Professor | Xin Wang | Asia Growth Partners

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Name	Xin Wang
Contact Information	wangx@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

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Name

Xin Wang

Contact Information

wangx@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	2001-2005 Bachelor: Chongqing Medical University, Pharmacy 2005-2008 Master: Shanghai Jiao Tong University, School of Pharmacy 2009-2013 PhD: Sanford-Burnham Medical Research Institute, Biomedical Sciences
Work Experience	2008-2009 Visiting Scholar: Sanford-Burnham Medical Research Institute 2013-2013 Postdoctoral: Sanford-Burnham Medical Research Institute 2013-2014 Postdoctoral: University of California, San Diego (UCSD), Neuroscience Department and Howard Hughes Medical Institute (HHMI) 2014-2015 Postdoctoral: Sanford-Burnham Medical Research Institute 2015-present Distinguished Professor: Xiamen University
Awards	National Outstanding Youth Science Fund Recipient (2023) 17th Fujian Youth Science and Technology Award (2023) Xiamen Science and Technology Progress First Prize (2018) First Batch of Outstanding Young Talents in Xiamen (2018) NSFC Excellent Young Scientists Fund Recipient (2018) Fujian High-level Innovative Talent Plan Expert (2017) Fujian Outstanding Youth Fund Recipient (2017) Minjiang Scholar Distinguished Professor (2016) National High-level Young Talent (2016) Young Scholar Award of Alzheimer's Association (2010)

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

2001-2005 Bachelor: Chongqing Medical University, Pharmacy
2005-2008 Master: Shanghai Jiao Tong University, School of Pharmacy
2009-2013 PhD: Sanford-Burnham Medical Research Institute, Biomedical Sciences

Work Experience

2008-2009 Visiting Scholar: Sanford-Burnham Medical Research Institute
2013-2013 Postdoctoral: Sanford-Burnham Medical Research Institute
2013-2014 Postdoctoral: University of California, San Diego (UCSD), Neuroscience Department and Howard Hughes Medical Institute (HHMI)
2014-2015 Postdoctoral: Sanford-Burnham Medical Research Institute
2015-present Distinguished Professor: Xiamen University

Awards

National Outstanding Youth Science Fund Recipient (2023)
17th Fujian Youth Science and Technology Award (2023)
Xiamen Science and Technology Progress First Prize (2018)
First Batch of Outstanding Young Talents in Xiamen (2018)
NSFC Excellent Young Scientists Fund Recipient (2018)
Fujian High-level Innovative Talent Plan Expert (2017)
Fujian Outstanding Youth Fund Recipient (2017)
Minjiang Scholar Distinguished Professor (2016)
National High-level Young Talent (2016)
Young Scholar Award of Alzheimer's Association (2010)

Areas of Focus	Neuroscience Alzheimer's Disease Synaptic Function Biomedical Sciences Neurodegenerative Diseases
Publications	β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function., Gao Y, Hong Y, Huang L, Zheng S, Zhang H, Wang S, Yao Y, Zhao Y, Zhu L, Xu Q, Chai X, Zeng Y, Zeng Y, Zheng L, Zhou Y, Luo H, Zhang X, Zhang H, Zhou Y, Fu G, Sun H, Huang TY, Zheng Q, Xu H, Wang X., 2023 β2-microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice., Zhao Y, Zheng Q, Hong Y, Gao Y, Hu J, Lang M, Zhang H, Zhou Y, Luo H, Zhang X, Sun H, Yan XX, Huang TY, Wang YJ, Xu H, Liu C, Wang X., 2023 Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability., Zhang H#, Zheng Q#, Guo T#, Zhang S#, Zheng S, Wang R, Deng Q, Yang G, Zhang S, Tang L, Qi Q, Zhu L, Zhang X-F, Luo H, Zhang X, Sun H, Gao Y, Zhang H, Zhou Y, Han A, Zhang C-S, Xu H, Wang X., 2022 USP25 inhibition ameliorates Alzheimer’s pathology through regulating APP processing and Aβ generation., Zheng Q#, Song B#, Li G#, Cai F#, Wu M, Zhao Y, Jiang L, Guo T, Shen M, Hou H, Zhou Y, Zhao Y, Di A, Zhang L, Zeng F, Zhang X-F, Luo H, Zhang X, Zhang H, Zeng Z, Huang T, Dong C, Qing H, Zhang Y, Zhang Q, Wang X, Wu Y, Xu H, Song W, and Wang X., 2022 SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate., Zhang H#, Hong Y#, Yang W, Wang R, Yao T, Wang J, Liu K, Yuan H, Xu C, Zhou Y, Li G, Zhang L, Luo H, Zhang X, Du D, Sun H, Zheng Q, Zhang Y-W, Zhao Y, Zhou Y, Xu H, Wang X., 2021 Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25., Zheng Q#, Li G#, Wang S, Zhou Y, Liu K, Gao Y, Zhou Y, Zheng L, Zhu L, Deng Q, Wu M, Di A, Zhang L, Zhao Y, Zhang H, Sun H, Dong C, Xu H, Wang X., 2021 The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability., Zeng F#, Ma X#, Zhu L#, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, and Wang X., 2019 Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction via modulation of glutamate receptor recycling in Down's syndrome., Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H., 2013

