1986 - B.S. in Basic Medicine: The Fourth Military Medical University
1991 - M.S. in Clinical Medicine: The Fourth Military Medical University
1996 - Ph.D. in Biochemistry and Molecular Biology: Shanghai Cancer Institute
1998-1999 - Max-Planck Institute for Biochemistry, Germany - Postdoctoral Fellow
2000-2006 - University of California Irvine - Postdoctoral Fellow/Senior Researcher
2006-Present - Xiamen University, School of Life Sciences - Professor
2012-2021 - Xiamen University, School of Life Sciences - Deputy Dean
Research
Wnt signaling pathway in normal development and tumorigenesis
SOX4 facilitates brown fat development and maintenance through EBF2-mediated thermogenic gene program in mice., Wang S, He T, Luo Y, Ren K, Shen H, Hou L, Wei Y, Fu T, Xie W, Wang P, Hu J, Zhu Y, Huang Z, Li Q, Li W, Guo H*, Li B*., 2024
Epigenetic regulation of DNA repair gene program by Hippo/YAP1-TET1 axis mediates sorafenib resistance in HCC., Mo C, You W, Rao Y, Lin Z, Wang S, He T, Shen H, Li X*, Zhang R*, Li B*., 2024
Loss of OVOL2 in Triple-Negative Breast Cancer Promotes Fatty Acid Oxidation Fueling Stemness Characteristics., Lu R, Hong J, Fu T, Zhu Y, Tong R, Ai D, Wang S, Huang Q, Chen C, Zhang Z, Zhang R*, Guo H*, Li B*., 2024
Rapid and sensitive detection of nucleic acids using an RAA-CRISPR/Cas12b one-pot detection assay (Rcod)., Lin KF, Yao KH, Li X, Li QH, Guo XJ, You WX, Ren WJ, Bian Y, Guo JG, Sun Z, Zhang R, Yang XQ*, Li ZY*, Li BA*., 2024
Aspirin Inhibits FAS-Mediated Apoptosis to Support Colorectal Cancer Survival., Ma H, Suleman M, Zhang F, Cao T, Wen S, Sun D, Chen L, Jiang B, Wang Y, Lin F, Wang J, Li B*, Li Q*., 2024
An extraction-free method for rapid detection of CYP2C19 * 2/3/17 polymorphisms in one tube using melting curve analysis., Guo J, You W, Lin K, Li Q, Guo X, Wang S, Bian Y, Ren W, Zhang R, Wang Y, Li B*., 2023
TET2 is recruited by CREB to promote Cebpb, Cebpa, and Pparg transcription by facilitating hydroxymethylation during adipocyte differentiation., Liu Y, He T, Li Z, Sun Z, Wang S, Shen H, Hou L, Li S, Wei Y, Zhuo B, Li S, Zhou C, Guo H, Zhang R, Li B*., 2023
Suppression of preadipocyte determination by Sox4 limits white adipocyte hyperplasia in obesity., He, T#, Wang, S#., Li S#., Shen, H#., Hou, L., Liu, Y., Wei Y., Xie, F., Zhang, Z., Zhao, Z., Mo, C., Guo, H., Huang, Q., Zhang, R*., Shen, D*., and Li, BA*., 2023
Fast and visual detection of nucleic acid using One-step RPA-CRISPR Detection (ORCD) System., Lin KF, Guo JG, Guo XJ, Li QH, Li X, Sun Z, Zhao ZH, Weng J, Wu JZ*, Zhang R*, Li BA*., 2023
SOX4 promotes beige adipocyte-mediated adaptive thermogenesis by facilitating PRDM16-PPARγ complex., Shen H#, He T#, Wang S#, Hou L#, Wei Y, Liu Y, Mo C, Zhao Z, You W, Guo H*, Li B*., 2022
An automated nucleic acid detection platform using digital microfluidics with an optimized Cas12a system., Sun # Z, Lin KF#, Zhao ZH#, Wang Y, Hong XX, Guo JG, Ruan QY, Lu LY, Li X, Zhang R*, Yang CY*, Li BA*., 2022
