Professor | Jun Huang | Asia Growth Partners

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Name	Jun Huang
Contact Information	jhuang@zju.edu.cn
Language ability	English, Chinese
Province	Zhejiang

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Name

Jun Huang

Contact Information

jhuang@zju.edu.cn

Language ability

English, Chinese

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Life Sciences
Academic Background & Achievements	1997-2001: Bachelor of Microbiology, Nankai University 2001-2006: PhD in Cell Biology, Peking University 2006-2009: Postdoctoral Fellow, Yale University School of Medicine 2009-2010: Postdoctoral Fellow, MD Anderson Cancer Center Recipient of the National Science Fund for Distinguished Young Scholars Recipient of the Special Government Allowance of the State Council
Work Experience	2010-present: Professor, Researcher, Doctoral Supervisor at Zhejiang University, Institute of Life Sciences
Awards	2006: First Class Natural Science Award from the Ministry of Education (Sixth Contributor) 2010: Zhejiang Outstanding Young Scientist Award 2011: Top Ten Science and Technology Innovation New Talent Award of Zhejiang University 2012: Selected for the Ministry of Education's New Century Excellent Talents Program 2013: National Science Fund for Distinguished Young Scholars 2016: Special Government Allowance of the State Council 2017: First Class Natural Science Award of Zhejiang Province (First Contributor)

University/Lab Affiliation and Title

Zhejiang University

Faculty

Life Sciences

Academic Background & Achievements

1997-2001: Bachelor of Microbiology, Nankai University
2001-2006: PhD in Cell Biology, Peking University
2006-2009: Postdoctoral Fellow, Yale University School of Medicine
2009-2010: Postdoctoral Fellow, MD Anderson Cancer Center
Recipient of the National Science Fund for Distinguished Young Scholars
Recipient of the Special Government Allowance of the State Council

Work Experience

2010-present: Professor, Researcher, Doctoral Supervisor at Zhejiang University, Institute of Life Sciences

Awards

2006: First Class Natural Science Award from the Ministry of Education (Sixth Contributor)
2010: Zhejiang Outstanding Young Scientist Award
2011: Top Ten Science and Technology Innovation New Talent Award of Zhejiang University
2012: Selected for the Ministry of Education's New Century Excellent Talents Program
2013: National Science Fund for Distinguished Young Scholars
2016: Special Government Allowance of the State Council
2017: First Class Natural Science Award of Zhejiang Province (First Contributor)

Areas of Focus	Molecular mechanisms of tumor development Molecular mechanisms of DNA damage repair
Publications	The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection, Dong S, Han J, Chen H, Liu T, Huen M, Yang Y, Guo C, Huang J, 2014 AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway, Lou J, Chen H, Han J, He H, Huen M, Feng X, Liu T, Huang J, 2017 BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability, Han J, Ruan C, Huen M, Wang J, Xie A, Fu C, Liu T, Huang J, 2017 SLFN11 inhibits checkpoint maintenance and homologous recombination repair, Mu Y, Lou J, Srivastava M, Zhao B, Feng X, Liu T, Chen J, Huang J, 2015 Acetylation-dependent function of human single-stranded DNA binding protein 1, Wu Y, Chen H, Lu J, Zhang M, Zhang R, Duan T, Wang X, Huang J, Kang T, 2015 The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection, Dong S, Han J, Chen H, Liu T, Huen MS, Yang Y, Guo C, Huang J, 2014 Quality control of homologous recombination, Liu T, Huang J, 2014 Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA, Ren W, Chen H, Sun Q, Tang X, Lim S, Huang J, Haiwei Song, 2014 The PSO4 complex associates with RPA and modulates the activation of ATR, Wan L, Huang J, 2014 Defining the protein-protein interaction network of the human Hippo pathway, Wang W, Li X, Huang J, Feng L, Dolinta KG, Chen J, 2014 hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity, Wan L, Lou J, Xia Y, Su B, Liu T, Cui J, Sun Y, Lou H, Huang J, 2013 Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair, Wan L, Han J, Liu T, Dong S, Xie F, Chen H, Huang J, 2013 PTPN14 is required for the density-dependent control of YAP1, Wang, W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J, 2012 RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage, Liu T, Chen H, Kim H, Huen M, Chen J, Huang J, 2012 FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-links repair, Liu T, Ghosal G, Yuan J, Chen J, Huang J, 2010 Regulation of chromatin architecture by a PWWP domain-containing DNA damage responsive factor EXPAND1/MUM1, Huen M, Huang J, Leung J, Sy S, Leung K, Ching Y, Tsao S, Chen J, 2010 SOSS complexes participate in the maintenance of genomic stability, Huang J, Gong Z, Ghosal G, Chen J, 2009 MERIT40 facilitates BRCA1 localization and DNA damage repair, Feng L, Huang J, Chen J, 2009 RAD18 transmits DNA damage signaling to elicit homologous recombination repair, Huang J, Huen M, Kim H, Leung C, Glover J, Yu X, Chen J, 2009 GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth, Zhang B, Huang J, Li H, Liu T, Wang Y, Waterman P, Mao A, Xu L, Zhai Z, Liu D, Marrack P, Shu H, 2008 Noncanonical E2 Variant-Independent Function of UBC13 in Promoting Checkpoint Protein Assembly, Huen M, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J, 2008 Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression, Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen J, Tindall D, Chen J, 2008 VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation, Huang J, Chen J, 2008 CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response, Kim H, Huang J, Chen J, 2007 The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis, Huang J, Xu L, Liu T, Chen D, Zhai Z, Shu H, 2006 SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways, Huang J, Teng L, Li L, Liu T, Chen D, Xu L, Zhai Z, Shu H, 2005 ZNF216 Is an A20-like and IkappaB Kinase gamma-Interacting Inhibitor of NF-kappaB Activation, Huang J, Teng L, Liu T, Li L, Chen D, Li F, Xu L, Zhai Z, Shu H, 2004 Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription, Huang J, Teng L, Liu T, Li L, Chen D, Li F, Xu L, Zhai Z, Shu H, 2003

