Professor | Shuhai Lin | Asia Growth Partners

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Name	Shuhai Lin
Contact Information	shuhai@xmu.edu.cn
Language ability	Chinese, English, German
Province	Fujian

Upload Avatar (500 x 500)

Name

Shuhai Lin

Contact Information

shuhai@xmu.edu.cn

Language ability

Chinese, English, German

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	2003 - BSc: College of Chinese Medicine, Guangzhou University of Chinese Medicine 2005 - MSc: School of Pharmaceutical Sciences, Sun Yat-sen University 2011 - Ph.D.: Department of Chemistry, Hong Kong Baptist University
Work Experience	2006-2007 - PepTech (Shanghai) Pharmaceutical Co., Ltd - Role not mentioned 2010-2010 - Exchange Student, Helmholtz Zentrum München, Germany 2011-2012 - Postdoctoral Fellow, Department of Chemistry, Hong Kong Baptist University 2012-2012 - Visiting Scholar, Helmholtz Zentrum München, Germany 2012-2014 - Research Assistant Professor, Department of Chemistry, Hong Kong Baptist University 2014-2015 - Senior Research Associate, School of Chinese Medicine, Hong Kong Baptist University 2015-2018 - Associate Professor, Professor, College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine 2018-2018 - Professor, Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital 2018-present - Professor, School of Life Sciences, Xiamen University

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

2003 - BSc: College of Chinese Medicine, Guangzhou University of Chinese Medicine
2005 - MSc: School of Pharmaceutical Sciences, Sun Yat-sen University
2011 - Ph.D.: Department of Chemistry, Hong Kong Baptist University

Work Experience

2006-2007 - PepTech (Shanghai) Pharmaceutical Co., Ltd - Role not mentioned
2010-2010 - Exchange Student, Helmholtz Zentrum München, Germany
2011-2012 - Postdoctoral Fellow, Department of Chemistry, Hong Kong Baptist University
2012-2012 - Visiting Scholar, Helmholtz Zentrum München, Germany
2012-2014 - Research Assistant Professor, Department of Chemistry, Hong Kong Baptist University
2014-2015 - Senior Research Associate, School of Chinese Medicine, Hong Kong Baptist University
2015-2018 - Associate Professor, Professor, College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine
2018-2018 - Professor, Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital
2018-present - Professor, School of Life Sciences, Xiamen University

