Professor | Tao Tao | Asia Growth Partners

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Name	Tao Tao
Contact Information	taotao@xmu.edu.cn
Language ability	English, Chinese
Province	Fujian

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Name

Tao Tao

Contact Information

taotao@xmu.edu.cn

Language ability

English, Chinese

Province

Fujian

University/Lab Affiliation and Title	Xiamen University
Faculty	Life Sciences
Academic Background & Achievements	1986 - B.S. in Biology: Wuhan University 1989 - M.S. in Biology: Wuhan University 2001 - Ph.D. in Biology: Case Western Reserve University
Work Experience	1989-1994 - Wuhan University - Assistant/ Lecturer/ Deputy Director of Graduate Education 2001-2003 - McGill University - Post-doctoral Fellow 2004-Present - Xiamen University - Professor, School of Life Sciences 2008-2012 - Xiamen University - Vice Dean, Graduate School 2012-2017 - Xiamen University - Executive Dean, Graduate School 2017-Present - Xiamen University - Dean, Overseas Education College/International College
Awards	2013-2017: Leader of '973' Project on p53 Functional Regulation Mechanism 2012-2016: Key Member of '973' Project on Mesodermal Stem Cell Regulation 2007-2010: Subproject Leader of '863' Major Project on Human Liver Protein Interaction 2010-2012: National Natural Science Foundation Project on Arx Nuclear Localization 2011: National Natural Science Foundation Project on PSMB6 in Liver Cancer 2013-2016: National Natural Science Foundation Project on Arx in Myoblast Differentiation

University/Lab Affiliation and Title

Xiamen University

Faculty

Life Sciences

Academic Background & Achievements

1986 - B.S. in Biology: Wuhan University
1989 - M.S. in Biology: Wuhan University
2001 - Ph.D. in Biology: Case Western Reserve University

Work Experience

1989-1994 - Wuhan University - Assistant/ Lecturer/ Deputy Director of Graduate Education
2001-2003 - McGill University - Post-doctoral Fellow
2004-Present - Xiamen University - Professor, School of Life Sciences
2008-2012 - Xiamen University - Vice Dean, Graduate School
2012-2017 - Xiamen University - Executive Dean, Graduate School
2017-Present - Xiamen University - Dean, Overseas Education College/International College

Awards

2013-2017: Leader of '973' Project on p53 Functional Regulation Mechanism
2012-2016: Key Member of '973' Project on Mesodermal Stem Cell Regulation
2007-2010: Subproject Leader of '863' Major Project on Human Liver Protein Interaction
2010-2012: National Natural Science Foundation Project on Arx Nuclear Localization
2011: National Natural Science Foundation Project on PSMB6 in Liver Cancer
2013-2016: National Natural Science Foundation Project on Arx in Myoblast Differentiation

