Professor | Yongqun Zhu | Asia Growth Partners

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Name	Yongqun Zhu
Contact Information	zhuyongqun@zju.edu.cn
Language ability	English, Chinese
Province	Zhejiang

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Name

Yongqun Zhu

Contact Information

zhuyongqun@zju.edu.cn

Language ability

English, Chinese

Province

Zhejiang

University/Lab Affiliation and Title	Zhejiang University
Faculty	Life Sciences
Academic Background & Achievements	1998-2002 Bachelor: Nankai University 2002-2007 PhD: Institute of Biophysics, Chinese Academy of Sciences Recipient of various prestigious awards and grants
Work Experience	2007-2010 Postdoctoral Researcher: Beijing Institute of Life Sciences 2010-2012 Research Associate: Howard Hughes Medical Institute, USA 2012-2017 Professor, Researcher, Doctoral Supervisor: Zhejiang University, Life Sciences Institute 2017-present Long-term Appointed Professor, Senior Researcher, Doctoral Supervisor: Zhejiang University, Life Sciences Institute 2020-present Distinguished Professor: Zhejiang University
Awards	2021 Tan Jiazhen Life Science Innovation Award 2020 16th China Youth Science and Technology Award 2020 First Class Natural Science Award from the Ministry of Education 2019 National Outstanding Youth Science Fund recipient 2017 Zhejiang Province Science and Technology Innovation Leader 2017 Youth Top-notch Talent by the Organization Department 2016 Young Chang Jiang Scholar by the Ministry of Education 2015 Key Project Leader of the National Natural Science Foundation of China 2014 Newton Advanced Fellow by the Royal Society, UK 2013 Outstanding Young Scientist Grant by the National Science Foundation of China 2012 Zhejiang Province Outstanding Young Scientist Fund recipient 2007 Excellent PhD Graduate of the Chinese Academy of Sciences 2006 President's Excellent Scholarship of the Chinese Academy of Sciences

University/Lab Affiliation and Title

Zhejiang University

Faculty

Life Sciences

Academic Background & Achievements

1998-2002 Bachelor: Nankai University
2002-2007 PhD: Institute of Biophysics, Chinese Academy of Sciences
Recipient of various prestigious awards and grants

Work Experience

2007-2010 Postdoctoral Researcher: Beijing Institute of Life Sciences
2010-2012 Research Associate: Howard Hughes Medical Institute, USA
2012-2017 Professor, Researcher, Doctoral Supervisor: Zhejiang University, Life Sciences Institute
2017-present Long-term Appointed Professor, Senior Researcher, Doctoral Supervisor: Zhejiang University, Life Sciences Institute
2020-present Distinguished Professor: Zhejiang University

Awards

2021 Tan Jiazhen Life Science Innovation Award
2020 16th China Youth Science and Technology Award
2020 First Class Natural Science Award from the Ministry of Education
2019 National Outstanding Youth Science Fund recipient
2017 Zhejiang Province Science and Technology Innovation Leader
2017 Youth Top-notch Talent by the Organization Department
2016 Young Chang Jiang Scholar by the Ministry of Education
2015 Key Project Leader of the National Natural Science Foundation of China
2014 Newton Advanced Fellow by the Royal Society, UK
2013 Outstanding Young Scientist Grant by the National Science Foundation of China
2012 Zhejiang Province Outstanding Young Scientist Fund recipient
2007 Excellent PhD Graduate of the Chinese Academy of Sciences
2006 President's Excellent Scholarship of the Chinese Academy of Sciences

Areas of Focus	Mechanisms of pathogen regulation of host immune signaling pathways Role of microbiota in host immune responses Structural basis and applications of pathogen-host interactions
Publications	Legionella effector LnaB is a phosphoryl AMPylase that impairs phosphosignalling, Yongqun Zhu et al., 2024 Structural Basis of Assembly and Torque Transmission of the Bacterial Flagellar Motor, Yongqun Zhu et al., 2021 Nε-Fatty acylation of Rho GTPases by a MARTX toxin effector, Yongqun Zhu et al., 2017 A bacterial effector deubiquitinase specifically hydrolyses linear ubiquitin chains to inhibit host inflammatory signalling, Yongqun Zhu et al., 2019 Threonine ADP-ribosylation of ubiquitin by a bacterial effector family blocks host ubiquitination, Yongqun Zhu et al., 2020 Structural basis of Cas3 inhibition by the bacteriophage protein AcrF3, Yongqun Zhu et al., 2016 Structural insights into the roles of the IcmS-IcmW complex in the type IVb secretion system of Legionella pneumophila, Yongqun Zhu et al., 2017 35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope, Yongqun Zhu et al., 2022 Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses, Yongqun Zhu et al., 2012 Structural insights into the secretin translocation channel in the type II secretion system, Yongqun Zhu et al., 2017 Complex Structure of OspI and Ubc13: The Molecular Basis of Ubc13 Deamidation and Convergence of Bacterial and Host E2 Recognition, Yongqun Zhu et al., 2013 Crystal Structure of LGR4-Rspo1 Complex: Insights into the divergent mechanisms of ligand recognition by Leucine-rich G-protein-coupled receptors (LGRs), Yongqun Zhu et al., 2015 Modulation of Host Ubiquitination Pathways by Pathogenic Bacterial Effector Proteins, Yongqun Zhu et al., 2020 Subversion of Macrophage Functions by Bacterial Protein Toxins and Effectors, Yongqun Zhu et al., 2017 Diversity of bacterial manipulation of the host ubiquitin pathways, Yongqun Zhu et al., 2015 MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process, Yongqun Zhu et al., 2016 Legionella pneumophila balances ubiquitin transglutamination, Yongqun Zhu et al., 2020 Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly, Yongqun Zhu et al., 2015 Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP, Yongqun Zhu et al., 2013 Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA, Yongqun Zhu et al., 2010 A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle, Yongqun Zhu et al., 2009 Structure of a Shigella effector reveals a new class of ubiquitin ligases, Yongqun Zhu et al., 2008 Structural Insights into the Enzymatic Mechanism of the Pathogenic MAPK Phosphothreonine Lyase, Yongqun Zhu et al., 2007 Crystal Structure of Human Spermidine/Spermine N1-Acetyltransferase (hSSAT): The First Structure of a New Sequence Family of Transferase Homologous Superfamily, Yongqun Zhu et al., 2006 Crystal Structure of the Copper Homeostasis Protein (CutCm) from Shigella flexneri at 1.7 Å Resolution: The First Structure of a New Sequence Family of TIM Barrels, Yongqun Zhu et al., 2005 Optimizing Protein Crystal Growth through Dynamic Seeding, Yongqun Zhu et al., 2005 Purification and Preliminary Crystallographic Studies of CutC, a Novel Copper Homeostasis Protein from Shigella flexneri, Yongqun Zhu et al., 2005