An NF-κB/OVOL2 circuit regulates glucose import and cell survival in non-small cell lung cancer., Zhang R#, Geng GJ#, Guo JG#, Mi YJ, Zhu XL, Li N, Liu HM, Lin JF, Wang JW, Zhao G, Ye GZ, Li BA*, Luo QC*, Jiang J*., 2022
\"HLA-10-SNP\
Poly(ADP-ribosyl)ation of OVOL2 regulates aneuploidy and cell death in cancer cells., Zhang R#, Hong JJ#, Yang Q, Ong CT, Li BA*, Liou YC*., 2018
Pygo2 regulates adiposity and glucose homeostasis via β-Catenin-Axin2-GSK3β signaling pathway., Xie YY#, Mo CL#, Cai YH, Wang WJ, Hong XX, Zhang KK, Liu QF, Liu YJ, Hong JJ, He T, Zheng ZZ, Mo W, and Li BA*., 2018
Tumor-originated exosomal lncUEGC1 as a circulating biomarker for early-stage gastric cancer., Lin LY, Yang L, Zeng Q, Wang L, Chen ML, Zhao ZH, Ye GD, Luo QC, Lv PY, Guo QW, Li BA*, Cai JC*, Cai WY*., 2018
PMP22 Regulates Self-Renewal and Chemoresistance of Gastric Cancer Cells., Cai W, Chen G, Luo Q, Liu J, Guo X, Zhang T, Ma F, Yuan L, Li BA*, Cai J*., 2017
Simultaneous detection of 45 fusion genes in leukemia by dual-color fluorescence real-time PCR., Zheng Z, Zhang P, He G, Liao K, Wang Z, Pan J, Du K, Du J, Li BA*., 2017
YAP-TEAD and HNF4α repress reciprocally to regulate hepatocarcinogenesis., Cai WY, Lin LY, Hao H, Zhang SM, Ma F, Hong XX, Zhang H, Liu QF, Ye GD, Sun GB, Liu YJ, Li SN, Xie YY, Cai JC, and Li BA*., 2017
Pygo2 activates MDR1 expression and mediates chemoresistance in breast cancer via the Wnt/β-catenin pathway., Zhang ZM, Wu JF, Luo QC, Liu QF, Wu QW, Ye GD, She HQ*, and Li BA*., 2016
OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and is Downregulated in Human Colorectal Tumors., Ye GD, Sun GB, Jiao P, Chen C, Liu QF, Huang XL, Zhang R, Cai WY, Li SN, Wu JF, Liu YJ, Wu RS, Xie YY, Chan EC, Liou YC, and Li BA*., 2016
Double-Negative Feedback Loop Between Wnt/β-catenin Signaling and HNF4α Regulates Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma., Yang M, Li SN, Anjum KM, Gui LX, Zhu SS, Liu J, Chen JK, Liu QF, Ye GD, Wang WJ, Wu JF, Cai WY, Sun GB, Liu YJ, Liu RF, Zhang ZM, Li BA*., 2013
Wnt/β-catenin pathway represses let-7 microRNAs expression via transactivation of Lin28 to augment breast cancer stem cell expansion., Cai WY, Wei TZ, Luo QC, Wu QW, Liu QF, Yang M, Ye GD, Wu JF, Chen YY, Sun GB, Liu YJ, Zhao WX, Zhang ZM, Li BA*., 2013
A novel tumor suppressor miRNA miR-520e contributes to suppression of hepatoma., Li BA*., 2012
The orphan receptor TR3 suppresses intestinal tumorigenesis in mice by downregulating Wnt signalling., Chen HZ, Liu QF, Li L, Wang WJ, Yao LM, Yang M, Liu B, Chen W, Zhan YY, Zhang MQ, Cai JC, Zheng ZH, Lin SC, Li BA*, Wu Q*., 2012
Pygo2 associates with MLL2 histone methyltransferase (HMT) and GCN5 histone acetyltransferase (HAT) complexes to augment Wnt target gene expression and breast cancer stem-like cell expansion., Chen J, Luo Q, Yuan Y, Huang X, Cai W, Li C, Wei T, Zhang L, Yang M, Liu Q, Ye G, Cheng P, Dai X and Li BA*., 2010
Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation., Gu B, Sun P, Yuan Y, Moraes RC, Li A, Teng A, Agrawal A, Rhéaume C, Bilanchone V, Veltmaat JM, Takemaru K, Millar S, Lee EY, Lewis MT, and Li BA*, Dai X*., 2009
