Xuerui Yang

yangxuerui@tsinghua.edu.cn

English, Chinese

Beijing

Tsinghua University

Life Sciences

• 1999-2003 Bachelor in Chemical Engineering, Tsinghua University
• 2003-2009 Dual PhD in Chemical Engineering/Biochemistry and Molecular Biology, Michigan State University
• 2009-2012 Postdoctoral Researcher, Irving Cancer Research Center, Systems Biology Joint Center, Columbia University

• 2012-Present Assistant Professor/Associate Professor, School of Life Sciences, Tsinghua University

RNA Bioinformatics and Cancer Systems Biology
Multimodal, multiscale, multi-omics data integration and multilevel regulatory networks and mechanisms analysis
Development of deep learning tools for large-scale complex biological data
Systematic, quantitative analysis of the translatome and the involvement of translational regulation in cancer
Systematic analysis of the non-coding transcriptome and systematic identification of non-coding RNA biological functions

• Reanalysis of ribosome profiling datasets reveals a function of rocaglamide A in perturbing the dynamics of translation elongation via eIF4A, Li, F., Fang, J., Yu, Y., Hao, S., Zou, Q., Zeng, Q., and Yang, X.*, 2023
• Survey of the binding preferences of RNA-binding proteins to RNA editing events, Hu, X., Zou, Q., Yao, L., and Yang, X.*, 2022
• De novo reconstruction of cell interaction landscapes from single-cell spatial transcriptome data with DeepLinc, Li, R. and Yang, X.*, 2022
• Identification of the cross-strand chimeric RNAs generated by fusions of bi-directional transcripts, Wang, Y., Zou, Q., Li, F., Zhao, W., Xu, H., Zhang, W., Deng, H., and Yang, X.*, 2021
• Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation, Wang, X., Hu, X., Song, W., Xu, H., Xiao, Z., Huang, R., Bai, Q., Zhang, F., Chen, Y., Liu, Y., Fang, J., Li, X., Shen, Q., Zhao, H., and Yang, X.*, 2021
• A Simple Blocking PCR-Based Method for the Synthesis of High-Copy dsDNA Tandem Repeats, Wang, X. and Yang, X.*, 2020
• COPII mitigates ER stress by promoting formation of ER whorls, Xu, F., Du, W., Zou, Q., Wang, Y., Zhang, X., Xing, X., Li, Y., Zhang, D., Wang, H., Zhang, W., Hu, X., Liu, X., Liu, X., Zhang, S., Yu, J., Fang, J., Li, F., Zhou, Y., Yue, T., Mi, N., Deng, H., Zou, P., Chen, X., Yang, X.*, and Yu, L.*, 2021
• Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells, Zhu, M., Zou, Q., Huang, R., Li, Y., Xing, X., Fang, J., Ma, L., Li, L., Yang, X.*, and Yu, L.*, 2021
• eIF3 Associates with 80S Ribosomes to Promote Translation Elongation, Mitochondrial Homeostasis, and Muscle Health, Lin, Y., Li, F., Huang, L., Polte, C., Duan, H., Fang, J., Sun, L., Xing, X., Tian, G., Cheng, Y.*, Ignatova, Z., Yang, X.*, and Wolf, D.A.*, 2020
• Survey of the translation shifts in hepatocellular carcinoma with ribosome profiling, Zou, Q., Xiao, Z., Huang, R., Wang, X., Wang, X., Zhao, H., and Yang, X.*, 2019
• Dependency of the Cancer-Specific Transcriptional Regulation Circuitry on the Promoter DNA Methylome, Liu, Y., Liu, Y., Huang, R., Song, W., Wang, J., Xiao, Z., Dong, S., Yang, Y., and Yang, X.*, 2019
• Function of HNRNPC in breast cancer cells by controlling the dsRNA-induced interferon response, Wu, Y., Zhao, W., Liu, Y., Tan, X., Li, X., Zou, Q., Xiao, Z., Xu, H., Wang, Y., and Yang, X.*, 2018
• Oncogenic Properties of NEAT1 in Prostate Cancer Cells Depend on the CDC5L-AGRN Transcriptional Regulation Circuit, Li, X., Wang, X., Song, W., Xu, H., Huang, R., Wang, Y., Zhao, W., Xiao, Z., and Yang, X.*, 2018
• De novo annotation and characterization of the translatome with ribosome profiling data, Xiao, Z., Huang, R., Xing, X., Chen, Y., Deng, H., and Yang, X.*, 2018
• Genome-wide assessment of differential translations with ribosome profiling data, Xiao, Z., Zou, Q., Liu, Y., and Yang, X.*, 2016