Professor | Yong Li | Asia Growth Partners

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Name	Yong Li
Contact Information	yongli@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

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Name

Yong Li

Contact Information

yongli@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	1990 - B.S. in Zoology: Nanjing University 1999 - Ph.D. in Molecular Biology: University of South Florida
Work Experience	1999-2001 - University of Pennsylvania - Postdoctoral Researcher 2001-2003 - Fox Chase Cancer Center - Postdoctoral Associate 2003-2007 - Van Andel Research Institute - Research Scientist 2007-2010 - University of Pittsburgh - Assistant Professor 2009-Present - Xiamen University - Professor, School of Life Sciences

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

1990 - B.S. in Zoology: Nanjing University
1999 - Ph.D. in Molecular Biology: University of South Florida

Work Experience

1999-2001 - University of Pennsylvania - Postdoctoral Researcher
2001-2003 - Fox Chase Cancer Center - Postdoctoral Associate
2003-2007 - Van Andel Research Institute - Research Scientist
2007-2010 - University of Pittsburgh - Assistant Professor
2009-Present - Xiamen University - Professor, School of Life Sciences

Areas of Focus	Drug-target interaction and structure-activity relationship Molecular mechanisms of drug regulation
Publications	Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR., Zheng W, Lu Y, Tian S, Ma F, Wei Y, Xu S, Li Y., 2018 Structural basis for the hepatoprotective effects of antihypertensive 1,4-dihydropyridine drugs., Wei Y, Lu Y, Zhu Y, Zheng W, Guo F, Yao B, Xu S, Wang Y, Jin L, Li Y., 2018 Identification of an Oleanane-type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity., Lu Y, Zheng W, Lin S, Guo F, Zhu Y, Wei Y, Liu X, Jin S, Jin L, Li Y., 2018 Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin α1., Zheng W, Wang R, Liu X, Tian S, Yao B, Chen A, Jin S, Li Y., 2018 A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly., Zheng W, Lu Y, Lin S, Wang R, Qiu L, Zhu Y, Yao B, Guo F, Jin S, Jin L, Li Y., 2017 Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease., Jin L, Wang R, Zhu Y, Zheng W, Han Y, Guo F, Ye F.B. & Li Y., 2015 Targeting nuclear receptors with marine natural products., Yang C, Li Q, Li Y., 2014 The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism., Jin L, Feng X, Pan Z, Inaba Y, Qiu L, Zheng W, Lin S, Wang R, Rong H, Wang Z, Li S, Xie W, and Li Y., 2013 Identification of the antibiotic ionomycin as an unexpected PPARγ ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes., Zheng W, Feng X, Qiu L, Pan Z, Wang R, Lin S, Hou D, Jin L, and Li Y., 2013 Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells., Wang S, Wang Z, Lin S, Zheng W, Wang R, Jin S, Chen J, Jin L, and Li Y., 2012 Revealing a steroid receptor ligand as a unique PPARγ agonist., Lin S, Han Y, Shi Y, Rong H, Zheng S, Jin S, Lin SY, Lin SC, Li Y., 2012 Structural basis for iloprost as a dual peroxisome proliferator-activated receptor alpha/delta agonist., Jin L, Lin S, Rong H, Zheng S, Jin S, Wang R, Li Y., 2011 Structural and functional insights into nuclear receptor signaling., Jin L, Li Y., 2010 Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORγ., Jin L, Martynowski D, Zheng S, Wada T, Xie W, and Li Y., 2010 Ligand-dependent and -independent regulation of PPAR gamma and orphan nuclear receptors., Xu HE* and Li Y., 2008 Molecular recognition of nitro-fatty acids by PPARγ., Li Y, Zhang J, Schopfer F, Martynowski D, Garcia-Barrio M, Kovach A, Suino-Powell K, Baker P, Freeman B, Chen Y, and Xu HE., 2008 Structural and Biochemical Basis for the Binding Selectivity of PPARγ to PGC1α., Li Y, Kovach A, Suino-Powell K, Martynowski D, and Xu HE*., 2008 Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans., Motola D, Cummins L, Rottiers V, Sharma K, Li T, Li Y, Powell K, Xu HE, Auchus RJ, Antebi A, and Mangelsdorf DJ., 2006

