Professor | Ai-Dong Han | Asia Growth Partners

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Name	Ai-Dong Han
Contact Information	ahan@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

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Name

Ai-Dong Han

Contact Information

ahan@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	1989 - B.S. in Botany: Nanjing University 1995 - M.S. in Genetics: Sun Yat-Sen University 1999 - Ph.D. in Microbiology: Institute of Microbiology, Chinese Academy of Sciences
Work Experience	1999-2007 - University of Colorado at Boulder - Postdoctoral Fellow/Visiting Scholar 2006-2008 - University of Southern California - Senior Research Associate 2008-Present - Xiamen University - Professor

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

1989 - B.S. in Botany: Nanjing University
1995 - M.S. in Genetics: Sun Yat-Sen University
1999 - Ph.D. in Microbiology: Institute of Microbiology, Chinese Academy of Sciences

Work Experience

1999-2007 - University of Colorado at Boulder - Postdoctoral Fellow/Visiting Scholar
2006-2008 - University of Southern California - Senior Research Associate
2008-Present - Xiamen University - Professor

Areas of Focus	Structural Biology Signal Transduction Intracellular Trafficking Protein Post-Translational Modification Microbe-Host Interactions
Publications	Atypical Legionella GTPase effector hijacks host vesicular transport factor p115 to regulate host lipid droplet, Chen, TT, Lin, Y, Zhang, S, Liu, S, Song, L, Zhong, W, Luo, ZQ and Han, A, 2022 The W-Acidic Motif of Histidine Kinase WalK Is Required for Signaling and Transcriptional Regulation in Streptococcus mutans, Kong, L, Su, M, Sang, J, Huang, S, Wang, M, Cai, Y, Xie, M, Wu, J, Wang, S, Foster, SJ, Zhang, J, and Han, A, 2022 Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics, Salamaga, B, Kong, L, Pasquina-Lemonche, L, Lafage, L, Muhlen, M, Gibson, J, Grybchuk, D, Tooke, A, Panchal, V, Culp, E, Tatham, E, O'Kane, M, Catley, T, Renshaw, S, Wright, G, Plevka, P, Bullough, P, Han, A, Hobbs, J and Foster, S, 2021 Biphasic regulation of transcriptional surge generated by the gene feedback loop in a two-component system, Liu, W, Li, X, Qi, H, Wu, Y, Qu, J, Yin, Z, Gao, X, Han, A and Shuai, J*, 2021 Structural insights into the signal transduction mechanism of the K+-sensing two-component system KdpDE, Xie, M, Wu, M, Han, A, 2020 Conformational dynamics of the essential sensor histidine kinase WalK, Cai, Y, Su M, Ahmad, A, Hu, X, Sang, J, Kong, L, Chen, X, Wang, C, Shuai, J, Han, A, 2017 Molecular basis of substrate specific acetylation by N-terminal acetyltransferase NatB, Hong, H, Cai, Y, Zhang, S, Ding, H, Wang, H and Han, A, 2017 Competitive inhibition of lysine acetyltransferase 2B by a small motif of the adenoviral oncoprotein E1A, Shi, S, Liu, K., Chen, Y, Zhang, S, Lin, J, Gong, C, Jin, Q, Yang, X, Chen, R, Ji, Z and Han, A, 2016 Conformational dynamics of response regulator regx3 from Mycobacterium tuberculosis, Ahmad, A, Cai, Y, Chen, X, Shuai, J and Han, A, 2015 Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains, Wang, C, Sang, J, Wang, J, Su, M, Downey, JS, Wu, Q, Wang, S, Cai, Y, Xu, X, Wu, J, Senadheera, DB, Cvitkovitch, DG, Chen, L, Goodman, SD and Han, A, 2013 Inhibition of the function of class IIa HDACs by blocking their interaction with Mef2, Jayathilaka, N, Han, A, Gaffney, KJ, Dey, R, Jarusiewicz, JA, Noridomi, K, Philips, MA, Lei, X, He, J, Ye, J, Gao, T, Petasis, NA and Chen, L, 2012 Quikgene: A gene synthesis method integrated with ligation-free cloning, Mao, Y, Lin, J, Zhou, A, Ji, K, Downey, JS, Chen, R and Han, A, 2011 Structure of p300 bound to Mef2 on DNA reveals a mechanism of enhanceosome assembly, He, J, Ye, J, Cai, Y, Riquelme, C, Liu, JO, Liu, X, Han, A and Chen, L, 2011 Crystal structure of a conserved n-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains, Guo, L, Han, A, Bates, DL, Cao, J and Chen, L, 2007 Mechanism of recruitment of class ii histone deacetylases by myocyte enhancer factor-2, Han, A, He, J, Wu, Y, Liu, JO and Chen, L, 2005 Sequence-specific recruitment of transcriptional co-repressor cabin1 by myocyte enhancer factor-2, Han, A, Pan, F, Stroud, JC, Youn, HD, Liu, JO and Chen, L, 2003

