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Yongqun Zhu
Life Science
Zhejiang University
Zhejiang
Language: English, Chinese
Pathogens
Host
Immune
Signaling
Proteins
Mechanisms
Microbiota
Structural Biology
Disease
Therapy
Areas of Focus
- Mechanisms of pathogen regulation of host immune signaling pathways
- Role of microbiota in host immune responses
- Structural basis and applications of pathogen-host interactions
Work Experience
- 2007-2010 Postdoctoral Researcher: Beijing Institute of Life Sciences
- 2010-2012 Research Associate: Howard Hughes Medical Institute, USA
- 2012-2017 Professor, Researcher, Doctoral Supervisor: Zhejiang University, Life Sciences Institute
- 2017-present Long-term Appointed Professor, Senior Researcher, Doctoral Supervisor: Zhejiang University, Life Sciences Institute
- 2020-present Distinguished Professor: Zhejiang University
Academic Background & Achievements
- 1998-2002 Bachelor: Nankai University
- 2002-2007 PhD: Institute of Biophysics, Chinese Academy of Sciences
- Recipient of various prestigious awards and grants
Publications
- Legionella effector LnaB is a phosphoryl AMPylase that impairs phosphosignalling, Yongqun Zhu et al., 2024
- Structural Basis of Assembly and Torque Transmission of the Bacterial Flagellar Motor, Yongqun Zhu et al., 2021
- Nε-Fatty acylation of Rho GTPases by a MARTX toxin effector, Yongqun Zhu et al., 2017
- A bacterial effector deubiquitinase specifically hydrolyses linear ubiquitin chains to inhibit host inflammatory signalling, Yongqun Zhu et al., 2019
- Threonine ADP-ribosylation of ubiquitin by a bacterial effector family blocks host ubiquitination, Yongqun Zhu et al., 2020
- Structural basis of Cas3 inhibition by the bacteriophage protein AcrF3, Yongqun Zhu et al., 2016
- Structural insights into the roles of the IcmS-IcmW complex in the type IVb secretion system of Legionella pneumophila, Yongqun Zhu et al., 2017
- 35B5 antibody potently neutralizes SARS-CoV-2 Omicron by disrupting the N-glycan switch via a conserved spike epitope, Yongqun Zhu et al., 2022
- Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses, Yongqun Zhu et al., 2012
- Structural insights into the secretin translocation channel in the type II secretion system, Yongqun Zhu et al., 2017
- Complex Structure of OspI and Ubc13: The Molecular Basis of Ubc13 Deamidation and Convergence of Bacterial and Host E2 Recognition, Yongqun Zhu et al., 2013
- Crystal Structure of LGR4-Rspo1 Complex: Insights into the divergent mechanisms of ligand recognition by Leucine-rich G-protein-coupled receptors (LGRs), Yongqun Zhu et al., 2015
- Modulation of Host Ubiquitination Pathways by Pathogenic Bacterial Effector Proteins, Yongqun Zhu et al., 2020
- Subversion of Macrophage Functions by Bacterial Protein Toxins and Effectors, Yongqun Zhu et al., 2017
- Diversity of bacterial manipulation of the host ubiquitin pathways, Yongqun Zhu et al., 2015
- MLKL channel in necroptosis is octamer formed by tetramers in a dyadic process, Yongqun Zhu et al., 2016
- Legionella pneumophila balances ubiquitin transglutamination, Yongqun Zhu et al., 2020
- Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly, Yongqun Zhu et al., 2015
- Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP, Yongqun Zhu et al., 2013
- Structural mechanism of host Rab1 activation by the bifunctional Legionella type IV effector SidM/DrrA, Yongqun Zhu et al., 2010
- A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle, Yongqun Zhu et al., 2009
- Structure of a Shigella effector reveals a new class of ubiquitin ligases, Yongqun Zhu et al., 2008
- Structural Insights into the Enzymatic Mechanism of the Pathogenic MAPK Phosphothreonine Lyase, Yongqun Zhu et al., 2007
- Crystal Structure of Human Spermidine/Spermine N1-Acetyltransferase (hSSAT): The First Structure of a New Sequence Family of Transferase Homologous Superfamily, Yongqun Zhu et al., 2006
- Crystal Structure of the Copper Homeostasis Protein (CutCm) from Shigella flexneri at 1.7 Å Resolution: The First Structure of a New Sequence Family of TIM Barrels, Yongqun Zhu et al., 2005
- Optimizing Protein Crystal Growth through Dynamic Seeding, Yongqun Zhu et al., 2005
- Purification and Preliminary Crystallographic Studies of CutC, a Novel Copper Homeostasis Protein from Shigella flexneri, Yongqun Zhu et al., 2005
Awards
- 2021 Tan Jiazhen Life Science Innovation Award
- 2020 16th China Youth Science and Technology Award
- 2020 First Class Natural Science Award from the Ministry of Education
- 2019 National Outstanding Youth Science Fund recipient
- 2017 Zhejiang Province Science and Technology Innovation Leader
- 2017 Youth Top-notch Talent by the Organization Department
- 2016 Young Chang Jiang Scholar by the Ministry of Education
- 2015 Key Project Leader of the National Natural Science Foundation of China
- 2014 Newton Advanced Fellow by the Royal Society, UK
- 2013 Outstanding Young Scientist Grant by the National Science Foundation of China
- 2012 Zhejiang Province Outstanding Young Scientist Fund recipient
- 2007 Excellent PhD Graduate of the Chinese Academy of Sciences
- 2006 President's Excellent Scholarship of the Chinese Academy of Sciences
