Professor | Dan Liu | Asia Growth Partners

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Name	Dan Liu
Contact Information	dliu919@ustc.edu.cn
Language ability	English, Chinese
Province	Anhui

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Name

Dan Liu

Contact Information

dliu919@ustc.edu.cn

Language ability

English, Chinese

Province

Anhui

University/Lab Affiliation and Title	University of Science and Technology of China
Faculty	Basic Medical Sciences
Academic Background & Achievements	1997-2007: PhD in Cell Biology from University of Science and Technology of China Postdoctoral research at University of Pennsylvania Published multiple research papers in top journals like Science, Signal Transduction and Targeted Therapy
Work Experience	2013-present: Professor at University of Science and Technology of China

University/Lab Affiliation and Title

University of Science and Technology of China

Faculty

Basic Medical Sciences

Academic Background & Achievements

1997-2007: PhD in Cell Biology from University of Science and Technology of China
Postdoctoral research at University of Pennsylvania
Published multiple research papers in top journals like Science, Signal Transduction and Targeted Therapy

Work Experience

2013-present: Professor at University of Science and Technology of China

Areas of Focus	Research on the regulatory network of biomolecular phase separation and post-translational modification of proteins Biological function identification of biomolecular phase separation and its correlation with diseases Discovery and optimization of disease-related drugs based on biomolecular phase separation
Publications	Predicting assembly mode of membraneless organelles by a FRET based crowding sensor, Feng Chen, Siyuan Shen, Xu Cao, Liang Zhang, Lunxu Liu, Daoke Yang, Yunyu Shi, Wei He, Xuebiao Yao, Dan Liu, 2023 A gene-encoded FRET fluorescent sensor designed for detecting asymmetric dimethylation levels in vitro and in living cells, Sun Xuan, Chen Feng, Zhang Lili, Liu Dan, 2023 Specific epitopes form extensive hydrogen-bonding networks to ensure efficient antibody binding of SARS-CoV-2: Implications for advanced antibody design, Wang, DJ, Ge, YS, Zhong, B, Liu, D, 2021 Design, synthesis and cell imaging of a simple peptide-based probe for the selective detection of RNA, Duan, WX, Huang, FY, Bi, YH, Zhu, LL, Wang, DJ, Liu, Y, Wu, J, Ge, YS, Liu, D, 2021 Neutrophil Decoys with Anti-Inflammatory and Anti-Oxidative Properties Reduce Secondary Spinal Cord Injury and Improve Neurological Functional Recovery, Bi, YH, Duan, WX, Chen, J, You, T, Li, SY, Jiang, W, Li, M, Wang, G, Pan, XY, Wu, J, Liu, D, Li, J, Wang, YC, 2021 Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation, Xu, L, Ali, M, Duan, WX, Yuan, X, Garba, F, Mullen, M, Sun, B, Poser, I, Duan, HQ, Lu, L, Tian, RJ, Ge, YS, Chu, LL, Pan, WJ, Wang, DM, Hyman, A, Green, H, Li, L, Dou, Z, Liu, D, Liu, X, Yao, XB, 2021 Genetically encoded FRET fluorescent sensor designed for detecting MOF histone acetyltransferase activity in vitro and in living cells, Han, QQ, Chen, F, Liu, SS, Ge, YS, Wu, J, Liu, D, 2021 Novel gene-encoded intermolecular FRET sensor for tracking glycosylation of CD147 in living cells, Lu, H, Zhu, LL, Li, WQ, Hu, SY, Ge, YS, Liu, D, 2021 Identification of the hot spot residues for pyridine derivative inhibitor CCT251455 and ATP substrate binding on monopolar spindle 1 (MPS1) kinase by molecular dynamic simulation, Chen, K, Duan, WX, Han, QQ, Sun, X, Li, WQ, Hu, SY, Wan, JJ, Wu, J, Ge, YS, Liu, D, 2019 Selective and sensitive detection of Zn(II) ion using a simplepeptide-based sensor, Wan, JJ, Duan, WX, Chen, K, Tao, YD, Dang, J, Zeng, KH, Ge, YS, Wu, J, Liu, D, 2018 Discovery of Cdc25A Lead Inhibitors with a Novel Chemotype by Virtual Screening: Application of Pharmacophore Modeling Based on a Training Set with a Limited Number of Unique Components, Ge, YS, Han, QQ, Duan, WX, Zhang, JQ, Chen, K, Wan, JJ, Liu, Y, Liu, D, 2017 Highly selective ratiometric peptide-based chemosensors for zinc ions and applications in living cell imaging: a study for reasonable structure design, Yang, JC, Rong, H, Shao, P, Tao, YD, Dang, J, Wang, P, Ge, YS, Wu, J, Liu, D, 2016 Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates, Liu, D, Vader, G, Vromans, MJ, Lampson, MA, Lens, SM, 2009 Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing, Liu, D, Davydenko, O, Lampson, MA, 2012 Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface, Welburn, JP, Vleugel, M, Liu, D, Yates, III JR, Lampson, MA, Fukagawa, T, Cheeseman, IM, 2010 Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase, Liu, D, Vleugel, M, Backer, CB, Hori, T, Fukagawa, T, Cheeseman, IM, Lampson, MA, 2010 Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis, Liu D, Zhang N, Du J, Cai X, Zhu M, Jin C, Dou Z, Feng C, Yang Y, Liu L, Takeyasu K, Xie W, Yao X, 2006 A novel genome-wide full-length kinesin prediction analysis reveals additional mammalian kinesins, Xue Y, Liu D, Fu C, Dou Z, Zhou Q, Yao X, 2006