Areas of Focus

Neuroscience
Alzheimer's Disease
Synaptic Function
Biomedical Sciences
Neurodegenerative Diseases

Publications

β2-microglobulin functions as an endogenous NMDAR antagonist to impair synaptic function., Gao Y, Hong Y, Huang L, Zheng S, Zhang H, Wang S, Yao Y, Zhao Y, Zhu L, Xu Q, Chai X, Zeng Y, Zeng Y, Zheng L, Zhou Y, Luo H, Zhang X, Zhang H, Zhou Y, Fu G, Sun H, Huang TY, Zheng Q, Xu H, Wang X*., 2023
β2-microglobulin coaggregates with Aβ and contributes to amyloid pathology and cognitive deficits in Alzheimer’s disease model mice., Zhao Y, Zheng Q, Hong Y, Gao Y, Hu J, Lang M, Zhang H, Zhou Y, Luo H, Zhang X, Sun H, Yan XX, Huang TY, Wang YJ, Xu H, Liu C, Wang X*., 2023
Metabolic reprogramming in astrocytes results in neuronal dysfunction in intellectual disability., Zhang H#, Zheng Q#, Guo T#, Zhang S#, Zheng S, Wang R, Deng Q, Yang G, Zhang S, Tang L, Qi Q, Zhu L, Zhang X-F, Luo H, Zhang X, Sun H, Gao Y, Zhang H, Zhou Y, Han A, Zhang C-S, Xu H, Wang X*., 2022
USP25 inhibition ameliorates Alzheimer’s pathology through regulating APP processing and Aβ generation., Zheng Q#, Song B#, Li G#, Cai F#, Wu M, Zhao Y, Jiang L, Guo T, Shen M, Hou H, Zhou Y, Zhao Y, Di A, Zhang L, Zeng F, Zhang X-F, Luo H, Zhang X, Zhang H, Zeng Z, Huang T, Dong C, Qing H, Zhang Y, Zhang Q, Wang X, Wu Y, Xu H*, Song W*, and Wang X*., 2022
SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate., Zhang H#, Hong Y#, Yang W, Wang R, Yao T, Wang J, Liu K, Yuan H, Xu C, Zhou Y, Li G, Zhang L, Luo H, Zhang X, Du D, Sun H, Zheng Q, Zhang Y-W, Zhao Y, Zhou Y, Xu H, Wang X*., 2021
Trisomy 21-induced dysregulation of microglial homeostasis in Alzheimer’s brains is mediated by USP25., Zheng Q#, Li G#, Wang S, Zhou Y, Liu K, Gao Y, Zhou Y, Zheng L, Zhu L, Deng Q, Wu M, Di A, Zhang L, Zhao Y, Zhang H, Sun H, Dong C, Xu H, Wang X*., 2021
The deubiquitinase USP6 affects memory and synaptic plasticity through modulating NMDA receptor stability., Zeng F#, Ma X#, Zhu L#, Xu Q, Zeng Y, Gao Y, Li G, Guo T, Zhang H, Tang X, Wang Z, Ye Z, Zheng L, Zhang H, Zheng Q, Li K, Lu J, Qi X, Luo H, Zhang X, Wang Z, Zhou Y, Yao Y, Ke R, Zhou Y, Liu Y, Sun H, Huang T, Shao Z, Xu H, and Wang X*., 2019
Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction via modulation of glutamate receptor recycling in Down's syndrome., Wang X, Zhao Y, Zhang X, Badie H, Zhou Y, Mu Y, Loo LS, Cai L, Thompson RC, Yang B, Chen Y, Johnson PF, Wu C, Bu G, Mobley WC, Zhang D, Gage FH, Ranscht B, Zhang YW, Lipton SA, Hong W, Xu H*., 2013

Neuroscience Alzheimer'S Synaptic Biomedical Neurodegenerative Research Cognitive Pathology Disease Function

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