Areas of Focus
- Structural biology, cellular and molecular biology, and biochemistry research focusing on cell signal sensing and energy metabolism
Work Experience
- 2008-2013 Special Research Fellow, Doctoral Supervisor
- 2013-present Professor, Doctoral Supervisor at Tsinghua University School of Life Sciences
Academic Background & Achievements
- 1995-1999 Bachelor: Jilin University
- 1999-2003 PhD: Peking Union Medical College
- 2003-2004 Senior Visiting Scholar: University of Lübeck
- 2004-2008 Postdoctoral Researcher: University of Texas Southwestern Medical Center
Publications
- The coupling mechanism of mammalian mitochondrial complex I, Gu et.al., 2022
- Mechanism of siRNA production by a plant Dicer-RNA complex in dicing-competent conformation, Wang et.al., 2021
- Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1, Gu et.al., 2019
- Structural basis of ubiquitin modification by the Legionella effector SdeA, Dong et.al., 2018
- Architecture of human mitochondrial respiratory megacomplex I2III2IV2, Guo et.al., 2017
- Structure of mammalian respiratory supercomplex I1III2IV1, Wu et.al., 2016
- The architecture of the mammalian respirasome, Gu et.al., 2016
- TMCO1 Is an ER Ca(2+) Load-Activated Ca(2+) Channel, Wang et.al., 2016
- Architecture of the Mammalian Mechanosensitive Piezo1 Channel, Ge et.al., 2015
- Structure of the eukaryotic MCM complex at 3.8 Å, Li et.al., 2015
- Structural basis for hijacking CBFβ and CUL5 E3 ligase complex by HIV-1 Vif, Guo et.al., 2014
- Structural insight into the type-II mitochondrial NADH dehydrogenases, Feng Y et.al., 2012
- Structural insight into brassinosteroid perception by BRI1, She et.al., 2011
Awards
- Beijing Science and Technology Award, Second Class
- 2016 Top Ten Advances in Life Sciences in China