Areas of Focus	Molecular mechanisms and functions of protein transport between the nucleus and cytoplasm Transcriptional regulation and post-translational modification in cell differentiation, tissue development, and disease
Publications	Identification and validation of the phosphorylation sites on Aristaless-related homeobox protein, Xiuyu Shi, Wenbo Lin, Xiang Gao, Wen Xie, Jeffrey A Golden, Tao Tao, 2020 PIK3R2/Pik3r2 activating mutations result in brain overgrowth and EEG changes, Xiuyu Shi, Youngshin Lim, Abigail K. Myers, Brenna L. Stallings, Almedia Mccoy, Jordan Zeiger, Joshua Scheck, Ginam Cho, Eric D. Marsh, Ghayda M. Mirzaa, Tao Tao, Jeffrey A. Golden, 2020 PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function, Xujie Liu, Wenbo Lin, Xiuyu Shi, Rebecca G. Davies, Kylie M. Wagstaff, Tao Tao, David A. Jans, 2018 DNA methylation of a non-CpG island promoter represses NQO1 expression in rat arsenic-transformed lung epithelial cells, Huang N, Pei X, Lin W, Chiu JF, Tao T, Li G, 2018 STK24 expression is modulated by DNA copy number/methylation in lung adenocarcinoma and predicts poor survival, Huang N, Lin W, Shi X, Tao T, 2018 Phosphatase UBLCP1 controls proteasome assembly, Sun S, Liu S, Zhang Z, Zeng W, Sun C, Tao T, Lin X, Feng XH, 2017 Competitive regulation of IPO4 transcription by ELK1 and GABP, Xu P, Lin W, Liu F, Tartakoff A, Tao T, 2017 Nuclear import of Nkx2-2 is mediated by multiple pathways, Lin W, Xu P, Guo Y, Jia Q, Tao T, 2017 Characterization of amino acid residues within the N-terminal region of Ubc9 that play a role in Ubc9 nuclear localization, Sekhri P, Tao T, Kaplan F, Zhang XD, 2015 The p53-induced factor Ei24 inhibits nuclear import through an importin β–binding–like domain, Lieu K, Shim EH, Wang JL, Lokareddy RK, Tao T, Cingolani G, Zambetti GP, Jans DA, 2014 A novel role of proteasomal β1 subunit in tumoriGenesis, Yuan FQ, Ma YN, You P, Lin WB, Lu HJ, Yu YH, Wang XM, Jiang J, Yang PY, Ma QL, Tao T, 2013 Nuclear import of aristaless-related homeobox protein via its NLS1 regulates its transcriptional function, Ye WD, Lin WB, Tartakoff AM, Ma QL, Tao T, 2013 Expression and subcellular distribution of importin 13 are regulated in brain development, You P, Peng Z, Wang YW, Tao T, 2013 Proteomic profiling of expression of proteasomal subunits from livers of mice treated with diethylnitrosamine, Yuan F, Lu J, You P, Yang Z, Yang P, Ma QL, Tao T, 2013 Increased importin 13 activity is associated with the pathoGenesis of pterygium, Xu K, Tao T, Jie J, Lu XD, Li XZ, Mehmood MA, He H, Liu Z, Xiao X, Yang J, Ma JX, Li W, Zhou YP, Liu ZG, 2013 Karyopherins in nuclear transport of homeodomain proteins during development, Ye WD, Lin WB, Tartakoff AM, Tao T, 2011 Gene diagnosis of oculopharyngeal muscular dystrophy in a Chinese family by a GeneScan method, You P, Ma QL, Tao T, 2010 Comparative and evolutionary aspects of macromolecular translocation across membranes, Tartakoff AM, Tao T, 2010 ARHI (DIRAS 3), an imprinted tumor suppressor Gene, binds to importins, and blocks nuclear import process of cargo proteins, Huang S, Chang IS, Lin WB, Ye WD, Luo RZ, Lu Z, Lu Y, Zhang K, Liao WS, Tao T, Bast Jr RC, Chen X, Yu Y, 2010 Importin 13 serves as a potential marker for corneal epithelial progenitor cells, Wang H, Tao T, Tang J, Mao YH, Li W, Peng J, Tan G, Zhou YP, Zhong JX, Tseng SC, Kawakita T, Zhao YX, Liu ZG, 2009 The roles of multiple importins for nuclear import of murine aristaless-related homeobox protein, Lin WB, Ye WD, Cai LL, Meng XY, Ke GF, Huang CX, Peng Z, Yu YH, Golden JA, Tartakoff AM, Tao T, 2009 Evolutionary and transcriptional analysis of karyopherin β superfamily proteins, Quan Y, Ji ZL, Wang X, Tartakoff AM, Tao T, 2008 Subunit-subunit interactions in the human 26s proteasome, Chen C, Huang CX, Chen SH, Liang J, Lin WB, Ke GF, Zhang HX, Wang B, Huang J, Han ZG, Ma LX, Huo KK, Yang XM, Yang PY, He FC, Tao T, 2008 Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin, Liang J, Ke GF, You WJ, Peng Z, Lan J, Kalesse M, Tartakoff AM, Kaplan F, Tao T, 2008 GEPS: the Gene Expression Pattern Scanner, Wang YP, Liang L, Han BC, Quan Y, Wang X, Tao T, Ji ZL, 2006

Areas of Focus

Molecular mechanisms and functions of protein transport between the nucleus and cytoplasm
Transcriptional regulation and post-translational modification in cell differentiation, tissue development, and disease