Areas of Focus

Molecular mechanisms of tumor development
Molecular mechanisms of DNA damage repair

Publications

The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection, Dong S, Han J, Chen H, Liu T, Huen M, Yang Y, Guo C, Huang J, 2014
AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway, Lou J, Chen H, Han J, He H, Huen M, Feng X, Liu T, Huang J, 2017
BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability, Han J, Ruan C, Huen M, Wang J, Xie A, Fu C, Liu T, Huang J, 2017
SLFN11 inhibits checkpoint maintenance and homologous recombination repair, Mu Y, Lou J, Srivastava M, Zhao B, Feng X, Liu T, Chen J, Huang J, 2015
Acetylation-dependent function of human single-stranded DNA binding protein 1, Wu Y, Chen H, Lu J, Zhang M, Zhang R, Duan T, Wang X, Huang J, Kang T, 2015
The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection, Dong S, Han J, Chen H, Liu T, Huen MS, Yang Y, Guo C, Huang J, 2014
Quality control of homologous recombination, Liu T, Huang J, 2014
Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA, Ren W, Chen H, Sun Q, Tang X, Lim S, Huang J, Haiwei Song, 2014
The PSO4 complex associates with RPA and modulates the activation of ATR, Wan L, Huang J, 2014
Defining the protein-protein interaction network of the human Hippo pathway, Wang W, Li X, Huang J, Feng L, Dolinta KG, Chen J, 2014
hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity, Wan L, Lou J, Xia Y, Su B, Liu T, Cui J, Sun Y, Lou H, Huang J, 2013
Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair, Wan L, Han J, Liu T, Dong S, Xie F, Chen H, Huang J, 2013
PTPN14 is required for the density-dependent control of YAP1, Wang, W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J, 2012
RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage, Liu T, Chen H, Kim H, Huen M, Chen J, Huang J, 2012
FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-links repair, Liu T, Ghosal G, Yuan J, Chen J, Huang J, 2010
Regulation of chromatin architecture by a PWWP domain-containing DNA damage responsive factor EXPAND1/MUM1, Huen M, Huang J, Leung J, Sy S, Leung K, Ching Y, Tsao S, Chen J, 2010
SOSS complexes participate in the maintenance of genomic stability, Huang J, Gong Z, Ghosal G, Chen J, 2009
MERIT40 facilitates BRCA1 localization and DNA damage repair, Feng L, Huang J, Chen J, 2009
RAD18 transmits DNA damage signaling to elicit homologous recombination repair, Huang J, Huen M, Kim H, Leung C, Glover J, Yu X, Chen J, 2009
GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth, Zhang B, Huang J, Li H, Liu T, Wang Y, Waterman P, Mao A, Xu L, Zhai Z, Liu D, Marrack P, Shu H, 2008
Noncanonical E2 Variant-Independent Function of UBC13 in Promoting Checkpoint Protein Assembly, Huen M, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J, 2008
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression, Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen J, Tindall D, Chen J, 2008
VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation, Huang J, Chen J, 2008
CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response, Kim H, Huang J, Chen J, 2007
The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis, Huang J, Xu L, Liu T, Chen D, Zhai Z, Shu H, 2006
SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways, Huang J, Teng L, Li L, Liu T, Chen D, Xu L, Zhai Z, Shu H, 2005
ZNF216 Is an A20-like and IkappaB Kinase gamma-Interacting Inhibitor of NF-kappaB Activation, Huang J, Teng L, Liu T, Li L, Chen D, Li F, Xu L, Zhai Z, Shu H, 2004
Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription, Huang J, Teng L, Liu T, Li L, Chen D, Li F, Xu L, Zhai Z, Shu H, 2003

Tumor Development Molecular Mechanisms Dna Damage Repair Research Oncology Cell Cycle Genomics Apoptosis Cancer

Changdong Lin - Tongji University

Haiyun Wang - Tongji University

Lei Xue - Tongji University

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