Areas of Focus	Mitochondrial Metabolism Reprogramming in Tumorigenesis Metabolic Fluctuations in Tumor Immune Microenvironment Identification of Novel Chemical Reactions in Cells Drug Metabolomics and Efficacy Evaluation
Publications	PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism., Sun M, Li L, Niu Y, Wang Y, Yan Q, Xie F, Qiao Y, Song J, Sun H, Li Z, Lai S, Chang H, Zhang H, Wang J, Yang C, Zhao H, Tan J, Li Y, Liu S, Lu B, Liu M, Kong G, Zhao Y, Zhang C, Lin SH, Luo C, Zhang S, Shan C., 2023 Reply to Firneisz: 'Rebound increase in circulating dipeptidyl peptidase-4 (DPP4) enzyme activity after acute Covid-19'., Lin SH, Yang Z., 2023 Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis., Xu XQ, Xu T, Ji W, Wang C, Ren Y, Xiong X, Zhou X, Lin SH, Xu Y, Qiu Y., 2023 SLC1A3 facilitates Newcastle disease virus replication by regulating glutamine catabolism., Liu P, Tang N, Meng C, Yin Y, Qiu X, Tan L, Sun Y, Song C, Liu W, Liao Y, Lin SH, Ding C., 2022 Plasma metabolome and cytokine profile reveal glycylproline modulating antibody-fading in convalescent COVID-19 patients., Yang Z, Wu D, Lu S, Qiu Y, Hua Z, Tan F, Zhang C, Zhang L, Zhang D, Zhou X, Cai Z, Shang Y, Lin SH., 2022 CPT2 K79 Acetylation Regulates Platelet Lifespan., Fan X, Wang Y, Cai X, Shen Y, Xu T, Xu Y, Cheng J, Wang X, Zhang L, Dai J, Lin S, Liu J., 2022 Themis is indispensable for IL-2 and IL-15 signaling in T cells., Liu Y, Cong Y, Niu Y, Yuan Y, Tan F, Lai Q, Hu Y, Hou B, Li J, Lin C, Zheng H, Dong J, Tang J, Chen Q, Brzostek J, Zhang X, Chen XL, Wang HR, Gascoigne NRJ, Xu B, Lin SH, Fu G., 2022 Multi-Omics Comparison of the Spontaneous Diabetes Mellitus and Diet-Induced Prediabetic Macaque Models., Yang Z, Yang D, Tan F, Wong CW, Yang JY, Zhou D, Cai Z, Lin SH., 2021 Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells., Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, Tan L, Song C, Qiu X, Liao Y, Yu S, Liu X, Lin SH, Ding C., 2022 Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1., Shi Z, Gan G, Xu X, Zhang J, Yuan Y, Bi B, Gao X, Xu P, Zeng W, Li J, Ye Y, Zhou A, Zhang N, Liu W, Lin S, Mi J., 2021 IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella., Lin Q, Rong L, Jia X, Li R, Yu B, Hu J, Luo X, Badea SR, Xu C, Fu G, Lai K, Lee MC, Zhang B, Gong H, Zhou N, Chen XL, Lin SH, Fu G, Huang JD., 2021 Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer., Guo W, Li K, Sun B, Xu D, Tong L, Yin H, Liao Y, Song H, Wang T, Jing B, Hu M, Liu S, Kuang Y, Ling J, Li Q, Wu Y, Wang Q, Yao F, Zhou BP, Lin SH, Deng J., 2021 Omics study reveals abnormal alterations of breastmilk proteins and metabolites in puerperant women with COVID-19., Zhao Y, Shang Y, Ren Y, Bie Y, Qiu Y, Yuan Y, Zhao Y, Zou L, Lin SH, Zhou X., 2020 Plasma Metabolomic and Lipidomic Alterations Associated with COVID-19., Wu D, Shu T, Yang X, Song JX, Zhang M, Yao C, Liu W, Huang M, Yu Y, Yang Q, Zhu T, Xu J, Mu J, Wang Y, Wang H, Tang T, Ren Y, Wu Y, Lin SH, Qiu Y, Zhang DY, Shang Y, Zhou X., 2020 Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer., Jin N, Bi A, Lan X, Xu J, Wang X, Liu Y, Wang T, Tang S, Zeng H, Chen Z, Tan M, Ai J, Xie H, Zhang T, Liu D, Huang R, Song Y, Leung EL, Yao X, Ding J, Geng M, Lin SH, Huang M., 2019 Transketolase Deficiency Protects the Liver from DNA Damage by Increasing Levels of Ribose 5-Phosphate and Nucleotides., Li M, Lu Y, Li Y, Tong L, Gu XC, Meng J, Zhu Y, Wu L, Feng M, Tian N, Zhang P, Xu T, Lin SH, Tong X., 2019 Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer., Chen GQ, Gong RH, Yang DJ, Zhang G, Lu AP, Yan SC, Lin SH, Bian ZX., 2017

Areas of Focus

Mitochondrial Metabolism Reprogramming in Tumorigenesis
Metabolic Fluctuations in Tumor Immune Microenvironment
Identification of Novel Chemical Reactions in Cells
Drug Metabolomics and Efficacy Evaluation