Publications

Identification and validation of the phosphorylation sites on Aristaless-related homeobox protein, Xiuyu Shi, Wenbo Lin, Xiang Gao, Wen Xie, Jeffrey A Golden, Tao Tao, 2020
PIK3R2/Pik3r2 activating mutations result in brain overgrowth and EEG changes, Xiuyu Shi, Youngshin Lim, Abigail K. Myers, Brenna L. Stallings, Almedia Mccoy, Jordan Zeiger, Joshua Scheck, Ginam Cho, Eric D. Marsh, Ghayda M. Mirzaa, Tao Tao, Jeffrey A. Golden, 2020
PKA-site phosphorylation of importin13 regulates its subcellular localization and nuclear transport function, Xujie Liu, Wenbo Lin, Xiuyu Shi, Rebecca G. Davies, Kylie M. Wagstaff, Tao Tao, David A. Jans, 2018
DNA methylation of a non-CpG island promoter represses NQO1 expression in rat arsenic-transformed lung epithelial cells, Huang N, Pei X, Lin W, Chiu JF, Tao T, Li G, 2018
STK24 expression is modulated by DNA copy number/methylation in lung adenocarcinoma and predicts poor survival, Huang N, Lin W, Shi X, Tao T, 2018
Phosphatase UBLCP1 controls proteasome assembly, Sun S, Liu S, Zhang Z, Zeng W, Sun C, Tao T, Lin X, Feng XH, 2017
Competitive regulation of IPO4 transcription by ELK1 and GABP, Xu P, Lin W, Liu F, Tartakoff A, Tao T, 2017
Nuclear import of Nkx2-2 is mediated by multiple pathways, Lin W, Xu P, Guo Y, Jia Q, Tao T, 2017
Characterization of amino acid residues within the N-terminal region of Ubc9 that play a role in Ubc9 nuclear localization, Sekhri P, Tao T, Kaplan F, Zhang XD, 2015
The p53-induced factor Ei24 inhibits nuclear import through an importin β–binding–like domain, Lieu K, Shim EH, Wang JL, Lokareddy RK, Tao T, Cingolani G, Zambetti GP, Jans DA, 2014
A novel role of proteasomal β1 subunit in tumoriGenesis, Yuan FQ, Ma YN, You P, Lin WB, Lu HJ, Yu YH, Wang XM, Jiang J, Yang PY, Ma QL, Tao T, 2013
Nuclear import of aristaless-related homeobox protein via its NLS1 regulates its transcriptional function, Ye WD, Lin WB, Tartakoff AM, Ma QL, Tao T, 2013
Expression and subcellular distribution of importin 13 are regulated in brain development, You P, Peng Z, Wang YW, Tao T, 2013
Proteomic profiling of expression of proteasomal subunits from livers of mice treated with diethylnitrosamine, Yuan F, Lu J, You P, Yang Z, Yang P, Ma QL, Tao T, 2013
Increased importin 13 activity is associated with the pathoGenesis of pterygium, Xu K, Tao T, Jie J, Lu XD, Li XZ, Mehmood MA, He H, Liu Z, Xiao X, Yang J, Ma JX, Li W, Zhou YP, Liu ZG, 2013
Karyopherins in nuclear transport of homeodomain proteins during development, Ye WD, Lin WB, Tartakoff AM, Tao T, 2011
Gene diagnosis of oculopharyngeal muscular dystrophy in a Chinese family by a GeneScan method, You P, Ma QL, Tao T, 2010
Comparative and evolutionary aspects of macromolecular translocation across membranes, Tartakoff AM, Tao T, 2010
ARHI (DIRAS 3), an imprinted tumor suppressor Gene, binds to importins, and blocks nuclear import process of cargo proteins, Huang S, Chang IS, Lin WB, Ye WD, Luo RZ, Lu Z, Lu Y, Zhang K, Liao WS, Tao T, Bast Jr RC, Chen X, Yu Y, 2010
Importin 13 serves as a potential marker for corneal epithelial progenitor cells, Wang H, Tao T, Tang J, Mao YH, Li W, Peng J, Tan G, Zhou YP, Zhong JX, Tseng SC, Kawakita T, Zhao YX, Liu ZG, 2009
The roles of multiple importins for nuclear import of murine aristaless-related homeobox protein, Lin WB, Ye WD, Cai LL, Meng XY, Ke GF, Huang CX, Peng Z, Yu YH, Golden JA, Tartakoff AM, Tao T, 2009
Evolutionary and transcriptional analysis of karyopherin β superfamily proteins, Quan Y, Ji ZL, Wang X, Tartakoff AM, Tao T, 2008
Subunit-subunit interactions in the human 26s proteasome, Chen C, Huang CX, Chen SH, Liang J, Lin WB, Ke GF, Zhang HX, Wang B, Huang J, Han ZG, Ma LX, Huo KK, Yang XM, Yang PY, He FC, Tao T, 2008
Interaction between importin 13 and myopodin suggests a nuclear import pathway for myopodin, Liang J, Ke GF, You WJ, Peng Z, Lan J, Kalesse M, Tartakoff AM, Kaplan F, Tao T, 2008
GEPS: the Gene Expression Pattern Scanner, Wang YP, Liang L, Han BC, Quan Y, Wang X, Tao T, Ji ZL, 2006

Protein Transport Nucleus Cytoplasm Molecular Mechanisms Transcriptional Regulation Post-Translational Modification Cell Differentiation Tissue Development Disease Karyopherins

Jiemin Weng - East China Normal University

Zhong Tao - East China Normal University

Aifu Lin - Zhejiang University

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