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Xin Wang
Life Science
Xiamen University
Fujian
Language: English, Chinese
Neuroscience
Alzheimer'S
Synaptic
Biomedical
Neurodegenerative
Research
Cognitive
Pathology
Disease
Function
Areas of Focus
- Neuroscience
- Alzheimer's Disease
- Synaptic Function
- Biomedical Sciences
- Neurodegenerative Diseases
Work Experience
- 2008-2009 Visiting Scholar: Sanford-Burnham Medical Research Institute
- 2013-2013 Postdoctoral: Sanford-Burnham Medical Research Institute
- 2013-2014 Postdoctoral: University of California, San Diego (UCSD), Neuroscience Department and Howard Hughes Medical Institute (HHMI)
- 2014-2015 Postdoctoral: Sanford-Burnham Medical Research Institute
- 2015-present Distinguished Professor: Xiamen University
Academic Background & Achievements
- 2001-2005 Bachelor: Chongqing Medical University, Pharmacy
- 2005-2008 Master: Shanghai Jiao Tong University, School of Pharmacy
- 2009-2013 PhD: Sanford-Burnham Medical Research Institute, Biomedical Sciences
Publications
- β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function., Gao Y, Hong Y, Huang L, Zheng S, Zhang H, Wang S, Yao Y, Zhao Y, Zhu L, Xu Q, Chai X, Zeng Y, Zeng Y, Zheng L, Zhou Y, Luo H, Zhang X, Zhang H, Zhou Y, Fu G, Sun H, Huang TY, Zheng Q, Xu H, Wang X*., 2023
- β2-microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice., Zhao Y, Zheng Q, Hong Y, Gao Y, Hu J, Lang M, Zhang H, Zhou Y, Luo H, Zhang X, Sun H, Yan XX, Huang TY, Wang YJ, Xu H, Liu C, Wang X*., 2023
- Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability., Zhang H#, Zheng Q#, Guo T#, Zhang S#, Zheng S, Wang R, Deng Q, Yang G, Zhang S, Tang L, Qi Q, Zhu L, Zhang X-F, Luo H, Zhang X, Sun H, Gao Y, Zhang H, Zhou Y, Han A, Zhang C-S, Xu H, Wang X*., 2022
- USP25 inhibition ameliorates Alzheimer’s pathology through regulating APP processing and Aβ generation., Zheng Q#, Song B#, Li G#, Cai F#, Wu M, Zhao Y, Jiang L, Guo T, Shen M, Hou H, Zhou Y, Zhao Y, Di A, Zhang L, Zeng F, Zhang X-F, Luo H, Zhang X, Zhang H, Zeng Z, Huang T, Dong C, Qing H, Zhang Y, Zhang Q, Wang X, Wu Y, Xu H*, Song W*, and Wang X*., 2022
- SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate., Zhang H#, Hong Y#, Yang W, Wang R, Yao T, Wang J, Liu K, Yuan H, Xu C, Zhou Y, Li G, Zhang L, Luo H, Zhang X, Du D, Sun H, Zheng Q, Zhang Y-W, Zhao Y, Zhou Y, Xu H, Wang X*., 2021
- Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25., Zheng Q#, Li G#, Wang S, Zhou Y, Liu K, Gao Y, Zhou Y, Zheng L, Zhu L, Deng Q, Wu M, Di A, Zhang L, Zhao Y, Zhang H, Sun H, Dong C, Xu H, Wang X*., 2021
- The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability., Zeng F#, Ma X#, Zhu L#, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, and Wang X*., 2019
- Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction via modulation of glutamate receptor recycling in Down's syndrome., Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H*., 2013
Awards
- National Outstanding Youth Science Fund Recipient (2023)
- 17th Fujian Youth Science and Technology Award (2023)
- Xiamen Science and Technology Progress First Prize (2018)
- First Batch of Outstanding Young Talents in Xiamen (2018)
- NSFC Excellent Young Scientists Fund Recipient (2018)
- Fujian High-level Innovative Talent Plan Expert (2017)
- Fujian Outstanding Youth Fund Recipient (2017)
- Minjiang Scholar Distinguished Professor (2016)
- National High-level Young Talent (2016)
- Young Scholar Award of Alzheimer's Association (2010)
