Upload Avatar (500 x 500)
Shuhai Lin
Life Science
Xiamen University
Fujian
Language: Chinese, English, German
Mitochondria
Metabolism
Tumorigenesis
Reprogramming
Signal Pathways
Metabolomics
Metabolic Flux
Cancer
Biochemistry
Cell Biology
Single-Cell
Subcellular
Tumor
Immune Microenvironment
Data Analysis
Big Data
Bioinformatics
Systems Biology
Chemical Reactions
Metabolic Pathways
Mass Spectrometry
Cell Metabolism
Analytical Chemistry
Chemical Biology
Proteomics
Cellular Networks
Drug Metabolism
Pharmacokinetics
Pharmacodynamics
Efficacy
Pharmaceutical Sciences
Biomedical Research
Areas of Focus
- Mitochondrial Metabolism Reprogramming in Tumorigenesis
- Metabolic Fluctuations in Tumor Immune Microenvironment
- Identification of Novel Chemical Reactions in Cells
- Drug Metabolomics and Efficacy Evaluation
Work Experience
- 2006-2007 - PepTech (Shanghai) Pharmaceutical Co., Ltd - Role not mentioned
- 2010-2010 - Exchange Student, Helmholtz Zentrum München, Germany
- 2011-2012 - Postdoctoral Fellow, Department of Chemistry, Hong Kong Baptist University
- 2012-2012 - Visiting Scholar, Helmholtz Zentrum München, Germany
- 2012-2014 - Research Assistant Professor, Department of Chemistry, Hong Kong Baptist University
- 2014-2015 - Senior Research Associate, School of Chinese Medicine, Hong Kong Baptist University
- 2015-2018 - Associate Professor, Professor, College of Basic Medical Sciences, Shanghai Jiao Tong University School of Medicine
- 2018-2018 - Professor, Center for Translational Medicine, Shanghai Jiao Tong University Affiliated Sixth People's Hospital
- 2018-present - Professor, School of Life Sciences, Xiamen University
Academic Background & Achievements
- 2003 - BSc: College of Chinese Medicine, Guangzhou University of Chinese Medicine
- 2005 - MSc: School of Pharmaceutical Sciences, Sun Yat-sen University
- 2011 - Ph.D.: Department of Chemistry, Hong Kong Baptist University
Publications
- PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism., Sun M, Li L, Niu Y, Wang Y, Yan Q, Xie F, Qiao Y, Song J, Sun H, Li Z, Lai S, Chang H, Zhang H, Wang J, Yang C, Zhao H, Tan J, Li Y, Liu S, Lu B, Liu M, Kong G, Zhao Y, Zhang C, Lin SH*, Luo C*, Zhang S*, Shan C*., 2023
- Reply to Firneisz: 'Rebound increase in circulating dipeptidyl peptidase-4 (DPP4) enzyme activity after acute Covid-19'., Lin SH*, Yang Z., 2023
- Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis., Xu XQ, Xu T, Ji W, Wang C, Ren Y, Xiong X, Zhou X*, Lin SH*, Xu Y*, Qiu Y*., 2023
- SLC1A3 facilitates Newcastle disease virus replication by regulating glutamine catabolism., Liu P, Tang N, Meng C, Yin Y, Qiu X, Tan L, Sun Y, Song C, Liu W, Liao Y, Lin SH*, Ding C*., 2022
- Plasma metabolome and cytokine profile reveal glycylproline modulating antibody-fading in convalescent COVID-19 patients., Yang Z, Wu D, Lu S, Qiu Y, Hua Z, Tan F, Zhang C, Zhang L, Zhang D, Zhou X*, Cai Z*, Shang Y*, Lin SH*., 2022
- CPT2 K79 Acetylation Regulates Platelet Lifespan., Fan X, Wang Y, Cai X, Shen Y, Xu T, Xu Y, Cheng J, Wang X, Zhang L*, Dai J*, Lin S*, Liu J*., 2022
- Themis is indispensable for IL-2 and IL-15 signaling in T cells., Liu Y, Cong Y, Niu Y, Yuan Y, Tan F, Lai Q, Hu Y, Hou B, Li J, Lin C, Zheng H, Dong J, Tang J, Chen Q, Brzostek J, Zhang X, Chen XL, Wang HR, Gascoigne NRJ, Xu B*, Lin SH*, Fu G*., 2022
- Multi-Omics Comparison of the Spontaneous Diabetes Mellitus and Diet-Induced Prediabetic Macaque Models., Yang Z, Yang D, Tan F, Wong CW, Yang JY, Zhou D*, Cai Z*, Lin SH*., 2021
- Newcastle disease virus degrades SIRT3 via PINK1-PRKN-dependent mitophagy to reprogram energy metabolism in infected cells., Gong Y, Tang N, Liu P, Sun Y, Lu S, Liu W, Tan L, Song C, Qiu X, Liao Y, Yu S, Liu X, Lin SH*, Ding C*., 2022
- Kynurenine derivative 3-HAA is an agonist ligand for transcription factor YY1., Shi Z, Gan G, Xu X, Zhang J, Yuan Y, Bi B, Gao X, Xu P, Zeng W, Li J, Ye Y, Zhou A, Zhang N, Liu W*, Lin S*, Mi J*., 2021
- IFN-γ-dependent NK cell activation is essential to metastasis suppression by engineered Salmonella., Lin Q, Rong L, Jia X, Li R, Yu B, Hu J, Luo X, Badea SR, Xu C, Fu G, Lai K, Lee MC, Zhang B, Gong H, Zhou N, Chen XL, Lin SH*, Fu G*, Huang JD*., 2021
- Dysregulated Glutamate Transporter SLC1A1 Propels Cystine Uptake via Xc- for Glutathione Synthesis in Lung Cancer., Guo W, Li K, Sun B, Xu D, Tong L, Yin H, Liao Y, Song H, Wang T, Jing B, Hu M, Liu S, Kuang Y, Ling J, Li Q, Wu Y, Wang Q, Yao F, Zhou BP, Lin SH*, Deng J*., 2021
- Omics study reveals abnormal alterations of breastmilk proteins and metabolites in puerperant women with COVID-19., Zhao Y, Shang Y, Ren Y, Bie Y, Qiu Y, Yuan Y, Zhao Y, Zou L*, Lin SH*, Zhou X*., 2020
- Plasma Metabolomic and Lipidomic Alterations Associated with COVID-19., Wu D, Shu T, Yang X, Song JX, Zhang M, Yao C, Liu W, Huang M, Yu Y, Yang Q, Zhu T, Xu J, Mu J, Wang Y, Wang H, Tang T, Ren Y, Wu Y, Lin SH*, Qiu Y*, Zhang DY*, Shang Y*, Zhou X*., 2020
- Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer., Jin N, Bi A, Lan X, Xu J, Wang X, Liu Y, Wang T, Tang S, Zeng H, Chen Z, Tan M, Ai J, Xie H, Zhang T, Liu D, Huang R, Song Y, Leung EL, Yao X, Ding J, Geng M*, Lin SH*, Huang M*., 2019
- Transketolase Deficiency Protects the Liver from DNA Damage by Increasing Levels of Ribose 5-Phosphate and Nucleotides., Li M, Lu Y, Li Y, Tong L, Gu XC, Meng J, Zhu Y, Wu L, Feng M, Tian N, Zhang P, Xu T, Lin SH*, Tong X*., 2019
- Halofuginone dually regulates autophagic flux through nutrient-sensing pathways in colorectal cancer., Chen GQ, Gong RH, Yang DJ, Zhang G, Lu AP, Yan SC, Lin SH*, Bian ZX*., 2017
