Areas of Focus
- Transmembrane transport of substances
- Structure and function of membrane transport proteins related to diseases
- Structure and working mechanism of voltage-gated ion channels
- Regulatory mechanisms of cholesterol metabolism
Work Experience
- 2005-2007 Postdoctoral Researcher, Department of Molecular Biology, Princeton University
- 2007-2017 Professor and Doctoral Supervisor, School of Medicine and Life Sciences, Tsinghua University
- 2017-2022 Shirley Tilghman Endowed Chair Professor, Department of Molecular Biology, Princeton University; Adjunct Professor, Department of Chemistry
- 2022-present Professor and Doctoral Supervisor, School of Life Sciences, Tsinghua University
Academic Background & Achievements
- 1996-2000 Bachelor of Biological Sciences and Technology, Tsinghua University
- 2000-2004 PhD in Molecular Biology, Princeton University
Publications
- Structural basis for the severe adverse interaction of sofosbuvir and amiodarone on L-type Cav channels, Nieng Yan, 2022
- Structure of human Cav2.2 channel blocked by the painkiller ziconotide, Nieng Yan, 2021
- Structural basis for catalysis and substrate specificity of human ACAT1, Nieng Yan, 2020
- Structures of human Nav1.7 channel in complex with auxiliary subunits and animal toxins, Nieng Yan, 2019
- Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1, Nieng Yan, 2018
- Structure of a eukaryotic voltage-gated sodium channel at near-atomic resolution, Nieng Yan, 2017
- Structural basis for the gating mechanism of the type 2 ryanodine receptor RyR2, Nieng Yan, 2016
- Structure of the voltage-gated calcium channel Cav1.1 at 3.6 Å resolution, Nieng Yan, 2016
- Structure of the voltage-gated calcium channel Cav1.1 complex, Nieng Yan, 2015
- Molecular basis of ligand recognition and transport by glucose transporters, Nieng Yan, 2015
- Structure of the rabbit ryanodine receptor RyR1 at near-atomic resolution, Nieng Yan, 2015
- Crystal structure of the human glucose transporter GLUT1, Nieng Yan, 2014
- Crystal structure of a bacterial homologue of glucose transporters GLUT1-4, Nieng Yan, 2012
- Crystal structure of an orthologue of the NaChBac voltage-gated sodium channel, Nieng Yan, 2012
- Structure of a fucose transporter in an outward-open conformation, Nieng Yan, 2010
