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Dan Liu
Basic Medical Sciences
University of Science and Technology of China
Anhui
Language: English, Chinese
Biomolecular Phase Separation
Post-Translational Modification
Regulatory Network
Protein
Disease Correlation
Drug Discovery
Optimization
Biological Function
Research
Network
Areas of Focus
- Research on the regulatory network of biomolecular phase separation and post-translational modification of proteins
- Biological function identification of biomolecular phase separation and its correlation with diseases
- Discovery and optimization of disease-related drugs based on biomolecular phase separation
Work Experience
- 2013-present: Professor at University of Science and Technology of China
Academic Background & Achievements
- 1997-2007: PhD in Cell Biology from University of Science and Technology of China
- Postdoctoral research at University of Pennsylvania
- Published multiple research papers in top journals like Science, Signal Transduction and Targeted Therapy
Publications
- Predicting assembly mode of membraneless organelles by a FRET based crowding sensor, Feng Chen, Siyuan Shen, Xu Cao, Liang Zhang, Lunxu Liu, Daoke Yang, Yunyu Shi, Wei He, Xuebiao Yao, Dan Liu, 2023
- A gene-encoded FRET fluorescent sensor designed for detecting asymmetric dimethylation levels in vitro and in living cells, Sun Xuan, Chen Feng, Zhang Lili, Liu Dan, 2023
- Specific epitopes form extensive hydrogen-bonding networks to ensure efficient antibody binding of SARS-CoV-2: Implications for advanced antibody design, Wang, DJ, Ge, YS, Zhong, B, Liu, D, 2021
- Design, synthesis and cell imaging of a simple peptide-based probe for the selective detection of RNA, Duan, WX, Huang, FY, Bi, YH, Zhu, LL, Wang, DJ, Liu, Y, Wu, J, Ge, YS, Liu, D, 2021
- Neutrophil Decoys with Anti-Inflammatory and Anti-Oxidative Properties Reduce Secondary Spinal Cord Injury and Improve Neurological Functional Recovery, Bi, YH, Duan, WX, Chen, J, You, T, Li, SY, Jiang, W, Li, M, Wang, G, Pan, XY, Wu, J, Liu, D, Li, J, Wang, YC, 2021
- Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation, Xu, L, Ali, M, Duan, WX, Yuan, X, Garba, F, Mullen, M, Sun, B, Poser, I, Duan, HQ, Lu, L, Tian, RJ, Ge, YS, Chu, LL, Pan, WJ, Wang, DM, Hyman, A, Green, H, Li, L, Dou, Z, Liu, D, Liu, X, Yao, XB, 2021
- Genetically encoded FRET fluorescent sensor designed for detecting MOF histone acetyltransferase activity in vitro and in living cells, Han, QQ, Chen, F, Liu, SS, Ge, YS, Wu, J, Liu, D, 2021
- Novel gene-encoded intermolecular FRET sensor for tracking glycosylation of CD147 in living cells, Lu, H, Zhu, LL, Li, WQ, Hu, SY, Ge, YS, Liu, D, 2021
- Identification of the hot spot residues for pyridine derivative inhibitor CCT251455 and ATP substrate binding on monopolar spindle 1 (MPS1) kinase by molecular dynamic simulation, Chen, K, Duan, WX, Han, QQ, Sun, X, Li, WQ, Hu, SY, Wan, JJ, Wu, J, Ge, YS, Liu, D, 2019
- Selective and sensitive detection of Zn(II) ion using a simplepeptide-based sensor, Wan, JJ, Duan, WX, Chen, K, Tao, YD, Dang, J, Zeng, KH, Ge, YS, Wu, J, Liu, D, 2018
- Discovery of Cdc25A Lead Inhibitors with a Novel Chemotype by Virtual Screening: Application of Pharmacophore Modeling Based on a Training Set with a Limited Number of Unique Components, Ge, YS, Han, QQ, Duan, WX, Zhang, JQ, Chen, K, Wan, JJ, Liu, Y, Liu, D, 2017
- Highly selective ratiometric peptide-based chemosensors for zinc ions and applications in living cell imaging: a study for reasonable structure design, Yang, JC, Rong, H, Shao, P, Tao, YD, Dang, J, Wang, P, Ge, YS, Wu, J, Liu, D, 2016
- Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates, Liu, D, Vader, G, Vromans, MJ, Lampson, MA, Lens, SM, 2009
- Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing, Liu, D, Davydenko, O, Lampson, MA, 2012
- Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface, Welburn, JP, Vleugel, M, Liu, D, Yates, III JR, Lampson, MA, Fukagawa, T, Cheeseman, IM, 2010
- Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase, Liu, D, Vleugel, M, Backer, CB, Hori, T, Fukagawa, T, Cheeseman, IM, Lampson, MA, 2010
- Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis, Liu D, Zhang N, Du J, Cai X, Zhu M, Jin C, Dou Z, Feng C, Yang Y, Liu L, Takeyasu K, Xie W, Yao X, 2006
- A novel genome-wide full-length kinesin prediction analysis reveals additional mammalian kinesins, Xue Y, Liu D, Fu C, Dou Z, Zhou Q, Yao X, 2006