Areas of Focus

Research on the regulatory network of biomolecular phase separation and post-translational modification of proteins
Biological function identification of biomolecular phase separation and its correlation with diseases
Discovery and optimization of disease-related drugs based on biomolecular phase separation

Publications

Predicting assembly mode of membraneless organelles by a FRET based crowding sensor, Feng Chen, Siyuan Shen, Xu Cao, Liang Zhang, Lunxu Liu, Daoke Yang, Yunyu Shi, Wei He, Xuebiao Yao, Dan Liu, 2023
A gene-encoded FRET fluorescent sensor designed for detecting asymmetric dimethylation levels in vitro and in living cells, Sun Xuan, Chen Feng, Zhang Lili, Liu Dan, 2023
Specific epitopes form extensive hydrogen-bonding networks to ensure efficient antibody binding of SARS-CoV-2: Implications for advanced antibody design, Wang, DJ, Ge, YS, Zhong, B, Liu, D, 2021
Design, synthesis and cell imaging of a simple peptide-based probe for the selective detection of RNA, Duan, WX, Huang, FY, Bi, YH, Zhu, LL, Wang, DJ, Liu, Y, Wu, J, Ge, YS, Liu, D, 2021
Neutrophil Decoys with Anti-Inflammatory and Anti-Oxidative Properties Reduce Secondary Spinal Cord Injury and Improve Neurological Functional Recovery, Bi, YH, Duan, WX, Chen, J, You, T, Li, SY, Jiang, W, Li, M, Wang, G, Pan, XY, Wu, J, Liu, D, Li, J, Wang, YC, 2021
Feedback control of PLK1 by Apolo1 ensures accurate chromosome segregation, Xu, L, Ali, M, Duan, WX, Yuan, X, Garba, F, Mullen, M, Sun, B, Poser, I, Duan, HQ, Lu, L, Tian, RJ, Ge, YS, Chu, LL, Pan, WJ, Wang, DM, Hyman, A, Green, H, Li, L, Dou, Z, Liu, D, Liu, X, Yao, XB, 2021
Genetically encoded FRET fluorescent sensor designed for detecting MOF histone acetyltransferase activity in vitro and in living cells, Han, QQ, Chen, F, Liu, SS, Ge, YS, Wu, J, Liu, D, 2021
Novel gene-encoded intermolecular FRET sensor for tracking glycosylation of CD147 in living cells, Lu, H, Zhu, LL, Li, WQ, Hu, SY, Ge, YS, Liu, D, 2021
Identification of the hot spot residues for pyridine derivative inhibitor CCT251455 and ATP substrate binding on monopolar spindle 1 (MPS1) kinase by molecular dynamic simulation, Chen, K, Duan, WX, Han, QQ, Sun, X, Li, WQ, Hu, SY, Wan, JJ, Wu, J, Ge, YS, Liu, D, 2019
Selective and sensitive detection of Zn(II) ion using a simplepeptide-based sensor, Wan, JJ, Duan, WX, Chen, K, Tao, YD, Dang, J, Zeng, KH, Ge, YS, Wu, J, Liu, D, 2018
Discovery of Cdc25A Lead Inhibitors with a Novel Chemotype by Virtual Screening: Application of Pharmacophore Modeling Based on a Training Set with a Limited Number of Unique Components, Ge, YS, Han, QQ, Duan, WX, Zhang, JQ, Chen, K, Wan, JJ, Liu, Y, Liu, D, 2017
Highly selective ratiometric peptide-based chemosensors for zinc ions and applications in living cell imaging: a study for reasonable structure design, Yang, JC, Rong, H, Shao, P, Tao, YD, Dang, J, Wang, P, Ge, YS, Wu, J, Liu, D, 2016
Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates, Liu, D, Vader, G, Vromans, MJ, Lampson, MA, Lens, SM, 2009
Polo-like kinase-1 regulates kinetochore-microtubule dynamics and spindle checkpoint silencing, Liu, D, Davydenko, O, Lampson, MA, 2012
Aurora B Phosphorylates Spatially Distinct Targets to Differentially Regulate the Kinetochore-Microtubule Interface, Welburn, JP, Vleugel, M, Liu, D, Yates, III JR, Lampson, MA, Fukagawa, T, Cheeseman, IM, 2010
Regulated targeting of protein phosphatase 1 to the outer kinetochore by KNL1 opposes Aurora B kinase, Liu, D, Vleugel, M, Backer, CB, Hori, T, Fukagawa, T, Cheeseman, IM, Lampson, MA, 2010
Interaction of Skp1 with CENP-E at the midbody is essential for cytokinesis, Liu D, Zhang N, Du J, Cai X, Zhu M, Jin C, Dou Z, Feng C, Yang Y, Liu L, Takeyasu K, Xie W, Yao X, 2006
A novel genome-wide full-length kinesin prediction analysis reveals additional mammalian kinesins, Xue Y, Liu D, Fu C, Dou Z, Zhou Q, Yao X, 2006

Biomolecular Phase Separation Post-Translational Modification Regulatory Network Protein Disease Correlation Drug Discovery Optimization Biological Function Research Network

Yan Zhang - Zhejiang University

Yi Feng - Fudan University

Xiaoyu Tong - Fudan University

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