Areas of Focus

Structural Biology
Signal Transduction
Intracellular Trafficking
Protein Post-Translational Modification
Microbe-Host Interactions

Publications

Atypical Legionella GTPase effector hijacks host vesicular transport factor p115 to regulate host lipid droplet, Chen, TT, Lin, Y, Zhang, S, Liu, S, Song, L, Zhong, W, Luo, ZQ and Han, A, 2022
The W-Acidic Motif of Histidine Kinase WalK Is Required for Signaling and Transcriptional Regulation in Streptococcus mutans, Kong, L, Su, M, Sang, J, Huang, S, Wang, M, Cai, Y, Xie, M, Wu, J, Wang, S, Foster, SJ, Zhang, J, and Han, A, 2022
Demonstration of the role of cell wall homeostasis in Staphylococcus aureus growth and the action of bactericidal antibiotics, Salamaga, B, Kong, L, Pasquina-Lemonche, L, Lafage, L, Muhlen, M, Gibson, J, Grybchuk, D, Tooke, A, Panchal, V, Culp, E, Tatham, E, O'Kane, M, Catley, T, Renshaw, S, Wright, G, Plevka, P, Bullough, P, Han, A*, Hobbs, J* and Foster, S*, 2021
Biphasic regulation of transcriptional surge generated by the gene feedback loop in a two-component system, Liu, W, Li, X, Qi, H, Wu, Y, Qu, J, Yin, Z, Gao, X, Han, A* and Shuai, J*, 2021
Structural insights into the signal transduction mechanism of the K+-sensing two-component system KdpDE, Xie, M, Wu, M, Han, A, 2020
Conformational dynamics of the essential sensor histidine kinase WalK, Cai, Y, Su M, Ahmad, A, Hu, X, Sang, J, Kong, L, Chen, X, Wang, C, Shuai, J, Han, A, 2017
Molecular basis of substrate specific acetylation by N-terminal acetyltransferase NatB, Hong, H, Cai, Y, Zhang, S, Ding, H, Wang, H and Han, A, 2017
Competitive inhibition of lysine acetyltransferase 2B by a small motif of the adenoviral oncoprotein E1A, Shi, S, Liu, K., Chen, Y, Zhang, S, Lin, J, Gong, C, Jin, Q, Yang, X, Chen, R, Ji, Z and Han, A, 2016
Conformational dynamics of response regulator regx3 from Mycobacterium tuberculosis, Ahmad, A, Cai, Y, Chen, X, Shuai, J and Han, A, 2015
Mechanistic insights revealed by the crystal structure of a histidine kinase with signal transducer and sensor domains, Wang, C, Sang, J, Wang, J, Su, M, Downey, JS, Wu, Q, Wang, S, Cai, Y, Xu, X, Wu, J, Senadheera, DB, Cvitkovitch, DG, Chen, L, Goodman, SD and Han, A, 2013
Inhibition of the function of class IIa HDACs by blocking their interaction with Mef2, Jayathilaka, N, Han, A, Gaffney, KJ, Dey, R, Jarusiewicz, JA, Noridomi, K, Philips, MA, Lei, X, He, J, Ye, J, Gao, T, Petasis, NA and Chen, L, 2012
Quikgene: A gene synthesis method integrated with ligation-free cloning, Mao, Y, Lin, J, Zhou, A, Ji, K, Downey, JS, Chen, R and Han, A, 2011
Structure of p300 bound to Mef2 on DNA reveals a mechanism of enhanceosome assembly, He, J, Ye, J, Cai, Y, Riquelme, C, Liu, JO, Liu, X, Han, A and Chen, L, 2011
Crystal structure of a conserved n-terminal domain of histone deacetylase 4 reveals functional insights into glutamine-rich domains, Guo, L, Han, A, Bates, DL, Cao, J and Chen, L, 2007
Mechanism of recruitment of class ii histone deacetylases by myocyte enhancer factor-2, Han, A, He, J, Wu, Y, Liu, JO and Chen, L, 2005
Sequence-specific recruitment of transcriptional co-repressor cabin1 by myocyte enhancer factor-2, Han, A, Pan, F, Stroud, JC, Youn, HD, Liu, JO and Chen, L, 2003

Molecular Mechanisms Transmembrane Signal Transduction Intracellular Trafficking Protein Acetylation N-Terminal Acetyltransferases Histone Acetyltransferases Histone Deacetylases Tau Phosphorylation Two-Component System

Hongquan Yang - Shanghai Normal University

Tongtong Guo - Shanghai Normal University

Qingqiu Gong - Shanghai Jiao Tong University

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