Areas of Focus
- Structural and dynamic properties of non-coding RNA and intrinsically disordered proteins
- Development of new NMR techniques, sample labeling methods, and computational tools
- Structural modeling of highly variable biomolecules and high-throughput drug screening
Work Experience
- 1997-1999 Engineer at Fujian Sida Computer Company
- 2010-2013 Postdoctoral Researcher at Purdue University, Department of Chemistry
- 2013-2016 Postdoctoral Researcher at University of Michigan and Duke University
- 2016-2024 Assistant Professor at Tsinghua University, School of Life Sciences
- 2024-present Associate Professor at Tsinghua University, School of Life Sciences
Academic Background & Achievements
- 1993-1997 Bachelor: Tsinghua University, Department of Modern Applied Physics
- 2000-2003 Master: Tsinghua University, Department of Biological Science and Technology
- 2004-2009 PhD: Purdue University, Department of Chemistry
Publications
- Simulating diffraction photographs based on molecular dynamics trajectories of a protein crystal: a new option to examine structure-solving strategies in protein crystallography, Liu N, Mikhailovskii O, Skrynnikov NR, Xue Y, 2023
- Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein, Luan X, Li X, Li Y, Su G, Yin W, Jiang Y, Xu N, Wang F, Cheng W, Jin Y, Zhang L, Xu HE, Xue Y, Zhang S, 2022
- Insights into the client protein release mechanism of the ATP-independent chaperone Spy, He W, Li X, Xue H, Yang Y, Mencius J, Bai L, Zhang J, Xu J, Wu B, Xue Y, Quan S, 2022
- Rational design of hairpin RNA excited states reveals multi-step transitions, Han G, Xue Y, 2022
- NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex, Li W, Kou J, Qin J, Li L, Zhang Z, Pan Y, Xue Y, Du W, 2021
- Characteristic chemical probing patterns of loop motifs improve prediction accuracy of RNA secondary structures, Cao J, Xue Y, 2021
- Chemical shift prediction of RNA imino groups: application toward characterizing RNA excited states, Wang Y, Han G, Jiang X, Yuwen T, Xue Y, 2021
- The microtubule end-binding affinity of EB1 is enhanced by a dimeric organization that is susceptible to phosphorylation, Song Y, Zhang Y, Pan Y, He J, Wang Y, Chen W, Guo J, Deng H, Xue Y, Fang X, Liang X, 2020
