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Jun Huang
Life Science
Zhejiang University
Zhejiang
Language: English, Chinese
Tumor
Development
Molecular
Mechanisms
Dna
Damage
Repair
Research
Oncology
Cell Cycle
Genomics
Apoptosis
Cancer
Areas of Focus
- Molecular mechanisms of tumor development
- Molecular mechanisms of DNA damage repair
Work Experience
- 2010-present: Professor, Researcher, Doctoral Supervisor at Zhejiang University, Institute of Life Sciences
Academic Background & Achievements
- 1997-2001: Bachelor of Microbiology, Nankai University
- 2001-2006: PhD in Cell Biology, Peking University
- 2006-2009: Postdoctoral Fellow, Yale University School of Medicine
- 2009-2010: Postdoctoral Fellow, MD Anderson Cancer Center
- Recipient of the National Science Fund for Distinguished Young Scholars
- Recipient of the Special Government Allowance of the State Council
Publications
- The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection, Dong S, Han J, Chen H, Liu T, Huen M, Yang Y, Guo C, Huang J, 2014
- AUNIP/C1orf135 directs DNA double-strand breaks towards the homologous recombination repair pathway, Lou J, Chen H, Han J, He H, Huen M, Feng X, Liu T, Huang J, 2017
- BRCA2 antagonizes classical and alternative nonhomologous end-joining to prevent gross genomic instability, Han J, Ruan C, Huen M, Wang J, Xie A, Fu C, Liu T, Huang J, 2017
- SLFN11 inhibits checkpoint maintenance and homologous recombination repair, Mu Y, Lou J, Srivastava M, Zhao B, Feng X, Liu T, Chen J, Huang J, 2015
- Acetylation-dependent function of human single-stranded DNA binding protein 1, Wu Y, Chen H, Lu J, Zhang M, Zhang R, Duan T, Wang X, Huang J, Kang T, 2015
- The Human SRCAP Chromatin Remodeling Complex Promotes DNA-End Resection, Dong S, Han J, Chen H, Liu T, Huen MS, Yang Y, Guo C, Huang J, 2014
- Quality control of homologous recombination, Liu T, Huang J, 2014
- Structural Basis of SOSS1 Complex Assembly and Recognition of ssDNA, Ren W, Chen H, Sun Q, Tang X, Lim S, Huang J, Haiwei Song, 2014
- The PSO4 complex associates with RPA and modulates the activation of ATR, Wan L, Huang J, 2014
- Defining the protein-protein interaction network of the human Hippo pathway, Wang W, Li X, Huang J, Feng L, Dolinta KG, Chen J, 2014
- hPrimpol1/CCDC111 is a human DNA primase-polymerase required for the maintenance of genome integrity, Wan L, Lou J, Xia Y, Su B, Liu T, Cui J, Sun Y, Lou H, Huang J, 2013
- Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair, Wan L, Han J, Liu T, Dong S, Xie F, Chen H, Huang J, 2013
- PTPN14 is required for the density-dependent control of YAP1, Wang, W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J, 2012
- RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage, Liu T, Chen H, Kim H, Huen M, Chen J, Huang J, 2012
- FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-links repair, Liu T, Ghosal G, Yuan J, Chen J, Huang J, 2010
- Regulation of chromatin architecture by a PWWP domain-containing DNA damage responsive factor EXPAND1/MUM1, Huen M, Huang J, Leung J, Sy S, Leung K, Ching Y, Tsao S, Chen J, 2010
- SOSS complexes participate in the maintenance of genomic stability, Huang J, Gong Z, Ghosal G, Chen J, 2009
- MERIT40 facilitates BRCA1 localization and DNA damage repair, Feng L, Huang J, Chen J, 2009
- RAD18 transmits DNA damage signaling to elicit homologous recombination repair, Huang J, Huen M, Kim H, Leung C, Glover J, Yu X, Chen J, 2009
- GIDE is a mitochondrial E3 ubiquitin ligase that induces apoptosis and slows growth, Zhang B, Huang J, Li H, Liu T, Wang Y, Waterman P, Mao A, Xu L, Zhai Z, Liu D, Marrack P, Shu H, 2008
- Noncanonical E2 Variant-Independent Function of UBC13 in Promoting Checkpoint Protein Assembly, Huen M, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J, 2008
- Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression, Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen J, Tindall D, Chen J, 2008
- VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation, Huang J, Chen J, 2008
- CCDC98 is a BRCA1-BRCT domain–binding protein involved in the DNA damage response, Kim H, Huang J, Chen J, 2007
- The p53-inducible E3 ubiquitin ligase p53RFP induces p53-dependent apoptosis, Huang J, Xu L, Liu T, Chen D, Zhai Z, Shu H, 2006
- SIKE is an IKK-relative kinases-associated suppressor of TLR3- and virus-triggered IRF-3 activation pathways, Huang J, Teng L, Li L, Liu T, Chen D, Xu L, Zhai Z, Shu H, 2005
- ZNF216 Is an A20-like and IkappaB Kinase gamma-Interacting Inhibitor of NF-kappaB Activation, Huang J, Teng L, Liu T, Li L, Chen D, Li F, Xu L, Zhai Z, Shu H, 2004
- Identification of a novel serine/threonine kinase that inhibits TNF-induced NF-kappaB activation and p53-induced transcription, Huang J, Teng L, Liu T, Li L, Chen D, Li F, Xu L, Zhai Z, Shu H, 2003
Awards
- 2006: First Class Natural Science Award from the Ministry of Education (Sixth Contributor)
- 2010: Zhejiang Outstanding Young Scientist Award
- 2011: Top Ten Science and Technology Innovation New Talent Award of Zhejiang University
- 2012: Selected for the Ministry of Education's New Century Excellent Talents Program
- 2013: National Science Fund for Distinguished Young Scholars
- 2016: Special Government Allowance of the State Council
- 2017: First Class Natural Science Award of Zhejiang Province (First Contributor)