Areas of Focus

Mechanisms of pathogen regulation of host immune signaling pathways
Role of microbiota in host immune responses
Structural basis and applications of pathogen-host interactions

Publications

Legionella effector LnaB is a phosphoryl AMPylase that impairs phosphosignalling, Yongqun Zhu et al., 2024
Structural Basis of Assembly and Torque Transmission of the Bacterial Flagellar Motor, Yongqun Zhu et al., 2021
Nε-Fatty acylation of Rho GTPases by a MARTX toxin effector, Yongqun Zhu et al., 2017
A bacterial effector deubiquitinase specifically hydrolyses linear ubiquitin chains to inhibit host inflammatory signalling, Yongqun Zhu et al., 2019
Threonine ADP-ribosylation of ubiquitin by a bacterial effector family blocks host ubiquitination, Yongqun Zhu et al., 2020
Structural basis of Cas3 inhibition by the bacteriophage protein AcrF3, Yongqun Zhu et al., 2016
Structural insights into the roles of the IcmS-IcmW complex in the type IVb secretion system of Legionella pneumophila, Yongqun Zhu et al., 2017
35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope, Yongqun Zhu et al., 2022
Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses, Yongqun Zhu et al., 2012
Structural insights into the secretin translocation channel in the type II secretion system, Yongqun Zhu et al., 2017
Complex Structure of OspI and Ubc13: The Molecular Basis of Ubc13 Deamidation and Convergence of Bacterial and Host E2 Recognition, Yongqun Zhu et al., 2013
Crystal Structure of LGR4-Rspo1 Complex: Insights into the divergent mechanisms of ligand recognition by Leucine-rich G-protein-coupled receptors (LGRs), Yongqun Zhu et al., 2015
Modulation of Host Ubiquitination Pathways by Pathogenic Bacterial Effector Proteins, Yongqun Zhu et al., 2020
Subversion of Macrophage Functions by Bacterial Protein Toxins and Effectors, Yongqun Zhu et al., 2017
Diversity of bacterial manipulation of the host ubiquitin pathways, Yongqun Zhu et al., 2015
MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process, Yongqun Zhu et al., 2016
Legionella pneumophila balances ubiquitin transglutamination, Yongqun Zhu et al., 2020
Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly, Yongqun Zhu et al., 2015
Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP, Yongqun Zhu et al., 2013
Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA, Yongqun Zhu et al., 2010
A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle, Yongqun Zhu et al., 2009
Structure of a Shigella effector reveals a new class of ubiquitin ligases, Yongqun Zhu et al., 2008
Structural Insights into the Enzymatic Mechanism of the Pathogenic MAPK Phosphothreonine Lyase, Yongqun Zhu et al., 2007
Crystal Structure of Human Spermidine/Spermine N1-Acetyltransferase (hSSAT): The First Structure of a New Sequence Family of Transferase Homologous Superfamily, Yongqun Zhu et al., 2006
Crystal Structure of the Copper Homeostasis Protein (CutCm) from Shigella flexneri at 1.7 Å Resolution: The First Structure of a New Sequence Family of TIM Barrels, Yongqun Zhu et al., 2005
Optimizing Protein Crystal Growth through Dynamic Seeding, Yongqun Zhu et al., 2005
Purification and Preliminary Crystallographic Studies of CutC, a Novel Copper Homeostasis Protein from Shigella flexneri, Yongqun Zhu et al., 2005

Pathogens Host Immune Signaling Proteins Mechanisms Microbiota Structural Biology Disease Therapy

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Huiyong Chen - Central South University

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