Professor | Yi Xue | Asia Growth Partners

Name	Yi Xue
Contact Information	yixue@mail.tsinghua.edu.cn
Language ability	English, Chinese
Province	Beijing

Name

Yi Xue

Contact Information

yixue@mail.tsinghua.edu.cn

Language ability

English, Chinese

Province

Beijing

University/Lab Affiliation and Title	Tsinghua University
Faculty	Life Sciences
Academic Background & Achievements	1993-1997 Bachelor: Tsinghua University, Department of Modern Applied Physics 2000-2003 Master: Tsinghua University, Department of Biological Science and Technology 2004-2009 PhD: Purdue University, Department of Chemistry
Work Experience	1997-1999 Engineer at Fujian Sida Computer Company 2010-2013 Postdoctoral Researcher at Purdue University, Department of Chemistry 2013-2016 Postdoctoral Researcher at University of Michigan and Duke University 2016-2024 Assistant Professor at Tsinghua University, School of Life Sciences 2024-present Associate Professor at Tsinghua University, School of Life Sciences

University/Lab Affiliation and Title

Tsinghua University

Faculty

Life Sciences

Academic Background & Achievements

1993-1997 Bachelor: Tsinghua University, Department of Modern Applied Physics
2000-2003 Master: Tsinghua University, Department of Biological Science and Technology
2004-2009 PhD: Purdue University, Department of Chemistry

Work Experience

1997-1999 Engineer at Fujian Sida Computer Company
2010-2013 Postdoctoral Researcher at Purdue University, Department of Chemistry
2013-2016 Postdoctoral Researcher at University of Michigan and Duke University
2016-2024 Assistant Professor at Tsinghua University, School of Life Sciences
2024-present Associate Professor at Tsinghua University, School of Life Sciences

Areas of Focus	Structural and dynamic properties of non-coding RNA and intrinsically disordered proteins Development of new NMR techniques, sample labeling methods, and computational tools Structural modeling of highly variable biomolecules and high-throughput drug screening
Publications	Simulating diffraction photographs based on molecular dynamics trajectories of a protein crystal: a new option to examine structure-solving strategies in protein crystallography, Liu N, Mikhailovskii O, Skrynnikov NR, Xue Y, 2023 Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein, Luan X, Li X, Li Y, Su G, Yin W, Jiang Y, Xu N, Wang F, Cheng W, Jin Y, Zhang L, Xu HE, Xue Y, Zhang S, 2022 Insights into the client protein release mechanism of the ATP-independent chaperone Spy, He W, Li X, Xue H, Yang Y, Mencius J, Bai L, Zhang J, Xu J, Wu B, Xue Y, Quan S, 2022 Rational design of hairpin RNA excited states reveals multi-step transitions, Han G, Xue Y, 2022 NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex, Li W, Kou J, Qin J, Li L, Zhang Z, Pan Y, Xue Y, Du W, 2021 Characteristic chemical probing patterns of loop motifs improve prediction accuracy of RNA secondary structures, Cao J, Xue Y, 2021 Chemical shift prediction of RNA imino groups: application toward characterizing RNA excited states, Wang Y, Han G, Jiang X, Yuwen T, Xue Y, 2021 The microtubule end-binding affinity of EB1 is enhanced by a dimeric organization that is susceptible to phosphorylation, Song Y, Zhang Y, Pan Y, He J, Wang Y, Chen W, Guo J, Deng H, Xue Y, Fang X, Liang X, 2020

Areas of Focus

Structural and dynamic properties of non-coding RNA and intrinsically disordered proteins
Development of new NMR techniques, sample labeling methods, and computational tools
Structural modeling of highly variable biomolecules and high-throughput drug screening

Publications

Simulating diffraction photographs based on molecular dynamics trajectories of a protein crystal: a new option to examine structure-solving strategies in protein crystallography, Liu N, Mikhailovskii O, Skrynnikov NR, Xue Y, 2023
Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein, Luan X, Li X, Li Y, Su G, Yin W, Jiang Y, Xu N, Wang F, Cheng W, Jin Y, Zhang L, Xu HE, Xue Y, Zhang S, 2022
Insights into the client protein release mechanism of the ATP-independent chaperone Spy, He W, Li X, Xue H, Yang Y, Mencius J, Bai L, Zhang J, Xu J, Wu B, Xue Y, Quan S, 2022
Rational design of hairpin RNA excited states reveals multi-step transitions, Han G, Xue Y, 2022
NADPH levels affect cellular epigenetic state by inhibiting HDAC3–Ncor complex, Li W, Kou J, Qin J, Li L, Zhang Z, Pan Y, Xue Y, Du W, 2021
Characteristic chemical probing patterns of loop motifs improve prediction accuracy of RNA secondary structures, Cao J, Xue Y, 2021
Chemical shift prediction of RNA imino groups: application toward characterizing RNA excited states, Wang Y, Han G, Jiang X, Yuwen T, Xue Y, 2021
The microtubule end-binding affinity of EB1 is enhanced by a dimeric organization that is susceptible to phosphorylation, Song Y, Zhang Y, Pan Y, He J, Wang Y, Chen W, Guo J, Deng H, Xue Y, Fang X, Liang X, 2020

Non-Coding Rna Intrinsically Disordered Proteins Nmr Techniques Sample Labeling Computational Tools Structural Modeling Biomolecules Drug Screening Molecular Dynamics High-Throughput

Chuanwen Sun - Shanghai Normal University

Haipeng Gong - Tsinghua University

Chuanwen Sun - Shanghai Normal University

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