescence via simultaneous metabolic alteration and blockage of cell death., L Yuan, L Zhai, L Qian, D Huang, Y Ding, H Xiang, X Liu, J. W Thompson, J Liu, YH He, XQ Chen, J Hu, QP Kong, M Tan, and XF Wang, 2018
Synthetic lethality between HER2 and transaldolase in intrinsically resistant HER2-positive breast cancers., Y Ding, C Gong, D Huang, R Chen, P Sui, KH. Lin, G Liang, L Yuan, H Xiang, J Chen, T Yin, PB. Alexander, QF Wang, EW Song, QJ Li, KC. Wood, and XF Wang, 2018
Menin enhances c-Myc-mediated transcription to promote cancer progression., G Wu, M Yuan, S Shen, X Ma, J Fang, L Zhu, L Sun, Z Liu, X He, D Huang, T Li, C Li, J Wu, X Hu, Z Li, L Song, K Qu, H Zhang, and P Gao, 2017
Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway., X Ma, L Wang, D Huang, Y Li, D Yang, T Li, F Li, L Sun, H Wei, K He, F Yu, D Zhao, L Hu, S Xing, Z Liu, K Li, J Guo, Z Yang, X Pan, A Li, Y Shi, J Wang, P Gao, and H Zhang, 2017
Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress., D Huang, T Li, L Wang, L Zhang, R Yan, K Li, S Xing, G Wu, L Hu, W Jia, S Lin, C. V. Dang, L Song, P Gao, and H Zhang, 2016
miR-290/371-Mbd2-Myc circuit regulates glycolytic metabolism to promote pluripotency., Y Cao, W Guo, S Tian, X He, X Wang, X Liu, K Gu, X Ma, D Huang, L Hu, Y Cai, H Zhang, Y Wang, and P Gao, 2015
Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1., X Ma, C Li, L Sun, D Huang, T Li, X He, G Wu, Z Yang, X Zhong, L Song, P Gao, and H Zhang, 2014
HIF-1-mediated suppression of acyl-CoA dehydrogenases and fatty acid oxidation is critical for cancer progression., D Huang, T Li, X Li, L Zhang, L Sun, X He, X Zhong, D Jia, L Song, G. L. Semenza, P Gao, and H Zhang, 2014
Hypoxia and cancer cell metabolism., D Huang, C Li, and H Zhang, 2014

Metabolites Tumor Immunity Regulation Mechanism Neuroinvasion Tumor Development Anti-Tumor Drugs Screening Exploration Therapy

Zhang Chao - Zhejiang University

Lihua Wang - Fudan University

Jie Qin - Fudan University

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