Publications

PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism., Sun M, Li L, Niu Y, Wang Y, Yan Q, Xie F, Qiao Y, Song J, Sun H, Li Z, Lai S, Chang H, Zhang H, Wang J, Yang C, Zhao H, Tan J, Li Y, Liu S, Lu B, Liu M, Kong G, Zhao Y, Zhang C, Lin SH*, Luo C*, Zhang S*, Shan C*., 2023
Reply to Firneisz: 'Rebound increase in circulating dipeptidyl peptidase-4 (DPP4) enzyme activity after acute Covid-19'., Lin SH*, Yang Z., 2023
Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis., Xu XQ, Xu T, Ji W, Wang C, Ren Y, Xiong X, Zhou X*, Lin SH*, Xu Y*, Qiu Y*., 2023
SLC1A3 facilitates Newcastle disease virus replication by regulating glutamine catabolism., Liu P, Tang N, Meng C, Yin Y, Qiu X, Tan L, Sun Y, Song C, Liu W, Liao Y, Lin SH*, Ding C*., 2022
Plasma metabolome and cytokine profile reveal glycylproline modulating antibody-fading in convalescent COVID-19 patients., Yang Z, Wu D, Lu S, Qiu Y, Hua Z, Tan F, Zhang C, Zhang L, Zhang D, Zhou X*, Cai Z*, Shang Y*, Lin SH*., 2022
CPT2 K79 Acetylation Regulates Platelet Lifespan., Fan X, Wang Y, Cai X, Shen Y, Xu T, Xu Y, Cheng J, Wang X, Zhang L*, Dai J*, Lin S*, Liu J*., 2022
Themis is indispensable for IL-2 and IL-15 signaling in T cells., Liu Y, Cong Y, Niu Y, Yuan Y, Tan F, Lai Q, Hu Y, Hou B, Li J, Lin C, Zheng H, Dong J, Tang J, Chen Q, Brzostek J, Zhang X, Chen XL, Wang HR, Gascoigne NRJ, Xu B*, Lin SH*, Fu G*., 2022
Multi-Omics Comparison of the Spontaneous Diabetes Mellitus and Diet-Induced Prediabetic Macaque Models., Yang Z, Yang D, Tan F, Wong CW, Yang JY, Zhou D*, Cai Z*, Lin SH*., 2021
Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells., Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, Tan L, Song C, Qiu X, Liao Y, Yu S, Liu X, Lin SH*, Ding C*., 2022
Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1., Shi Z, Gan G, Xu X, Zhang J, Yuan Y, Bi B, Gao X, Xu P, Zeng W, Li J, Ye Y, Zhou A, Zhang N, Liu W*, Lin S*, Mi J*., 2021
IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella., Lin Q, Rong L, Jia X, Li R, Yu B, Hu J, Luo X, Badea SR, Xu C, Fu G, Lai K, Lee MC, Zhang B, Gong H, Zhou N, Chen XL, Lin SH*, Fu G*, Huang JD*., 2021
Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer., Guo W, Li K, Sun B, Xu D, Tong L, Yin H, Liao Y, Song H, Wang T, Jing B, Hu M, Liu S, Kuang Y, Ling J, Li Q, Wu Y, Wang Q, Yao F, Zhou BP, Lin SH*, Deng J*., 2021
Omics study reveals abnormal alterations of breastmilk proteins and metabolites in puerperant women with COVID-19., Zhao Y, Shang Y, Ren Y, Bie Y, Qiu Y, Yuan Y, Zhao Y, Zou L*, Lin SH*, Zhou X*., 2020
Plasma Metabolomic and Lipidomic Alterations Associated with COVID-19., Wu D, Shu T, Yang X, Song JX, Zhang M, Yao C, Liu W, Huang M, Yu Y, Yang Q, Zhu T, Xu J, Mu J, Wang Y, Wang H, Tang T, Ren Y, Wu Y, Lin SH*, Qiu Y*, Zhang DY*, Shang Y*, Zhou X*., 2020
Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer., Jin N, Bi A, Lan X, Xu J, Wang X, Liu Y, Wang T, Tang S, Zeng H, Chen Z, Tan M, Ai J, Xie H, Zhang T, Liu D, Huang R, Song Y, Leung EL, Yao X, Ding J, Geng M*, Lin SH*, Huang M*., 2019
Transketolase Deficiency Protects the Liver from DNA Damage by Increasing Levels of Ribose 5-Phosphate and Nucleotides., Li M, Lu Y, Li Y, Tong L, Gu XC, Meng J, Zhu Y, Wu L, Feng M, Tian N, Zhang P, Xu T, Lin SH*, Tong X*., 2019
Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer., Chen GQ, Gong RH, Yang DJ, Zhang G, Lu AP, Yan SC, Lin SH*, Bian ZX*., 2017

Mitochondria Metabolism Tumorigenesis Reprogramming Signal Pathways Metabolomics Metabolic Flux Cancer Biochemistry Cell Biology Single-Cell Subcellular Tumor Immune Microenvironment Data Analysis Big Data Bioinformatics Systems Biology Chemical Reactions Metabolic Pathways Mass Spectrometry Cell Metabolism Analytical Chemistry Chemical Biology Proteomics Cellular Networks Drug Metabolism Pharmacokinetics Pharmacodynamics Efficacy Pharmaceutical Sciences Biomedical Research

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