Areas of Focus

Drug-target interaction and structure-activity relationship
Molecular mechanisms of drug regulation

Publications

Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR., Zheng W, Lu Y, Tian S, Ma F, Wei Y, Xu S, Li Y*., 2018
Structural basis for the hepatoprotective effects of antihypertensive 1,4-dihydropyridine drugs., Wei Y, Lu Y, Zhu Y, Zheng W, Guo F, Yao B, Xu S, Wang Y, Jin L*, Li Y*., 2018
Identification of an Oleanane-type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity., Lu Y, Zheng W, Lin S, Guo F, Zhu Y, Wei Y, Liu X, Jin S, Jin L*, Li Y*., 2018
Structural insights into the nuclear import of the histone acetyltransferase males-absent-on-the-first by importin α1., Zheng W, Wang R, Liu X, Tian S, Yao B, Chen A, Jin S, Li Y*., 2018
A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly., Zheng W, Lu Y, Lin S, Wang R, Qiu L, Zhu Y, Yao B, Guo F, Jin S, Jin L, Li Y*., 2017
Selective targeting of nuclear receptor FXR by avermectin analogues with therapeutic effects on nonalcoholic fatty liver disease., Jin L, Wang R, Zhu Y, Zheng W, Han Y, Guo F, Ye F.B. & Li Y*., 2015
Targeting nuclear receptors with marine natural products., Yang C, Li Q, Li Y*., 2014
The antiparasitic drug ivermectin is a novel FXR ligand that regulates metabolism., Jin L, Feng X, Pan Z, Inaba Y, Qiu L, Zheng W, Lin S, Wang R, Rong H, Wang Z, Li S, Xie W, and Li Y*., 2013
Identification of the antibiotic ionomycin as an unexpected PPARγ ligand with a unique binding mode and effective glucose-lowering activity in a mouse model of diabetes., Zheng W, Feng X, Qiu L, Pan Z, Wang R, Lin S, Hou D, Jin L*, and Li Y*., 2013
Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells., Wang S, Wang Z, Lin S, Zheng W, Wang R, Jin S, Chen J, Jin L, and Li Y*., 2012
Revealing a steroid receptor ligand as a unique PPARγ agonist., Lin S, Han Y, Shi Y, Rong H, Zheng S, Jin S, Lin SY, Lin SC*, Li Y*., 2012
Structural basis for iloprost as a dual peroxisome proliferator-activated receptor alpha/delta agonist., Jin L, Lin S, Rong H, Zheng S, Jin S, Wang R, Li Y*., 2011
Structural and functional insights into nuclear receptor signaling., Jin L, Li Y*., 2010
Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor RORγ., Jin L, Martynowski D, Zheng S, Wada T, Xie W, and Li Y*., 2010
Ligand-dependent and -independent regulation of PPAR gamma and orphan nuclear receptors., Xu HE* and Li Y*., 2008
Molecular recognition of nitro-fatty acids by PPARγ., Li Y*, Zhang J, Schopfer F, Martynowski D, Garcia-Barrio M, Kovach A, Suino-Powell K, Baker P, Freeman B, Chen Y, and Xu HE*., 2008
Structural and Biochemical Basis for the Binding Selectivity of PPARγ to PGC1α., Li Y*, Kovach A, Suino-Powell K, Martynowski D, and Xu HE*., 2008
Identification of Ligands for DAF-12 that Govern Dauer Formation and Reproduction in C. elegans., Motola D, Cummins L, Rottiers V, Sharma K, Li T, Li Y, Powell K, Xu HE, Auchus RJ, Antebi A, and Mangelsdorf DJ., 2006

Drug Development Nuclear Receptors Metabolic Diseases Protein Structure Signaling Pathways Therapeutic Strategies Molecular Mechanisms Drug Repositioning Structure-Activity Relationship Pharmacology

Hua Gu - Tongji University

Yang Xiaotong - Shanghai Normal University

Dan Li - Shanghai Jiao Tong University

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