Professor | Xinquan Wang | Asia Growth Partners

Name	Xinquan Wang
Contact Information	xinquanwang@mail.tsinghua.edu.cn
Language ability	Chinese, English
Province	Beijing

Name

Xinquan Wang

Contact Information

xinquanwang@mail.tsinghua.edu.cn

Language ability

Chinese, English

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	1990-1995 Bachelor: Fudan University 1995-2000 PhD: Institute of Biophysics, Chinese Academy of Sciences
Work Experience	2000-2003 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher 2003-2008 - Stanford University, USA - Postdoctoral Researcher 2008-2013 - Tsinghua University, School of Life Sciences - Associate Professor 2013-Present - Tsinghua University, School of Life Sciences - Professor

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

1990-1995 Bachelor: Fudan University
1995-2000 PhD: Institute of Biophysics, Chinese Academy of Sciences

Work Experience

2000-2003 - Institute of Biophysics, Chinese Academy of Sciences - Assistant Researcher
2003-2008 - Stanford University, USA - Postdoctoral Researcher
2008-2013 - Tsinghua University, School of Life Sciences - Associate Professor
2013-Present - Tsinghua University, School of Life Sciences - Professor

Areas of Focus	Structural Biology
Publications	Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2, Wang X* et al., 2022 Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry, Wang X* et al., 2021 Bat and pangolin coronavirus spike glycoprotein structures provide insights into sars-cov-2 evolution, Wang X* et al., 2021 Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution, Wang X* et al., 2020 Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor, Wang X* et al., 2020 Structural definition of a neutralization epitope on the n-terminal domain of mers-cov spike glycoprotein, Wang X* et al., 2019 Functional relevance of interleukin-1 receptor inter-domain flexibility for cytokine binding and signaling, Wang X* et al., 2019 Structural definition of a unique neutralization epitope on the receptor-binding domain of mers-cov spike glycoprotein, Wang X* et al., 2018 Cryo-em structure of the sars coronavirus spike glycoprotein in complex with its host cell receptor ace2, Wang X* et al., 2018 Cryo-electron microscopy structures of the sars-cov spike glycoprotein reveal a prerequisite conformational state for receptor binding, Wang X* et al., 2017 Potent neutralization of mers-cov by human neutralizing monoclonal antibodies to the viral spike glycoprotein, Wang X* et al., 2014 Structure of mers-cov spike receptor-binding domain complexed with human receptor dpp4, Wang X* et al., 2013 Structural basis for r-spondin recognition by lgr4/5/6 receptors, Wang X* et al., 2013 Structural insights into the interaction of il-33 with its receptors, Wang X* et al., 2013 Structural insights into the assembly and activation of il-1beta with its receptors, Wang X* et al., 2010

Areas of Focus

Structural Biology

Publications

Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2, Wang X* et al., 2022
Antibody neutralization of SARS-CoV-2 through ACE2 receptor mimicry, Wang X* et al., 2021
Bat and pangolin coronavirus spike glycoprotein structures provide insights into sars-cov-2 evolution, Wang X* et al., 2021
Cryo-EM structures of HKU2 and SADS-CoV spike glycoproteins provide insights into coronavirus evolution, Wang X* et al., 2020
Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor, Wang X* et al., 2020
Structural definition of a neutralization epitope on the n-terminal domain of mers-cov spike glycoprotein, Wang X* et al., 2019
Functional relevance of interleukin-1 receptor inter-domain flexibility for cytokine binding and signaling, Wang X* et al., 2019
Structural definition of a unique neutralization epitope on the receptor-binding domain of mers-cov spike glycoprotein, Wang X* et al., 2018
Cryo-em structure of the sars coronavirus spike glycoprotein in complex with its host cell receptor ace2, Wang X* et al., 2018
Cryo-electron microscopy structures of the sars-cov spike glycoprotein reveal a prerequisite conformational state for receptor binding, Wang X* et al., 2017
Potent neutralization of mers-cov by human neutralizing monoclonal antibodies to the viral spike glycoprotein, Wang X* et al., 2014
Structure of mers-cov spike receptor-binding domain complexed with human receptor dpp4, Wang X* et al., 2013
Structural basis for r-spondin recognition by lgr4/5/6 receptors, Wang X* et al., 2013
Structural insights into the interaction of il-33 with its receptors, Wang X* et al., 2013
Structural insights into the assembly and activation of il-1beta with its receptors, Wang X* et al., 2010

Structural Biology X-Ray Crystallography Biochemistry Biophysics Cytokines Host Immune Response Viral Infection Immune Evasion Cellular Mechanisms Protein Structures

Fang Yu - Shanghai Normal University

Lu Qing - Shanghai Jiao Tong University

Geng Wu - Shanghai Jiao Tong University

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